pentamidine has been researched along with Disease Models, Animal in 55 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study is to investigate the possible role of a small molecule able to bind and inhibit S100B, pentamidine, in the modulation of disease progression in the relapsing-remitting experimental autoimmune encephalomyelitis mouse model of multiple sclerosis." | 7.96 | The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model. ( Amadio, S; Casalbore, P; Clementi, ME; Di Sante, G; Michetti, F; Ria, F; Sampaolese, B; Valentini, M; Volonté, C, 2020) |
| "Mice were divided into: control group, colitis group (4% DSS for four days) and two pentamidine-treated colitis groups (0." | 7.78 | The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice. ( Capoccia, E; Cirillo, C; Cuomo, R; Esposito, G; Sarnelli, G; Scuderi, C; Steardo, L, 2012) |
| " The aim of this study is to investigate the possible role of a small molecule able to bind and inhibit S100B, pentamidine, in the modulation of disease progression in the relapsing-remitting experimental autoimmune encephalomyelitis mouse model of multiple sclerosis." | 3.96 | The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model. ( Amadio, S; Casalbore, P; Clementi, ME; Di Sante, G; Michetti, F; Ria, F; Sampaolese, B; Valentini, M; Volonté, C, 2020) |
| "Mice were divided into: control group, colitis group (4% DSS for four days) and two pentamidine-treated colitis groups (0." | 3.78 | The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice. ( Capoccia, E; Cirillo, C; Cuomo, R; Esposito, G; Sarnelli, G; Scuderi, C; Steardo, L, 2012) |
| " The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia." | 3.74 | Carbamate prodrugs of N-alkylfuramidines. ( Boykin, DW; Hall, JE; Jones, SK; Rahmathullah, SM; Tidwell, RR, 2008) |
| "Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health." | 1.51 | Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model. ( Barrett, MP; de Koning, HP; Gillingwater, K; Giordani, F; Khalaf, AI; Munday, JC; Scott, FJ; Suckling, CJ, 2019) |
| "Pentamidine is an effective antimicrobial agent against several human pathogens, but studies have also suggested that this drug inhibits inflammation." | 1.46 | Pentamidine blocks hepatotoxic injury in mice. ( Choi, JH; Cingolani, F; Czaja, MJ; Ilyas, G; Ravenelle, F; Tanaka, KE; Zhao, E, 2017) |
| "Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection." | 1.42 | Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. ( Boykin, DW; Bridges, AS; Brun, R; Ching, S; Gem, CO; Jones, SK; Liu, Q; Murilla, GA; Mutuku, JN; Paine, MF; Thuita, JK; Tidwell, RR; Wang, MZ; Wolf, KK, 2015) |
| "African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei." | 1.42 | Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis. ( Arias, JL; de Koning, HP; Garcia-Salcedo, JA; Hernández-Quero, J; Maceira, J; Magez, S; Muñóz-Torres, M; Ortiz-González, M; Soriano, M; Unciti-Broceta, JD, 2015) |
| "Pentamidine was radioiodinated with (131)I." | 1.40 | Evaluation of (131)I-pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters. ( Bekiş, R; Er, Ö; Eren, MŞ; Girginkardeşler, N; Inceboz, T; Lambrecht, FY; Özbilgin, A; Yilmaz, O, 2014) |
| "Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis." | 1.40 | Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi. ( Campos-Estrada, C; Díaz, MV; López-Muñoz, R; Maya, JD; Miranda, MR; Pereira, CA; Reigada, C, 2014) |
| " Furthermore, these compounds distributed to target tissues (liver and spleen) and had a moderate oral bioavailability (up to 25%), a large volume of distribution, and an elimination half-life ranging from 1 to 2 days in mice." | 1.36 | Novel arylimidamides for treatment of visceral leishmaniasis. ( Boykin, DW; Hall, JE; Kyle, DE; Liu, Q; Madhubala, R; Mandal, S; Munde, M; Pandharkar, T; Parman, T; Riccio, E; Srivastava, A; Stephens, CE; Sweat, JM; Tidwell, RR; Wang, MZ; Werbovetz, KA; Wilson, WD; Zhu, X, 2010) |
| " The amidoxime and N-methoxyamidine of 5a were the only produgs to provide cures (1/4 cures) in the same mouse model on oral dosage at 4x25mg/kg." | 1.36 | Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. ( Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD, 2010) |
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| " Fourteen compounds without previously known ototoxicity were discovered to be selectively toxic to hair cells." | 1.35 | Using the zebrafish lateral line to screen for ototoxicity. ( Chiu, LL; Cunningham, LL; Ou, HC; Raible, DW; Rubel, EW, 2008) |
| "The efficiency of antileishmanial agents may be enhanced by improving their bioavailability with a colloidal drug carrier." | 1.29 | Action of pentamidine-bound nanoparticles against Leishmania on an in vivo model. ( Astier, A; Bories, C; Deniau, M; Durand, R; Fusai, T; Houin, R; Paul, M; Rivollet, D, 1994) |
| "Pentamidine treatment did not interfere with the phagocytic ability of AM phi." | 1.28 | Pneumocystis carinii induction of tumor necrosis factor-alpha by alveolar macrophages: modulation by pentamidine isethionate. ( Corsini, E; Craig, WA; Dykstra, C; Rosenthal, GJ; Tidwell, RR, 1992) |
| "Pentamidine was administered three times weekly via a Bird micronebulizer." | 1.27 | Pentamidine aerosol in prophylaxis and treatment of murine Pneumocystis carinii pneumonia. ( Brun-Pascaud, M; Farinotti, R; Girard, PM; Kernbaum, S; Tamisier, L, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.45) | 18.7374 |
| 1990's | 8 (14.55) | 18.2507 |
| 2000's | 15 (27.27) | 29.6817 |
| 2010's | 25 (45.45) | 24.3611 |
| 2020's | 4 (7.27) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez, JL | 1 |
| Stephens, CE | 2 |
| Wenzler, T | 7 |
| Brun, R | 10 |
| Tanious, FA | 1 |
| Wilson, WD | 6 |
| Barszcz, T | 2 |
| Werbovetz, KA | 4 |
| Boykin, DW | 9 |
| Rahmathullah, SM | 1 |
| Tidwell, RR | 10 |
| Jones, SK | 3 |
| Hall, JE | 4 |
| Shilabin, AG | 1 |
| Kasanah, N | 1 |
| Tekwani, BL | 2 |
| Hamann, MT | 1 |
| Bakunov, SA | 2 |
| Bakunova, SM | 2 |
| Samoylenko, V | 1 |
| Ashfaq, MK | 1 |
| Jacob, MR | 1 |
| Khan, SI | 1 |
| Manly, SP | 1 |
| Joshi, VC | 1 |
| Walker, LA | 1 |
| Muhammad, I | 1 |
| Ghebru, M | 1 |
| Wang, MZ | 3 |
| Zhu, X | 1 |
| Srivastava, A | 1 |
| Liu, Q | 2 |
| Sweat, JM | 1 |
| Pandharkar, T | 1 |
| Riccio, E | 1 |
| Parman, T | 1 |
| Munde, M | 2 |
| Mandal, S | 1 |
| Madhubala, R | 1 |
| Kyle, DE | 1 |
| Branowska, D | 1 |
| Farahat, AA | 2 |
| Kumar, A | 3 |
| Liu, Y | 1 |
| Ismail, MA | 2 |
| Bialy, SA | 1 |
| Nanjunda, R | 1 |
| Hu, L | 1 |
| Patel, A | 1 |
| Bondada, L | 1 |
| Yang, S | 1 |
| Thompson, AM | 1 |
| Marshall, AJ | 1 |
| Maes, L | 1 |
| Yarlett, N | 1 |
| Bacchi, CJ | 1 |
| Gaukel, E | 1 |
| Wring, SA | 1 |
| Launay, D | 1 |
| Braillard, S | 1 |
| Chatelain, E | 1 |
| Mowbray, CE | 1 |
| Denny, WA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Di Sante, G | 1 |
| Amadio, S | 1 |
| Sampaolese, B | 1 |
| Clementi, ME | 1 |
| Valentini, M | 1 |
| Volonté, C | 1 |
| Casalbore, P | 1 |
| Ria, F | 1 |
| Michetti, F | 1 |
| Cardoso Santos, C | 1 |
| Meuser Batista, M | 1 |
| Inam Ullah, A | 1 |
| Rama Krishna Reddy, T | 1 |
| Soeiro, MNC | 1 |
| Ndung'u, K | 1 |
| Murilla, GA | 3 |
| Thuita, JK | 3 |
| Ngae, GN | 1 |
| Auma, JE | 1 |
| Gitonga, PK | 1 |
| Thungu, DK | 1 |
| Kurgat, RK | 1 |
| Chemuliti, JK | 1 |
| Mdachi, RE | 2 |
| Klein, MG | 1 |
| Shou, M | 1 |
| Stohlman, J | 1 |
| Solhjoo, S | 1 |
| Haigney, M | 1 |
| Goldstein, RE | 1 |
| Flagg, TP | 1 |
| Haigney, MC | 1 |
| Zhao, E | 1 |
| Ilyas, G | 1 |
| Cingolani, F | 1 |
| Choi, JH | 1 |
| Ravenelle, F | 1 |
| Tanaka, KE | 1 |
| Czaja, MJ | 1 |
| Yenigun, VB | 1 |
| Sirito, M | 1 |
| Amcheslavky, A | 1 |
| Czernuszewicz, T | 1 |
| Colonques-Bellmunt, J | 1 |
| García-Alcover, I | 1 |
| Wojciechowska, M | 1 |
| Bolduc, C | 1 |
| Chen, Z | 1 |
| López Castel, A | 1 |
| Krahe, R | 1 |
| Bergmann, A | 1 |
| Paul, A | 1 |
| Gillingwater, K | 3 |
| Giordani, F | 1 |
| Khalaf, AI | 1 |
| Munday, JC | 1 |
| de Koning, HP | 4 |
| Suckling, CJ | 1 |
| Barrett, MP | 2 |
| Scott, FJ | 1 |
| Muñoz, BY | 1 |
| Mantilla, JC | 1 |
| Escobar, P | 1 |
| Ihn, HJ | 1 |
| Kim, K | 1 |
| Cho, HS | 1 |
| Park, EK | 1 |
| Valle, IV | 1 |
| Machado, ME | 1 |
| Araújo, CDCB | 1 |
| da Cunha-Junior, EF | 1 |
| da Silva Pacheco, J | 1 |
| Torres-Santos, EC | 1 |
| da Silva, LCRP | 1 |
| Cabral, LM | 1 |
| do Carmo, FA | 1 |
| Sathler, PC | 1 |
| Barros, NB | 1 |
| Migliaccio, V | 1 |
| Facundo, VA | 1 |
| Ciancaglini, P | 1 |
| Stábeli, RG | 1 |
| Nicolete, R | 1 |
| Silva-Jardim, I | 1 |
| Coonrod, LA | 1 |
| Nakamori, M | 2 |
| Wang, W | 1 |
| Carrell, S | 1 |
| Hilton, CL | 1 |
| Bodner, MJ | 1 |
| Siboni, RB | 1 |
| Docter, AG | 1 |
| Haley, MM | 1 |
| Thornton, CA | 2 |
| Berglund, JA | 2 |
| Inceboz, T | 1 |
| Lambrecht, FY | 1 |
| Eren, MŞ | 1 |
| Girginkardeşler, N | 1 |
| Bekiş, R | 1 |
| Yilmaz, O | 1 |
| Er, Ö | 1 |
| Özbilgin, A | 1 |
| Díaz, MV | 1 |
| Miranda, MR | 1 |
| Campos-Estrada, C | 1 |
| Reigada, C | 1 |
| Maya, JD | 1 |
| Pereira, CA | 1 |
| López-Muñoz, R | 1 |
| Wolf, KK | 1 |
| Bridges, AS | 1 |
| Mutuku, JN | 1 |
| Gem, CO | 1 |
| Ching, S | 1 |
| Paine, MF | 1 |
| Unciti-Broceta, JD | 1 |
| Arias, JL | 1 |
| Maceira, J | 1 |
| Soriano, M | 1 |
| Ortiz-González, M | 1 |
| Hernández-Quero, J | 1 |
| Muñóz-Torres, M | 1 |
| Magez, S | 1 |
| Garcia-Salcedo, JA | 1 |
| Cirillo, C | 2 |
| Capoccia, E | 2 |
| Iuvone, T | 1 |
| Cuomo, R | 2 |
| Sarnelli, G | 2 |
| Steardo, L | 2 |
| Esposito, G | 2 |
| Chakraborty, M | 1 |
| Selma-Soriano, E | 1 |
| Magny, E | 1 |
| Couso, JP | 1 |
| Pérez-Alonso, M | 1 |
| Charlet-Berguerand, N | 1 |
| Artero, R | 1 |
| Llamusi, B | 1 |
| Stokes, JM | 1 |
| MacNair, CR | 1 |
| Ilyas, B | 1 |
| French, S | 1 |
| Côté, JP | 1 |
| Bouwman, C | 1 |
| Farha, MA | 1 |
| Sieron, AO | 1 |
| Whitfield, C | 1 |
| Coombes, BK | 1 |
| Brown, ED | 1 |
| Kagira, JM | 1 |
| Ngotho, JM | 1 |
| Ndung'u, JM | 1 |
| Sanderson, L | 1 |
| Dogruel, M | 1 |
| Rodgers, J | 1 |
| Thomas, SA | 1 |
| Anbazhagan, M | 1 |
| Warf, MB | 1 |
| Matthys, CM | 1 |
| Cooper, TA | 1 |
| Scuderi, C | 1 |
| Lionakis, MS | 1 |
| Chamilos, G | 1 |
| Lewis, RE | 1 |
| Wiederhold, NP | 1 |
| Raad, II | 1 |
| Samonis, G | 1 |
| Kontoyiannis, DP | 1 |
| Anene, BM | 1 |
| Ezeokonkwo, RC | 1 |
| Mmesirionye, TI | 1 |
| Tettey, JN | 1 |
| Brock, JM | 1 |
| Cushion, MT | 1 |
| Walzer, PD | 1 |
| Ashbaugh, A | 1 |
| Rebholz, S | 1 |
| Brubaker, R | 1 |
| Vanden Eynde, JJ | 1 |
| Mayence, A | 1 |
| Huang, TL | 1 |
| Chiu, LL | 1 |
| Cunningham, LL | 1 |
| Raible, DW | 1 |
| Rubel, EW | 1 |
| Ou, HC | 1 |
| Hughes, WT | 1 |
| Killmar, JT | 1 |
| Oz, HS | 1 |
| Murray, HW | 1 |
| Hariprashad, J | 1 |
| Fichtl, RE | 1 |
| Dreyfuss, G | 1 |
| Pénicaut, B | 1 |
| Nicolas, JA | 1 |
| Craciunescu, D | 1 |
| Loiseau, P | 1 |
| Fusai, T | 2 |
| Deniau, M | 3 |
| Durand, R | 3 |
| Bories, C | 2 |
| Paul, M | 3 |
| Rivollet, D | 3 |
| Astier, A | 3 |
| Houin, R | 3 |
| Boulard, Y | 1 |
| Fessi, H | 1 |
| Loiseau, PM | 1 |
| Gutierrez-Rios, MT | 1 |
| De Frutos, MI | 1 |
| Craciunescu, DG | 1 |
| Chandler, FW | 1 |
| McClure, HM | 1 |
| Campbell, WG | 1 |
| Watts, JC | 1 |
| Corsini, E | 1 |
| Dykstra, C | 1 |
| Craig, WA | 1 |
| Rosenthal, GJ | 1 |
| Geratz, JD | 1 |
| Ohemeng, KA | 1 |
| Bell, CA | 1 |
| Berger, BJ | 1 |
| Debs, RJ | 1 |
| Blumenfeld, W | 1 |
| Brunette, EN | 1 |
| Straubinger, RM | 1 |
| Montgomery, AB | 1 |
| Lin, E | 1 |
| Agabian, N | 1 |
| Papahadjopoulos, D | 1 |
| Girard, PM | 1 |
| Brun-Pascaud, M | 1 |
| Farinotti, R | 1 |
| Tamisier, L | 1 |
| Kernbaum, S | 1 |
55 other studies available for pentamidine and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
Topics: Animals; Antiparasitic Agents; Disease Models, Animal; Guanidines; Leishmania; Mice; Molecular Struc | 2007 |
Carbamate prodrugs of N-alkylfuramidines.
Topics: Animals; Benzamidines; Carbamates; Cysts; Disease Models, Animal; Furans; Lung; Pneumocystis carinii | 2008 |
Kinetic studies and bioactivity of potential manzamine prodrugs.
Topics: Administration, Oral; Animals; Antimalarials; Candida albicans; Carbolines; Chlorocebus aethiops; Cr | 2008 |
Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.
Topics: Animals; Antiprotozoal Agents; Benzofurans; Cations; Disease Models, Animal; Leishmania; Mice; Molec | 2008 |
Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.
Topics: Animals; Anti-Infective Agents; Antiparasitic Agents; Aspergillus fumigatus; Brain; Candida albicans | 2009 |
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles.
Topics: Amidines; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Disease Models, Animal; Female; L | 2010 |
Novel arylimidamides for treatment of visceral leishmaniasis.
Topics: Amidines; Animals; Antiprotozoal Agents; Biological Availability; Cricetinae; Disease Models, Animal | 2010 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Pro | 2010 |
Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Mice; Pentamidine; Plasmodium falciparum; Try | 2011 |
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Ani | 2013 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mic | 2018 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model.
Topics: Animals; Brain; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Ex | 2020 |
Drug screening using shape-based virtual screening and
Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Cells, Cultured; Disease Models, Animal; Drug Evaluat | 2021 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentam | 2020 |
Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart.
Topics: Action Potentials; Animals; Disease Models, Animal; Heart Failure; Heart Ventricles; Myocytes, Cardi | 2017 |
Pentamidine blocks hepatotoxic injury in mice.
Topics: Animals; Biopsy, Needle; Blotting, Western; Cytokines; Disease Models, Animal; Galactosamine; Immuno | 2017 |
(CCUG)
Topics: Animals; Apoptosis; Disease Models, Animal; DNA Repeat Expansion; Drosophila melanogaster; Drosophil | 2017 |
Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity.
Topics: Animals; Benzimidazoles; Cell Survival; Disease Models, Animal; Indoles; Mice; Parasitic Sensitivity | 2018 |
In vitro and in vivo efficacy of diamidines against Trypanosoma equiperdum strains.
Topics: Animals; Disease Models, Animal; Dourine; Drug Resistance; Female; Horse Diseases; Horses; Mice; Neg | 2018 |
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.
Topics: Animals; Cell Cycle; Disease Models, Animal; Metabolomics; Mice; Pentamidine; Structure-Activity Rel | 2019 |
Therapeutic response and safety of the topical, sequential use of antiseptic, keratolytic, and pentamidine creams (3-PACK) on Leishmania (Viannia) braziliensis-infected mice.
Topics: Animals; Anti-Infective Agents, Local; Chlorhexidine; Disease Models, Animal; Drug Therapy, Combinat | 2019 |
Pentamidine Inhibits Titanium Particle-Induced Osteolysis
Topics: Animals; Cell Differentiation; Cell Survival; Disease Models, Animal; Macrophages; Male; Mice; Mice, | 2019 |
Oral pentamidine-loaded poly(d,l-lactic-co-glycolic) acid nanoparticles: an alternative approach for leishmaniasis treatment.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Biological Availability; Disease Models, Animal | 2019 |
Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: macrophage as target cell.
Topics: Animals; Antiprotozoal Agents; Combretum; Disease Models, Animal; Interleukin-10; Interleukin-12; Le | 2013 |
Reducing levels of toxic RNA with small molecules.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Male; Mice; Myotonic Dystrophy; Pentamidin | 2013 |
Evaluation of (131)I-pentamidine for scintigraphy of experimentally Leishmania tropica-infected hamsters.
Topics: Animals; Disease Models, Animal; Iodine Radioisotopes; Leishmania tropica; Leishmaniasis, Cutaneous; | 2014 |
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Biological Transport; Cell Survival; Chagas Disease; Disease Models, | 2014 |
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.
Topics: Amidines; Animals; Chlorocebus aethiops; Disease Models, Animal; Furans; Humans; Mice; Neglected Dis | 2015 |
Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.
Topics: Animals; Antibodies, Protozoan; Chitosan; Disease Models, Animal; Drug Carriers; Drug Resistance; El | 2015 |
S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Densitometry; Dinoprostone; Disease M | 2015 |
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.
Topics: Animals; Arrhythmias, Cardiac; Diastole; Disease Models, Animal; Drosophila melanogaster; Drosophila | 2015 |
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Colistin; Disease | 2017 |
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.
Topics: Administration, Oral; Animals; Benzamidines; Chlorocebus aethiops; Disease Models, Animal; Dose-Resp | 2009 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model.
Topics: Animals; Disease Models, Animal; Female; Mice; Parasitic Sensitivity Tests; Pentamidine; Trypanocida | 2009 |
Pentamidine reverses the splicing defects associated with myotonic dystrophy.
Topics: Alternative Splicing; Animals; Disease Models, Animal; HeLa Cells; Humans; Mice; Myotonic Dystrophy; | 2009 |
Chemical reversal of the RNA gain of function in myotonic dystrophy.
Topics: Alternative Splicing; Animals; Disease Models, Animal; Humans; Mice; Myotonic Dystrophy; Pentamidine | 2009 |
The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice.
Topics: Animals; Antiprotozoal Agents; Colitis; Colon; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Dise | 2012 |
Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Fusarium; Lung Diseases, Fungal; Mice; Mice, Inb | 2006 |
A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.
Topics: Animals; Diminazene; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Resistance | 2006 |
In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.
Topics: Alkanes; Animals; Antifungal Agents; Benzamidines; Disease Models, Animal; Humans; Immunocompromised | 2006 |
Using the zebrafish lateral line to screen for ototoxicity.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluatio | 2008 |
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.
Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Tria | 1994 |
Treatment of experimental visceral leishmaniasis in a T-cell-deficient host: response to amphotericin B and pentamidine.
Topics: Amphotericin B; Animals; Disease Models, Animal; Female; Immunocompromised Host; Immunosuppression T | 1993 |
Trypanocidal activity and platinum plasma kinetics of cis-Pt pentamidine iodide in Trypanosoma brucei sheep model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Iodides; Male; Organoplatinum Com | 1993 |
Action of pentamidine-bound nanoparticles against Leishmania on an in vivo model.
Topics: Animals; Antimony; Antiprotozoal Agents; Colloids; Disease Models, Animal; Drug Carriers; Female; Le | 1994 |
Ultrastructural changes in parasites induced by nanoparticle-bound pentamidine in a Leishmania major/mouse model.
Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Drug Carriers; Kupffer Cells; Leishmania majo | 1997 |
Activity of pentamidine-loaded poly (D,L-lactide) nanoparticles against Leishmania infantum in a murine model.
Topics: Animals; Antiprotozoal Agents; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Re | 1997 |
Structure-activity relationships for new organometallic complexes active against bloodstream forms of Trypanosoma brucei brucei.
Topics: Animals; Disease Models, Animal; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Orga | 2001 |
Pulmonary pneumocystosis in nonhuman primates.
Topics: Animals; Aotus trivirgatus; Disease Models, Animal; Haplorhini; Lung; Male; Monkey Diseases; Pan tro | 1976 |
Pneumocystis carinii induction of tumor necrosis factor-alpha by alveolar macrophages: modulation by pentamidine isethionate.
Topics: Animals; Disease Models, Animal; Female; Interferon-gamma; L-Lactate Dehydrogenase; Macrophage Activ | 1992 |
Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia.
Topics: Animals; Disease Models, Animal; DNA, Fungal; Dose-Response Relationship, Drug; Drug Design; Giardia | 1990 |
Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.
Topics: Aerosols; Amidines; Animals; Disease Models, Animal; Immunosuppression Therapy; Injections, Intraven | 1987 |
Pentamidine aerosol in prophylaxis and treatment of murine Pneumocystis carinii pneumonia.
Topics: Aerosols; Amidines; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; Disease Mo | 1987 |