pentamidine has been researched along with Central Nervous System Toxoplasmosis in 17 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 9.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| " However, the impact of PCP prophylaxis on the incidence of bacterial pneumonia in HIV-positive patients using pentamidine or co-trimoxazole is still unknown." | 7.70 | [Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine]. ( Braun, J; Dalhoff, K; Friedrich, HJ; Kämmerer, R; Koch, A; Kothe, H, 1998) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 7.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 6.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 5.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| " However, the impact of PCP prophylaxis on the incidence of bacterial pneumonia in HIV-positive patients using pentamidine or co-trimoxazole is still unknown." | 3.70 | [Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine]. ( Braun, J; Dalhoff, K; Friedrich, HJ; Kämmerer, R; Koch, A; Kothe, H, 1998) |
| "No patient in the trimethoprim-sulfamethoxazole group and no patient seronegative for Toxoplasma gondii developed toxoplasmic encephalitis, compared with 12 of 36 (33%; 95% Cl, 19% to 51%) seropositive patients in the pentamidine group (trimethoprim-sulfamethoxazole compared with pentamidine, P = 0." | 3.68 | Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS. ( Brew, BJ; Carr, A; Cooper, DA; Harkness, JL; Marriott, DJ; Penny, R; Tindall, B, 1992) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 3.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "The prevention of cerebral toxoplasmosis and of Pneumocystis carinii pneumonia is an essential objective in the management of patients infected with HIV." | 2.68 | Prevention of Pneumocystis carinii pneumonia and of cerebral toxoplasmosis by roxithromycin in HIV-infected patients. ( Carles, M; Dellamonica, P; Durant, J; Hazime, F; Pechere, JC, 1995) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 2.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| "Nineteen episodes of cerebral toxoplasmosis were diagnosed during the study." | 2.67 | Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. LFPMI Study Group. Ligue Française de Prévention des Maladies Infectieuses. ( Beuscart, C; Borsa Lebas, F; Canton, P; Leclercq, P; Marchou, B; May, T; Micoud, M; Mouton, Y; Reynes, J; Saba, J, 1994) |
| "The risk to develop cerebral toxoplasmosis appeared significantly higher in the group of patients who stopped sulfamethoxazole-trimethoprim consecutively to cutaneous hypersensitivity." | 1.30 | [Cerebral toxoplasmosis in HIV infected patients intolerant of cotrimoxazole]. ( Beuscart, C; Canton, P; Leport, C; May, T; Rabaud, C; Reynes, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (88.24) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bejjanki, H | 1 |
| Olaoye, OA | 1 |
| Santos, AH | 1 |
| Koratala, A | 1 |
| Opravil, M | 2 |
| Pechère, M | 2 |
| Lazzarin, A | 3 |
| Heald, A | 2 |
| Rüttimann, S | 2 |
| Iten, A | 2 |
| Furrer, H | 1 |
| Oertle, D | 2 |
| Praz, G | 2 |
| Vuitton, DA | 1 |
| Hirschel, B | 1 |
| von Overbeck, J | 1 |
| Durant, J | 1 |
| Hazime, F | 1 |
| Carles, M | 1 |
| Pechere, JC | 1 |
| Dellamonica, P | 1 |
| Torres, RA | 1 |
| Barr, M | 1 |
| Thorn, M | 1 |
| Gregory, G | 1 |
| Kiely, S | 1 |
| Chanin, E | 1 |
| Carlo, C | 1 |
| Martin, M | 1 |
| Thornton, J | 1 |
| Tocchetti, A | 1 |
| Tambini, R | 1 |
| Allegro, A | 1 |
| Longoni, E | 1 |
| Rinaldi, E | 1 |
| May, T | 2 |
| Beuscart, C | 2 |
| Reynes, J | 2 |
| Marchou, B | 1 |
| Leclercq, P | 1 |
| Borsa Lebas, F | 1 |
| Saba, J | 1 |
| Micoud, M | 1 |
| Mouton, Y | 1 |
| Canton, P | 2 |
| Mallolas, J | 1 |
| Zamora, L | 1 |
| Gatell, JM | 1 |
| Miró, JM | 1 |
| Vernet, E | 1 |
| Valls, ME | 1 |
| Soriano, E | 1 |
| SanMiguel, JG | 1 |
| Girard, PM | 1 |
| Landman, R | 1 |
| Gaudebout, C | 2 |
| Olivares, R | 1 |
| Saimot, AG | 1 |
| Jelazko, P | 1 |
| Certain, A | 1 |
| Boué, F | 1 |
| Bouvet, E | 1 |
| Antinori, A | 2 |
| Murri, R | 1 |
| Ammassari, A | 1 |
| De Luca, A | 2 |
| Linzalone, A | 1 |
| Cingolani, A | 1 |
| Damiano, F | 1 |
| Maiuro, G | 1 |
| Vecchiet, J | 1 |
| Scoppettuolo, G | 1 |
| Rizzardi, GP | 1 |
| Musicco, M | 1 |
| Frigerio, D | 1 |
| Maillard, M | 1 |
| Lucchini, M | 1 |
| Moroni, M | 2 |
| Bossi, P | 1 |
| Caumes, E | 1 |
| Astagneau, P | 1 |
| Li, TS | 1 |
| Paris, L | 1 |
| Mengual, X | 1 |
| Katlama, C | 1 |
| Bricaire, F | 1 |
| Koch, A | 1 |
| Kothe, H | 1 |
| Braun, J | 1 |
| Kämmerer, R | 1 |
| Friedrich, HJ | 1 |
| Dalhoff, K | 1 |
| Mussini, C | 1 |
| Pezzotti, P | 1 |
| Govoni, A | 1 |
| Borghi, V | 1 |
| d'Arminio Monforte, A | 1 |
| Mongiardo, N | 1 |
| Cerri, MC | 1 |
| Chiodo, F | 1 |
| Concia, E | 1 |
| Bonazzi, L | 1 |
| Ortona, L | 1 |
| Esposito, R | 1 |
| Cossarizza, A | 1 |
| De Rienzo, B | 1 |
| Rabaud, C | 1 |
| Leport, C | 1 |
| Carr, A | 1 |
| Tindall, B | 1 |
| Brew, BJ | 1 |
| Marriott, DJ | 1 |
| Harkness, JL | 1 |
| Penny, R | 1 |
| Cooper, DA | 1 |
| Köppen, S | 1 |
| Grünewald, T | 1 |
| Jautzke, G | 1 |
| Gottschalk, J | 1 |
| Pohle, HD | 1 |
| Ruf, B | 1 |
11 trials available for pentamidine and Central Nervous System Toxoplasmosis
| Article | Year |
|---|---|
Dapsone/pyrimethamine may prevent mycobacterial disease in immunosuppressed patients infected with the human immunodeficiency virus.
Topics: Adult; CD4 Lymphocyte Count; Dapsone; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Huma | 1995 |
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients.
Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Animals; Dapsone; Drug Adm | 1995 |
Prevention of Pneumocystis carinii pneumonia and of cerebral toxoplasmosis by roxithromycin in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Candidiasis; Digestive System; Drug Therapy, Combinati | 1995 |
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Dapsone; Encephalitis; Female; Humans; Male; | 1993 |
Four different regimens for prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Dapsone; Drug Therapy, Combination; Female; Follow-Up | 1994 |
Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. LFPMI Study Group. Ligue Française de Prévention des Maladies Infectieuses.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Female; Follow-Up Studies; HIV Infections; H | 1994 |
Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Dapsone; Drug Therapy, Co | 1993 |
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group.
Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence | 1993 |
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe | 1995 |
Risks and benefits of aerosolized pentamidine and cotrimoxazole in primary prophylaxis of Pneumocystis carinii pneumonia in HIV-1-infected patients: a two-year Italian multicentric randomized controlled trial. The Italian PCP Study Group.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Female; HIV-1; Humans; Male; Pentamidine; Pn | 1996 |
Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type I-infected patients: the changes in opportunistic prophylaxis study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Anti-HIV Age | 2000 |
6 other studies available for pentamidine and Central Nervous System Toxoplasmosis
| Article | Year |
|---|---|
Liver transplant, toxoplasmosis and kidney stones: connecting the dots.
Topics: Aftercare; Antimalarials; Antiprotozoal Agents; Atovaquone; Brain; Brain Edema; Female; Humans; Kidn | 2019 |
[Epidemiologic characteristics of cerebral toxoplasmosis in 399 HIV-infected patients followed between 1983 and 1994].
Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antibodies, Protozoan; | 1998 |
[Incidence of bacterial pneumonia in HIV-positive patients treated with preventive co-trimoxazole or pentamidine].
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Agents; CD4 Lymphocy | 1998 |
[Cerebral toxoplasmosis in HIV infected patients intolerant of cotrimoxazole].
Topics: AIDS-Related Opportunistic Infections; Drug Eruptions; Drug Therapy, Combination; Follow-Up Studies; | 1998 |
Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Protozoan; CD4-Positive T-Lymphocytes; Ence | 1992 |
Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine.
Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Encephalitis; Female; HIV Infe | 1992 |