pentamidine has been researched along with Brain Inflammation in 8 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 9.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 7.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 6.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| "To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)." | 5.08 | Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995) |
| "In a meta-analysis, we examined the efficacy of aerosolized pentamidine, trimethoprim-sulfamethoxazole, and dapsone or dapsone/pyrimethamine for the prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in patients with HIV infection." | 4.79 | Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients. ( Bucher, HC; Griffith, L; Guyatt, GH; Opravil, M, 1997) |
| "No patient in the trimethoprim-sulfamethoxazole group and no patient seronegative for Toxoplasma gondii developed toxoplasmic encephalitis, compared with 12 of 36 (33%; 95% Cl, 19% to 51%) seropositive patients in the pentamidine group (trimethoprim-sulfamethoxazole compared with pentamidine, P = 0." | 3.68 | Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS. ( Brew, BJ; Carr, A; Cooper, DA; Harkness, JL; Marriott, DJ; Penny, R; Tindall, B, 1992) |
| "The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP." | 3.68 | Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992) |
| "Dapsone was more effective in the primary prophylaxis of toxoplasmic encephalitis, with six toxoplasmic encephalitis events occurring among those receiving aerosolized pentamidine, compared to none among those taking dapsone (p = 0." | 2.67 | Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. ( Barr, M; Carlo, C; Chanin, E; Gregory, G; Kiely, S; Martin, M; Thorn, M; Thornton, J; Torres, RA, 1993) |
| " Overall results from these studies indicate patients who are eligible for PCP prophylaxis should be advised to take double-strength trimethoprim/sulfamethoxazole (TMP/SMX) on a daily basis, a dosage found more effective than thrice-weekly." | 1.30 | Optimizing PCP therapy. ( Cadman, J; Torres, G, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Opravil, M | 2 |
| Hirschel, B | 1 |
| Lazzarin, A | 1 |
| Heald, A | 1 |
| Pechère, M | 1 |
| Rüttimann, S | 1 |
| Iten, A | 1 |
| von Overbeck, J | 1 |
| Oertle, D | 1 |
| Praz, G | 1 |
| Torres, RA | 1 |
| Barr, M | 1 |
| Thorn, M | 1 |
| Gregory, G | 1 |
| Kiely, S | 1 |
| Chanin, E | 1 |
| Carlo, C | 1 |
| Martin, M | 1 |
| Thornton, J | 1 |
| Girard, PM | 1 |
| Landman, R | 1 |
| Gaudebout, C | 2 |
| Olivares, R | 1 |
| Saimot, AG | 1 |
| Jelazko, P | 1 |
| Certain, A | 1 |
| Boué, F | 1 |
| Bouvet, E | 1 |
| Antinori, A | 1 |
| Murri, R | 1 |
| Ammassari, A | 1 |
| De Luca, A | 1 |
| Linzalone, A | 1 |
| Cingolani, A | 1 |
| Damiano, F | 1 |
| Maiuro, G | 1 |
| Vecchiet, J | 1 |
| Scoppettuolo, G | 1 |
| Bucher, HC | 1 |
| Griffith, L | 1 |
| Guyatt, GH | 1 |
| Torres, G | 1 |
| Cadman, J | 1 |
| Carr, A | 1 |
| Tindall, B | 1 |
| Brew, BJ | 1 |
| Marriott, DJ | 1 |
| Harkness, JL | 1 |
| Penny, R | 1 |
| Cooper, DA | 1 |
| Köppen, S | 1 |
| Grünewald, T | 1 |
| Jautzke, G | 1 |
| Gottschalk, J | 1 |
| Pohle, HD | 1 |
| Ruf, B | 1 |
1 review available for pentamidine and Brain Inflammation
| Article | Year |
|---|---|
Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.
Topics: Administration, Inhalation; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal | 1997 |
4 trials available for pentamidine and Brain Inflammation
| Article | Year |
|---|---|
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients.
Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Animals; Dapsone; Drug Adm | 1995 |
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Dapsone; Encephalitis; Female; Humans; Male; | 1993 |
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group.
Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence | 1993 |
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe | 1995 |
3 other studies available for pentamidine and Brain Inflammation
| Article | Year |
|---|---|
Optimizing PCP therapy.
Topics: Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; CD4 Lymphocyte Count | 1997 |
Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Protozoan; CD4-Positive T-Lymphocytes; Ence | 1992 |
Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine.
Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Encephalitis; Female; HIV Infe | 1992 |