pentamidine has been researched along with Benign Neoplasms in 26 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentamidine (PTM) is an aromatic diamidine approved for the treatment of parasitic infections that has been recently proposed for possible repositioning as an anticancer drug." | 1.72 | Selective delivery of pentamidine toward cancer cells by self-assembled nanoparticles. ( Andreana, I; Arpicco, S; Bincoletto, V; Gazzano, E; Gianquinto, E; Kryza, D; Lollo, G; Piatti, G; Riganti, C; Spyrakis, F; Stella, B, 2022) |
| "The LD50 of pentamidine on cancer cells maintained in vitro is correlated with the endo-exonuclease enzyme activity." | 1.32 | The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer. ( Alaoui-Jamali, MA; Chow, TY; Griller, D; Yeh, C; Yuen, L, 2004) |
| "In children with malignancy, TMP/SMX is well tolerated, but adverse reactions that necessitate discontinuation can occur." | 1.29 | Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole. ( Buchanan, GR; Cash, J; Mustafa, MM; Pappo, A; Winick, NJ, 1994) |
| "Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic." | 1.27 | Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987) |
| " Trimethoprim-sulfamethoxazole (TMP-SMX) was used at one of two dosage levels in the treatment of 20 children with PCP and cancer." | 1.25 | Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole. ( Feldman, S; Hughes, WT; Sanyal, SK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (50.00) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Huang, TL | 1 |
| Mayence, A | 1 |
| Vanden Eynde, JJ | 1 |
| Andreana, I | 1 |
| Gazzano, E | 1 |
| Gianquinto, E | 1 |
| Piatti, G | 1 |
| Bincoletto, V | 1 |
| Kryza, D | 1 |
| Lollo, G | 1 |
| Spyrakis, F | 1 |
| Riganti, C | 1 |
| Arpicco, S | 1 |
| Stella, B | 1 |
| Parveen, N | 1 |
| Chiu, WJ | 1 |
| Shen, LC | 1 |
| Chou, RH | 1 |
| Sun, CM | 1 |
| Yu, C | 1 |
| Orgel, E | 1 |
| Rushing, T | 1 |
| SNAPPER, I | 1 |
| GALLICO, E | 1 |
| JAEGER, E | 1 |
| MENKES, G | 1 |
| RENTCHNICK, P | 1 |
| STEEN, S | 1 |
| ROE, JH | 1 |
| CASSIDY, JW | 1 |
| TATUM, AC | 1 |
| RICE, EW | 1 |
| Chow, TY | 1 |
| Alaoui-Jamali, MA | 1 |
| Yeh, C | 1 |
| Yuen, L | 1 |
| Griller, D | 1 |
| BICHEL, J | 1 |
| Prasad, P | 1 |
| Nania, JJ | 1 |
| Shankar, SM | 1 |
| Kim, SY | 1 |
| Dabb, AA | 1 |
| Glenn, DJ | 1 |
| Snyder, KM | 1 |
| Chuk, MK | 1 |
| Loeb, DM | 1 |
| BREWER, AE | 1 |
| HEILMEYER, L | 1 |
| Sieve, RM | 1 |
| Betcher, DL | 1 |
| Pui, CH | 1 |
| Hughes, WT | 2 |
| Evans, WE | 1 |
| Crist, WM | 1 |
| Mustafa, MM | 1 |
| Pappo, A | 1 |
| Cash, J | 1 |
| Winick, NJ | 1 |
| Buchanan, GR | 1 |
| Pérez, JM | 1 |
| Requena, JM | 1 |
| Craciunescu, D | 1 |
| Doadrio, JC | 1 |
| Alonso, C | 1 |
| Groll, AH | 1 |
| Ritter, J | 1 |
| Müller, FM | 1 |
| Geelhoed, GW | 1 |
| Hubbard, SB | 1 |
| Powell, RD | 1 |
| Doppman, JL | 1 |
| DeVita, VT | 1 |
| Feldman, S | 1 |
| Sanyal, SK | 1 |
| Sizoo, W | 1 |
| Wolvius, GG | 1 |
| Peters, SG | 1 |
| Prakash, UB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of the Safety and Intravenous Pentamidine for Pneumocystis Jirovecii Pneumonia in Patients With Hematologic Malignancies and Stem Cell Transplant Recipients.[NCT02669706] | 50 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pentamidine and Benign Neoplasms
| Article | Year |
|---|---|
Some non-conventional biomolecular targets for diamidines. A short survey.
Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myot | 2014 |
[Guidelines for Prevention of Pneumocystis carinii Pneumonitis in Children and Adolescents with Cancer].
Topics: Adolescent; Age Factors; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infectiv | 2001 |
24 other studies available for pentamidine and Benign Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Selective delivery of pentamidine toward cancer cells by self-assembled nanoparticles.
Topics: Antineoplastic Agents; Cell Survival; Drug Carriers; Nanoparticles; Neoplasms; Pentamidine; Squalene | 2022 |
The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain.
Topics: Calcium; Humans; Magnetic Resonance Spectroscopy; Neoplasms; Pentamidine; Protein Binding; Signal Tr | 2022 |
Efficacy and tolerability of intravenous pentamidine isethionate for Pneumocystis jiroveci prophylaxis in a pediatric oncology population.
Topics: Administration, Intravenous; Adolescent; Adult; Antibiotic Prophylaxis; Antifungal Agents; Child; Ch | 2014 |
About the forms of myelogenic plasmocytoma (myeloma) and its therapeutic influence by pentamidine.
Topics: Bone Marrow; Humans; Multiple Myeloma; Neoplasms; Pentamidine | 1948 |
Stilbamidine and pentamidine in multiple myeloma.
Topics: Bone Marrow; Humans; Multiple Myeloma; Neoplasms; Pentamidine; Stilbamidines | 1947 |
[Modern trends in chemotherapy of tumors].
Topics: Colchicine; Ethers; Folic Acid Antagonists; Hormones; Humans; Mechlorethamine; Mitosis; Neoplasms; N | 1952 |
[Diamidine therapy of generalized plasmocytoma].
Topics: Bone Marrow; Humans; Neoplasms; Neoplasms, Plasma Cell; Pentamidine; Plasmacytoma; Stilbamidines | 1950 |
[Pentolysis. II. A new method of diagnosis of malignant tumors].
Topics: Hematologic Diseases; Humans; Lymphatic Diseases; Neoplasms; Pentamidine | 1951 |
Failure to observe pentolysis by the serum of rats bearing malignant tumors.
Topics: Animals; Lymphatic Diseases; Neoplasms; Pentamidine; Rats | 1952 |
The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; | 2004 |
[Diamidine therapy of myelomatosis].
Topics: Bone Marrow; Humans; Multiple Myeloma; Neoplasms; Pentamidine; Spinal Cord; Stilbamidines | 1950 |
Pneumocystis pneumonia in children receiving chemotherapy.
Topics: Adolescent; Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Antineoplastic Agents; Child; Chil | 2008 |
Intravenous pentamidine is effective as second line Pneumocystis pneumonia prophylaxis in pediatric oncology patients.
Topics: Antifungal Agents; Bone Marrow Transplantation; Child; Child, Preschool; Humans; Immunocompromised H | 2008 |
Multiple myeloma treated with stilbamidine and pentamidine.
Topics: Humans; Multiple Myeloma; Neoplasms; Pentamidine; Stilbamidines | 1948 |
Recent observations in myeloma patients with special consideration of treatment with stilbamidine and pentamidine.
Topics: Humans; Multiple Myeloma; Neoplasms; Pentamidine; Stilbamidines | 1949 |
Pentamidine.
Topics: Adolescent; Child; Drug Stability; Humans; Neoplasms; Opportunistic Infections; Pentamidine; Pneumon | 1994 |
Prevention of Pneumocystis carinii pneumonia in children with cancer.
Topics: Adolescent; Child; Humans; Neoplasms; Pentamidine; Pneumonia, Pneumocystis; Precursor Cell Lymphobla | 1994 |
Aerosolized pentamidine for the prevention of Pneumocystis carinii pneumonia in children with cancer intolerant or allergic to trimethoprim/sulfamethoxazole.
Topics: Adolescent; Aerosols; Child; Child, Preschool; Drug Hypersensitivity; Female; Humans; Male; Neoplasm | 1994 |
Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells.
Topics: Antineoplastic Agents; Cell Division; DNA; Drug Screening Assays, Antitumor; Hot Temperature; Humans | 1993 |
Clinical characteristics of Pneumocystis carinii pneumonia.
Topics: Humans; Immunologic Deficiency Syndromes; Neoplasms; Pentamidine; Pneumonia, Pneumocystis | 1979 |
Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole.
Topics: Administration, Oral; Adolescent; Amidines; Child; Child, Preschool; Drug Combinations; Drug Evaluat | 1975 |
[Pneumocystis pneumonia as a complication in cytostatic therapy].
Topics: Adolescent; Antineoplastic Agents; Female; Humans; Male; Neoplasms; Pentamidine; Pneumonia, Pneumocy | 1976 |
Pneumocystis carinii pneumonia. Review of 53 cases.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk | 1987 |