pentamidine has been researched along with Arrhythmias, Cardiac in 5 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 9.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 7.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 5.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 3.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varkevisser, R | 1 |
| Houtman, MJ | 1 |
| Linder, T | 1 |
| de Git, KC | 1 |
| Beekman, HD | 1 |
| Tidwell, RR | 1 |
| Ijzerman, AP | 1 |
| Stary-Weinzinger, A | 1 |
| Vos, MA | 1 |
| van der Heyden, MA | 1 |
| Chakraborty, M | 1 |
| Selma-Soriano, E | 1 |
| Magny, E | 1 |
| Couso, JP | 1 |
| Pérez-Alonso, M | 1 |
| Charlet-Berguerand, N | 1 |
| Artero, R | 1 |
| Llamusi, B | 1 |
| Eisenhauer, MD | 1 |
| Eliasson, AH | 1 |
| Taylor, AJ | 1 |
| Coyne, PE | 1 |
| Wortham, DC | 1 |
| Girgis, I | 1 |
| Gualberti, J | 1 |
| Langan, L | 1 |
| Malek, S | 1 |
| Mustaciuolo, V | 1 |
| Costantino, T | 1 |
| McGinn, TG | 1 |
| Stein, KM | 1 |
| Fenton, C | 1 |
| Lehany, AM | 1 |
| Okin, PM | 1 |
| Kligfield, P | 1 |
1 trial available for pentamidine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients.
Topics: Adult; Anti-Infective Agents; Arrhythmias, Cardiac; Echocardiography; Echocardiography, Doppler; Ele | 1997 |
4 other studies available for pentamidine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.
Topics: Animals; Anti-Arrhythmia Agents; Antiprotozoal Agents; Arrhythmias, Cardiac; Cell Membrane; Dogs; En | 2013 |
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.
Topics: Animals; Arrhythmias, Cardiac; Diastole; Disease Models, Animal; Drosophila melanogaster; Drosophila | 2015 |
Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Arrhythmias, Cardiac; Cohort Studies; Dose-Respo | 1994 |
Incidence of QT interval prolongation during pentamidine therapy of Pneumocystis carinii pneumonia.
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Humans; Middle Aged; Pentamidine; Pneumonia, | 1991 |