pentamidine has been researched along with Arrhythmia in 5 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 9.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 7.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| " pentamidine therapy in HIV-infected patients has been associated in case reports and one uncontrolled prospective series with frequent prolongation of the rate-corrected QT interval (QTc) and a high risk for potentially lethal ventricular arrhythmias, especially torsade de pointes." | 5.08 | A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients. ( Costantino, T; Girgis, I; Gualberti, J; Langan, L; Malek, S; McGinn, TG; Mustaciuolo, V, 1997) |
| "There have been 15 published cases of probable pentamidine-induced torsade de pointes (TdP)." | 3.69 | Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients. ( Coyne, PE; Eisenhauer, MD; Eliasson, AH; Taylor, AJ; Wortham, DC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varkevisser, R | 1 |
| Houtman, MJ | 1 |
| Linder, T | 1 |
| de Git, KC | 1 |
| Beekman, HD | 1 |
| Tidwell, RR | 1 |
| Ijzerman, AP | 1 |
| Stary-Weinzinger, A | 1 |
| Vos, MA | 1 |
| van der Heyden, MA | 1 |
| Chakraborty, M | 1 |
| Selma-Soriano, E | 1 |
| Magny, E | 1 |
| Couso, JP | 1 |
| Pérez-Alonso, M | 1 |
| Charlet-Berguerand, N | 1 |
| Artero, R | 1 |
| Llamusi, B | 1 |
| Eisenhauer, MD | 1 |
| Eliasson, AH | 1 |
| Taylor, AJ | 1 |
| Coyne, PE | 1 |
| Wortham, DC | 1 |
| Girgis, I | 1 |
| Gualberti, J | 1 |
| Langan, L | 1 |
| Malek, S | 1 |
| Mustaciuolo, V | 1 |
| Costantino, T | 1 |
| McGinn, TG | 1 |
| Stein, KM | 1 |
| Fenton, C | 1 |
| Lehany, AM | 1 |
| Okin, PM | 1 |
| Kligfield, P | 1 |
1 trial available for pentamidine and Arrhythmia
| Article | Year |
|---|---|
A prospective study of the effect of I.V. pentamidine therapy on ventricular arrhythmias and QTc prolongation in HIV-infected patients.
Topics: Adult; Anti-Infective Agents; Arrhythmias, Cardiac; Echocardiography; Echocardiography, Doppler; Ele | 1997 |
4 other studies available for pentamidine and Arrhythmia
| Article | Year |
|---|---|
Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.
Topics: Animals; Anti-Arrhythmia Agents; Antiprotozoal Agents; Arrhythmias, Cardiac; Cell Membrane; Dogs; En | 2013 |
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction.
Topics: Animals; Arrhythmias, Cardiac; Diastole; Disease Models, Animal; Drosophila melanogaster; Drosophila | 2015 |
Incidence of cardiac arrhythmias during intravenous pentamidine therapy in HIV-infected patients.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Arrhythmias, Cardiac; Cohort Studies; Dose-Respo | 1994 |
Incidence of QT interval prolongation during pentamidine therapy of Pneumocystis carinii pneumonia.
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Humans; Middle Aged; Pentamidine; Pneumonia, | 1991 |