pentamidine has been researched along with African Sleeping Sickness in 167 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For Chagas disease, two anti-fungal triazoles are now in clinical trial." | 4.88 | Management of trypanosomiasis and leishmaniasis. ( Barrett, MP; Croft, SL, 2012) |
| "Pentamidine has a long history in the treatment of human African trypanosomiasis (HAT) and leishmaniasis." | 3.74 | Pentamidine dosage: a base/salt confusion. ( Dorlo, TP; Kager, PA, 2008) |
| "Metronidazole has been claimed in several earlier reports to be active in human cases of leishmaniasis and trypanosomiasis." | 3.66 | Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei. ( Keithly, JS; Langreth, SG, 1983) |
| "Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death." | 2.82 | Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies. ( Allen, JL; Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Josenando, T; Lubaki, JP; Lutumba, P; Manuel, F; Merolle, A; Mesu, VK; Mpanya, A; Mpoto, AM; Munungu, BF; Olson, CA; Pohlig, G; Serge, KK; Thompson, M; Tidwell, RR; Yeramian, PD, 2016) |
| "Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration." | 2.82 | Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. ( Bernhard, SC; Bilenge, CM; Blum, J; Burri, C; Dala, A; Deo, GK; Dituvanga, ND; Franco, JR; Kuikumbi, FM; Lubaki, JP; Macharia, S; Mesu, VK; Mintwo, AF; Mpanya, A; Mpoto, AM; Munungi, AK; Munungu, BF; Mutantu, PN; N'tombe, PM; Olson, CA; Pohlig, G; Tidwell, RR, 2016) |
| "Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years." | 2.75 | A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. ( Boelaert, M; Büscher, P; Lejon, V; Ngoyi, DM, 2010) |
| " The 'terminal' elimination rate constant could be determined in six patients and subsequent kinetic calculations showed a three to fourfold variation in plasma clearance and 'terminal' half-life (median 1126 (range 553-2036) ml min-1 and 265 (107-446) h, respectively)." | 2.68 | Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness. ( Bronner, U; Doua, F; Ericsson, O; Gustafsson, LL; Miézan, T; Rais, M; Rombo, L, 1995) |
| "Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment." | 2.49 | Chemotherapy for second-stage human African trypanosomiasis. ( Kennedy, A; Lutje, V; Seixas, J, 2013) |
| " However, a need for protracted and complicated drug dosing regimens slowed widespread implementation of eflornithine monotherapy." | 2.47 | Drug resistance in human African trypanosomiasis. ( Barrett, MP; Burchmore, RJ; Kazibwe, AJ; Matovu, E; Vincent, IM, 2011) |
| " A combination chemotherapy, eflornithine alongside nifurtimox, has been introduced to decrease the time frame and overall dosing of eflornithine and reducing the risk of drug resistance emerging." | 2.46 | Potential new drugs for human African trypanosomiasis: some progress at last. ( Barrett, MP, 2010) |
| "Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS." | 2.46 | Diamidines for human African trypanosomiasis. ( Barrett, MP; Boykin, DW; Brun, R; Burri, C; De Koning, HP; Generaux, CN; Murilla, GA; Olson, CA; Paine, MF; Pohlig, G; Thuita, JK; Tidwell, RR; Wang, MZ; Wilson, WD, 2010) |
| "Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment." | 2.46 | Chemotherapy for second-stage Human African trypanosomiasis. ( Kennedy, A; Lutje, V; Seixas, J, 2010) |
| "Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that has re-emerged in recent years." | 2.42 | Current chemotherapy of human African trypanosomiasis. ( Docampo, R; Moreno, SN, 2003) |
| "Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, has remained a disease with no effective treatment." | 2.42 | Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis. ( Nok, AJ, 2003) |
| "Relapses were noted in 3." | 2.38 | Human trypanosomiasis in the Ivory Coast: therapy and problems. ( Doua, F; Yapo, FB, 1993) |
| "Human African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp." | 1.62 | Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug. ( Brown, RC; Burrell-Saward, H; Christie, M; Croft, SL; da Silva, M; Dailey, LA; Dreiss, CA; Fidanboylu, M; Liu, B; Lorenz, C; Persaud, SJ; Sanderson, L; Sekhar, GN; Thomas, SA; Valero, M; Yardley, V, 2021) |
| "Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health." | 1.51 | Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model. ( Barrett, MP; de Koning, HP; Gillingwater, K; Giordani, F; Khalaf, AI; Munday, JC; Scott, FJ; Suckling, CJ, 2019) |
| "We present a case of East-African trypanosomiasis (EAT) in a 56-year-old Dutch woman returning from holiday in Tanzania and Kenya." | 1.48 | A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( Hanssen, JLJ; Scheper, H; van Lieshout, L; Visser, LG; Wijsman, CA, 2018) |
| "Human African trypanosomiasis (HAT) is one of the most complex parasitic diseases known to humankind." | 1.48 | Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania. ( Chen, JX; Chen, MX; Chen, XL; Chen, ZY; Lin, YY; Liu, Q; Xie, HG; Zhang, Y; Zheng, H; Zhou, XN, 2018) |
| "Human African Trypanosomiasis (HAT) is caused by two subspecies of the genus Trypanosoma, namely Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense." | 1.46 | Bistacrines as potential antitrypanosomal agents. ( Bruhn, H; Fuß, A; Göllner, S; Holzgrabe, U; Katzowitsch, E; Krauth-Siegel, RL; Kucharski, A; Miliu, A; Schirmeister, T; Schmidt, I; Stich, A, 2017) |
| "Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance." | 1.43 | Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei. ( Cordeiro-da-Silva, A; Costa, DM; Gaspar, L; Graça, NA; Loukil, H; Loureiro, I; MacDougall, J; Pemberton, IK; Pruvost, A; Ramos, I; Roura, M; Tavares, J; Thoo-Lin, PK, 2016) |
| "Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection." | 1.42 | Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. ( Boykin, DW; Bridges, AS; Brun, R; Ching, S; Gem, CO; Jones, SK; Liu, Q; Murilla, GA; Mutuku, JN; Paine, MF; Thuita, JK; Tidwell, RR; Wang, MZ; Wolf, KK, 2015) |
| "African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei." | 1.42 | Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis. ( Arias, JL; de Koning, HP; Garcia-Salcedo, JA; Hernández-Quero, J; Maceira, J; Magez, S; Muñóz-Torres, M; Ortiz-González, M; Soriano, M; Unciti-Broceta, JD, 2015) |
| "African trypanosomiasis is a parasitic infection sporadically imported to Europe by tourists or immigrants returning from endemic areas." | 1.40 | Outcome of acute East African trypanosomiasis in a Polish traveller treated with pentamidine. ( Clerinx, J; Geysen, D; Paul, M; Smuszkiewicz, P; Stefaniak, J; Van Esbroeck, M, 2014) |
| "Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment." | 1.40 | Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. ( Boykin, DW; Brun, R; Miller, PN; Wang, MZ; Wenzler, T; Wu, H; Yang, S, 2014) |
| "the data showed a highly improved oral bioavailability of the [(123)I]-labeled pro-drugs compared to [(123)I]-labeled pentamidine." | 1.40 | In vivo SPECT imaging of [¹²³I]-labeled pentamidine pro-drugs for the treatment of human African trypanosomiasis, pharmacokinetics, and bioavailability studies in rats. ( Clement, B; Cohrs, B; Culman, J; Lützen, U; Zhao, Y; Zuhayra, M, 2014) |
| "African sleeping sickness is a neglected tropical disease transmitted by tsetse flies." | 1.40 | In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. ( Boykin, DW; Braissant, O; Brun, R; Ismail, MA; Patrick, DA; Tidwell, RR; Wang, MZ; Wenzler, T; Yang, S, 2014) |
| " The compound was orally bioavailable and displayed good plasma and brain exposure in mice." | 1.40 | Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis. ( Brun, R; Buckner, FS; Chatterjee, AK; Creason, SA; Duster, NA; Gelb, MH; Gillespie, JR; Glynne, R; Hulverson, MA; McQueen, J; Molteni, V; Nagendar, P; Nagle, A; Norcross, NR; Ranade, RM; Supek, F; Tatipaka, HB; Wenzler, T, 2014) |
| "Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei." | 1.40 | Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei. ( Jacobs, RT; Meng, Q; Nare, B; Wu, P; Zhang, J; Zhou, H, 2014) |
| " Our compound optimization that has led to synthesis of several potent 4-anilinoquinazolines, including NEU617, 23a, a highly potent, orally bioavailable inhibitor of trypanosome replication." | 1.39 | Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis. ( Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C, 2013) |
| "Human African trypanosomiasis (HAT, also called sleeping sickness), a neglected tropical disease endemic to sub-Saharan Africa, is caused by the parasites Trypanosoma brucei gambiense and T." | 1.39 | Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. ( Boykin, DW; Braissant, O; Brun, R; Wang, MZ; Wenzler, T; Yang, S, 2013) |
| "Human African Trypanosomiasis, or African Sleeping Sickness, is a parasitic infection caused by Trypanosoma brucei (gambiense or rhodesiense), and one of the declared neglected tropical diseases." | 1.37 | Trypanosoma brucei infection in a HIV positive Ugandan male. ( Dill, EA; Kirkpatrick, BD; Renault, C, 2011) |
| "Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa." | 1.36 | Human African trypanosomiasis. ( Blum, J; Brun, R; Burri, C; Chappuis, F, 2010) |
| "Validation in an in vivo model of African trypanosomiasis showed promising results for this compound." | 1.36 | Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. ( Al-Salabi, MI; Augustyns, K; Berg, M; Castagna, V; Cos, P; de Koning, HP; Degano, M; Giannese, F; Grellier, P; Haemers, A; Joossens, J; Kohl, L; Maes, L; Steyaert, J; Van der Veken, P; Versées, W, 2010) |
| " An orally bioavailable prodrug of CPD-0801, DB868, is metabolized primarily in the liver to the active form." | 1.36 | Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. ( Generaux, CN; Goldsmith, RB; Gray, DR; Reisner, HM; Tidwell, RR; Yan, Z, 2010) |
| " The amidoxime and N-methoxyamidine of 5a were the only produgs to provide cures (1/4 cures) in the same mouse model on oral dosage at 4x25mg/kg." | 1.36 | Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. ( Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD, 2010) |
| "During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used." | 1.35 | Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. ( De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA, 2009) |
| "Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense, and is a major cause of systemic and neurological disability throughout sub-Saharan Africa." | 1.35 | Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. ( Barrett, MP; Bradley, B; Kennedy, PG; Rodgers, J; Stone, TW, 2009) |
| "We report a case of West African trypanosomiasis due to Trypanosoma brucei gambiense involving a Frenchman living in Libreville, Gabon." | 1.35 | [Double trypanosomal chancre revealing West African trypanosomiasis in a Frenchman living in Gabon]. ( Bricaire, F; Caumes, E; Danis, M; Hope-Rapp, E; Klement, E; Moussa Coulibaly, O, 2009) |
| " brucei brucei and 25- to 50-mg/kg twice-daily dosing against T." | 1.35 | Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor. ( Bacchi, CJ; Barker, RH; Hendrick, CL; Hirth, B; Rattendi, D; Rodriguez, A; Sybertz, E; Yarlett, N, 2009) |
| " rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg x 4 days." | 1.35 | Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. ( Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA, 2009) |
| " Pharmacokinetic studies of mice following intraperitoneal dosing showed that the half-life of Genz-644131 was threefold greater than that of MDL 73811 (7." | 1.35 | Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. ( Bacchi, CJ; Barker, RH; Celatka, CA; Fitzpatrick, R; Hirth, B; Kaiser, M; Klinger, JD; Liu, H; Phillips, MA; Rodriguez, A; Sybertz, E; Willert, EK; Xiang, Y; Yarlett, N, 2009) |
| "Human African trypanosomiasis, also known as African sleeping sickness, is a neglected tropical disease with inadequate therapeutic options." | 1.35 | The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. ( Abdulla, M; Ang, KH; Arkin, M; Crews, P; McKerrow, JH; Rubio, BK; Tenney, K, 2009) |
| "African sleeping sickness is a fatal parasitic disease, and all drugs currently in use for treatment have strong liabilities." | 1.35 | New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. ( Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T, 2009) |
| " Complete cures were achieved with oral dosing of the prodrug DB289 in all three models without any overt toxicity." | 1.35 | Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. ( Brun, R; Kagira, JM; Karanja, SM; Mdachi, RE; Ngotho, JM; Thuita, JK; Tidwell, R; Wenzler, T, 2008) |
| "Pentamidine treatment for first-stage illness was very safe and effective among pre-school children." | 1.34 | Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children. ( Chappuis, F; Eperon, G; Loutan, L; Schmid, C, 2007) |
| "The parasites that give rise to human African trypanosomiasis (HAT) are auxotrophs for various nutrients from the human host, including purines." | 1.33 | Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. ( Baliani, A; Barrett, MP; Brun, R; Bueno, GJ; Gilbert, IH; Stewart, ML; Yardley, V, 2005) |
| " Compound 6a produced cures at an oral dosage of 5 mg/kg." | 1.32 | Synthesis and antiprotozoal activity of aza-analogues of furamidine. ( Boykin, DW; Brun, R; Easterbrook, JD; Ismail, MA; Tanious, FA; Wilson, WD, 2003) |
| "In human African trypanosomiasis (HAT), two disease stages are defined: the first, or haemo-lymphatic stage, and the second, or meningo-encephalitic stage." | 1.32 | Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire. ( Büscher, P; Cuny, G; Djé, N; Garcia, A; Jamonneau, V; Lejon, V; Miezan, TW; N'Guessan, P; Solano, P, 2003) |
| "This paper gives an overview of the treatment of Human African Trypanosomiasis from the early 20th century until today." | 1.31 | [Human african trypanosomiasis: A history of its therapies and their failures]. ( Legros, D; Ollivier, G, 2001) |
| "Human African Trypanosomiasis (HAT) is a re-emerging disease whose usual treatments are becoming less efficient because of the increasing parasite resistance." | 1.31 | Availability and affordability of treatment for Human African Trypanosomiasis. ( Etchegorry, MG; Helenport, JP; Jannin, J; Legros, D; Pecoul, B, 2001) |
| "This report describes a case of West African trypanosomiasis involving a Caucasian Frenchman living in Conackry, Guinea." | 1.31 | [Human African trypanosomiasis from Trypanosoma brucei gambiense with inoculation chancre in a French expatriate]. ( Chapuis, P; Djossou, F; Le Bras, M; Longy-Boursier, M; Malvy, D; Weill, FX, 2001) |
| "Diminazene aceturate was more efficient and provided a 40 mg-kg dose was utilised, it was possible to reduce the period of DFMO to approximately 12 days." | 1.28 | Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO). ( Jennings, FW, 1992) |
| "Pentamidine treatment appeared in the CSF." | 1.27 | [Trial of pentamidine in the treatment of trypanosomiasis of sheep inoculated with Trypanosoma brucei brucei]. ( Amevigbe, M; Bosgiraud, C; Bouteille, B; Darde, ML; Dubost, G; Dumas, M; Nicolas, JA; Pestre-Alexandre, M; Vallat, JM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (17.37) | 18.7374 |
| 1990's | 19 (11.38) | 18.2507 |
| 2000's | 47 (28.14) | 29.6817 |
| 2010's | 68 (40.72) | 24.3611 |
| 2020's | 4 (2.40) | 2.80 |
| Authors | Studies |
|---|---|
| Ismail, MA | 7 |
| Brun, R | 26 |
| Easterbrook, JD | 1 |
| Tanious, FA | 2 |
| Wilson, WD | 12 |
| Boykin, DW | 16 |
| Arafa, RK | 3 |
| Wenzler, T | 16 |
| Stephens, CE | 1 |
| Baliani, A | 1 |
| Bueno, GJ | 1 |
| Stewart, ML | 1 |
| Yardley, V | 2 |
| Barrett, MP | 13 |
| Gilbert, IH | 1 |
| Dardonville, C | 4 |
| Kaiser, M | 5 |
| Tanious, F | 1 |
| George, TG | 1 |
| Endeshaw, MM | 1 |
| Morgan, RE | 1 |
| Mahasenan, KV | 1 |
| Delfín, DA | 1 |
| Mukherjee, MS | 1 |
| Yakovich, AJ | 1 |
| Fotie, J | 1 |
| Li, C | 1 |
| Werbovetz, KA | 2 |
| Rodríguez, F | 1 |
| Rozas, I | 1 |
| Nguyen, B | 1 |
| García, RN | 1 |
| Rubio, BK | 1 |
| Tenney, K | 1 |
| Ang, KH | 1 |
| Abdulla, M | 1 |
| Arkin, M | 1 |
| McKerrow, JH | 1 |
| Crews, P | 1 |
| Barker, RH | 2 |
| Liu, H | 1 |
| Hirth, B | 2 |
| Celatka, CA | 1 |
| Fitzpatrick, R | 1 |
| Xiang, Y | 1 |
| Willert, EK | 1 |
| Phillips, MA | 1 |
| Bacchi, CJ | 4 |
| Rodriguez, A | 2 |
| Yarlett, N | 3 |
| Klinger, JD | 1 |
| Sybertz, E | 2 |
| Patrick, DA | 3 |
| Bakunov, SA | 2 |
| Bakunova, SM | 2 |
| Kumar, EV | 1 |
| Chen, H | 1 |
| Jones, SK | 2 |
| Barzcz, T | 1 |
| Tidwell, RR | 11 |
| Rattendi, D | 2 |
| Hendrick, CL | 1 |
| Hall, JE | 2 |
| Hu, L | 2 |
| Patel, A | 2 |
| Munde, M | 3 |
| Branowska, D | 1 |
| Farahat, AA | 2 |
| Kumar, A | 4 |
| Liu, Y | 1 |
| Sokolova, AY | 1 |
| Wyllie, S | 1 |
| Patterson, S | 1 |
| Oza, SL | 1 |
| Read, KD | 1 |
| Fairlamb, AH | 3 |
| Bialy, SA | 1 |
| Nanjunda, R | 1 |
| Chai, Y | 1 |
| Caminos, AP | 1 |
| Panozzo-Zenere, EA | 1 |
| Wilkinson, SR | 1 |
| Tekwani, BL | 1 |
| Labadie, GR | 1 |
| Hwang, JY | 1 |
| Smithson, D | 1 |
| Zhu, F | 1 |
| Holbrook, G | 1 |
| Connelly, MC | 1 |
| Guy, RK | 2 |
| Patel, G | 1 |
| Karver, CE | 1 |
| Behera, R | 1 |
| Guyett, PJ | 1 |
| Sullenberger, C | 1 |
| Edwards, P | 1 |
| Roncal, NE | 1 |
| Mensa-Wilmot, K | 1 |
| Pollastri, MP | 1 |
| Bondada, L | 1 |
| Yang, S | 4 |
| Wang, MZ | 6 |
| Tatipaka, HB | 1 |
| Gillespie, JR | 1 |
| Chatterjee, AK | 1 |
| Norcross, NR | 1 |
| Hulverson, MA | 1 |
| Ranade, RM | 1 |
| Nagendar, P | 1 |
| Creason, SA | 1 |
| McQueen, J | 1 |
| Duster, NA | 1 |
| Nagle, A | 1 |
| Supek, F | 1 |
| Molteni, V | 1 |
| Glynne, R | 1 |
| Buckner, FS | 1 |
| Gelb, MH | 1 |
| Wu, P | 1 |
| Zhang, J | 1 |
| Meng, Q | 1 |
| Nare, B | 1 |
| Jacobs, RT | 1 |
| Zhou, H | 1 |
| Ronga, L | 1 |
| Del Favero, M | 1 |
| Cohen, A | 1 |
| Soum, C | 1 |
| Le Pape, P | 1 |
| Savrimoutou, S | 1 |
| Pinaud, N | 1 |
| Mullié, C | 1 |
| Daulouede, S | 1 |
| Vincendeau, P | 1 |
| Farvacques, N | 1 |
| Agnamey, P | 1 |
| Pagniez, F | 1 |
| Hutter, S | 1 |
| Azas, N | 1 |
| Sonnet, P | 1 |
| Guillon, J | 1 |
| Carrillo, AK | 1 |
| Guiguemde, WA | 1 |
| Pomel, S | 2 |
| Dubar, F | 1 |
| Forge, D | 1 |
| Loiseau, PM | 4 |
| Biot, C | 1 |
| Eadsforth, TC | 1 |
| Pinto, A | 1 |
| Luciani, R | 1 |
| Tamborini, L | 1 |
| Cullia, G | 1 |
| De Micheli, C | 1 |
| Marinelli, L | 1 |
| Cosconati, S | 1 |
| Novellino, E | 1 |
| Lo Presti, L | 1 |
| Cordeiro da Silva, A | 1 |
| Conti, P | 1 |
| Hunter, WN | 1 |
| Costi, MP | 1 |
| Abdeen, S | 1 |
| Salim, N | 1 |
| Mammadova, N | 1 |
| Summers, CM | 1 |
| Goldsmith-Pestana, K | 1 |
| McMahon-Pratt, D | 1 |
| Schultz, PG | 1 |
| Horwich, AL | 1 |
| Chapman, E | 1 |
| Johnson, SM | 1 |
| Jagu, E | 1 |
| Diez-Martinez, A | 1 |
| Ramiandrasoa, F | 1 |
| Krauth-Siegel, RL | 2 |
| Pethe, S | 1 |
| Blonski, C | 1 |
| Labruère, R | 1 |
| Fueyo González, FJ | 1 |
| Ebiloma, GU | 1 |
| Izquierdo García, C | 1 |
| Bruggeman, V | 1 |
| Sánchez Villamañán, JM | 1 |
| Donachie, A | 1 |
| Balogun, EO | 1 |
| Inaoka, DK | 1 |
| Shiba, T | 1 |
| Harada, S | 1 |
| Kita, K | 1 |
| de Koning, HP | 14 |
| Schmidt, I | 1 |
| Göllner, S | 1 |
| Fuß, A | 1 |
| Stich, A | 2 |
| Kucharski, A | 1 |
| Schirmeister, T | 1 |
| Katzowitsch, E | 1 |
| Bruhn, H | 1 |
| Miliu, A | 1 |
| Holzgrabe, U | 1 |
| Thompson, AM | 1 |
| Marshall, AJ | 1 |
| Maes, L | 2 |
| Gaukel, E | 1 |
| Wring, SA | 1 |
| Launay, D | 1 |
| Braillard, S | 1 |
| Chatelain, E | 1 |
| Mowbray, CE | 1 |
| Denny, WA | 1 |
| Alghamdi, AH | 1 |
| Munday, JC | 3 |
| Campagnaro, GD | 1 |
| Gurvic, D | 1 |
| Svensson, F | 1 |
| Okpara, CE | 1 |
| Quintana, J | 1 |
| Martin Abril, ME | 1 |
| Milić, P | 1 |
| Watson, L | 1 |
| Paape, D | 1 |
| Settimo, L | 1 |
| Dimitriou, A | 1 |
| Wielinska, J | 1 |
| Smart, G | 1 |
| Anderson, LF | 1 |
| Woodley, CM | 1 |
| Kelly, SPY | 1 |
| Ibrahim, HM | 1 |
| Hulpia, F | 1 |
| Al-Salabi, MI | 2 |
| Eze, AA | 1 |
| Sprenger, T | 1 |
| Teka, IA | 1 |
| Gudin, S | 1 |
| Weyand, S | 1 |
| Field, M | 1 |
| Carrington, M | 1 |
| O'Neill, P | 1 |
| Zachariae, U | 1 |
| Ndung'u, K | 1 |
| Murilla, GA | 4 |
| Thuita, JK | 5 |
| Ngae, GN | 1 |
| Auma, JE | 1 |
| Gitonga, PK | 1 |
| Thungu, DK | 1 |
| Kurgat, RK | 1 |
| Chemuliti, JK | 1 |
| Mdachi, RE | 3 |
| Sanderson, L | 2 |
| da Silva, M | 1 |
| Sekhar, GN | 1 |
| Brown, RC | 1 |
| Burrell-Saward, H | 1 |
| Fidanboylu, M | 1 |
| Liu, B | 1 |
| Dailey, LA | 1 |
| Dreiss, CA | 1 |
| Lorenz, C | 1 |
| Christie, M | 1 |
| Persaud, SJ | 1 |
| Croft, SL | 2 |
| Valero, M | 1 |
| Thomas, SA | 2 |
| van Genderen, PJJ | 1 |
| Nouwen, JL | 1 |
| De Mendonça Melo, M | 1 |
| Rijnders, BJA | 1 |
| van Hellemond, JJ | 1 |
| Gómez-Junyent, J | 1 |
| Pinazo, MJ | 1 |
| Castro, P | 1 |
| Fernández, S | 1 |
| Mas, J | 1 |
| Chaguaceda, C | 1 |
| Pellicé, M | 1 |
| Gascón, J | 1 |
| Muñoz, J | 1 |
| Suganuma, K | 2 |
| Molefe, NI | 1 |
| Inoue, N | 3 |
| Paul, A | 1 |
| Wijsman, CA | 1 |
| Hanssen, JLJ | 1 |
| Scheper, H | 1 |
| Visser, LG | 1 |
| van Lieshout, L | 1 |
| Liu, Q | 3 |
| Chen, XL | 1 |
| Chen, MX | 1 |
| Xie, HG | 1 |
| Chen, ZY | 1 |
| Lin, YY | 1 |
| Zheng, H | 1 |
| Chen, JX | 1 |
| Zhang, Y | 1 |
| Zhou, XN | 1 |
| Thomas, JA | 1 |
| Baker, N | 5 |
| Hutchinson, S | 1 |
| Dominicus, C | 1 |
| Trenaman, A | 1 |
| Glover, L | 2 |
| Alsford, S | 2 |
| Horn, D | 6 |
| Kennedy, PGE | 1 |
| Rodgers, J | 3 |
| Giordani, F | 2 |
| Khalaf, AI | 1 |
| Gillingwater, K | 1 |
| Suckling, CJ | 1 |
| Scott, FJ | 1 |
| Boodman, C | 1 |
| Libman, M | 1 |
| Ndao, M | 1 |
| Yansouni, CP | 1 |
| Lutje, V | 2 |
| Seixas, J | 2 |
| Kennedy, A | 2 |
| Braissant, O | 2 |
| Graf, FE | 2 |
| Ludin, P | 2 |
| Pyana, PP | 1 |
| Büscher, P | 5 |
| Mäser, P | 3 |
| Paul, M | 1 |
| Stefaniak, J | 1 |
| Smuszkiewicz, P | 1 |
| Van Esbroeck, M | 1 |
| Geysen, D | 1 |
| Clerinx, J | 1 |
| Miller, PN | 1 |
| Wu, H | 1 |
| Allamanda, P | 1 |
| Hakimi, H | 1 |
| Zhou, M | 1 |
| Angeles, JM | 1 |
| Kawazu, S | 1 |
| Pyana Pati, P | 1 |
| Van Reet, N | 1 |
| Mumba Ngoyi, D | 1 |
| Ngay Lukusa, I | 1 |
| Karhemere Bin Shamamba, S | 1 |
| Arias, JL | 2 |
| Unciti-Broceta, JD | 2 |
| Maceira, J | 2 |
| Del Castillo, T | 1 |
| Hernández-Quero, J | 2 |
| Magez, S | 2 |
| Soriano, M | 2 |
| García-Salcedo, JA | 2 |
| Cohrs, B | 1 |
| Zhao, Y | 1 |
| Lützen, U | 1 |
| Culman, J | 1 |
| Clement, B | 1 |
| Zuhayra, M | 1 |
| Wolf, KK | 1 |
| Bridges, AS | 1 |
| Mutuku, JN | 1 |
| Gem, CO | 1 |
| Ching, S | 1 |
| Paine, MF | 2 |
| Ortiz-González, M | 1 |
| Muñóz-Torres, M | 1 |
| Graça, NA | 1 |
| Gaspar, L | 1 |
| Costa, DM | 1 |
| Loureiro, I | 1 |
| Thoo-Lin, PK | 1 |
| Ramos, I | 1 |
| Roura, M | 1 |
| Pruvost, A | 1 |
| Pemberton, IK | 1 |
| Loukil, H | 1 |
| MacDougall, J | 1 |
| Tavares, J | 1 |
| Cordeiro-da-Silva, A | 1 |
| Deschamps, JY | 2 |
| Desquesnes, M | 2 |
| Dorso, L | 1 |
| Ravel, S | 2 |
| Bossard, G | 1 |
| Charbonneau, M | 1 |
| Garand, A | 1 |
| Roux, FA | 1 |
| Song, J | 1 |
| Rothert, M | 1 |
| Henke, B | 1 |
| Jeacock, L | 1 |
| Beitz, E | 1 |
| Sbaraglini, ML | 1 |
| Vanrell, MC | 1 |
| Bellera, CL | 1 |
| Benaim, G | 1 |
| Carrillo, C | 1 |
| Talevi, A | 1 |
| Romano, PS | 1 |
| Burri, C | 4 |
| Yeramian, PD | 1 |
| Allen, JL | 1 |
| Merolle, A | 1 |
| Serge, KK | 1 |
| Mpanya, A | 2 |
| Lutumba, P | 1 |
| Mesu, VK | 2 |
| Bilenge, CM | 2 |
| Lubaki, JP | 2 |
| Mpoto, AM | 2 |
| Thompson, M | 1 |
| Munungu, BF | 2 |
| Manuel, F | 1 |
| Josenando, T | 2 |
| Bernhard, SC | 2 |
| Olson, CA | 3 |
| Blum, J | 3 |
| Pohlig, G | 3 |
| N'tombe, PM | 1 |
| Deo, GK | 1 |
| Mutantu, PN | 1 |
| Kuikumbi, FM | 1 |
| Mintwo, AF | 1 |
| Munungi, AK | 1 |
| Dala, A | 1 |
| Macharia, S | 1 |
| Franco, JR | 2 |
| Dituvanga, ND | 1 |
| Arquint, C | 1 |
| Schmidt, RS | 1 |
| Schaub, N | 1 |
| Kunz Renggli, C | 1 |
| Krezdorn, J | 1 |
| Balmer, O | 1 |
| Caccone, A | 1 |
| Hedley, L | 1 |
| Fink, D | 1 |
| Sparkes, D | 1 |
| Chiodini, PL | 2 |
| Dorlo, TP | 1 |
| Kager, PA | 2 |
| Karanja, SM | 1 |
| Ngotho, JM | 2 |
| Kagira, JM | 2 |
| Tidwell, R | 1 |
| 't Hooft, EM | 1 |
| Ndung'u, JM | 1 |
| Dogruel, M | 1 |
| Stone, TW | 1 |
| Bradley, B | 1 |
| Kennedy, PG | 1 |
| Hope-Rapp, E | 1 |
| Moussa Coulibaly, O | 1 |
| Klement, E | 1 |
| Danis, M | 1 |
| Bricaire, F | 1 |
| Caumes, E | 1 |
| Sykes, ML | 1 |
| Avery, VM | 1 |
| Chappuis, F | 2 |
| Schlitzer, M | 1 |
| Nadjm, B | 1 |
| Van Tulleken, C | 1 |
| Macdonald, D | 1 |
| Soeiro, MN | 1 |
| de Castro, SL | 1 |
| de Souza, EM | 1 |
| Batista, DG | 1 |
| Silva, CF | 1 |
| Lejon, V | 3 |
| Ngoyi, DM | 1 |
| Boelaert, M | 1 |
| Berg, M | 1 |
| Kohl, L | 1 |
| Van der Veken, P | 1 |
| Joossens, J | 1 |
| Castagna, V | 1 |
| Giannese, F | 1 |
| Cos, P | 1 |
| Versées, W | 1 |
| Steyaert, J | 1 |
| Grellier, P | 1 |
| Haemers, A | 1 |
| Degano, M | 1 |
| Augustyns, K | 1 |
| HARDING, RD | 1 |
| Goldsmith, RB | 1 |
| Gray, DR | 1 |
| Yan, Z | 1 |
| Generaux, CN | 2 |
| Reisner, HM | 1 |
| Dill, EA | 1 |
| Renault, C | 1 |
| Kirkpatrick, BD | 1 |
| Vincent, IM | 1 |
| Burchmore, RJ | 1 |
| Kazibwe, AJ | 1 |
| Matovu, E | 1 |
| Truc, P | 2 |
| Lando, A | 1 |
| Penchenier, L | 1 |
| Vatunga, G | 1 |
| Simon, F | 1 |
| Mura, M | 1 |
| Pagès, F | 1 |
| Morand, G | 1 |
| Louis, F | 1 |
| Gautret, P | 1 |
| Eckert, S | 1 |
| Sanchez-Flores, A | 1 |
| Leung, KF | 1 |
| Turner, DJ | 1 |
| Field, MC | 1 |
| Berriman, M | 1 |
| Richter, J | 1 |
| Göbels, S | 1 |
| Göbel, T | 1 |
| Westenfeld, R | 1 |
| Müller-Stöver, I | 1 |
| Häussinger, D | 1 |
| Polack, B | 1 |
| Roux, F | 1 |
| Porcheddu, A | 1 |
| Giacomelli, G | 1 |
| De Luca, L | 1 |
| Nok, AJ | 1 |
| Bray, PG | 1 |
| Ward, SA | 1 |
| Docampo, R | 1 |
| Moreno, SN | 1 |
| Jamonneau, V | 1 |
| Solano, P | 1 |
| Garcia, A | 1 |
| Djé, N | 1 |
| Miezan, TW | 2 |
| N'Guessan, P | 1 |
| Cuny, G | 1 |
| LOTTE, AJ | 1 |
| PILLE, G | 1 |
| GELFAND, M | 1 |
| ALVES, WD | 1 |
| GALL, D | 1 |
| MASSEGUIN, A | 1 |
| CAUSSE, M | 1 |
| RICOSSE, M | 1 |
| LE GAC, P | 1 |
| NEUJEAN, G | 1 |
| HAWKING, F | 1 |
| Legros, D | 3 |
| Savignoni, A | 1 |
| Etchegorry, MG | 2 |
| Mbulamberi, D | 1 |
| Abel, PM | 1 |
| Kiala, G | 1 |
| Lôa, V | 1 |
| Behrend, M | 1 |
| Musolf, J | 1 |
| Fleischmann, H | 1 |
| Théophile, J | 1 |
| Krishna, S | 1 |
| Anene, BM | 1 |
| Ezeokonkwo, RC | 1 |
| Mmesirionye, TI | 1 |
| Tettey, JN | 1 |
| Brock, JM | 1 |
| Werbovetz, K | 1 |
| Simarro, PP | 2 |
| Ndongo, P | 1 |
| Nguema, E | 1 |
| Louis, FJ | 1 |
| Jannin, J | 3 |
| Suzuki, T | 1 |
| Ueta, YY | 1 |
| Xuan, X | 1 |
| Saitoh, H | 1 |
| Suzuki, H | 1 |
| Uslan, DZ | 1 |
| Jacobson, KM | 1 |
| Kumar, N | 1 |
| Berbari, EF | 1 |
| Orenstein, R | 1 |
| Balasegaram, M | 1 |
| Harris, S | 1 |
| Checchi, F | 1 |
| Hamel, C | 1 |
| Karunakara, U | 1 |
| Eperon, G | 1 |
| Schmid, C | 1 |
| Loutan, L | 1 |
| Williamson, J | 1 |
| Dukes, P | 1 |
| Keithly, JS | 1 |
| Langreth, SG | 1 |
| Steck, EA | 1 |
| Kinnamon, KE | 1 |
| Davidson, DE | 1 |
| Duxbury, RE | 1 |
| Johnson, AJ | 1 |
| Masters, RE | 1 |
| Doua, F | 6 |
| Boa Yapo, F | 2 |
| Bronner, U | 1 |
| Gustafsson, LL | 1 |
| Ericsson, O | 1 |
| Miézan, T | 1 |
| Rais, M | 1 |
| Rombo, L | 1 |
| Yapo, FB | 1 |
| Berger, BJ | 1 |
| Carter, NS | 1 |
| Pépin, J | 1 |
| Milord, F | 1 |
| De Groof, D | 1 |
| Bruneel, H | 1 |
| Mungoma, K | 1 |
| Ruppol, JF | 1 |
| Dreyfuss, G | 4 |
| Pénicaut, B | 2 |
| Nicolas, JA | 4 |
| Craciunescu, D | 3 |
| Loiseau, P | 1 |
| Ponce-de-León, S | 1 |
| Lisker-Melman, M | 1 |
| Kato-Maeda, M | 1 |
| Gamboa-Domínguez, A | 1 |
| Ontiveros, C | 1 |
| Behrens, RH | 1 |
| González-Ruiz, A | 1 |
| Sanon Singaro, JR | 1 |
| Baltz, T | 1 |
| Pentreath, VW | 1 |
| Alafiatayo, RA | 1 |
| Barclay, GR | 1 |
| Crawley, B | 1 |
| Oppenheim, BA | 1 |
| Cattand, P | 1 |
| Youan, BB | 1 |
| Coulibaly, S | 1 |
| Miezan, TB | 1 |
| Bamba, M | 1 |
| Dumas, M | 3 |
| Bouteille, B | 3 |
| Barrett, SV | 1 |
| Doadrio, L | 1 |
| Parrondo, E | 1 |
| Craciunescu, DG | 2 |
| Gutierrez-Rios, MT | 1 |
| De Frutos, MI | 1 |
| Donkor, IO | 1 |
| Assefa, H | 1 |
| Lane, S | 1 |
| Vargas, M | 1 |
| Goldberg, B | 1 |
| Bacchi, C | 1 |
| Ollivier, G | 1 |
| Helenport, JP | 1 |
| Pecoul, B | 1 |
| Malvy, D | 1 |
| Djossou, F | 1 |
| Weill, FX | 1 |
| Chapuis, P | 1 |
| Longy-Boursier, M | 1 |
| Le Bras, M | 1 |
| Nathan, HC | 1 |
| Soto, KV | 1 |
| Moreira, R | 1 |
| Chunosoff, L | 1 |
| Hutner, SH | 1 |
| Limbos, P | 1 |
| Thomas, H | 1 |
| Beelaerts, W | 1 |
| Van Caesbroeck, D | 1 |
| Raether, W | 1 |
| Seidenath, H | 1 |
| Basson, W | 1 |
| Page, ML | 1 |
| Myburgh, DP | 1 |
| Sterner, G | 1 |
| Nåsander, L | 1 |
| Jennings, FW | 1 |
| Sima, FO | 1 |
| Mir, M | 1 |
| Mateo, MJ | 1 |
| Roche, J | 1 |
| Kern, P | 1 |
| Parrondo-Iglesias, E | 1 |
| Dubost, G | 3 |
| Braendli, B | 1 |
| Dankwa, E | 1 |
| Junghanss, T | 1 |
| Thomson, KD | 1 |
| Baeriswyl, S | 1 |
| Kunz, C | 1 |
| Jefferies, D | 1 |
| Jenni, L | 1 |
| Gutteridge, WE | 1 |
| Bosgiraud, C | 1 |
| Amevigbe, M | 1 |
| Pestre-Alexandre, M | 1 |
| Darde, ML | 1 |
| Vallat, JM | 1 |
| Gayral, P | 1 |
| Pearson, RD | 1 |
| Hewlett, EL | 1 |
| Arrøe, M | 1 |
| Willumsen, L | 1 |
| Tvede, M | 1 |
| Bennike, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis[NCT00802594] | Phase 2 | 30 participants (Actual) | Interventional | 2001-08-31 | Completed | ||
| Phase II b Trial of DB289 for the Treatment of Stage I African Trypanosomiasis[NCT00803933] | Phase 2 | 111 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 reviews available for pentamidine and African Sleeping Sickness
| Article | Year |
|---|---|
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Blood-Brain Barrier; Brain; Delayed Diagnosis; Humans; Incidence; Neg | 2019 |
Chemotherapy for second-stage human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurti | 2013 |
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option.
Topics: Antiprotozoal Agents; Chagas Disease; Drug Repositioning; Humans; Leishmaniasis; Neglected Diseases; | 2016 |
[Agents for the treatment of African sleeping sickness. Those developed in the last century].
Topics: Animals; Eflornithine; History, 20th Century; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; | 2009 |
Diamidine activity against trypanosomes: the state of the art.
Topics: Animals; Chagas Disease; Drug Resistance; Humans; Pentamidine; Trypanocidal Agents; Trypanosoma bruc | 2008 |
Chemotherapy for second-stage Human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Nifurti | 2010 |
Diamidines for human African trypanosomiasis.
Topics: Animals; Benzamidines; Biotransformation; Brain; Clinical Trials as Topic; Drug Design; Drug Resista | 2010 |
Potential new drugs for human African trypanosomiasis: some progress at last.
Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Ef | 2010 |
Drug resistance in human African trypanosomiasis.
Topics: Animals; Drug Resistance; Eflornithine; Humans; Membrane Transport Proteins; Nifurtimox; Pentamidine | 2011 |
New pentamidine analogues in medicinal chemistry.
Topics: Antiprotozoal Agents; Chemistry, Pharmaceutical; Drug Design; Humans; Pentamidine; Trypanosoma; Tryp | 2012 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Cha | 2012 |
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.
Topics: Animals; Aquaglyceroporins; Drug Resistance; Humans; Melarsoprol; Pentamidine; Phylogeny; Trypanocid | 2013 |
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis.
Topics: Animals; Drug Resistance; HIV; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypa | 2003 |
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Topics: Animals; Antiprotozoal Agents; Drug Resistance; Humans; Leishmania mexicana; Leishmaniasis, Cutaneou | 2003 |
Current chemotherapy of human African trypanosomiasis.
Topics: Animals; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma; | 2003 |
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic | 2006 |
Human trypanosomiasis in the Ivory Coast: therapy and problems.
Topics: Animals; Cote d'Ivoire; Eflornithine; Humans; Melarsoprol; Pentamidine; Recurrence; Trypanosoma bruc | 1993 |
The treatment of human African trypanosomiasis.
Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocid | 1994 |
The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.
Topics: Animals; Arsenicals; Cattle; Drug Resistance; Humans; Pentamidine; Trypanocidal Agents; Trypanosoma | 1999 |
Transporters in African trypanosomes: role in drug action and resistance.
Topics: Africa South of the Sahara; Animals; Arsenicals; Biological Transport; Eflornithine; Humans; Nitroim | 2001 |
[Use of pentamidine in protozoan diseases].
Topics: Humans; Leishmaniasis; Pentamidine; Pneumonia, Pneumocystis; Protozoan Infections; Trypanosomiasis, | 1990 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suram | 1985 |
Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoal diseases.
Topics: Amidines; Humans; Leishmaniasis; Pentamidine; Pneumonia, Pneumocystis; Protozoan Infections; Trypano | 1985 |
5 trials available for pentamidine and African Sleeping Sickness
| Article | Year |
|---|---|
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.
Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Repu | 2016 |
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.
Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Repu | 2016 |
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.
Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Repu | 2016 |
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies.
Topics: Administration, Oral; Adolescent; Adult; Angola; Antiprotozoal Agents; Benzamidines; Democratic Repu | 2016 |
Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Angola; Benzamidines; Child; Democratic Republic of t | 2016 |
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
Topics: Agglutination Tests; Antibodies, Protozoan; Eflornithine; Humans; Melarsoprol; Pentamidine; Treatmen | 2010 |
Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine.
Topics: Adolescent; Adult; Animals; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Female; Humans; I | 2003 |
Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness.
Topics: Adult; Aged; Animals; Biomarkers; Blood Pressure; Drug Therapy, Combination; Female; Follow-Up Studi | 1995 |
139 other studies available for pentamidine and African Sleeping Sickness
| Article | Year |
|---|---|
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Aza Compounds; Benzamidines; Mice; Plasmodium falcipar | 2003 |
Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
Topics: Animals; Antiprotozoal Agents; Carbamates; Cations; Circular Dichroism; DNA; Fluorenes; Guanidines; | 2005 |
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites.
Topics: Animals; Cell Line; Female; Furaldehyde; Hydrazones; Leishmania donovani; Mice; Nitrofurans; Nucleos | 2005 |
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
Topics: Animals; DNA; Female; Guanidines; Imidazolines; Mice; Nucleoside Transport Proteins; Structure-Activ | 2006 |
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
Topics: Animals; Cell Line; Kinetoplastida; Leishmania donovani; Microtubules; Models, Chemical; Models, Mol | 2007 |
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Topics: Animals; Antimalarials; Cell Line; DNA; Female; Guanidines; Hemeproteins; Hemin; Imidazolines; Malar | 2008 |
The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness.
Topics: Animals; Humans; Marine Biology; Molecular Structure; Parasitic Sensitivity Tests; Peroxides; Porife | 2009 |
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Topics: Adenosylmethionine Decarboxylase; Animals; Brain; Caco-2 Cells; Deoxyadenosines; Humans; Kinetics; M | 2009 |
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.
Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphtha | 2009 |
Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Dogs; Random Allocation; Rats; Trypanocidal Ag | 2009 |
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocid | 2009 |
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Topics: Animals; Antiprotozoal Agents; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Parasitic Sen | 2009 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Pro | 2010 |
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Nifurtimox; Trypanocidal Agents; Tr | 2010 |
Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Mice; Pentamidine; Plasmodium falciparum; Try | 2011 |
Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.
Topics: Amides; Animals; Antiprotozoal Agents; Cell Line; DNA; Guanidines; Humans; Malaria, Falciparum; Mode | 2011 |
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Diamines; Humans; Inhibitory Concentration 50; Kineto | 2012 |
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Topics: Animals; Benzamides; Cell Line; Drug Evaluation, Preclinical; Humans; Structure-Activity Relationshi | 2013 |
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; | 2013 |
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Ani | 2013 |
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrug | 2014 |
Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Topics: Administration, Oral; Animals; Biological Availability; Cell Line, Tumor; Cell Membrane Permeability | 2014 |
Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.
Topics: Animals; Boron Compounds; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Design; F | 2014 |
Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Female; Hep G2 Cells; Hu | 2014 |
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Topics: Drug Discovery; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Panobinostat; Sul | 2015 |
New heterocyclic compounds: Synthesis and antitrypanosomal properties.
Topics: Aminoquinolines; Animals; Benzimidazoles; Cell Line; Ferrous Compounds; Halogenation; Heterocyclic C | 2015 |
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity.
Topics: Animals; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Leukemia; Macrophages; Meth | 2015 |
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness.
Topics: Animals; Antiprotozoal Agents; Chaperonin 10; Chaperonin 60; Drug Evaluation, Preclinical; High-Thro | 2016 |
Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Topics: Animals; Antiprotozoal Agents; Humans; Leishmania donovani; Leishmaniasis, Visceral; NADH, NADPH Oxi | 2017 |
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Topics: Cell Line; Drug Discovery; Humans; Hydroxybenzoates; Membrane Potential, Mitochondrial; Mitochondria | 2017 |
Bistacrines as potential antitrypanosomal agents.
Topics: Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Mice; Molecular Structure; | 2017 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mic | 2018 |
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter
Topics: Animals; Aquaporin 2; Aquaporins; Drug Resistance; Melarsoprol; Mutation; Pentamidine; Trypanocidal | 2020 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentam | 2020 |
Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.
Topics: Animals; Blood-Brain Barrier; Female; Humans; Male; Mice; Mice, Inbred BALB C; Neglected Diseases; P | 2021 |
Single-dose pentamidine substantially reduces viability of trypanosomes in human East African trypanosomiasis.
Topics: Animals; Humans; Pentamidine; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 2021 |
Human African Trypanosomiasis in a Spanish traveler returning from Tanzania.
Topics: Diagnosis, Differential; Female; Humans; Middle Aged; Pentamidine; Spain; Suramin; Tanzania; Travel; | 2017 |
An ATP-Based Luciferase Viability Assay for Animal African Trypanosomes Using a 96-Well Plate.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Diminazene; Drug Evaluation, Preclinical; Humans; In | 2017 |
Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity.
Topics: Animals; Benzimidazoles; Cell Survival; Disease Models, Animal; Indoles; Mice; Parasitic Sensitivity | 2018 |
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller.
Topics: Animals; Delayed Diagnosis; Diagnosis, Differential; Female; Humans; Kenya; Malaria; Middle Aged; Ne | 2018 |
Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania.
Topics: Adult; China; Communicable Diseases, Imported; Female; Humans; Parks, Recreational; Pentamidine; Pol | 2018 |
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Topics: Cell Biology; Humans; Lysosomes; Melarsoprol; Mitochondria; Mitochondrial Proteins; Mitosis; Nifurti | 2018 |
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.
Topics: Animals; Cell Cycle; Disease Models, Animal; Metabolomics; Mice; Pentamidine; Structure-Activity Rel | 2019 |
Case Report:
Topics: Coinfection; Congo; Female; Fever; HIV Infections; HIV-1; Humans; Middle Aged; Multiple Myeloma; Pen | 2019 |
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Topics: Amidines; Animals; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Humans; Injec | 2013 |
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.
Topics: Aquaporin 2; DNA, Protozoan; Drug Resistance; Humans; Melarsoprol; Molecular Sequence Data; Mutation | 2013 |
Green fluorescent diamidines as diagnostic probes for trypanosomes.
Topics: Fluorescent Dyes; Humans; Microscopy, Fluorescence; Pentamidine; Trypanocidal Agents; Trypanosoma br | 2014 |
Outcome of acute East African trypanosomiasis in a Polish traveller treated with pentamidine.
Topics: Diagnosis, Differential; Erythema; Fever; Humans; Insect Bites and Stings; Male; Middle Aged; Pentam | 2014 |
Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.
Topics: Amidines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamidines; Blood-Brai | 2014 |
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Topics: Amidines; Animals; Dose-Response Relationship, Drug; Female; Humans; Melarsoprol; Mice; Pentamidine; | 2014 |
Establishment of ATP-based luciferase viability assay in 96-well plate for Trypanosoma congolense.
Topics: Adenosine Triphosphate; Animals; Cell Division; Dimethyl Sulfoxide; Diminazene; High-Throughput Scre | 2014 |
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
Topics: Adult; Animals; Aquaglyceroporins; Base Sequence; Democratic Republic of the Congo; DNA, Protozoan; | 2014 |
Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis.
Topics: Animals; Drug Carriers; Endocytosis; Epitopes; Female; Lactic Acid; Mice, Inbred C57BL; Nanoparticle | 2015 |
In vivo SPECT imaging of [¹²³I]-labeled pentamidine pro-drugs for the treatment of human African trypanosomiasis, pharmacokinetics, and bioavailability studies in rats.
Topics: Administration, Oral; Animals; Biological Availability; Blood-Brain Barrier; Brain; Humans; Male; Pe | 2014 |
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.
Topics: Amidines; Animals; Chlorocebus aethiops; Disease Models, Animal; Furans; Humans; Mice; Neglected Dis | 2015 |
Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.
Topics: Animals; Antibodies, Protozoan; Chitosan; Disease Models, Animal; Drug Carriers; Drug Resistance; El | 2015 |
Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei.
Topics: Animals; Cell Line; Drug Stability; Female; Hepatocytes; Humans; Inhibitory Concentration 50; Liver; | 2016 |
Refractory hypoglycaemia in a dog infected with Trypanosoma congolense.
Topics: Africa South of the Sahara; Animals; Antiprotozoal Agents; Dog Diseases; Dogs; Female; Fever; Glucos | 2016 |
Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2.
Topics: Animals; Aquaglyceroporins; Drug Resistance; Humans; Pentamidine; Trypanocidal Agents; Trypanosoma b | 2016 |
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
Topics: Amino Acid Sequence; Aquaporins; Comparative Genomic Hybridization; DNA, Protozoan; Drug Resistance; | 2016 |
African sleeping sickness.
Topics: Animals; Eflornithine; Humans; Insect Vectors; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents | 2016 |
Pentamidine dosage: a base/salt confusion.
Topics: Antiprotozoal Agents; Guidelines as Topic; Humans; Leishmaniasis; Pentamidine; Trypanocidal Agents; | 2008 |
Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes.
Topics: Animals; Arsenicals; Drug Resistance; Humans; Molecular Structure; Pentamidine; Trypanocidal Agents; | 2008 |
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Benzamidines; Female; Humans; Mice; Molecular S | 2008 |
Canine African trypanosoma.
Topics: Animals; Anti-Allergic Agents; Clemastine; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Ne | 2008 |
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration.
Topics: Administration, Oral; Animals; Benzamidines; Chlorocebus aethiops; Disease Models, Animal; Dose-Resp | 2009 |
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Bl | 2009 |
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
Topics: Animals; Blood-Brain Barrier; Central Nervous System Protozoal Infections; Female; Inhibitory Concen | 2009 |
[Double trypanosomal chancre revealing West African trypanosomiasis in a Frenchman living in Gabon].
Topics: Africa, Western; Antiprotozoal Agents; Chancre; France; Humans; Male; Middle Aged; Necrosis; Pentami | 2009 |
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.
Topics: Animals; Diminazene; Humans; Indicators and Reagents; Oxazines; Pentamidine; Sensitivity and Specifi | 2009 |
Human African trypanosomiasis.
Topics: Africa; Animals; Biomedical Research; Communicable Disease Control; Eflornithine; Endemic Diseases; | 2010 |
East African trypanosomiasis in a pregnant traveler.
Topics: Adult; Communicable Diseases, Emerging; Female; Humans; Infant, Newborn; London; Pentamidine; Pregna | 2009 |
Killer coma: the evolving story of sleeping sickness treatment.
Topics: Animals; Biomedical Research; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithi | 2010 |
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.
Topics: Adenosine; Animals; Antiprotozoal Agents; Carrier Proteins; Gene Knockdown Techniques; Melarsoprol; | 2010 |
Late results of treatment of sleeping sickness in Sierra Leone by antrypol tryparsamide pentamidine and propamidine singly and in various combinations.
Topics: Animals; Arsenicals; Benzamidines; Humans; Pentamidine; Sierra Leone; Trypanosomiasis, African | 1945 |
Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Benzamidines; Cross Reactions; Enzyme-Linked | 2010 |
Trypanosoma brucei infection in a HIV positive Ugandan male.
Topics: Adult; Animals; Fatal Outcome; HIV Seropositivity; Humans; Male; Pentamidine; Trypanocidal Agents; T | 2011 |
Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease.
Topics: Adult; Angola; Animals; Eflornithine; Female; Follow-Up Studies; Humans; Lymphocyte Count; Male; Nuc | 2012 |
Urban transmission of human African trypanosomiasis, Gabon.
Topics: Gabon; Humans; Male; Middle Aged; Pentamidine; Trypanocidal Agents; Trypanosomiasis, African; Urban | 2012 |
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Topics: Aquaglyceroporins; Drug Resistance; Eflornithine; Endocytosis; Glycosylation; High-Throughput Screen | 2012 |
A returning traveller with fever, facial swelling, and skin lesions.
Topics: Adrenal Cortex Hormones; Animals; Diagnosis, Differential; Disease Progression; Face; Fever; Humans; | 2012 |
Atypical hyperpachymorph Trypanosoma (Nannomonas) congolense forest-type in a dog returning from Senegal.
Topics: Animals; DNA, Protozoan; Dog Diseases; Dogs; Fatal Outcome; France; Injections, Intramuscular; Male; | 2012 |
[The return of sleeping sickness in an epidemic form: international action for drugs].
Topics: Africa, Central; Animals; Disease Outbreaks; Eflornithine; Humans; International Cooperation; Melars | 2002 |
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire.
Topics: Animals; Antibodies, Protozoan; DNA, Protozoan; Humans; Immunoglobulin M; Latex Fixation Tests; Leuk | 2003 |
[Interpretation of experimental results in the chemo-prophylaxis of trypanosomiasis gambiense].
Topics: Amidines; Animals; Biomedical Research; Black People; Humans; Pentamidine; Trypanosoma brucei gambie | 1953 |
[Pharmacologic comments on the diamidines and their use in trypanosomiasis].
Topics: Amidines; Animals; Black People; Humans; Pentamidine; Stilbenes; Trypanosomiasis; Trypanosomiasis, A | 1953 |
Three early cases of Rhodesian sleeping sickness treated with pentamidine isethionate.
Topics: Animals; Black People; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, African | 1954 |
The chemoprophylaxis of sleeping sickness with the diamidines.
Topics: Amidines; Animals; Chemoprevention; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, African | 1954 |
[Preliminary note on combined lomidine and moranyl in the prevention of sleeping sickness].
Topics: Amidines; Animals; Biomedical Research; Humans; Pentamidine; Suramin; Trypanosomiasis; Trypanosomias | 1955 |
Trypanosomiasis in Oubangui-Chari; principal reservoirs of infection and the results of chemoprophylaxis with pentamidine and lomidine.
Topics: Animals; Black People; Chemoprevention; Humans; Pentamidine; Trypanosomiasis; Trypanosomiasis, Afric | 1953 |
[Chemotherapy and chemoprophylaxis of sleeping sickness caused by Trypanosoma gambiense].
Topics: Animals; Arsenicals; Chemoprevention; Humans; Pentamidine; Suramin; Trypanosoma brucei gambiense; Tr | 1959 |
Trypanocidal action of p-biguanidoacetophenone amidinohydrazone.
Topics: Acetophenones; Animals; Guanidine; Guanidines; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma b | 1962 |
[Extensive measures of chemoprophylaxis by intramuscular injection of aromatic diamidines (lomidine) applied for many years with the aim of eradication of sleeping sickness in the territories of French Africa contaminated by that endemia].
Topics: Africa; Amidines; Animals; Chemoprevention; Humans; Injections, Intramuscular; Pentamidine; Trypanos | 1954 |
Retaking sleeping sickness control in Angola.
Topics: Adolescent; Adult; Age Distribution; Aged; Angola; Animals; Child; Child, Preschool; Disease Outbrea | 2004 |
A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.
Topics: Animals; Diminazene; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Resistance | 2006 |
The elimination of Trypanosoma brucei gambiense sleeping sickness in the focus of Luba, Bioko Island, Equatorial Guinea.
Topics: Agglutination Tests; Animals; Disease Outbreaks; Disease Vectors; Endemic Diseases; Equatorial Guine | 2006 |
Beneficial effect of erythropoietin administration on murine infection with Trypanosoma congolense.
Topics: Anemia; Animals; Antibodies, Monoclonal; DNA Primers; DNA Probes; Erythropoietin; Female; Gene Expre | 2006 |
A woman with fever and rash after African safari.
Topics: Africa; Exanthema; Female; Fever; Humans; Melarsoprol; Middle Aged; Pentamidine; Suramin; Travel; Tr | 2006 |
Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo.
Topics: Adolescent; Adult; Animals; Child; Cohort Studies; Democratic Republic of the Congo; Disease Progres | 2006 |
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school children.
Topics: Adolescent; Age Factors; Animals; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; I | 2007 |
Drug sensitivity of pleomorphic Trypanosoma rhodesiense.
Topics: Animals; Arsenicals; Drug Resistance, Microbial; Ethidium; Mice; Pentamidine; Quinolinium Compounds; | 1983 |
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.
Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoen | 1984 |
Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei.
Topics: Animals; Antimony Sodium Gluconate; Cricetinae; Leishmaniasis; Leishmaniasis, Visceral; Mesocricetus | 1983 |
Trypanosoma rhodesiense: evaluation of the antitrypanosomal action of 2,5-bis(4-guanylphenyl)furan dihydrochloride.
Topics: Amidines; Animals; Benzamidines; Female; Macaca mulatta; Male; Pentamidine; Trypanocidal Agents; Try | 1982 |
[Current therapy of trypanosomiasis].
Topics: Adenosylmethionine Decarboxylase; Animals; Arsenicals; Deoxyadenosines; Drug Resistance; Eflornithin | 1994 |
Polyamine and pentamidine metabolism in African trypanosomes.
Topics: Animals; Drug Resistance; Microsomes, Liver; Pentamidine; Polyamines; Rats; Trypanosoma brucei bruce | 1993 |
[A strategy to control Trypanosomiasis due to Trypanosoma brucei gambiense in an endemic region of Zaire. Association of a serological test and early treatment of suspected cases. Preliminary results].
Topics: Agglutination Tests; Animals; Clinical Protocols; Communicable Disease Control; Communicable Disease | 1993 |
Trypanocidal activity and platinum plasma kinetics of cis-Pt pentamidine iodide in Trypanosoma brucei sheep model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Iodides; Male; Organoplatinum Com | 1993 |
Trypanosoma brucei rhodesiense infection imported to Mexico from a tourist resort in Kenya.
Topics: Animals; Antifungal Agents; Diagnosis, Differential; Humans; Kenya; Leg; Male; Mexico; Middle Aged; | 1996 |
The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis.
Topics: Adolescent; Adult; Aged; Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, P | 1996 |
Endotoxin antibodies in African sleeping sickness.
Topics: Antibodies, Bacterial; Central Nervous System Diseases; Endotoxins; Gram-Negative Bacteria; Humans; | 1997 |
[Correspondence of the World Health Organization relative to the editorial by T. Ancelle (Med. Trop. 1996; 56: 347-348)].
Topics: Africa; Eflornithine; France; Global Health; Humans; International Cooperation; Melarsoprol; Pentami | 1997 |
In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense.
Topics: Administration, Oral; Animals; Cote d'Ivoire; Eflornithine; Infusions, Parenteral; Injections, Intra | 1997 |
[Current status of trypanosomiasis].
Topics: Africa; Animals; Autoantibodies; Blood-Brain Barrier; Brain Diseases; Follow-Up Studies; Forecasting | 1997 |
Anti-sleeping sickness drugs and cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocida | 2000 |
Treatment of human African trypanosomiasis.
Topics: Acetanilides; Africa; Humans; Melarsoprol; Nitroimidazoles; Pentamidine; Suramin; Thiadiazoles; Tryp | 2000 |
Antitrypanosomal properties of cis-platinum-pentamidine bromide, thiocyanate and seleniocyanate on Trypanosoma brucei brucei mouse and sheep models.
Topics: Animals; Drug Evaluation, Preclinical; Female; Male; Mice; Models, Animal; Organoplatinum Compounds; | 2001 |
Structure-activity relationships for new organometallic complexes active against bloodstream forms of Trypanosoma brucei brucei.
Topics: Animals; Disease Models, Animal; Female; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Orga | 2001 |
Trypanocidal activity of dicationic compounds related to pentamidine.
Topics: Animals; Cations, Divalent; Cattle; DNA; Drug Design; Drug Evaluation, Preclinical; Female; Inhibito | 2001 |
[Human african trypanosomiasis: A history of its therapies and their failures].
Topics: Arsenicals; Drug Resistance; History, 20th Century; History, 21st Century; Humans; Melarsoprol; Pent | 2001 |
Availability and affordability of treatment for Human African Trypanosomiasis.
Topics: Eflornithine; Health Services Accessibility; Humans; Melarsoprol; Pentamidine; Research; Suramin; Tr | 2001 |
[Human African trypanosomiasis from Trypanosoma brucei gambiense with inoculation chancre in a French expatriate].
Topics: Animals; Antibodies, Protozoan; Erythema; Fever; France; Guinea; Humans; Immunoglobulin G; Immunoglo | 2001 |
Chemotherapy of sleeping sickness.
Topics: Arsenicals; Humans; Melarsoprol; Pentamidine; Suramin; Trypanosomiasis, African | 1979 |
Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice.
Topics: Amidines; Animals; Carbanilides; Chemical Phenomena; Chemistry; Diminazene; Female; Imidocarb; Male; | 1979 |
[Kidney failure during treatment of T. rhodesiense trypanosomiasis with pentamidin].
Topics: Acute Kidney Injury; Adolescent; Adult; Amidines; Female; Humans; Male; Pentamidine; Trypanosoma; Tr | 1977 |
Trypanocidal effect of diamidine 98/202 in experimental Trypanosoma rhodesiense infection of the stumptailed macaque (Macaca arctoides).
Topics: Amidines; Animals; Blood-Brain Barrier; Cerebrospinal Fluid; Diminazene; Drug Resistance, Microbial; | 1976 |
Human trypanosomiasis in Southern Africa.
Topics: Complement System Proteins; Humans; Immunoglobulin M; Immunoglobulins; Male; Melarsoprol; Military M | 1977 |
African trypanosomiasis: a danger for tourists visiting Gambia?
Topics: Adult; Female; Gambia; Humans; Pentamidine; Travel; Trypanosomiasis, African | 1977 |
Editorial: African trypanosomiasis.
Topics: Humans; Insect Control; Pentamidine; Trypanosomiasis, African; Tsetse Flies | 1976 |
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug | 1992 |
[Control of human African trypanosomiasis in Luba in equatorial Guinea:evaluation of three methods].
Topics: Animals; Diptera; Guinea; Insect Control; Insect Vectors; Mass Screening; Melarsoprol; Pentamidine; | 1991 |
[Trypanocidal activity and plasma kinetics of cis-Pt(II) pentamidine in the parasitized sheep].
Topics: Animals; Kinetics; Male; Organoplatinum Compounds; Pentamidine; Sheep; Trypanocidal Agents; Trypanos | 1990 |
[East African sleeping sickness (Trypanosoma rhodesiense infection) in 2 Swiss travelers to the tropics].
Topics: Adult; Animals; Diagnosis, Differential; Humans; Malaria; Male; Pentamidine; Rwanda; Switzerland; Tr | 1990 |
Tryparsamide.
Topics: Drug Therapy, Combination; Humans; Melarsoprol; Nigeria; Pentamidine; Suramin; Trypanocidal Agents; | 1989 |
In vitro drug sensitivity of Trypanosoma gambiense isolates.
Topics: Animals; Arsenicals; Cote d'Ivoire; Humans; Melarsoprol; Pentamidine; Suramin; Trypanocidal Agents; | 1989 |
The effect of trypanocidal drugs on the transmission of Trypanosoma brucei brucei by Glossina morsitans centralis.
Topics: Animals; Diminazene; Pentamidine; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma brucei | 1987 |
[Trial of pentamidine in the treatment of trypanosomiasis of sheep inoculated with Trypanosoma brucei brucei].
Topics: Amidines; Animals; Pentamidine; Sheep; Trypanosoma brucei brucei; Trypanosomiasis, African | 1988 |
[Antiparasitic activity of Cis-Pt (II) pentamidine in experimental trypanosomiasis of sheep caused by Trypanosoma brucei brucei].
Topics: Amidines; Animals; Organoplatinum Compounds; Pentamidine; Sheep; Trypanocidal Agents; Trypanosoma br | 1988 |
[Acute African trypanosomiasis imported into Denmark].
Topics: Adult; Denmark; Humans; Male; Pentamidine; Travel; Trypanosomiasis, African | 1985 |