pentamidine has been researched along with AIDS-Related Complex in 5 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
AIDS-Related Complex: A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and toxicity of pentamidine inhaled once a month to prevent Pneumocystis carinii pneumonia (PCP) was investigated in 102 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 3.67 | Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine. ( Chernoff, D; Conte, JE; Feigal, D; Golden, JA; Hollander, H, 1989) |
| "89 patients were clinically in the AIDS stage and 33 in the AIDS-related complex (ARC) stage." | 1.28 | [The prevention of Pneumocystis carinii pneumonia by pentamidine inhalation]. ( Elsing, C; Erckenbrecht, J; Hengels, KH; Jablonowski, H; Strohmeyer, G, 1992) |
| "In an open prospective study in the AIDS Outpatient Department of the Frankfurt University Clinic the efficacy of pentamidine aerosol at a dosage of 200 mg every 14 days in the primary and secondary prophylaxis of pneumocystis carinii pneumonia was tested." | 1.28 | [Prospective study of primary and secondary prevention of Pneumocystis carinii pneumonia with pentamidine aerosol]. ( Brodt, R; Gottstein, A; Helm, EB; Jacobi, V; Müller, H; Müller, R; Odewald, J; Rehmet, S; Staszewski, S; Trinder, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Girard, PM | 1 |
| Landman, R | 1 |
| Gaudebout, C | 2 |
| Olivares, R | 1 |
| Saimot, AG | 1 |
| Jelazko, P | 1 |
| Certain, A | 1 |
| Boué, F | 1 |
| Bouvet, E | 1 |
| Jablonowski, H | 1 |
| Elsing, C | 1 |
| Erckenbrecht, J | 1 |
| Hengels, KH | 1 |
| Strohmeyer, G | 1 |
| Hirschel, B | 1 |
| Lazzarin, A | 1 |
| Chopard, P | 1 |
| Opravil, M | 1 |
| Furrer, HJ | 1 |
| Rüttimann, S | 1 |
| Vernazza, P | 1 |
| Chave, JP | 1 |
| Ancarani, F | 1 |
| Gabriel, V | 1 |
| Staszewski, S | 1 |
| Trinder, S | 1 |
| Gottstein, A | 1 |
| Odewald, J | 1 |
| Rehmet, S | 1 |
| Brodt, R | 1 |
| Jacobi, V | 1 |
| Müller, R | 1 |
| Müller, H | 1 |
| Helm, EB | 1 |
| Golden, JA | 1 |
| Chernoff, D | 1 |
| Hollander, H | 1 |
| Feigal, D | 1 |
| Conte, JE | 1 |
2 trials available for pentamidine and AIDS-Related Complex
| Article | Year |
|---|---|
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group.
Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence | 1993 |
A controlled study of inhaled pentamidine for primary prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adolescent; Adult; Aerosols; Aged; A | 1991 |
3 other studies available for pentamidine and AIDS-Related Complex
| Article | Year |
|---|---|
[The prevention of Pneumocystis carinii pneumonia by pentamidine inhalation].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adolescent; Adult; AIDS-Related Comp | 1992 |
[Prospective study of primary and secondary prevention of Pneumocystis carinii pneumonia with pentamidine aerosol].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; Adult; AIDS-Related Complex; Humans; | 1990 |
Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine.
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Complex; Amidines; Coho | 1989 |