Page last updated: 2024-08-17

penicillanic acid and Critical Illness

penicillanic acid has been researched along with Critical Illness in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (1.85)	29.6817
2010's	44 (81.48)	24.3611
2020's	9 (16.67)	2.80

Authors

Authors	Studies
Agarwal, SK; Buckley, MS; D'Alessio, PA; Kane-Gill, SL; Kobic, E; Komerdelj, IA; Martinez, BK; Rangan, P; Tinta, NC; Yerondopoulos, MJ; Ziadat, DS	1
Kim, HI; Kim, HS; Kim, YK; Lee, DH; Lee, SH; Park, S	1
Akers, KS; Chung, KK; DeLuca, JP; Livezey, JR; Nadeau, RJ; Por, ED; Pruskowski, KA; Selig, DJ	1
Bazan, NS; Elmazar, MM; Naiim, CM; Sabri, NA	1
Agyekum, RS; Anderson, BJ; Cosgriff, CV; Dunn, TG; Giannini, HM; Hennessy, S; Ittner, CAG; Jones, TK; Meyer, NJ; Miano, TA; Oniyide, O; Reilly, JP; Shashaty, MGS; Townsend, R; Turner, AP; Weisman, AR; Wilson, FP; Yang, W	1
François, T; Luc, A; Novy, E; Pape, E; Scala-Bertola, J	1
Bardonneau, G; Biais, M; Carrié, C; Gruson, D; Ouattara, A; Pereira, B; Petit, L	1
Caissy, JA; El-Haffaf, I; Marsot, A	1
Carlier, M; De Cock, PAJG; de Jaeger, A; De Paepe, P; Delanghe, JR; Della Pasqua, OE; Robays, H; van Dijkman, SC; Vande Walle, J; Verstraete, AG; Willems, J	1
Chan, JD; Dellit, TH; Lynch, JB	1
Aardema, H; Alffenaar, JW; Dieperink, W; Kosterink, JGW; Nannan Panday, P; van Hateren, K; Wessels, M; Zijlstra, JG	1
Cotta, MO; Lefrant, JY; Lipman, J; Muller, L; Roberts, JA; Roger, C; Wallis, SC	1
Bennis, Y; Bodeau, S; Kontar, L; Lemaire-Hurtel, AS; Maizel, J; Masmoudi, K; Quinton, MC; Slama, M; Zerbib, Y	1
Mueller, BA; Shaw, AR	1
Borgia, G; Cascella, M; Corcione, S; Cuomo, A; De Rosa, FG; Gentile, I; Maraolo, AE; Nappa, S	1
Fusco, NM; Hassinger, AB; Holsen, MR; Meaney, CJ	1
Awdishu, L	1
Guerra Valero, YC; Lipman, J; Naicker, S; Ordenez Meija, JL; Parker, SL; Roberts, JA; Wallis, SC	1
Juang, P; Kollef, MH; Micek, ST	1
Carlier, M; Carrette, S; De Waele, JJ; Decruyenaere, J; Depuydt, P; Hoste, E; Lipman, J; Roberts, JA; Stove, V; Verstraete, A; Wallis, SC	1
Kollef, MH	1
Allen, N; Fish, DN; Newell, M; Rafferty, KD; Sturm, AW; Toschlog, E; Waibel, B	1
Cies, JJ; Kuti, JL; Schlichting, C; Shankar, V	1
Asín-Prieto, E; Isla, A; Maynar, J; Rodríguez-Gascón, A; Sánchez-Izquierdo, JÁ; Soraluce, A; Trocóniz, IF	1
Althaus, K; Busemann, C; Friesecke, S; Greinacher, A; Hron, G; Knutson, F; Lubenow, N; Thiele, T	1
Boelens, J; Carlier, M; Carrette, S; Claeys, G; De Waele, JJ; Decruyenaere, J; Depuydt, P; Hoste, E; Leroux-Roels, I; Stove, V; Verstraete, AG	1
Boots, RJ; Jarrett, P; Kirkpatrick, CM; Lipman, J; Roberts, JA; Varghese, JM	1
Akers, KS; Cannon, JW; Chung, KK; Cota, JM; Murray, CK; Niece, KL	1
Boselli, E; Felton, TW; Hope, WW; Lodise, TP; Neely, MN; Roberts, JA; Van Guilder, M	1
Bentley, AM; Felton, TW; Goodwin, J; Hope, WW; Isalska, B; Malagon, I; McCalman, K; Whalley, S	1
Piérard, D; Spapen, H; Yusuf, E	1
Andersen, MH; Arendrup, MC; Bestle, MH; Cozzi-Lepri, A; Drenck, NE; Grarup, J; Hein, L; Helweg-Larsen, J; Jensen, JU; Johansen, ME; Larsen, KM; Lauritsen, AØ; Lundgren, B; Lundgren, JD; Løken, J; Mohr, T; Møller, JK; Olesen, B; Petersen, JA; Reinholdt, K; Strange, D; Søe-Jensen, P; Thormar, K; Tousi, H; Østergaard, C	1
Amyot, J; Awissi, DK; Beauchamp, A; Fagnan, M; Hébert, E; Lavallée, C; Lavigne, V; Leblanc, M; Lebrun, G; Munoz, DL; Pichette, V; Robitaille, R; Savoie, M; Tétreault, N; Varin, F	1
Abdul-Aziz, MH; Akova, M; Bassetti, M; De Waele, JJ; Dimopoulos, G; Dulhunty, J; Kaukonen, KM; Koulenti, D; Lipman, J; Martin, C; Montravers, P; Rello, J; Rhodes, A; Roberts, JA; Starr, T; Wallis, SC	1
Davies, SW; Dietch, ZC; Efird, JT; Guidry, CA; Sawyer, RG; Shah, PM; Willis, RN	1
Buenger, LE; Chung, EK; Crumby, AS; Dees, J; Healy, DP; Kays, MB; Knoderer, CA; Nichols, K	1
Bezouška, J; Havel, E; Kaška, M; Malbrain, ML; Martínková, J; Šafránek, P	1
Cotton, F; Creteur, J; Gustot, T; Hites, M; Jacobs, F; Lheureux, O; Surin, R; Taccone, FS; Trepo, E; Vincent, JL; Wolff, F	1
Gonzales, JP; Heil, EL; Mehrotra, S; Nicolau, DP; Oliver, WD; Robinett, K; Saleeb, P	1
Calvo, G; Fernández, J; Llauradó-Serra, M; Martín-Loeches, I; Pontes, C; Rodríguez, A; Soy, D; Torres, A; Ulldemolins, M; Vaquer, S	1
Hammond, DA; Lusardi, K; Meena, NK; Painter, JT; Smith, MN	1
Cotta, MO; Lipman, J; Little, PJ; McDonald, C; McWhinney, B; Roberts, JA; Ungerer, JP	1
Aduroja, OA; Amde, M; Connor, MJ; Fissell, WH; Gould, ER; Groszek, JJ; Madonia, PN; Nesbitt, R; Salem, C; Shotwell, MS; Taylor, ME; Tolwani, AJ; Wei, P	1
Cotta, MO; Lipman, J; Roberts, JA	1
Ghazi, IM; Kuti, JL; Nicolau, DP; Quintiliani, R; Shore, E	1
Döbbeler, G; Frey, L; Huseyn-Zada, M; Jung, J; Nagel, D; Scharf, C; Vogeser, M; Zander, J; Zoller, M	1
Bao, H; Lv, Y; Wang, D; Xue, J; Yan, Z	1
Chan, YH; Cheng, WY; Fan, SY; Leung, SM; Shum, HP; Yan, WW	1
Breilh, D; Jaber, S; Jean-Pierre, H; Jung, B; Legeron, R; Mahul, M; Molinari, N; Signe, J; Uhlemann, AC	1
Blondiaux, N; Courcol, RJ; Durocher, A; Favory, R; Nseir, S; Onimus, T; Roussel-Delvallez, M; Wallet, F	1
Bellomo, R; Cole, L; Lipman, J; Liu, X; Nair, P; Roberts, DM; Roberts, JA; Roberts, MS	1
Bento, L; Estilita, J; Gonçalves-Pereira, J; Gouveia, J; Janeiro, S; Monteiro, C; Oliveira, BS; Paulino, C; Póvoa, P; Salgueiro, A; Vieira, A	1
Lee, GC; Liou, H; Neldner, K; Quan, CF; Yee, R	1
Drusano, GL; Lodise, TP; Lomaestro, B	1

Reviews

6 review(s) available for penicillanic acid and Critical Illness

Article	Year
Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini-review and population pharmacokinetic analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:8 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Tazobactam	2022
Piperacillin-Tazobactam in Intensive Care Units: A Review of Population Pharmacokinetic Analyses. Clinical pharmacokinetics, 2021, Volume: 60, Issue:7 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Intensive Care Units; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Prospective Studies; Tazobactam	2021
Antibiotic Dosing in Continuous Renal Replacement Therapy. Advances in chronic kidney disease, 2017, Volume: 24, Issue:4 Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Computer Simulation; Critical Illness; Humans; Levofloxacin; Meropenem; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Renal Replacement Therapy; Sepsis; Tazobactam; Thienamycins	2017
Management of multidrug-resistant Pseudomonas aeruginosa in the intensive care unit: state of the art. Expert review of anti-infective therapy, 2017, Volume: 15, Issue:9 Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Ceftazidime; Cephalosporins; Critical Illness; Disease Management; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Humans; Intensive Care Units; Penicillanic Acid; Pseudomonas aeruginosa; Pseudomonas Infections; Risk Factors; Tazobactam; Treatment Outcome	2017
Drug-induced kidney disease in the ICU: mechanisms, susceptibility, diagnosis and management strategies. Current opinion in critical care, 2017, Volume: 23, Issue:6 Topics: Acute Kidney Injury; Critical Illness; Disease Susceptibility; Drug Therapy, Combination; Humans; Intensive Care Units; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Renal Replacement Therapy; Risk Factors; Vancomycin	2017
Prolonged vs intermittent infusion of piperacillin/tazobactam in critically ill patients: a narrative and systematic review. Journal of critical care, 2014, Volume: 29, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Female; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Randomized Controlled Trials as Topic; Retrospective Studies	2014

Trials

6 trial(s) available for penicillanic acid and Critical Illness

Article	Year
Extended infusion of piperacillin-tazobactam versus intermittent infusion in critically ill egyptian patients: a cost-effectiveness study. Scientific reports, 2022, 06-27, Volume: 12, Issue:1 Topics: Anti-Bacterial Agents; Cost-Benefit Analysis; Critical Illness; Egypt; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2022
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Renal Replacement Therapy; Serum; Young Adult	2014
Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial. Intensive care medicine, 2014, Volume: 40, Issue:3 Topics: beta-Lactamase Inhibitors; Creatine; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Male; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins	2014
Pulmonary penetration of piperacillin and tazobactam in critically ill patients. Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Critical Illness; Drug Combinations; Drug Resistance, Bacterial; Female; Humans; Lung; Male; Middle Aged; Monte Carlo Method; Penicillanic Acid; Permeability; Piperacillin; Tazobactam	2014
Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime. Critical care medicine, 2015, Volume: 43, Issue:3 Topics: Age Factors; Aged; Anti-Bacterial Agents; APACHE; Candidiasis, Invasive; Cefuroxime; Ciprofloxacin; Critical Illness; Denmark; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Intensive Care Units; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Single-Blind Method; Thienamycins	2015
Clinical outcomes of extended versus intermittent administration of piperacillin/tazobactam for the treatment of hospital-acquired pneumonia: a randomized controlled trial. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017, Volume: 36, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; China; Chromatography, High Pressure Liquid; Costs and Cost Analysis; Critical Illness; Cross Infection; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Pneumonia, Bacterial; Treatment Outcome; Young Adult	2017

Other Studies

42 other study(ies) available for penicillanic acid and Critical Illness

Article	Year
Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study. Journal of critical care, 2022, Volume: 67 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Cefepime; Cohort Studies; Critical Illness; Drug Therapy, Combination; Humans; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Propensity Score; Retrospective Studies; Vancomycin	2022
Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation. The Journal of antimicrobial chemotherapy, 2022, 04-27, Volume: 77, Issue:5 Topics: Adult; Anti-Bacterial Agents; Critical Illness; Extracorporeal Membrane Oxygenation; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Republic of Korea; Tazobactam	2022
Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive care medicine, 2022, Volume: 48, Issue:9 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Biomarkers; Cefepime; Creatinine; Critical Illness; Cystatin C; Drug Therapy, Combination; Humans; Penicillanic Acid; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Renal Dialysis; Retrospective Studies; Vancomycin	2022
Is therapeutic drug monitoring really helpful for managing piperacillin/tazobactam therapy in critically ill patients? Intensive care medicine, 2022, Volume: 48, Issue:11 Topics: Anti-Bacterial Agents; Critical Illness; Drug Monitoring; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2022
Piperacillin-tazobactam should be preferred to third-generation cephalosporins to treat wild-type inducible AmpC-producing Enterobacterales in critically ill patients with hospital or ventilator-acquired pneumonia. Journal of critical care, 2020, Volume: 56 Topics: Aged; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Cephalosporins; Critical Illness; Cross Infection; Enterobacter; Family Characteristics; Female; Hospitals; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Penicillanic Acid; Piperacillin, Tazobactam Drug Combination; Pneumonia, Ventilator-Associated; Retrospective Studies; Ventilators, Mechanical	2020
Dose optimization of piperacillin/tazobactam in critically ill children. The Journal of antimicrobial chemotherapy, 2017, 07-01, Volume: 72, Issue:7 Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Tazobactam	2017
Hospital Length of Stay Among Patients Receiving Intermittent Versus Prolonged Piperacillin/Tazobactam Infusion in the Intensive Care Units. Journal of intensive care medicine, 2018, Volume: 33, Issue:2 Topics: Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Female; Hospital Mortality; Humans; Infusions, Intravenous; Intensive Care Units; Length of Stay; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies	2018
Target attainment with continuous dosing of piperacillin/tazobactam in critical illness: a prospective observational study. International journal of antimicrobial agents, 2017, Volume: 50, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chromatography, Liquid; Critical Illness; Female; Humans; Male; Middle Aged; Netherlands; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Tandem Mass Spectrometry; Young Adult	2017
Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients. International journal of antimicrobial agents, 2017, Volume: 50, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chromatography; Critical Illness; Female; Hemofiltration; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Renal Insufficiency; Time Factors	2017
Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:9 Topics: Aged; Anti-Bacterial Agents; Critical Care; Critical Illness; Drug Monitoring; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nervous System Diseases; Penicillanic Acid; Piperacillin; Retrospective Studies; Tazobactam	2017
Increased Risk of Acute Kidney Injury in Critically Ill Children Treated With Vancomycin and Piperacillin/Tazobactam. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017, Volume: 18, Issue:12 Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Ceftriaxone; Child; Child, Preschool; Critical Illness; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Intensive Care Units, Pediatric; Logistic Models; Male; Odds Ratio; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2017
A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent. Journal of pharmaceutical and biomedical analysis, 2018, Jan-30, Volume: 148 Topics: Calibration; Chromatography, High Pressure Liquid; Critical Illness; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Renal Replacement Therapy; Sensitivity and Specificity; Tandem Mass Spectrometry; Tazobactam; Urine	2018
Vancomycin/Piperacillin-tazobactam Nephrotoxicity in the Critically Ill. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 03-17, Volume: 70, Issue:7 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2020
Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used? Critical care (London, England), 2013, May-03, Volume: 17, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Creatinine; Critical Illness; Drug Delivery Systems; Female; Humans; Infusions, Intravenous; Kidney; Male; Meropenem; Metabolic Clearance Rate; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins	2013
Antibiotics for the critically ill: more than just selecting appropriate initial therapy. Critical care (London, England), 2013, May-23, Volume: 17, Issue:3 Topics: Critical Illness; Drug Delivery Systems; Female; Humans; Kidney; Male; Meropenem; Metabolic Clearance Rate; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2013
Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients. Pharmacotherapy, 2014, Volume: 34, Issue:1 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Obesity, Morbid; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2014
Population pharmacokinetics of piperacillin/tazobactam in critically ill young children. The Pediatric infectious disease journal, 2014, Volume: 33, Issue:2 Topics: Bacterial Infections; Child; Child, Preschool; Cohort Studies; Critical Illness; Female; Humans; Infant; Intensive Care Units, Pediatric; Male; Monte Carlo Method; Penicillanic Acid; Philadelphia; Piperacillin; Piperacillin, Tazobactam Drug Combination	2014
Alternative diagnosis to heparin-induced thrombocytopenia in two critically ill patients despite a positive PF4/heparin-antibody test. Upsala journal of medical sciences, 2013, Volume: 118, Issue:4 Topics: Aged; Critical Illness; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Femoral Neck Fractures; Heparin; Humans; Methotrexate; Pancytopenia; Penicillanic Acid; Piperacillin; Platelet Count; Platelet Factor 4; Purpura, Thrombocytopenic; Tazobactam; Thrombocytopenia; Transfusion Reaction	2013
Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration. International journal of antimicrobial agents, 2014, Volume: 43, Issue:4 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Extracellular Fluid; Female; Half-Life; Hemofiltration; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Sepsis; Tazobactam	2014
Modified Augmented Renal Clearance score predicts rapid piperacillin and tazobactam clearance in critically ill surgery and trauma patients. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:3 Suppl 2 Topics: Adult; Aged, 80 and over; Anti-Bacterial Agents; Creatinine; Critical Illness; Cross-Sectional Studies; Female; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Tazobactam; Wounds and Injuries; Young Adult	2014
Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Bayes Theorem; Creatinine; Critical Illness; Drug Dosage Calculations; Drug Therapy, Computer-Assisted; Female; Humans; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Precision Medicine; Pseudomonas aeruginosa; Young Adult	2014
Pharmacokinetics of an extended 4-hour infusion of piperacillin-tazobactam in critically ill patients undergoing continuous renal replacement therapy. Pharmacotherapy, 2015, Volume: 35, Issue:6 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Pseudomonas aeruginosa; Pseudomonas Infections; Tertiary Care Centers	2015
Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DA The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:1 Topics: Aged; Anti-Bacterial Agents; Blood Chemical Analysis; Critical Illness; Female; Humans; Infusions, Intravenous; Intensive Care Units; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins; Treatment Outcome	2016
Top Guns: The "Maverick" and "Goose" of Empiric Therapy. Surgical infections, 2016, Volume: 17, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Insufficiency; Retrospective Studies; Risk Assessment; Vancomycin	2016
Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1 Topics: Age Factors; Anti-Bacterial Agents; Area Under Curve; Child; Child, Preschool; Computer Simulation; Critical Illness; Drug Administration Schedule; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Glomerular Filtration Rate; Half-Life; Humans; Infant; Intensive Care Units; Male; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sex Factors	2016
A pilot study on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving piperacillin/tazobactam. Anaesthesiology intensive therapy, 2016, Volume: 48, Issue:1 Topics: Adult; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Pilot Projects; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2016
Serum β-lactam concentrations in critically ill patients with cirrhosis: a matched case-control study. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:7 Topics: Aged; Anti-Bacterial Agents; Belgium; Case-Control Studies; Chromatography, High Pressure Liquid; Critical Illness; Databases, Factual; Drug Monitoring; Female; Humans; Liver Cirrhosis; Logistic Models; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sepsis; Thienamycins	2016
Ceftolozane-Tazobactam Pharmacokinetics in a Critically Ill Patient on Continuous Venovenous Hemofiltration. Antimicrobial agents and chemotherapy, 2015, Dec-28, Volume: 60, Issue:3 Topics: Anti-Bacterial Agents; Cephalosporins; Critical Illness; Drug Resistance, Multiple, Bacterial; Hemofiltration; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Prospective Studies; Prosthesis-Related Infections; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam	2015
Piperacillin population pharmacokinetics in critically ill patients with multiple organ dysfunction syndrome receiving continuous venovenous haemodiafiltration: effect of type of dialysis membrane on dosing requirements. The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Weight; Chromatography, Liquid; Critical Illness; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Mass Spectrometry; Microbial Sensitivity Tests; Middle Aged; Multiple Organ Failure; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Tertiary Care Centers; Young Adult	2016
Comparative Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam or Cefepime: A Retrospective Cohort Study. Pharmacotherapy, 2016, Volume: 36, Issue:5 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Arkansas; Cefepime; Cephalosporins; Critical Illness; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2016
Is high-dose β-lactam therapy associated with excessive drug toxicity in critically ill patients? Minerva anestesiologica, 2016, Volume: 82, Issue:9 Topics: Adult; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chemical and Drug Induced Liver Injury; Cholestasis; Critical Illness; Drug Monitoring; Female; Humans; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Retrospective Studies; Seizures; Thienamycins; Thrombocytopenia	2016
Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT. Clinical journal of the American Society of Nephrology : CJASN, 2016, 08-08, Volume: 11, Issue:8 Topics: Acute Kidney Injury; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Dialysis Solutions; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Time Factors	2016
We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how? Critical care (London, England), 2016, 06-06, Volume: 20, Issue:1 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Penicillanic Acid; Piperacillin	2016
Treatment of multidrug-resistant Pseudomonas aeruginosa with ceftolozane/tazobactam in a critically ill patient receiving continuous venovenous haemodiafiltration. International journal of antimicrobial agents, 2016, Volume: 48, Issue:3 Topics: Aged; Anti-Infective Agents, Urinary; beta-Lactamase Inhibitors; Cephalosporins; Chromatography, High Pressure Liquid; Critical Illness; Drug Resistance, Multiple, Bacterial; Hemofiltration; Humans; Male; Penicillanic Acid; Plasma; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam; Treatment Outcome; United States	2016
Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients. International journal of antimicrobial agents, 2016, Volume: 48, Issue:4 Topics: Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Drug Monitoring; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Serum	2016
Clinical Outcomes of Extended Versus Intermittent Infusion of Piperacillin/Tazobactam in Critically Ill Patients: A Prospective Clinical Trial. Pharmacotherapy, 2017, Volume: 37, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Critical Illness; Female; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2017
Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing. Critical care medicine, 2017, Volume: 45, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Mass Index; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Monte Carlo Method; Obesity; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Shock, Septic	2017
Daily serum piperacillin monitoring is advisable in critically ill patients. International journal of antimicrobial agents, 2010, Volume: 35, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Drug Monitoring; Female; France; Hospitals, Teaching; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Serum; Tazobactam; Time Factors	2010
Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study. Critical care medicine, 2012, Volume: 40, Issue:5 Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Ciprofloxacin; Critical Illness; Female; Hemofiltration; Humans; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Tazobactam; Thienamycins; Vancomycin	2012
Continuous infusion of piperacillin/tazobactam in septic critically ill patients--a multicenter propensity matched analysis. PloS one, 2012, Volume: 7, Issue:11 Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Critical Illness; Female; Humans; Infections; Intensive Care Units; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Portugal	2012
Outcomes of extended-infusion piperacillin-tazobactam: a retrospective analysis of critically ill patients. Clinical therapeutics, 2012, Volume: 34, Issue:12 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Drug Administration Schedule; Female; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies	2012
Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Feb-01, Volume: 44, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; beta-Lactams; Cohort Studies; Critical Illness; Cross Infection; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Models, Biological; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas Infections; Retrospective Studies	2007