penicillamine and Urinary Calculi studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Urinary Calculi: Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.

Research Excerpts

Excerpt	Relevance	Reference
"We reviewed the charts of all 11 children with cystinuria treated at our clinic using a gradual dose escalation of penicillamine."	7.74	Penicillamine therapy for pediatric cystinuria: experience from a cohort of American children. ( Coughlin, CR; DeBerardinis, RJ; Kaplan, P, 2008)
" Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine."	6.73	Cystinuria in children and young adults: success of monitoring free-cystine urine levels. ( Dello Strologo, L; Laurenzi, C; Legato, A; Pastore, A, 2007)
"We reviewed the charts of all 11 children with cystinuria treated at our clinic using a gradual dose escalation of penicillamine."	3.74	Penicillamine therapy for pediatric cystinuria: experience from a cohort of American children. ( Coughlin, CR; DeBerardinis, RJ; Kaplan, P, 2008)
" To improve the medical treatment of patients with cystinuria, this strategy was performed to guide the fluid intake and the administration of SH compounds (tiopronin, D-penicillamine, and MESNA)."	3.71	Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria. ( Christensson, A; Denneberg, T; Fjellstedt, E; Jeppsson, JO; Tiselius, HG, 2001)
"46 pregnancies in patients with cystinuria treated with a high fluid intake alone or in combination with D-penicillamine resulted in 41 normal births."	3.66	Pregnancy and cystinuria. ( Gregory, MC; Mansell, MA, 1983)
"During a 4-year period 9 cases of severe recurrent cystine stones and cystinuria were treated with mercaptopropionylglycine."	3.65	Mercaptopropionylglycine: a progress in cystine stone therapy. ( Hautmann, R; Lutzeyer, W; Stuhlsatz, HW; Terhorst, B, 1977)
" Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine."	2.73	Cystinuria in children and young adults: success of monitoring free-cystine urine levels. ( Dello Strologo, L; Laurenzi, C; Legato, A; Pastore, A, 2007)
"Captopril was added for failure of or intolerance to D-penicillamine or alpha-mercaptopropionylglycine."	2.68	Medical treatment of cystinuria: results of contemporary clinical practice. ( Chow, GK; Streem, SB, 1996)
"Cystinuria is an autosomal recessive disorder, and primary manifestation is the repeated formation of cystine calculi."	1.30	[Clinical study on cystinuria in children--the stone management and the prevention of calculi recurrence]. ( Asanuma, H; Kawamura, T; Nagakura, K; Nakai, H; Shishido, S; Takeda, M; Yamafuji, M, 1998)
" A relatively high dosage resulted in a reduction of the cytinuria."	1.25	[Cystine stone therapy with mercapto-propyonyl-glycine (MPG) (Thiola) (author's transl)]. ( Stuhlsatz, HW; Terhorst, B, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (79.49)	18.7374
1990's	5 (12.82)	18.2507
2000's	3 (7.69)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
DeBerardinis, RJ	1
Coughlin, CR	1
Kaplan, P	1
LOTZ, M	2
BARTTER, FC	2
POTTS, JT	1
Dello Strologo, L	1
Laurenzi, C	1
Legato, A	1
Pastore, A	1
Earll, JM	1
Kolb, FO	1
Gregory, MC	1
Mansell, MA	1
Evans, WP	1
Resnick, MI	1
Boyce, WH	1
Laurenti, C	1
De Dominicis, C	1
Gallucci, M	1
Iori, F	1
Dal Forno, S	1
Franco, G	1
Denneberg, T	2
Jeppsson, JO	2
Stenberg, P	1
Williams, G	1
Chaudary, M	1
Castro, JE	1
Combe, C	1
Deforges-Lasseur, C	1
Chehab, Z	1
de Précigout, V	1
Aparicio, M	1
Chow, GK	1
Streem, SB	1
Asanuma, H	1
Nakai, H	1
Takeda, M	1
Shishido, S	1
Kawamura, T	1
Nagakura, K	1
Yamafuji, M	1
Akakura, K	1
Egoshi, K	1
Ueda, T	1
Nozumi, K	1
Kotake, T	1
Masai, M	1
Ito, H	1
Fjellstedt, E	1
Christensson, A	1
Tiselius, HG	1
Perfumo, F	1
Basile, G	1
Ginevri, F	1
Gusmano, R	1
Terhorst, B	3
Stuhlsatz, HW	2
Hautmann, R	1
Lutzeyer, W	1
Dore, B	1
Irani, J	1
Marroncle, M	1
Aubert, J	1
Böwering, R	1
Wenzl, H	2
Mauermayer, W	2
Chatys-Górska, L	1
Zawadzki, J	1
Tató, L	1
Sidoti, O	1
Krízek, V	1
Sajner, J	1
Thomas, WC	1
Melchior, H	1
Milne, MD	1
Harada, T	1
Takahashi, Y	1
Kato, T	1
Bremer, HJ	1
Revúsová, V	1
Zvara, V	1
Stephens, AD	1
Watts, RW	1
Herrin, JT	1
Thomas, J	1
Steg, A	1
Aboulker, P	1
Frimpter, GW	1
López-Engelking, R	1
Mugler, A	1
MacDonald, WB	1
Fellers, FX	1

Article	Year
[The hyperaminoacidurias with special reference to cystinuria]. Minerva medica, 1979, Oct-13, Volume: 70, Issue:44 Topics: Amino Acids; Biological Transport; Carrier Proteins; Child; Cystinuria; Female; Humans; Microvilli;	1979
Symposium on renal lithiasis. Medical aspects of renal calculous disease. Treatment and prophylaxis. The Urologic clinics of North America, 1974, Volume: 1, Issue:2 Topics: Acidosis, Renal Tubular; Allopurinol; Anti-Bacterial Agents; Bacterial Infections; Cystinuria; Diet;	1974

Article	Year
Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Pediatric nephrology (Berlin, Germany), 2007, Volume: 22, Issue:11 Topics: Adolescent; Adult; Alkalies; Chelating Agents; Child; Child, Preschool; Cystine; Cystinuria; Diureti	2007
Medical treatment of cystinuria: results of contemporary clinical practice. The Journal of urology, 1996, Volume: 156, Issue:5 Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Child; Child, Preschool; Cys	1996
[Therapy of cystine urolithiasis by penicillamine]. Casopis lekaru ceskych, 1973, Jan-12, Volume: 112, Issue:2 Topics: Adolescent; Adult; Clinical Trials as Topic; Cystinuria; Drug Tolerance; Female; Humans; Male; Middl	1973
The treatment of cystinuria with N-acetyl-D-penicillamine, a comparison with the results of D-penicillamine treatment. The Quarterly journal of medicine, 1971, Volume: 40, Issue:159 Topics: Acylation; Adolescent; Adult; Child; Cysteine; Cystinuria; Desensitization, Immunologic; Drug Hypers	1971

Article	Year
Penicillamine therapy for pediatric cystinuria: experience from a cohort of American children. The Journal of urology, 2008, Volume: 180, Issue:6 Topics: Adolescent; Child; Child, Preschool; Cystinuria; Female; Humans; Infant; Male; Penicillamine; Retros	2008
TREATMENT OF CYSTINURIA. British medical journal, 1965, Mar-27, Volume: 1, Issue:5438 Topics: Cystinuria; Diet; Diet Therapy; Drug Therapy; Humans; Infusions, Parenteral; Methionine; Penicillami	1965
RECENT ADVANCES IN THE THERAPY OF CYSTINURIA. Military medicine, 1965, Volume: 130 Topics: Cystinuria; Drug Therapy; Humans; Penicillamine; Toxicology; Urinary Calculi	1965
The prevention and medical treatment of urinary calculi. II. The Medical letter on drugs and therapeutics, 1967, May-19, Volume: 9, Issue:10 Topics: Allopurinol; Bicarbonates; Enzyme Therapy; Humans; Penicillamine; Urinary Calculi; Xanthine Oxidase	1967
Treatment of cystinuria and cystine stone disease. Modern treatment, 1967, Volume: 4, Issue:3 Topics: Cystine; Cystinuria; Humans; Penicillamine; Urinary Calculi	1967
Pregnancy and cystinuria. Lancet (London, England), 1983, Nov-19, Volume: 2, Issue:8360 Topics: Birth Weight; Cystinuria; Female; Follow-Up Studies; Genetic Counseling; Humans; Penicillamine; Preg	1983
Homozygous cystinuria--evaluation of 35 patients. The Journal of urology, 1982, Volume: 127, Issue:4 Topics: Adolescent; Adult; Aged; Bicarbonates; Child; Cystinuria; Female; Fluid Therapy; Follow-Up Studies;	1982
[Medical treatment of cystine lithiasis in children]. Journal d'urologie, 1984, Volume: 90, Issue:2 Topics: Amino Acids, Sulfur; Child; Cystine; Female; Humans; Male; Penicillamine; Recurrence; Tiopronin; Uri	1984
Alternative treatment of cystinuria with alpha-merkaptopropionylglycine, Thiola. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1983, Volume: 20 Topics: Adolescent; Adult; Aged; Amino Acids, Sulfur; Cystine; Cystinuria; Dipeptides; Female; Humans; Male;	1983
Cystine stones. Urology, 1980, Volume: 16, Issue:4 Topics: Adolescent; Adult; Aged; Child, Preschool; Cystine; Cystinuria; Female; Humans; Male; Middle Aged; P	1980
[Cystine lithiasis and its treatment with d-penicillamine. The experience in a nephrology service in a 23-year period. Apropos of 26 patients]. Annales d'urologie, 1993, Volume: 27, Issue:2 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystinuria; Female; Follow-Up Studies; Huma	1993
[Clinical study on cystinuria in children--the stone management and the prevention of calculi recurrence]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1998, Volume: 89, Issue:9 Topics: Adolescent; Adult; Child; Child, Preschool; Cystinuria; Female; Follow-Up Studies; Humans; Infant; L	1998
The long-term outcome of cystinuria in Japan. Urologia internationalis, 1998, Volume: 61, Issue:2 Topics: Adult; Chelating Agents; Cystine; Cystinuria; Female; Follow-Up Studies; Humans; Hydrogen-Ion Concen	1998
Cystine analyses of separate day and night urine as a basis for the management of patients with homozygous cystinuria. Urological research, 2001, Volume: 29, Issue:5 Topics: Adult; Aged; Circadian Rhythm; Cystinuria; Dose-Response Relationship, Drug; Female; Homozygote; Hum	2001
[Cystine stone therapy with mercapto-propyonyl-glycine (MPG) (Thiola) (author's transl)]. Der Urologe. Ausg. A, 1975, Volume: 14, Issue:4 Topics: Adult; Amino Acids; Amino Acids, Sulfur; Cystinuria; Drug Tolerance; Female; Humans; Long-Term Care;	1975
Mercaptopropionylglycine: a progress in cystine stone therapy. The Journal of urology, 1977, Volume: 117, Issue:5 Topics: Adult; Amino Acids, Sulfur; Cystine; Cystinuria; Female; Follow-Up Studies; Humans; Male; Penicillam	1977
[Cystinic lithiasis. Current aspects of the urologic treatment]. Journal d'urologie, 1990, Volume: 96, Issue:5 Topics: Adult; Aged; Cystinuria; Female; Humans; Kidney Calculi; Lithotripsy; Male; Middle Aged; Nephrostomy	1990
[Drug prevention of recurring urolithiasis]. MMW, Munchener medizinische Wochenschrift, 1974, Jan-04, Volume: 116, Issue:1 Topics: Allopurinol; Aluminum; Ammonium Chloride; Ascorbic Acid; Citrates; Glycine; Humans; Magnesium; Penic	1974
[Satisfactory prophylaxis of urinary lithiasis with D-penicillamine in cystinuria]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1970, Apr-08, Volume: 46, Issue:17 Topics: Adult; Cysteine; Cystine; Cystinuria; Diet Therapy; Female; Humans; Penicillamine; Urinary Calculi	1970
[Favorable outcome of conservative treatment of cystine urolithiasis in an infant]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1974, Sep-15, Volume: 27, Issue:18 Topics: Cystinuria; Homozygote; Humans; Infant; Male; Penicillamine; Urinary Calculi	1974
[The medical and surgical treatment of cystinuria]. Minerva pediatrica, 1974, Oct-27, Volume: 26, Issue:33 Topics: Antacids; Chelating Agents; Child; Child, Preschool; Cystinuria; Humans; Infant; Male; Penicillamine	1974
[Drug therapy in urinary calculi. II. Peroral litholysis and prevention]. Urologia internationalis, 1972, Volume: 27, Issue:3 Topics: Administration, Oral; Allopurinol; Cystine; Humans; Magnesium; Oxalates; Penicillamine; Phosphates;	1972
Amino acid metabolism in cystinuria. The Biochemical journal, 1971, Volume: 122, Issue:1 Topics: Adolescent; Adult; Aged; Amino Acids; Biological Transport, Active; Child; Cystinuria; Female; Human	1971
[Cases of cystinuria with urinary tract stones in sisters]. Hinyokika kiyo. Acta urologica Japonica, 1971, Volume: 17, Issue:9 Topics: Adolescent; Adult; Amino Acids; Cystinuria; Female; Humans; Kidney Calculi; Penicillamine; Urinary B	1971
[Cystinuria, types, diagnosis and treatment]. Monatsschrift fur Kinderheilkunde, 1969, Volume: 117, Issue:1 Topics: Age Factors; Arginine; Child; Cystinuria; Heterozygote; Homozygote; Humans; Lysine; Ornithine; Penic	1969
[Problems in the therapy of cystine urolithiasis using penicillamine]. Bratislavske lekarske listy, 1970, Volume: 53, Issue:3 Topics: Adolescent; Cystine; Female; Humans; Male; Penicillamine; Proteinuria; Urinary Calculi	1970
The child with urolithiasis. Practical considerations in diagnosis and management. Clinical pediatrics, 1971, Volume: 10, Issue:6 Topics: Adolescent; Allopurinol; Child; Humans; Infant; Penicillamine; Radiography; Urinary Calculi	1971
[Medical treatment of uric lithiasis and cystinic lithiasis]. Annales de chirurgie, 1967, Volume: 21, Issue:25 Topics: Bicarbonates; Citrates; Diet Therapy; Humans; Kidney Calculi; Penicillamine; Potassium; Tromethamine	1967
Medical management of cystinuria. The American journal of the medical sciences, 1968, Volume: 255 Topics: Adolescent; Adult; Bicarbonates; Cystinuria; Diet Therapy; Female; Humans; Male; Methionine; Middle	1968
[Use of penicillamine and allopurinol in the treatment of urinary lithiasis due to cystinuria and hyperuricemia]. Gaceta medica de Mexico, 1968, Volume: 98, Issue:8 Topics: Adult; Allopurinol; Child, Preschool; Cystinuria; Female; Humans; Penicillamine; Uric Acid; Urinary	1968
[A case of mixed cystine lithiasis. Effect of a hydromineral treatment associated with D-penicillamine]. Rein et foie, maladies de la nutrition; actualites, 1968, Volume: 11 Topics: Adult; Calcium; Chromatography; Cystinuria; Female; Humans; Mineral Waters; Penicillamine; Phosphoru	1968
[Hereditary cystinuria associated with urolithiasis and it's treatment with d-penicillamine]. Munchener medizinische Wochenschrift (1950), 1969, May-30, Volume: 111, Issue:22 Topics: Adolescent; Adult; Cystinuria; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Penicilla	1969
Penicillamine in the treatment of patients with cystiuria. JAMA, 1966, Aug-08, Volume: 197, Issue:6 Topics: Adolescent; Adult; Child; Child, Preschool; Cystinuria; Female; Humans; Male; Middle Aged; Penicilla	1966

penicillamine and Urinary Calculi

Research Excerpts

Research

Studies (39)

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