Page last updated: 2024-11-07

penicillamine and Thrombocytopenia

penicillamine has been researched along with Thrombocytopenia in 55 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Thrombocytopenia: A subnormal level of BLOOD PLATELETS.

Research Excerpts

ExcerptRelevanceReference
"Oral chelation therapy with d-penicillamine (d-PCN) has been proven to be effective in the treatment of mild-to-moderate lead poisoning."9.09Adverse effects of reduced-dose d-penicillamine in children with mild-to-moderate lead poisoning. ( Shannon, MW; Townsend, MK, 2000)
"Alclofenac and D-penicillamine were compared under controlled, double-blind conditions in the treatment of 35 patients with active rheumatoid arthritis over a period of 26 weeks."9.04The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. ( Aylward, M; Holly, F; Maddock, J; Rees, P, 1975)
"Twenty-three patients with the chronic progressive or intermittent relapsing form of multiple sclerosis (MS) were treated with d-penicillamine over a period from 6 weeks to 12 months."9.04Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study. ( Cendrowski, W; Czlonkowska, A, 1976)
" No increase in elevated creatinine, direct or indirect bilirubin, thrombocytopenia or neutropenia was apparent in those treated with D-penicillamine."7.74D-Penicillamine administration and the incidence of retinopathy of prematurity. ( Alder, SC; Baer, VL; Barraza, J; Burnett, J; Christensen, RD; Horn, JT; Lambert, DK; Richards, M; Richards, SC; Schmutz, N; Wiedmeier, SE, 2007)
"HLA phenotype frequencies were studied in 21 rheumatoid arthritis (RA) patients with haematotoxic reactions to aurothioglucose (AuTG) or D-penicillamine (DP), 65 matched RA controls and 277 healthy controls."7.67HLA associations in aurothioglucose- and D-penicillamine-induced haematotoxic reactions in rheumatoid arthritis. ( Reekers, P; Speerstra, F; van de Putte, LB; Vandenbroucke, JP, 1985)
"The long term efficacy and tolerability of sulphasalazine (SASP) in the treatment of 21 patients with active classical or definite rheumatoid arthritis (RA) were examined and compared with the effects of penicillamine in a similarly active group of RA patients."7.67The long term effects of sulphasalazine in the treatment of rheumatoid arthritis and a comparative study with penicillamine. ( Bacon, PA; Crockson, AP; Farr, M; Tunn, E, 1984)
"The prevalence of eosinophilia in 66 patients with rheumatoid arthritis receiving D-penicillamine was determined in a retrospective study."7.67Eosinophilia in rheumatoid patients treated with D-penicillamine. ( Edelman, J; Maguire, KF; Owen, ET, 1984)
"The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 X 10(9)/1)."7.67Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine. ( Brooks, PM; Gallus, AS; Geddes, R; Hill, W; Tampi, R; Thomas, D, 1984)
" proteinuria, haematological abnormalities, stomatitis, diarrhoea and dermatitis) in rheumatoid arthritis (RA) to sodium aurothiomalate (gold) and to D-penicillamine (PA) were studied in 32 patients."7.67HLA antigens and adverse drug reactions to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. ( Bjelle, A; Dahlqvist, SR; Möller, E; Ström, H, 1985)
"In a retrospective cohort study we reviewed our experience using D-penicillamine in children with low-level lead poisoning (whole blood lead levels 25 to 40 micrograms/dL) to determine its efficacy and the incidence of side effects."7.67Efficacy and toxicity of D-penicillamine in low-level lead poisoning. ( Graef, J; Lovejoy, FH; Shannon, M, 1988)
"To assess therapeutic effect and toxicity of D-penicillamine in relation to HLA antigens, 111 consecutive patients with rheumatoid arthritis (RA) were followed for a period of 7-9 years."7.67Longterm followup of treatment with D-penicillamine for rheumatoid arthritis: effectivity and toxicity in relation to HLA antigens. ( Ament, BJ; Feltkamp, BW; Moens, HJ; van der Korst, JK, 1987)
"In a 3-centre study involving 144 patients with rheumatoid arthritis (RA), a relationship between side effects from D-penicillamine and HLA antigens, allotypic markers of the IgG heavy chain (Gm) and allotypes of complement components Bf, C4A and C4B was sought."7.67Genetic markers in rheumatoid arthritis relationship to toxicity from D-penicillamine. ( Hannah, MC; Major, GA; Mathews, JD; McCluskey, J; Muirden, KD; Property, DN; Stockman, A; Tait, BD; Zilko, PJ, 1986)
"One hundred fourteen patients with definite or classic rheumatoid arthritis were followed prospectively between January 1976 and April 1981 to monitor their toxicity pattern to D-penicillamine."7.66Prior gold therapy does not influence the adverse effects of D-penicillamine in rheumatoid arthritis. ( Buchanan, WW; Howard-Lock, HE; Kean, WF; Lock, CJ, 1982)
"The difficulties encountered in administering D-penicillamine to 40 patients with rheumatoid arthritis (RA) over a six to 24 month period are recorded."7.66Difficulties in the use of D-penicillamine in the treatment of rheumatoid arthritis. ( Barraclough, D; Kincaid-Smith, P; Macdonald, I; Muirden, KD; Richter, D; Stockman, A, 1979)
"One hundred and one patients with rheumatoid arthritis were followed prospectively to assess the efficacy and toxicity of therapy with D-penicillamine."7.66The toxicity pattern of D-penicillamine therapy. A guide to its use in rheumatoid arthritis. ( Anastassiades, TP; Dwosh, IL; Ford, PM; Kean, WF; Kelly, HG, 1980)
"A case of a 52-year-old white woman who developed hemolytic anemia and thrombocytopenia after receiving D-penicillamine is presented."7.65Hemolytic anemia and thrombocytopenia associated with penicillamine ingestion. ( Harrison, EE; Hickman, JW, 1975)
"Immune thrombocytopenia is a rare complication of progressive systemic sclerosis (PSS)."5.28Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. ( Kashiwagi, H; Kato, S; Kono, I; Matsui, Y; Natsuda, H; Sakauchi, M; Suzuki, H; Takemura, H; Yamane, K, 1992)
"Oral chelation therapy with d-penicillamine (d-PCN) has been proven to be effective in the treatment of mild-to-moderate lead poisoning."5.09Adverse effects of reduced-dose d-penicillamine in children with mild-to-moderate lead poisoning. ( Shannon, MW; Townsend, MK, 2000)
"Twenty-three patients with the chronic progressive or intermittent relapsing form of multiple sclerosis (MS) were treated with d-penicillamine over a period from 6 weeks to 12 months."5.04Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study. ( Cendrowski, W; Czlonkowska, A, 1976)
"Alclofenac and D-penicillamine were compared under controlled, double-blind conditions in the treatment of 35 patients with active rheumatoid arthritis over a period of 26 weeks."5.04The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. ( Aylward, M; Holly, F; Maddock, J; Rees, P, 1975)
" No increase in elevated creatinine, direct or indirect bilirubin, thrombocytopenia or neutropenia was apparent in those treated with D-penicillamine."3.74D-Penicillamine administration and the incidence of retinopathy of prematurity. ( Alder, SC; Baer, VL; Barraza, J; Burnett, J; Christensen, RD; Horn, JT; Lambert, DK; Richards, M; Richards, SC; Schmutz, N; Wiedmeier, SE, 2007)
" The administration of the NO donor S-Nitroso-N-acyl-D-penicillamine (SNAP) plus ADP or LPS, significantly prevented thrombocytopenia induced by ADP and by LPS."3.70Platelet activation and modulation of the induction of nitric oxide synthase in the conscious rat. ( Doni, MG; Picunio, S; Simioni, M, 1999)
"The long term efficacy and tolerability of sulphasalazine (SASP) in the treatment of 21 patients with active classical or definite rheumatoid arthritis (RA) were examined and compared with the effects of penicillamine in a similarly active group of RA patients."3.67The long term effects of sulphasalazine in the treatment of rheumatoid arthritis and a comparative study with penicillamine. ( Bacon, PA; Crockson, AP; Farr, M; Tunn, E, 1984)
"The prevalence of eosinophilia in 66 patients with rheumatoid arthritis receiving D-penicillamine was determined in a retrospective study."3.67Eosinophilia in rheumatoid patients treated with D-penicillamine. ( Edelman, J; Maguire, KF; Owen, ET, 1984)
"The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 X 10(9)/1)."3.67Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine. ( Brooks, PM; Gallus, AS; Geddes, R; Hill, W; Tampi, R; Thomas, D, 1984)
" proteinuria, haematological abnormalities, stomatitis, diarrhoea and dermatitis) in rheumatoid arthritis (RA) to sodium aurothiomalate (gold) and to D-penicillamine (PA) were studied in 32 patients."3.67HLA antigens and adverse drug reactions to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. ( Bjelle, A; Dahlqvist, SR; Möller, E; Ström, H, 1985)
"In a retrospective cohort study we reviewed our experience using D-penicillamine in children with low-level lead poisoning (whole blood lead levels 25 to 40 micrograms/dL) to determine its efficacy and the incidence of side effects."3.67Efficacy and toxicity of D-penicillamine in low-level lead poisoning. ( Graef, J; Lovejoy, FH; Shannon, M, 1988)
"To assess therapeutic effect and toxicity of D-penicillamine in relation to HLA antigens, 111 consecutive patients with rheumatoid arthritis (RA) were followed for a period of 7-9 years."3.67Longterm followup of treatment with D-penicillamine for rheumatoid arthritis: effectivity and toxicity in relation to HLA antigens. ( Ament, BJ; Feltkamp, BW; Moens, HJ; van der Korst, JK, 1987)
"In a 3-centre study involving 144 patients with rheumatoid arthritis (RA), a relationship between side effects from D-penicillamine and HLA antigens, allotypic markers of the IgG heavy chain (Gm) and allotypes of complement components Bf, C4A and C4B was sought."3.67Genetic markers in rheumatoid arthritis relationship to toxicity from D-penicillamine. ( Hannah, MC; Major, GA; Mathews, JD; McCluskey, J; Muirden, KD; Property, DN; Stockman, A; Tait, BD; Zilko, PJ, 1986)
"HLA phenotype frequencies were studied in 21 rheumatoid arthritis (RA) patients with haematotoxic reactions to aurothioglucose (AuTG) or D-penicillamine (DP), 65 matched RA controls and 277 healthy controls."3.67HLA associations in aurothioglucose- and D-penicillamine-induced haematotoxic reactions in rheumatoid arthritis. ( Reekers, P; Speerstra, F; van de Putte, LB; Vandenbroucke, JP, 1985)
"One hundred fourteen patients with definite or classic rheumatoid arthritis were followed prospectively between January 1976 and April 1981 to monitor their toxicity pattern to D-penicillamine."3.66Prior gold therapy does not influence the adverse effects of D-penicillamine in rheumatoid arthritis. ( Buchanan, WW; Howard-Lock, HE; Kean, WF; Lock, CJ, 1982)
"One hundred and one patients with rheumatoid arthritis were followed prospectively to assess the efficacy and toxicity of therapy with D-penicillamine."3.66The toxicity pattern of D-penicillamine therapy. A guide to its use in rheumatoid arthritis. ( Anastassiades, TP; Dwosh, IL; Ford, PM; Kean, WF; Kelly, HG, 1980)
"The difficulties encountered in administering D-penicillamine to 40 patients with rheumatoid arthritis (RA) over a six to 24 month period are recorded."3.66Difficulties in the use of D-penicillamine in the treatment of rheumatoid arthritis. ( Barraclough, D; Kincaid-Smith, P; Macdonald, I; Muirden, KD; Richter, D; Stockman, A, 1979)
"A case of a 52-year-old white woman who developed hemolytic anemia and thrombocytopenia after receiving D-penicillamine is presented."3.65Hemolytic anemia and thrombocytopenia associated with penicillamine ingestion. ( Harrison, EE; Hickman, JW, 1975)
"In a 53-year-old woman an acute allergic thrombocytopenia (acute Werlhf's disease) occurred after treatment with D-penicillamine for one month which led to death."3.65[Severe side-effects of treatment with D-penicillamine (author's transl)]. ( Hennemann, HH; Hubertus, H; Stocker, WG, 1975)
"Many of the adverse reactions produced by penicillamine and other compounds with an active sulfhydryl group form a distinctive pattern when viewed as a class."2.37Adverse effects profile of sulfhydryl compounds in man. ( Jaffe, IA, 1986)
"The aim of this study was to assess the clinical efficacy and safety of chelation treatment with penicillamine (PCA) in cross combination with sodium 2, 3-dimercapto-1-propane sulfonate (DMPS) repeatedly in patients with Wilson's disease (WD)."1.39Clinical efficacy and safety of chelation treatment with typical penicillamine in cross combination with DMPS repeatedly for Wilson's disease. ( Chen, L; Fang, F; Li, XF; Liu, Y; Xu, SQ; Zhu, HY, 2013)
"Immune thrombocytopenia is a rare complication of progressive systemic sclerosis (PSS)."1.28Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. ( Kashiwagi, H; Kato, S; Kono, I; Matsui, Y; Natsuda, H; Sakauchi, M; Suzuki, H; Takemura, H; Yamane, K, 1992)
" Adverse effects occurred more frequently after rapid increases in dosage."1.27The toxicity of D-penicillamine in systemic sclerosis. ( Blair, S; Medsger, TA; Steen, VD, 1986)
"Moderate thrombocytopenia was observed in three of the five bleeders and in two of the others."1.26Platelet function and coagulation in patients with Wilson disease. ( Bowie, JW; Goldstein, NP; Owen, CA, 1976)
" An overestimation of rare side-effects of drugs should not block the application of certain medicaments, however, they should be given only in such a high dosage as it is necessary."1.26[Hematotoxic lesions caused by non-steroidal antirheumatic agents]. ( Hüge, W; Stobbe, H, 1980)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199047 (85.45)18.7374
1990's3 (5.45)18.2507
2000's4 (7.27)29.6817
2010's1 (1.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xu, SQ1
Li, XF1
Zhu, HY1
Liu, Y1
Fang, F1
Chen, L1
Cocco, GA1
Loudianos, G1
Pes, GM1
Tolu, F1
Lepori, MB1
Barrocu, M1
Sechi, GP1
HEINRICH, F1
KALTENBACH, M1
Christensen, RD1
Alder, SC1
Richards, SC1
Lambert, DK1
Schmutz, N1
Wiedmeier, SE1
Burnett, J1
Baer, VL1
Horn, JT1
Richards, M1
Barraza, J1
Panayi, GS1
Huston, G1
Shah, RR1
Mitchell, SC1
Idle, JR1
Smith, RL1
Waring, RH1
Farr, M1
Tunn, E1
Crockson, AP1
Bacon, PA1
Kean, WF2
Lock, CJ1
Howard-Lock, HE1
Buchanan, WW2
Dalmau Obrador, J1
Martí-Vilalta, JL1
Aguilar Barberá, M1
Edelman, J1
Maguire, KF1
Owen, ET1
Thomas, D1
Gallus, AS1
Brooks, PM1
Tampi, R1
Geddes, R1
Hill, W1
Klepach, GL1
Wray, SH1
Dwosh, IL1
Anastassiades, TP1
Ford, PM1
Kelly, HG1
Stobbe, H1
Hüge, W1
Picunio, S1
Simioni, M1
Doni, MG1
Shannon, MW1
Townsend, MK1
Yamauchi, Y1
Colombo, B1
Gerloni, V1
Harth, M1
Hickey, JP1
Coulter, WK1
Thompson, JM1
Disney, TF1
Maddock, J1
Rees, P1
Holly, F1
Aylward, M1
Stockman, A2
Richter, D1
Barraclough, D1
Muirden, KD3
Macdonald, I1
Kincaid-Smith, P1
Hill, HF1
Davis, P1
Bleehen, SS1
Cendrowski, W1
Czlonkowska, A1
Huskisson, EC2
Olhagen, B1
Harrison, EE1
Hickman, JW1
Hennemann, HH1
Hubertus, H1
Stocker, WG1
Owen, CA1
Goldstein, NP1
Bowie, JW1
Natsuda, H1
Matsui, Y1
Sakauchi, M1
Kato, S1
Takemura, H1
Suzuki, H1
Kono, I1
Yamane, K1
Kashiwagi, H1
Singal, DP1
Jaffe, IA1
Steen, VD1
Blair, S1
Medsger, TA1
Magnus, JH1
Gran, JT1
Mikkelsen, K1
Nygaard, H1
Brath, HK1
Dahlqvist, SR1
Ström, H1
Bjelle, A1
Möller, E1
Shannon, M1
Graef, J1
Lovejoy, FH1
Moens, HJ1
Ament, BJ1
Feltkamp, BW1
van der Korst, JK1
Zilko, PJ1
Major, GA1
Tait, BD1
Property, DN1
Mathews, JD1
Hannah, MC1
McCluskey, J1
Speerstra, F1
Reekers, P1
van de Putte, LB1
Vandenbroucke, JP1
Stacher, A1
Alexander, M1
Wille, G1
Gibson, TJ1
Balme, HW1
Berry, H1
Burry, HC1
Grahame, R1
Hart, FD1
Henderson, DR1
Wojtulewski, JA1
Werner, T1
Weinmann, HM1
Boudin, G1
Pépin, B1
Wallnöfer, H1
Hanusch, M1
Day, AT1
Golding, JR1
Lee, PN1
Butterworth, AD1
Camus, JP1
Crouzet, J1
Guillien, P1
Benichou, C1
Lievre, JA1
Gordon, MH1
Ehrlich, GE1
Kobíková, M1
Stáva, Z1
Waskönig, FW1
Meyer, W1
Fulghum, DD1
Katz, R1

Reviews

7 reviews available for penicillamine and Thrombocytopenia

ArticleYear
[Wilson's disease (hepatolenticular degeneration)].
    Medicina clinica, 1984, Jun-09, Volume: 83, Issue:2

    Topics: Adolescent; Adult; Anemia, Hemolytic; Central Nervous System Diseases; Child; Combined Modality Ther

1984
[D-penicillamine-induced immune deficiency].
    Ryoikibetsu shokogun shirizu, 2000, Issue:32

    Topics: Agranulocytosis; Antirheumatic Agents; Humans; Immunologic Deficiency Syndromes; Immunosuppressive A

2000
[Penicillamine: its use in rheumatoid arthritis].
    Recenti progressi in medicina, 1979, Volume: 66, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Eruptions; Drug Evaluation; Female; Fever; Gastrointestinal

1979
D-penicillamine in the treatment of rheumatoid arthritis and progressive systemic sclerosis.
    The British journal of dermatology, 1976, Volume: 94, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Chelating Agents; Collagen; Copper; Humans; Leukopenia; Nephrotic Sy

1976
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986
Adverse effects profile of sulfhydryl compounds in man.
    The American journal of medicine, 1986, Volume: 80, Issue:3

    Topics: Anemia, Aplastic; Autoimmune Diseases; Captopril; Drug Eruptions; Glomerulonephritis; Humans; Neutro

1986
[10 years of penicillamine].
    Medizinische Klinik, 1966, Nov-18, Volume: 61, Issue:46

    Topics: Cystinuria; Drug Eruptions; Gold; Hepatolenticular Degeneration; Humans; Lead Poisoning; Leukopenia;

1966

Trials

12 trials available for penicillamine and Thrombocytopenia

ArticleYear
Adverse effects of reduced-dose d-penicillamine in children with mild-to-moderate lead poisoning.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:1

    Topics: Adolescent; Blood Cell Count; Chelating Agents; Child; Child, Preschool; Drug Eruptions; Female; Hum

2000
The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis.
    Current medical research and opinion, 1975, Volume: 3, Issue:5

    Topics: Arthritis, Rheumatoid; Blood Proteins; Blood Sedimentation; C-Reactive Protein; Clinical Trials as T

1975
Treatment of rheumatoid arthritis with penicillamine.
    Seminars in arthritis and rheumatism, 1977, Volume: 6, Issue:4

    Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Dru

1977
Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3

    Topics: Adult; Ageusia; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Dyspepsia; Erythema; Fem

1976
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986
Controlled trial of D(-)penicillamine in severe rheumatoid arthritis.
    Lancet (London, England), 1973, Feb-10, Volume: 1, Issue:7798

    Topics: Administration, Oral; Adult; Aged; Albuminuria; Anorexia Nervosa; Arthritis, Rheumatoid; Carbonates;

1973
Trial comparing D-penicillamine and gold in rheumatoid arthritis. Preliminary report.
    Annals of the rheumatic diseases, 1974, Volume: 33, Issue:6

    Topics: Agglutination Tests; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Feeding a

1974
[Treatment of chronic hepatitis with immunosuppressive agents and D-penicillamine].
    Wiener medizinische Wochenschrift (1946), 1973, Jun-23, Volume: 123, Issue:25

    Topics: Agranulocytosis; Azathioprine; Chronic Disease; Clinical Trials as Topic; Drug Hypersensitivity; Fem

1973
Penicillamine in rheumatoid disease: a long-term study.
    British medical journal, 1974, Feb-02, Volume: 1, Issue:5900

    Topics: Agranulocytosis; Arthritis, Rheumatoid; Blood Sedimentation; Body Weight; Clinical Trials as Topic;

1974
[100 cases of common rheumatoid polyarthritis, treated with D-penicillamin].
    Annales de medecine interne, 1974, Volume: 125, Issue:1

    Topics: Adult; Aged; Antibody Specificity; Arthritis, Rheumatoid; Clinical Trials as Topic; Copper; Dyspepsi

1974
Penicillamine for treatment of rheumatoid arthritis.
    JAMA, 1974, Sep-02, Volume: 229, Issue:10

    Topics: Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Copper; Drug Evaluation; Gastr

1974
Absence of toxic or therapeutic interaction between penicillamine and previously administered gold in a trial of penicillamine in rheumatoid disease.
    Postgraduate medical journal, 1974, Volume: 50 Suppl 2

    Topics: Clinical Trials as Topic; Drug Interactions; Gold; Humans; Penicillamine; Proteinuria; Rheumatic Dis

1974

Other Studies

37 other studies available for penicillamine and Thrombocytopenia

ArticleYear
Clinical efficacy and safety of chelation treatment with typical penicillamine in cross combination with DMPS repeatedly for Wilson's disease.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2013, Volume: 33, Issue:5

    Topics: Administration, Oral; Adolescent; Chelating Agents; Chelation Therapy; Child; Copper; Drug Administr

2013
"Acquired" hepatocerebral degeneration in a patient heterozygote carrier for a novel mutation in ATP7B gene.
    Movement disorders : official journal of the Movement Disorder Society, 2009, Aug-15, Volume: 24, Issue:11

    Topics: Adenosine Triphosphatases; Adult; Amino Acid Substitution; Basal Ganglia; Cation Transport Proteins;

2009
[WILSON'S DISEASE IN THE FORM OF A PANHEMOCYTOPENIA].
    Medizinische Klinik, 1965, Mar-26, Volume: 60

    Topics: Blood; Blood Coagulation Tests; Copper; Drug Therapy; Hemorrhagic Disorders; Hepatolenticular Degene

1965
D-Penicillamine administration and the incidence of retinopathy of prematurity.
    Journal of perinatology : official journal of the California Perinatal Association, 2007, Volume: 27, Issue:2

    Topics: Bilirubin; Chelating Agents; Creatinine; Female; Humans; Incidence; Infant, Newborn; Male; Neutropen

2007
Deficient sulphoxidation status and D-penicillamine toxicity.
    Lancet (London, England), 1983, Feb-19, Volume: 1, Issue:8321

    Topics: Arthritis, Rheumatoid; Humans; Penicillamine; Proteinuria; Sulfoxides; Thrombocytopenia

1983
The long term effects of sulphasalazine in the treatment of rheumatoid arthritis and a comparative study with penicillamine.
    Clinical rheumatology, 1984, Volume: 3, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Eruptions; Drug Tolerance; Dyspepsia; Female; Humans; Male;

1984
Prior gold therapy does not influence the adverse effects of D-penicillamine in rheumatoid arthritis.
    Arthritis and rheumatism, 1982, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Drug Eruptions; Drug Interactions; Dysgeusia;

1982
Eosinophilia in rheumatoid patients treated with D-penicillamine.
    The Journal of rheumatology, 1984, Volume: 11, Issue:5

    Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Eosinophilia; Female; Humans;

1984
Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine.
    Annals of the rheumatic diseases, 1984, Volume: 43, Issue:3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Platelets; Cell Survival; Humans; Middle Aged; Penicillami

1984
Bilateral serous retinal detachment with thrombocytopenia during penicillamine therapy.
    Annals of ophthalmology, 1981, Volume: 13, Issue:2

    Topics: Adult; Female; Fluorescein Angiography; Fundus Oculi; Hepatolenticular Degeneration; Humans; Macula

1981
The toxicity pattern of D-penicillamine therapy. A guide to its use in rheumatoid arthritis.
    Arthritis and rheumatism, 1980, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Child; Digestive System; Dose-R

1980
[Hematotoxic lesions caused by non-steroidal antirheumatic agents].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1980, Dec-01, Volume: 35, Issue:23

    Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Arthritis, Rheumatoid; Aspirin; Diclofenac; Female;

1980
Platelet activation and modulation of the induction of nitric oxide synthase in the conscious rat.
    Life sciences, 1999, Volume: 65, Issue:14

    Topics: Adenosine Diphosphate; Animals; Blood Pressure; Enzyme Induction; Heart Rate; Iloprost; Lipopolysacc

1999
Editorial: D-penicillamine in rheumatoid arthritis.
    Lancet (London, England), 1975, May-17, Volume: 1, Issue:7916

    Topics: Arthritis, Rheumatoid; Blood Cell Count; Drug Eruptions; Humans; Penicillamine; Proteinuria; Thrombo

1975
Gold-induced thrombocytopenia.
    The Journal of rheumatology, 1978,Summer, Volume: 5, Issue:2

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Dimercaprol; Female; Gold Sodium Th

1978
Difficulties in the use of D-penicillamine in the treatment of rheumatoid arthritis.
    Australian and New Zealand journal of medicine, 1979, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Arthritis, Rheumatoid; Biopsy; Dose-Response Relationship, Drug; Female; Humans;

1979
[D-penicillamine].
    Reumatizam, 1976, Volume: 23, Issue:5

    Topics: Arthritis, Rheumatoid; Humans; Penicillamine; Thrombocytopenia

1976
[Immunosuppressive treatment of rheumatologic diseases].
    Lakartidningen, 1976, Apr-21, Volume: 73, Issue:17

    Topics: Arthritis; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Immunity, Cellular; Immunosuppres

1976
Editorial: Penicillamine: more lessons from experience.
    British medical journal, 1975, Jul-19, Volume: 3, Issue:5976

    Topics: Arthritis, Rheumatoid; Blood Cell Count; Drug Hypersensitivity; Humans; Penicillamine; Proteinuria;

1975
Hemolytic anemia and thrombocytopenia associated with penicillamine ingestion.
    Southern medical journal, 1975, Volume: 68, Issue:1

    Topics: Anemia, Hemolytic; Blood Cell Count; Female; Humans; Middle Aged; Penicillamine; Prednisone; Prothro

1975
[Severe side-effects of treatment with D-penicillamine (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1975, Aug-08, Volume: 100, Issue:32

    Topics: Acute Disease; Adult; Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Male; Middle Age

1975
Platelet function and coagulation in patients with Wilson disease.
    Archives of internal medicine, 1976, Volume: 136, Issue:2

    Topics: Adolescent; Adult; Blood Coagulation; Blood Platelets; Child; Female; Hemorrhage; Hepatolenticular D

1976
Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy.
    Internal medicine (Tokyo, Japan), 1992, Volume: 31, Issue:2

    Topics: Blood Platelets; Female; Humans; Immunoglobulin G; Middle Aged; Penicillamine; Scleroderma, Systemic

1992
Is there a need to reclassify adult rheumatoid arthritis?
    British journal of rheumatology, 1990, Volume: 29, Issue:5

    Topics: Arthritis, Rheumatoid; Female; Genes; Genetic Predisposition to Disease; Gold; HLA-DQ Antigens; HLA-

1990
The toxicity of D-penicillamine in systemic sclerosis.
    Annals of internal medicine, 1986, Volume: 104, Issue:5

    Topics: Arthritis, Rheumatoid; Digestive System Diseases; Dose-Response Relationship, Drug; Drug Eruptions;

1986
Toxicity to D-penicillamine in rheumatoid arthritis.
    Scandinavian journal of rheumatology, 1987, Volume: 16, Issue:6

    Topics: Arthritis, Rheumatoid; Drug Eruptions; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged;

1987
HLA antigens and adverse drug reactions to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis.
    Clinical rheumatology, 1985, Volume: 4, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Diarrhea; Drug Eruptions; Female; Gold Sodium Thiomalate; Histoc

1985
Efficacy and toxicity of D-penicillamine in low-level lead poisoning.
    The Journal of pediatrics, 1988, Volume: 112, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Lead; Lead Poisoning; Leukopenia; Penicillamine

1988
Longterm followup of treatment with D-penicillamine for rheumatoid arthritis: effectivity and toxicity in relation to HLA antigens.
    The Journal of rheumatology, 1987, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Follow-Up Studies; HLA Antigens; HLA-

1987
Genetic markers in rheumatoid arthritis relationship to toxicity from D-penicillamine.
    The Journal of rheumatology, 1986, Volume: 13, Issue:2

    Topics: Arthritis, Rheumatoid; Disease Susceptibility; Genetic Markers; Histocompatibility Antigens Class II

1986
HLA associations in aurothioglucose- and D-penicillamine-induced haematotoxic reactions in rheumatoid arthritis.
    Tissue antigens, 1985, Volume: 26, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aurothioglucose; Female; Gene Frequency; Gold; Histocompatibilit

1985
[Immunosuppressive therapy in hematology].
    Folia haematologica (Leipzig, Germany : 1928), 1972, Volume: 97, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Myelophthis

1972
[D-penicillamine therapy in liver diseases. Preliminary results in 44 cases].
    MMW, Munchener medizinische Wochenschrift, 1974, Feb-01, Volume: 116, Issue:5

    Topics: Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Leukopenia; Liver Cirrhosis; Liver Diseases

1974
[Possible accidents due to penicillamine during treatment of Wilson's disease].
    Bulletin de l'Academie nationale de medecine, 1972, Volume: 156, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Adult; Child; Epilepsy; Female; Hepatolenticular Degeneration; Huma

1972
[Penicillamine in the treatment of scleroderma].
    Ceskoslovenska dermatologie, 1973, Volume: 48, Issue:6

    Topics: Adult; Drug Evaluation; Female; Humans; Male; Middle Aged; Penicillamine; Proteinuria; Scleroderma,

1973
[The basal therapy of rheumatoid arthritis with d-penicillamine (author's transl)].
    Munchener medizinische Wochenschrift (1950), 1973, Nov-09, Volume: 115, Issue:45

    Topics: Arthritis, Rheumatoid; Humans; Penicillamine; Proteinuria; Thrombocytopenia; Time Factors

1973
Penicillamine for scleroderma.
    Archives of dermatology, 1968, Volume: 98, Issue:1

    Topics: Animals; Drug Hypersensitivity; Feeding and Eating Disorders; Humans; Joint Diseases; Leukopenia; Pe

1968