penicillamine has been researched along with Stevens-Johnson Syndrome in 3 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Toxic epidermal necrolysis with epidermal shedding over almost the entire body occurred in a patient with classical rheumatoid arthritis treated with sulindac, penicillamine and a combination analgesic containing paracetamol and chlormezanone." | 3.67 | Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts. ( Ahlmén, M; Fagerberg, B; Roupe, G; Suurküla, M, 1986) |
| "In a 53-year-old woman an acute allergic thrombocytopenia (acute Werlhf's disease) occurred after treatment with D-penicillamine for one month which led to death." | 3.65 | [Severe side-effects of treatment with D-penicillamine (author's transl)]. ( Hennemann, HH; Hubertus, H; Stocker, WG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ward, K | 1 |
| Weir, DG | 1 |
| Hennemann, HH | 1 |
| Hubertus, H | 1 |
| Stocker, WG | 1 |
| Roupe, G | 1 |
| Ahlmén, M | 1 |
| Fagerberg, B | 1 |
| Suurküla, M | 1 |
3 other studies available for penicillamine and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Life threatening agranulocytosis and toxic epidermal necrolysis during low dose penicillamine therapy.
Topics: Agranulocytosis; Female; Humans; Liver Cirrhosis, Biliary; Middle Aged; Penicillamine; Stevens-Johns | 1981 |
[Severe side-effects of treatment with D-penicillamine (author's transl)].
Topics: Acute Disease; Adult; Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Male; Middle Age | 1975 |
Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts.
Topics: Acetaminophen; Arthritis, Rheumatoid; Biopsy; Chlormezanone; Drug Combinations; Female; Humans; Inte | 1986 |