penicillamine has been researched along with Seizures in 24 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 7.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| "The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids." | 7.65 | Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures. ( Lieff, B; Schlesinger, K, 1975) |
| "Besides the clinical applications of penicillamine, some reports show that use of D-penicillamine (D-pen) has been associated with adverse effects such as seizures." | 3.80 | Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways. ( Dehpour, AR; Heidary, MR; Javadi-Paydar, M; Jazaeri, F; Rahimi, N; Sadeghzadeh, M, 2014) |
| "The involvement of the L-arginine-nitric oxide (NO) pathway in the pathogenesis of hyperoxia-induced seizures was studied by using agents controlling NO levels." | 3.70 | L-arginine-NO pathway and CNS oxygen toxicity. ( Bitterman, H; Bitterman, N, 1998) |
| "The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids." | 3.65 | Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures. ( Lieff, B; Schlesinger, K, 1975) |
| "We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy." | 1.27 | Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy. ( Aisen, AM; Brewer, GJ; Hill, GM; Terry, CA, 1987) |
| "papio as well as nonseizure-prone primates." | 1.26 | The influence of D-penicillamine treatment upon seizure activity and trace metal status in the Senegalese baboon, Papio papio. ( Alley, MC; Fisher, GL; Killam, EK, 1981) |
| "The onset of convulsions induced by these convulsants coincides with the fall in GABA content and GAD activity in the mesencephalon area, and in contrast, the cessation of the convulsions by PN supplement coincides with the recovery in both the parameters." | 1.26 | Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions. ( Abe, M; Matsuda, M, 1979) |
| "During the convulsions by TSC 16hr after the AOAA-pretreatment, the GABA content in synaptosomes was less than that from the group treated with AOAA alone, though its GABA level was higher than the normal level." | 1.26 | Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions. ( Abe, M, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trocello, JM | 1 |
| Woimant, F | 1 |
| El Balkhi, S | 1 |
| Guichard, JP | 1 |
| Poupon, J | 1 |
| Chappuis, P | 1 |
| Feillet, F | 1 |
| Rahimi, N | 1 |
| Sadeghzadeh, M | 1 |
| Javadi-Paydar, M | 1 |
| Heidary, MR | 1 |
| Jazaeri, F | 1 |
| Dehpour, AR | 1 |
| ISRAELS, S | 1 |
| HAWORTH, JC | 1 |
| GOURLEY, B | 1 |
| FORD, JD | 1 |
| Abbaslou, P | 1 |
| Zaman, T | 1 |
| Alley, MC | 1 |
| Killam, EK | 1 |
| Fisher, GL | 1 |
| Marroni, M | 1 |
| Bellomo, G | 1 |
| Bucaneve, G | 1 |
| Stagni, G | 1 |
| Baldelli, F | 1 |
| Bitterman, N | 1 |
| Bitterman, H | 1 |
| Matsuda, M | 8 |
| Abe, M | 5 |
| Hoshino, M | 1 |
| Sakurai, T | 1 |
| Kawamata, I | 1 |
| Schlesinger, K | 1 |
| Lieff, B | 1 |
| Murakami, Y | 1 |
| Mizuno, A | 1 |
| Mizobuchi, T | 1 |
| Ishibashi, Y | 1 |
| Hori, S | 1 |
| Asakura, T | 1 |
| Kurioka, S | 1 |
| Lingam, S | 1 |
| Wilson, J | 1 |
| Nazer, H | 1 |
| Mowat, AP | 1 |
| Brewer, GJ | 1 |
| Terry, CA | 1 |
| Aisen, AM | 1 |
| Hill, GM | 1 |
| Reinken, L | 1 |
| Sprince, H | 1 |
| Parker, CM | 1 |
| Smith, GG | 1 |
| Smith, DB | 1 |
| Gallagher, BB | 1 |
| Swaiman, KF | 1 |
| Milstein, JM | 1 |
| Sutton, GG | 1 |
| Oldstone, MB | 1 |
1 review available for penicillamine and Seizures
| Article | Year |
|---|---|
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
23 other studies available for penicillamine and Seizures
| Article | Year |
|---|---|
Extensive striatal, cortical, and white matter brain MRI abnormalities in Wilson disease.
Topics: Adolescent; Cerebral Cortex; Cerebrum; Chelating Agents; Chelation Therapy; Corpus Striatum; Hepatol | 2013 |
Effects of D-penicillamine on pentylenetetrazole-induced seizures in mice: involvement of nitric oxide/NMDA pathways.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Male; Mice; N-Methylaspartate; Nitric | 2014 |
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism | 1964 |
A Child with elemental mercury poisoning and unusual brain MRI findings.
Topics: Acrodynia; Antidotes; Brain; Chelating Agents; Child; Humans; Inhalation Exposure; Magnetic Resonanc | 2006 |
The influence of D-penicillamine treatment upon seizure activity and trace metal status in the Senegalese baboon, Papio papio.
Topics: Animals; Copper; Electroencephalography; Female; Male; Papio; Penicillamine; Photic Stimulation; Sei | 1981 |
Isotretinoin: possible cause of acute seizure and confusion.
Topics: Adult; Confusion; Humans; Isotretinoin; Male; Myxedema; Penicillamine; Seizures | 1993 |
L-arginine-NO pathway and CNS oxygen toxicity.
Topics: Animals; Arginine; Central Nervous System; Electroencephalography; Enzyme Inhibitors; Hyperoxia; Ind | 1998 |
gamma-Aminobutyric acid in subcellular fractions of mouse brain and its relation to convulsions.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Penicillamine; Seizures; Semicarbazi | 1979 |
Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Glutamat | 1979 |
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid | 1978 |
gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Dec | 1977 |
A correlation between changes in gamma-aminobutyric acid metabolism and seizures induced by antivitamin B6.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Dec | 1976 |
Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.
Topics: Aldehydes; Animals; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Mice; Penicillamine; Pyridoxine | 1976 |
Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures.
Topics: Acoustic Stimulation; Animal Feed; Animals; Brain Chemistry; Electroshock; Genotype; Mice; Mice, Inb | 1975 |
The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Isoniazid; Male; Mice; Penicillamine; Pyridoxa | 1976 |
c-Fos mRNA induction under vitamin B6 antagonist-induced seizure.
Topics: Animals; Blotting, Northern; Brain; Hydrazines; Male; Mice; Mice, Inbred ICR; Penicillamine; Proto-O | 1989 |
Effects of carbon dioxide on onsets of seizures in mice induced by antagonists of vitamin B6.
Topics: Animals; Carbon Dioxide; Mice; Penicillamine; Pyridoxine; Seizures; Semicarbazides | 1987 |
Neurological abnormalities in Wilson's disease are reversible.
Topics: Adolescent; Child; Child Behavior Disorders; Ethylenediamines; Female; Hepatolenticular Degeneration | 1987 |
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.
Topics: Adolescent; Adult; Basal Ganglia; Female; Frontal Lobe; Hepatolenticular Degeneration; Humans; Magne | 1987 |
3-mercaptopropionic acid: convulsant and lethal properties compared with other sulfur-convulsants; protection therefrom.
Topics: Animals; Central Nervous System Stimulants; Glucose; Homocysteine; Lethal Dose 50; Male; Methionine | 1970 |
The effect of penicillamine on seizure threshold. The role of pyridoxine.
Topics: Animals; Disease Models, Animal; Male; Myoclonus; Penicillamine; Pyridoxine; Rats; Seizures; Tryptop | 1970 |
Pyridoxine dependency and penicillamine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney Function Tests; Penicillamine; Ph | 1970 |
Evidence against pyridoxine deficiency as the mechanism of penicillin seizures.
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Methanol; Penicillamine; Penicillins; Pyridi | 1969 |