penicillamine and Sclerosis, Systemic studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

Excerpt	Relevance	Reference
"The use of penicillamine in the treatment of rheumatoid arthritis and scheroderma is reviewed."	9.04	The use of penicillamine in the treatment of rheumatoid arthritis and scleroderma. ( Baum, J, 1979)
"D-penicillamine-associated bronchiolitis obliterans (BO) is a rare but well-known pulmonary complication in patients with rheumatoid arthritis or progressive systemic sclerosis."	8.79	Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. ( Boehler, A; Russi, EW; Speich, R; Vogt, P; Weder, W, 1996)
"A case of a bullous eruption occurred in a patient being treated with penicillamine for sclerodermatous graft-versus-host disease following bone marrow transplantation."	7.72	Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease. ( Cetkovská, P; Pizinger, K; Skálová, A, 2003)
"D: -Penicillamine-induced pemphigus occurs infrequently, typically in patients with rheumatoid arthritis."	7.70	Pemphigus vulgaris induced by D-penicillamine therapy in a patient with systemic sclerosis. ( Jimenez, S; Shapiro, M; Werth, VP, 2000)
" Both patients (one case of progressive systemic sclerosis and one of rheumatoid arthritis) were currently taking D-penicillamine."	7.68	Unilateral ptosis as an initial manifestation of D-penicillamine induced myasthenia gravis. ( Fries, JF; Kornfeld, P; Lee, YS; Raynauld, JP, 1993)
"A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g."	7.67	D-penicillamine induced crescentic glomerulonephritis: report and review of the literature. ( Brichard, S; Cosyns, JP; Devogelaer, JP; Nagant de Deuxchaisnes, C; Pirson, Y; Vandenbroucke, JM, 1987)
"The development of autoimmune diseases in some patients treated with D-penicillamine (DPA) suggests that the reported occurrence of a conduction disorder at the neuromuscular junction and the development of a reversible myasthenia gravis in rheumatoid disease, progressive systemic sclerosis or Wilson's disease after the use of DPA are part of a general predisposition for autoimmune disease related to DPA therapy."	7.67	[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis]. ( Cossermelli, W; De Assis, JL; Marchiori, PE; Scaff, M, 1984)
"5 patients suffering from progressive scleroderma with interstitial pulmonary fibrosis have been treated since 1971 with D-penicillamine (Artamin) as basic therapeutic agent."	7.65	[Treatment of interstitial pulmonary fibrosis with D-penicillamine in progressive scleroderma: a long-term study (author's transl)]. ( Bröll, H; Eberl, R; Tausch, G, 1976)
"Proteinuria is observed in 10% of the patients, often secondary to extramembranous glomerulopathy."	5.30	[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D]. ( Bridoux, F; Ducq, P; Gheerbrant, JD; Kyndt, X; Makdassi, R; Reumaux, D; Vanhille, P, 1999)
"Immune thrombocytopenia is a rare complication of progressive systemic sclerosis (PSS)."	5.28	Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. ( Kashiwagi, H; Kato, S; Kono, I; Matsui, Y; Natsuda, H; Sakauchi, M; Suzuki, H; Takemura, H; Yamane, K, 1992)
"The use of penicillamine in the treatment of rheumatoid arthritis and scheroderma is reviewed."	5.04	The use of penicillamine in the treatment of rheumatoid arthritis and scleroderma. ( Baum, J, 1979)
"We report the case of a 34-year-old white woman with a history of progressive systemic scleroderma (PSS) and diffuse alveolar hemorrhage (DAH) that may be either a rare complication of PSS or induced by D-penicillamine."	4.80	A case study and national database report of progressive systemic sclerosis and associated conditions. ( Mannino, D; Phillips, B; Phillips, D, 1998)
"D-penicillamine-associated bronchiolitis obliterans (BO) is a rare but well-known pulmonary complication in patients with rheumatoid arthritis or progressive systemic sclerosis."	4.79	Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. ( Boehler, A; Russi, EW; Speich, R; Vogt, P; Weder, W, 1996)
" We report a case of a patient affected by SS, with isolated pulmonary hypertension, who developed bronchiolitis secondary to penicillamine."	3.73	Pulmonary involvement in systemic sclerosis due to therapy and as a complication. ( Chiappini, F; Maugeri, L; Zoli, A, 2005)
"A case of a bullous eruption occurred in a patient being treated with penicillamine for sclerodermatous graft-versus-host disease following bone marrow transplantation."	3.72	Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease. ( Cetkovská, P; Pizinger, K; Skálová, A, 2003)
"A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe."	3.70	In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine. ( Katayama, Y; Kohriyama, K; Matsui, T, 1999)
"D: -Penicillamine-induced pemphigus occurs infrequently, typically in patients with rheumatoid arthritis."	3.70	Pemphigus vulgaris induced by D-penicillamine therapy in a patient with systemic sclerosis. ( Jimenez, S; Shapiro, M; Werth, VP, 2000)
"A case of drug-provoked fever is described in a scleroderma patient on penicillamine."	3.68	[Fever caused by penicillin. Description of a clinical case]. ( Baratta, E; Biscarini, L, 1990)
" Both patients (one case of progressive systemic sclerosis and one of rheumatoid arthritis) were currently taking D-penicillamine."	3.68	Unilateral ptosis as an initial manifestation of D-penicillamine induced myasthenia gravis. ( Fries, JF; Kornfeld, P; Lee, YS; Raynauld, JP, 1993)
"The development of autoimmune diseases in some patients treated with D-penicillamine (DPA) suggests that the reported occurrence of a conduction disorder at the neuromuscular junction and the development of a reversible myasthenia gravis in rheumatoid disease, progressive systemic sclerosis or Wilson's disease after the use of DPA are part of a general predisposition for autoimmune disease related to DPA therapy."	3.67	[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis]. ( Cossermelli, W; De Assis, JL; Marchiori, PE; Scaff, M, 1984)
"A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g."	3.67	D-penicillamine induced crescentic glomerulonephritis: report and review of the literature. ( Brichard, S; Cosyns, JP; Devogelaer, JP; Nagant de Deuxchaisnes, C; Pirson, Y; Vandenbroucke, JM, 1987)
"Histological, immunohistological and electron microscopical investigations on the glomerular renal lesions in penicillamine-induced nephropathy were carried out by studying biopsy material of eight patients with rheumatoid arthritis (4 cases), allergic alveolitis (3 cases) and systemic scleroderma (1 case) under the treatment with D-penicillamine."	3.66	[Morphology and pathogenesis of penicillamine-induced nephropathy]. ( Henzgen, S; Waldmann, G, 1983)
"The taste function and the zinc and copper levels in serum and urine were followed for up tp 16 weeks in ten patients who were started on penicillamine therapy for generalized scleroderma (9 patients) and rheumatoid arthritis (one patient)."	3.66	Taste dysfunction and changes in zinc and copper metabolism during penicillamine therapy for generalized scleroderma. ( Knudsen, L; Weismann, K, 1978)
"5 patients suffering from progressive scleroderma with interstitial pulmonary fibrosis have been treated since 1971 with D-penicillamine (Artamin) as basic therapeutic agent."	3.65	[Treatment of interstitial pulmonary fibrosis with D-penicillamine in progressive scleroderma: a long-term study (author's transl)]. ( Bröll, H; Eberl, R; Tausch, G, 1976)
"The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma."	2.82	Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy. ( Gigante, A; Leodori, G; Pellicano, C; Rosato, E; Villa, A, 2022)
"To test the hypothesis that systemic sclerosis (SSc) patients taking high-dose D-penicillamine (D-Pen) would have greater softening of skin, lower frequency of renal crisis, and better survival than patients taking low-dose D-Pen."	2.69	High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: analysis of a two-year, double-blind, randomized, controlled clinical trial. ( Abeles, M; Andrews, B; Barr, W; Clements, PJ; Collier, D; Furst, DE; Lally, E; Martin, RW; Mayes, M; Medsger, TA; Moreland, LW; Seibold, JR; Steen, V; Varga, J; Weiner, S; Weinstein, A; Weisman, MH; White, B; Wigley, F; Wong, WK, 1999)
"For patients with systemic sclerosis of recent onset, extracorporeal photochemotherapy is a well-tolerated treatment that may partially reverse the process that results in cutaneous sclerosis."	2.67	Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial. ( Barr, WG; Freundlich, B; Jegasothy, BV; Jimenez, SA; Kahaleh, MB; Perez, MI; Rietschel, RL; Rook, AH; Varga, J; Wintroub, B, 1992)
"Although rare, vasculitis is a complication of SSc."	2.49	Systemic vasculitis during the course of systemic sclerosis: report of 12 cases and review of the literature. ( Cacoub, P; Guillevin, L; Hachulla, E; Hatron, PY; Meyer, O; Michon-Pasturel, U; Mouthon, L; Quéméneur, T; Vanhille, P, 2013)
"The use of D-penicillamine in systemic sclerosis (SSc) has been controversial."	2.41	D-penicillamine in systemic sclerosis? Yes! ( Baker, C; Lucas, M; Medsger, TA; Wildy, KS, 2001)
" The course of skin thickening and the occurrence of renal crisis and of death were examined in a recent randomized controlled 2-year trial of high- dosage DPA (750-1000 mg/d) versus low-dose DPA (125 mg every other day)."	2.40	Penicillamine in the treatment of systemic sclerosis. ( Clements, PJ, 1999)
"Although the aetiology of systemic sclerosis is unknown, its prevalence has been reported to be increased in workers exposed to silica."	2.39	[Systemic sclerosis]. ( Gustafsson, R, 1994)
"Systemic scleroderma is an acquired disorder which typically results in fibrosis of the skin and internal organs."	2.38	Activation of dermal connective tissue in scleroderma. ( Kähäri, VM, 1993)
"None of the patients with morphea had a history of thyroid pathology and the thyroid screenings were within normal limits."	2.38	[Scleroderma and thyroid diseases]. ( Claudy, A; Mourier-Clavreul, MC; Rousset, H, 1989)
"After 6 years of follow-up, the mesenteric panniculitis and systemic sclerosis both remained stable."	1.40	Limited systemic sclerosis initially presenting with mesenteric panniculitis. ( Arroyo-Ávila, M; Vilá, LM, 2014)
"Localized disease manifests as patches (morphea) or bandlike (linear scleroderma) areas of skin thickening."	1.35	Diagnosis and treatment of scleroderma. ( Adnan, ZA, 2008)
"We report a case of diffuse systemic sclerosis (skin, joints, esophagus, and Raynaud's phenomenon) in a 41-year-old Caucasian male with a 15-year history of ankylosing spondylitis and an episode of severe myocarditis of unknown origin."	1.35	Ankylosing spondylitis and systemic sclerosis: a rare combination. ( Meyer, O; Nlomé-Nzé, M; Ouédraogo, DD; Palazzo, E; Somogyi-Demerjian, N, 2009)
"Co-occurence of systemic sclerosis and collagenous colitis is particularly rare."	1.34	Collagenous colitis in a patient with systemic sclerosis: a rare entity. ( Coban, S; Ekiz, F; Ensari, A; Gören, D; Ormeci, N; Savas, B, 2007)
"The connective tissue disease systemic sclerosis (SSc) is still a challenge to every rheumatologist."	1.33	[Systemic sclerosis--a challenge in rheumatology]. ( Müller-Ladner, U; Saar, P, 2006)
"She was diagnosed as having systemic sclerosis (SSc) based on the skin sclerosis of her arms, chest, and face."	1.32	Improvement of skin sclerosis after occurrence of anticentromere antibody in a patient with diffuse cutaneous systemic sclerosis. ( Echigo, T; Hasegawa, M; Hayakawa, I; Sato, S; Shirasaki, F; Takehara, K, 2004)
"We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment."	1.32	[Minimal changes nephrotic syndrome associated to penicillamine treatment]. ( Basterrechea, MA; de Arriba, G; García-Martín, F; Giménez-Vega, E; Sánchez, J; Sánchez-Heras, M, 2004)
"Progressive systemic sclerosis (PSS), or scleroderma, is a rare disease in the pediatric population."	1.31	Clinical trials for pediatric scleroderma. ( Lehman, TJ; Rosenkranz, ME, 2002)
"To evaluate functional impairment in systemic sclerosis (SSc) patients with diffuse cutaneous scleroderma at the time of entry into a trial of a therapeutic intervention (D-penicillamine)."	1.30	Correlates of the disability index of the health assessment questionnaire: a measure of functional impairment in systemic sclerosis. ( Abeles, M; Andrews, B; Barr, W; Clements, PJ; Collier, D; Furst, DE; Hurwitz, EL; Lally, E; Martin, R; Mayes, M; Medsger, TA; Moreland, L; Seibold, J; Steen, V; Varga, J; Weiner, S; Weinstein, A; Weisman, M; White, B; Wigley, F; Wong, WK, 1999)
"Proteinuria is observed in 10% of the patients, often secondary to extramembranous glomerulopathy."	1.30	[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D]. ( Bridoux, F; Ducq, P; Gheerbrant, JD; Kyndt, X; Makdassi, R; Reumaux, D; Vanhille, P, 1999)
"Progressive renal failure in patients with scleroderma is a sinister development that is usually attributed to impaired renal blood flow."	1.30	Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies. ( Hillis, GS; Khan, IH; Rees, AJ; Simpson, JG, 1997)
"Sera from 97 patients and suction blister fluid from 13 patients were radioimmunoassayed."	1.29	The use of serologic markers for collagen synthesis and degradation in systemic sclerosis. ( Bjerring, P; Halkier-Sørensen, L; Heickendorff, L; Søndergaard, K; Zachariae, H, 1995)
"There was a significant association of trauma with childhood-onset scleroderma (P < 0."	1.29	Childhood-onset scleroderma: is it different from adult-onset disease. ( Atherton, D; Black, CM; David, J; Harper, J; Hasson, N; Trivedi, P; Vancheeswaran, R; Woo, P, 1996)
"A case of systemic sclerosis (SS) which developed keloidal lesions (nodular scleroderma) on the chest during D-penicillamine (DPC) therapy is reported."	1.28	Nodular scleroderma in systemic sclerosis under D-penicillamine therapy. ( Denpo, K; Nakajima, H; Ono, H; Sasaki, T, 1992)
"Immune thrombocytopenia is a rare complication of progressive systemic sclerosis (PSS)."	1.28	Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. ( Kashiwagi, H; Kato, S; Kono, I; Matsui, Y; Natsuda, H; Sakauchi, M; Suzuki, H; Takemura, H; Yamane, K, 1992)
"A 45-year-old woman had recurrent morphea lesions over 10 times in 6 years."	1.28	Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. ( Mizutani, H; Mizutani, T; Okada, H; Shimizu, M; Tanaka, H, 1992)
"In all patients with diffuse systemic sclerosis there was objective improvement."	1.28	Penicillamine in systemic sclerosis: a reappraisal. ( Guindi, RT; Sattar, MA; Sugathan, TN, 1990)
"A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine."	1.28	Lupus erythematosus-like eruption due to D-penicillamine in progressive systemic sclerosis. ( Lazarova, AZ; Obreshkova, EV; Tsankov, NK; Vasileva, SG, 1990)
" Urinary excretion of the collagen-specific amino acids hydroxyproline and hydroxylysine, and of proline was used as a guideline for monitoring the bioavailability of D-penicillamine."	1.28	The progress of oesophageal involvement in progressive systemic sclerosis during D-penicillamine treatment. ( Aggestrup, S; Hendel, L; Stentoft, P, 1989)
" Adverse effects occurred more frequently after rapid increases in dosage."	1.27	The toxicity of D-penicillamine in systemic sclerosis. ( Blair, S; Medsger, TA; Steen, VD, 1986)
"The bioavailability of D-penicillamine was measured in 24 patients with generalized scleroderma (Progressive Systemic Sclerosis, PSS)."	1.27	Bioavailability of D-penicillamine in relation to gastrointestinal involvement of generalized scleroderma. ( Ammitzbøll, T; Asboe-Hansen, G; Hendel, L; Kreuzig, F, 1987)
"Tiopronine was tried in 4 of these patients with 3 interpretables follow-ups."	1.27	[Treatment of systemic scleroderma with D-penicillamine. Results in 14 patients treated for more than a year]. ( Bourgeois, P; Brion, N; Elleuch, M; Kahn, MF, 1986)
" This is the first case reported in which long-term administration of penicillamine was followed by the development of systemic sclerosis-like lesions."	1.27	Systemic sclerosis-like lesions during long-term penicillamine therapy for Wilson's disease. ( Hatoko, M; Miyagawa, S; Okuchi, T; Sakamoto, K; Yoshioka, A, 1987)
" D-penicillamine bioavailability was examined after oral, duodenal, intravenous and rectal administration."	1.27	Bioavailability of D-penicillamine in a patient with gastrointestinal progressive systemic sclerosis. ( Ammitzbøll, T; Asboe-Hansen, G; Hendel, L; Kreuzig, F; Worning, H, 1986)
"Forty-four systemic sclerosis patients who received a mean dose of 636 mg of D-penicillamine for 2."	1.27	The effect of D-penicillamine on pulmonary findings in systemic sclerosis. ( Medsger, TA; Owens, GR; Redmond, C; Rodnan, GP; Steen, VD, 1985)
"Treatment with danazol was associated with a reduction in both the breast size and the prolactin level."	1.27	Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. ( Kahl, LE; Klein, I; Medsger, TA, 1985)
"Twenty-two patients with progressive systemic sclerosis were treated with D-penicillamine in doses ranging up to 1250 mg/day for periods varying between a few months and four years."	1.26	Penicillamine therapy in systemic sclerosis. ( Black, CM; Jayson, MI; Lovell, C; Wilson, RS, 1977)
"A case of severe diffuse systemic sclerosis with cardiomegaly and cardiac failure is described."	1.26	Treatment of scleroderma heart by D-penicillamine. ( Muers, M; Stokes, W, 1976)
"Four patients with systemic sclerosis (scleroderma) were treated with (D)-penicillamine (1."	1.26	(D)-penicillamine treatment in systemic sclerosis (scleroderma). Effect on nutritional capillary circulation. ( Björkholm, M; Fagrell, B; Holm, G; Mellstedt, H, 1977)
"In a retrospective study on progressive systemic sclerosis, we compared 73 patients who had received D-penicillamine therapy for a minimum of 6 consecutive months with 45 patients who had not received this drug."	1.26	D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis. ( Medsger, TA; Rodnan, GP; Steen, VD, 1982)
"A 25-year-old woman with progressive systemic sclerosis was treated with D-penicillamine."	1.26	[Cholestatic jaundice induced by D-penicillamine and oral steroid contraceptive in progressive systemic sclerosis (author's transl)]. ( Julius, U; Wozel, G, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	129 (54.43)	18.7374
1990's	61 (25.74)	18.2507
2000's	40 (16.88)	29.6817
2010's	5 (2.11)	24.3611
2020's	2 (0.84)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
An Open Label Extension Study of Brentuximab Vedotin Treatment in Active Diffuse Cutaneous Systemic Sclerosis (Diffuse Scleroderma)[NCT05149768]	Phase 2	11 participants (Anticipated)	Interventional	2024-06-01	Not yet recruiting
The Effectiveness of ECP in Diffuse Cutaneous Systemic Sclerosis[NCT04986605]	Phase 2	15 participants (Anticipated)	Interventional	2023-12-01	Not yet recruiting
A Pilot Study of Adcetris Treatment in Active Diffuse Cutaneous Systemic Sclerosis (Diffuse Scleroderma)[NCT03198689]	Phase 2	11 participants (Actual)	Interventional	2019-05-07	Completed
An Observational, Long-term Follow-up Study of Eligible Individuals Declining To Participate in the Scleroderma Cyclophosphamide or Transplantation (SCOT) Study (SCSSc-02)[NCT00860548]		19 participants (Actual)	Observational	2005-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy. The American journal of the medical sciences, 2022, Volume: 364, Issue:5 Topics: Acute Kidney Injury; Antibodies, Antineutrophil Cytoplasmic; Humans; Kidney; Penicillamine; Peroxida	2022
Systemic vasculitis during the course of systemic sclerosis: report of 12 cases and review of the literature. Medicine, 2013, Volume: 92, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Biomar	2013
[Efficacy of anti-thymocyte globulin and cyclosporin A combined therapy in aplastic anemia complicated with limited cutaneous systemic sclerosis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2005, Volume: 28, Issue:2 Topics: Aged; Anemia, Aplastic; Antilymphocyte Serum; Cyclosporine; Female; Granulocyte Colony-Stimulating F	2005
[Treatment of systemic sclerosis]. Zeitschrift fur Rheumatologie, 2006, Volume: 65, Issue:4 Topics: Cyclophosphamide; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Hematopoietic S	2006
[Therapeutic management of systemic sclerosis]. Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:12 Pt 2 Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Anti-Inflam	2006
Scleroderma: therapeutic options. Cutis, 1984, Volume: 34, Issue:3 Topics: Alprostadil; Captopril; Colchicine; Griseofulvin; Humans; Immunosuppressive Agents; Nifedipine; Peni	1984
[Treatment of systemic scleroderma]. Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:6-7 Topics: Calcium Channel Blockers; Captopril; Clinical Trials as Topic; Colchicine; Factor XIII; Humans; Peni	1984
[Hydrocortisone and cuprenil phonophoresis in the therapy of scleroderma]. Vestnik dermatologii i venerologii, 1980, Issue:10 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Drug Combinations; Drug Evaluation; Female	1980
[Systemic sclerosis]. Nordisk medicin, 1994, Volume: 109, Issue:8-9 Topics: Adjuvants, Immunologic; Adult; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Locali	1994
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Outcome measurement in scleroderma clinical trials. Seminars in arthritis and rheumatism, 1993, Volume: 23, Issue:1 Topics: Clinical Trials as Topic; Dimethyl Sulfoxide; Female; Humans; Male; Penicillamine; Photopheresis; Pr	1993
Activation of dermal connective tissue in scleroderma. Annals of medicine, 1993, Volume: 25, Issue:6 Topics: Cell Adhesion Molecules; Chemotaxis, Leukocyte; Collagen; Connective Tissue; Cyclosporine; Cytokines	1993
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. The European respiratory journal, 1996, Volume: 9, Issue:6 Topics: Antirheumatic Agents; Bronchiolitis Obliterans; Humans; Lung Transplantation; Male; Middle Aged; Pen	1996
Treatment of systemic sclerosis. Rheumatic diseases clinics of North America, 1996, Volume: 22, Issue:4 Topics: Antirheumatic Agents; Calcinosis; Clinical Trials as Topic; Gastrointestinal Diseases; Heart Disease	1996
D-penicillamine-induced crescentic glomerulonephritis and antimyeloperoxidase antibodies in a patient with scleroderma. Case report and review of the literature. American journal of nephrology, 1997, Volume: 17, Issue:6 Topics: Aged; Autoantibodies; Biopsy; Female; Glomerulonephritis; Humans; Kidney Glomerulus; Microscopy, Ele	1997
A case study and national database report of progressive systemic sclerosis and associated conditions. Journal of women's health, 1998, Volume: 7, Issue:9 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Cause of Deat	1998
D-penicillamine-induced crescentic glomerulonephritis in a patient with scleroderma. Nephron, 2000, Volume: 84, Issue:1 Topics: Acute Kidney Injury; Aged; Glomerulonephritis; Humans; Male; Penicillamine; Scleroderma, Systemic	2000
[Systemic scleroderma]. Ryoikibetsu shokogun shirizu, 2000, Issue:29 Pt 4 Topics: Diagnosis, Differential; Humans; Penicillamine; Peripheral Nervous System Diseases; Prognosis; Scler	2000
Clinical trials for the treatment of systemic sclerosis/scleroderma. Current rheumatology reports, 1999, Volume: 1, Issue:1 Topics: Antirheumatic Agents; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Male; Penicillamin	1999
Penicillamine in the treatment of systemic sclerosis. Current rheumatology reports, 1999, Volume: 1, Issue:1 Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hu	1999
[Scleroderma]. Ryoikibetsu shokogun shirizu, 2000, Issue:31 Topics: Antibodies, Antinuclear; Autoimmunity; Collagen; Cytokines; Diagnosis, Differential; Humans; Penicil	2000
[Scleroderma]. Ryoikibetsu shokogun shirizu, 2000, Issue:31 Topics: Autoantibodies; Cytokines; Humans; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Lymp	2000
Combination therapies for systemic sclerosis. Springer seminars in immunopathology, 2001, Volume: 23, Issue:1-2 Topics: Antirheumatic Agents; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Penicillamine; Sc	2001
[Systemic sclerosis]. Ryoikibetsu shokogun shirizu, 2001, Issue:35 Topics: Alprostadil; Collagen; Cytokines; Diagnosis, Differential; Fibrillins; Humans; Microfilament Protein	2001
Juvenile systemic scleroderma. Current rheumatology reports, 2001, Volume: 3, Issue:5 Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; H	2001
D-penicillamine in systemic sclerosis? Yes! Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:4 Topics: Antirheumatic Agents; Collagen; Dose-Response Relationship, Drug; Double-Blind Method; Fibrosis; Hum	2001
D-penicillamine is not an effective treatment in systemic sclerosis. Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:4 Topics: Antirheumatic Agents; Double-Blind Method; Humans; Penicillamine; Randomized Controlled Trials as To	2001
Treating systemic sclerosis in 2001. Joint bone spine, 2001, Volume: 68, Issue:5 Topics: Antineoplastic Agents; Antirheumatic Agents; Combined Modality Therapy; Drug Therapy, Combination; F	2001
Current treatment options in systemic Sclerosis (Scleroderma). Acta medica Austriaca, 2002, Volume: 29, Issue:1 Topics: Antirheumatic Agents; Gastrointestinal Diseases; Hematopoietic Stem Cell Transplantation; Humans; Hy	2002
[Indications and limits of long-term therapy with immunosuppressive (and cytostatic) agents in various chronic skin diseases]. Zeitschrift fur arztliche Fortbildung, 1977, Jun-15, Volume: 71, Issue:12 Topics: Arthritis, Reactive; Azathioprine; Chronic Disease; Cyclophosphamide; Dermatomyositis; Humans; Immun	1977
Penicillamine types in the sclerodermas. Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 3 Topics: Humans; Penicillamine; Raynaud Disease; Scleroderma, Systemic	1977
D-penicillamine in the treatment of rheumatoid arthritis and progressive systemic sclerosis. The British journal of dermatology, 1976, Volume: 94, Issue:6 Topics: Animals; Arthritis, Rheumatoid; Chelating Agents; Collagen; Copper; Humans; Leukopenia; Nephrotic Sy	1976
[Effects and adverse effects of D-penicillamine]. Medizinische Klinik, 1975, Aug-01, Volume: 70, Issue:31 Topics: Bone Marrow Diseases; Chronic Disease; Cystinuria; Erythropoiesis; Hepatitis; Hepatolenticular Degen	1975
Treatment of systemic sclerosis. Current opinion in rheumatology, 1992, Volume: 4, Issue:6 Topics: Cyclosporine; Humans; Methotrexate; Penicillamine; Photochemotherapy; Raynaud Disease; Scleroderma,	1992
Drug-induced scleroderma. Bailliere's clinical rheumatology, 1991, Volume: 5, Issue:1 Topics: Amphetamine; Bleomycin; Cocaine; Diethylpropion; Drug-Related Side Effects and Adverse Reactions; Hu	1991
Treatment of systemic sclerosis. Annals of the rheumatic diseases, 1991, Volume: 50 Suppl 4 Topics: Colchicine; Humans; Immunosuppressive Agents; Penicillamine; Scleroderma, Systemic	1991
Photopheresis in the treatment of autoimmune disease: experience with pemphigus vulgaris and systemic sclerosis. Annals of the New York Academy of Sciences, 1991, Dec-30, Volume: 636 Topics: Autoimmune Diseases; Humans; Leukapheresis; Pemphigus; Penicillamine; PUVA Therapy; Scleroderma, Sys	1991
Current topics in the diagnosis and treatment of scleroderma. Comprehensive therapy, 1991, Volume: 17, Issue:6 Topics: Adult; Female; Humans; Nifedipine; Penicillamine; Scleroderma, Systemic	1991
D-penicillamine. Bailliere's clinical rheumatology, 1990, Volume: 4, Issue:3 Topics: Arthritis, Juvenile; Arthritis, Rheumatoid; Drug Prescriptions; Humans; Penicillamine; Rheumatic Dis	1990
The current treatment of scleroderma. Drugs, 1989, Volume: 37, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Male; Penicillamine; Scleroderma, Systemic	1989
Treatment of systemic sclerosis. Rheumatic diseases clinics of North America, 1989, Volume: 15, Issue:3 Topics: Humans; Immunosuppressive Agents; Penicillamine; Scleroderma, Systemic	1989
[Scleroderma and thyroid diseases]. Annales de dermatologie et de venereologie, 1989, Volume: 116, Issue:10 Topics: Aged; Confidence Intervals; Female; Humans; Incidence; Male; Middle Aged; Penicillamine; Prospective	1989
D-penicillamine: chemistry and clinical use in rheumatic disease. Seminars in arthritis and rheumatism, 1986, Volume: 15, Issue:4 Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Drug Eruptions; Gold Sodium Thiomalate; Hematologic Dise	1986
[D-penicillamine and collagen]. Annales de biologie clinique, 1986, Volume: 44, Issue:3 Topics: Aminopropionitrile; Arthritis, Rheumatoid; Autoantibodies; Bronchi; Cicatrix; Collagen; Collagen Dis	1986
[Therapeutic use of d-penicillamine]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1972, Oct-09, Volume: 27, Issue:41 Topics: Arthritis, Rheumatoid; Basement Membrane; Collagen; Copper; Cystinuria; Hematopoiesis; Hepatolenticu	1972
Copper and taste sensitivity. Nutrition reviews, 1968, Volume: 26, Issue:6 Topics: Arthritis, Rheumatoid; Ceruloplasmin; Copper; Cystinuria; Depression, Chemical; Hepatolenticular Deg	1968
[Penicillamine in the light of current clinical research]. Lijecnicki vjesnik, 1970, Volume: 92, Issue:12 Topics: Antidotes; Arthritis; Arthritis, Rheumatoid; Chronic Disease; Collagen; Copper; Depression, Chemical	1970

Article	Year
Course of the modified Rodnan skin thickness score in systemic sclerosis clinical trials: analysis of three large multicenter, double-blind, randomized controlled trials. Arthritis and rheumatism, 2009, Volume: 60, Issue:8 Topics: Adult; Age of Onset; Animals; Antirheumatic Agents; Cattle; Collagen Type I; Disease Progression; Fe	2009
Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis and rheumatism, 2002, Volume: 46, Issue:11 Topics: Adult; Female; Humans; Kidney Diseases; Male; Middle Aged; Penicillamine; Retrospective Studies; Scl	2002
Effect of D-penicillamine on pulmonary fibrosis in patients with systemic sclerosis. Annals of the rheumatic diseases, 2003, Volume: 62, Issue:10 Topics: Adult; Antirheumatic Agents; Female; Humans; Male; Middle Aged; Penicillamine; Pulmonary Fibrosis; R	2003
Minocycline is not effective in systemic sclerosis: results of an open-label multicenter trial. Arthritis and rheumatism, 2004, Volume: 50, Issue:2 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Dose-Response Relations	2004
High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial: lessons learned. Seminars in arthritis and rheumatism, 2004, Volume: 33, Issue:4 Topics: Adult; Antirheumatic Agents; Disability Evaluation; Dose-Response Relationship, Drug; Female; Follow	2004
65Zinc absorption in untreated and D-penicillamine-treated patients with generalized scleroderma: determination by whole-body counting technique. Acta dermato-venereologica, 1982, Volume: 62, Issue:5 Topics: Administration, Oral; Humans; Penicillamine; Scleroderma, Systemic; Whole-Body Counting; Zinc Radioi	1982
Progressive systemic sclerosis. Clinics in rheumatic diseases, 1983, Volume: 9, Issue:3 Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Colchicine; Drug Evaluation; Follow-Up Studies; H	1983
[Treatment of systemic scleroderma]. Annales de dermatologie et de venereologie, 1984, Volume: 111, Issue:6-7 Topics: Calcium Channel Blockers; Captopril; Clinical Trials as Topic; Colchicine; Factor XIII; Humans; Peni	1984
Therapy for severe interstitial lung disease in systemic sclerosis. A retrospective study. Arthritis and rheumatism, 1994, Volume: 37, Issue:9 Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Count; Cyclophosphamide; Female; Humans; Immunosuppressive	1994
Photopheresis for scleroderma? Let's abandon the innuendos and get to the data. The Journal of rheumatology, 1993, Volume: 20, Issue:6 Topics: Blood Component Removal; Costs and Cost Analysis; Extracorporeal Circulation; Humans; Penicillamine;	1993
[A prospective study of plasma exchange in the treatment of diffuse scleroderma]. Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:9 Topics: Adult; Antirheumatic Agents; Combined Modality Therapy; Female; Humans; Male; Penicillamine; Plasma	1995
High-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis: analysis of a two-year, double-blind, randomized, controlled clinical trial. Arthritis and rheumatism, 1999, Volume: 42, Issue:6 Topics: Adult; Antirheumatic Agents; Creatine Kinase; Dose-Response Relationship, Drug; Double-Blind Method;	1999
The Disability Index of the Health Assessment Questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial. Arthritis and rheumatism, 2001, Volume: 44, Issue:3 Topics: Disability Evaluation; Dose-Response Relationship, Drug; Health Status Indicators; Humans; Logistic	2001
Long-term therapy with plasma exchange in systemic sclerosis: effects on laboratory markers reflecting disease activity. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2001, Volume: 25, Issue:1 Topics: Adult; Aged; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Biomarkers; Combined Modalit	2001
Treatment of generalized scleroderma with inhibitors of connective tissue formation. Acta dermato-venereologica, 1975, Volume: 55, Issue:6 Topics: Adult; Age Factors; Clinical Trials as Topic; Connective Tissue; Depression, Chemical; Dextrothyroxi	1975
The use of penicillamine in the treatment of rheumatoid arthritis and scleroderma. Scandinavian journal of rheumatology. Supplement, 1979, Issue:28 Topics: Adult; Arthritis, Rheumatoid; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation;	1979
Long-term evaluation of penicillamine or cyclofenil in systemic sclerosis. Results from a two-year randomized study. Scandinavian journal of rheumatology, 1992, Volume: 21, Issue:5 Topics: Adult; Aged; Cyclofenil; Electrocardiography; Esophagus; Exercise; Female; Heart; Humans; Immune Sys	1992
Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial. Archives of dermatology, 1992, Volume: 128, Issue:3 Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Immunotherapy; Leukapheresis; Leukocytes; Ma	1992
A 15-year prospective study of treatment of rapidly progressive systemic sclerosis with D-penicillamine [see comment]. The Journal of rheumatology, 1991, Volume: 18, Issue:10 Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Penicillamine; Retrospective Studies; Sc	1991
D-penicillamine treatment of lung involvement in patients with systemic sclerosis (scleroderma). Arthritis and rheumatism, 1987, Volume: 30, Issue:7 Topics: Clinical Trials as Topic; Humans; Penicillamine; Pulmonary Fibrosis; Scleroderma, Systemic; Time Fac	1987
[Effectiveness of long-term use of dimethyl sulfoxide in the complex treatment of patients with systemic scleroderma]. Terapevticheskii arkhiv, 1985, Volume: 57, Issue:8 Topics: Adolescent; Adult; Clinical Trials as Topic; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; D	1985

Article	Year
Generalized scleroderma-like induration associated with D-penicillamine elastosis perforans serpiginosa in Wilson's disease. International journal of dermatology, 2023, Volume: 62, Issue:2 Topics: Hepatolenticular Degeneration; Humans; Penicillamine; Scleroderma, Localized; Scleroderma, Systemic;	2023
Limited systemic sclerosis initially presenting with mesenteric panniculitis. BMJ case reports, 2014, Oct-17, Volume: 2014 Topics: Antirheumatic Agents; Biopsy; Diagnosis, Differential; Fat Necrosis; Female; Follow-Up Studies; Huma	2014
Asymptomatic annular plaques on the neck. Cutis, 2014, Volume: 94, Issue:4 Topics: Adult; Antirheumatic Agents; Biopsy; Drug-Related Side Effects and Adverse Reactions; Female; Humans	2014
Annular keratotic papules on the extremities. Journal of the American Academy of Dermatology, 2015, Volume: 73, Issue:5 Topics: Adult; Antirheumatic Agents; Elastic Tissue; Extremities; Female; Humans; Penicillamine; Scleroderma	2015
Diagnosis and treatment of scleroderma. Acta medica Indonesiana, 2008, Volume: 40, Issue:2 Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Female; Humans; Immunosuppressive Agents; Male; Penic	2008
Ankylosing spondylitis and systemic sclerosis: a rare combination. Joint bone spine, 2009, Volume: 76, Issue:3 Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Drug Therapy, Combination; Histocompatibility	2009
[Effect of Wenyang Huazhuo Tongluo recipe contained serum on proliferation and cell cycle of systemic sclerosis skin fibroblasts]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2009, Volume: 32, Issue:6 Topics: Adult; Cell Cycle; Cell Proliferation; Cells, Cultured; Drug Combinations; Drugs, Chinese Herbal; Fe	2009
Anti-MuSK- and anti-AChR-positive myasthenia gravis induced by d-penicillamine. Journal of neuroimmunology, 2012, Sep-15, Volume: 250, Issue:1-2 Topics: Aged; Antirheumatic Agents; Autoantibodies; Autoantigens; Female; Humans; Myasthenia Gravis; Penicil	2012
Clinical trials for pediatric scleroderma. Current rheumatology reports, 2002, Volume: 4, Issue:6 Topics: Antirheumatic Agents; Child; Clinical Trials as Topic; Cyclophosphamide; Humans; Methotrexate; Penic	2002
Predictors and outcomes of scleroderma renal crisis: data from the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis and rheumatism, 2002, Volume: 46, Issue:11 Topics: Humans; Kidney Diseases; Penicillamine; Randomized Controlled Trials as Topic; Scleroderma, Systemic	2002
D-penicillamine induced polymyositis and morphea in a woman with Hashimoto thyroiditis. Journal of the European Academy of Dermatology and Venereology : JEADV, 2002, Volume: 16, Issue:5 Topics: Aged; Antirheumatic Agents; Female; Humans; Penicillamine; Polymyositis; Scleroderma, Localized; Scl	2002
Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature. The Journal of rheumatology, 2003, Volume: 30, Issue:7 Topics: Aged; Anti-Glomerular Basement Membrane Disease; Antirheumatic Agents; Fatal Outcome; Glomerulonephr	2003
Epidermolysis bullosa acquisita-like reaction associated with penicillamine therapy for sclerodermatous graft-versus-host disease. Journal of the American Academy of Dermatology, 2003, Volume: 49, Issue:6 Topics: Bone Marrow Transplantation; Cyclosporine; Epidermolysis Bullosa Acquisita; Graft vs Host Disease; H	2003
[Obliterating bronchiolitis induced by D-penicillamine in the female patient with systemic scleroderma]. Terapevticheskii arkhiv, 2004, Volume: 76, Issue:3 Topics: Adult; Beclomethasone; Bronchiolitis Obliterans; Cyclophosphamide; Female; Humans; Methylprednisolon	2004
[Minimal changes nephrotic syndrome associated to penicillamine treatment]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24, Issue:2 Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Middle	2004
Improvement of skin sclerosis after occurrence of anticentromere antibody in a patient with diffuse cutaneous systemic sclerosis. Clinical rheumatology, 2004, Volume: 23, Issue:4 Topics: Administration, Oral; Adult; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Centromer	2004
D-penicillamine-induced pemphigus vulgaris in a patient with scleroderma-rheumatoid arthritis overlap syndrome. Acta dermato-venereologica, 2004, Volume: 84, Issue:4 Topics: Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Middle Aged; Pemphigus; Penicillamine; Ris	2004
Pulmonary involvement in systemic sclerosis due to therapy and as a complication. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2005, Volume: 63, Issue:2 Topics: Antirheumatic Agents; Bronchiectasis; Bronchiolitis; Female; Follow-Up Studies; Humans; Hypertension	2005
A case of nodular scleroderma. The Journal of dermatology, 2005, Volume: 32, Issue:12 Topics: Adult; Biopsy, Needle; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Immunohistochem	2005
[Systemic sclerosis--a challenge in rheumatology]. Zeitschrift fur Rheumatologie, 2006, Volume: 65, Issue:5 Topics: Antibodies, Antinuclear; Gastrointestinal Diseases; Humans; Hypertension, Pulmonary; Immunosuppressi	2006
Collagenous colitis in a patient with systemic sclerosis: a rare entity. Journal of the National Medical Association, 2007, Volume: 99, Issue:6 Topics: Abdomen; Aged; Autoimmune Diseases; Colitis, Collagenous; Comorbidity; Diarrhea; Female; Humans; Lop	2007
Eosinophilic fasciitis (Shulman syndrome) in association with morphoea and systemic sclerosis. Acta dermato-venereologica, 1980, Volume: 60, Issue:2 Topics: Eosinophils; Fascia; Humans; Inflammation; Male; Middle Aged; Penicillamine; Scleroderma, Localized;	1980
[D-Penicillamine effect on collagen synthesis and structural maintenance Red Sirius staining with polarized-light examination. The value of this staining in cases of collagen diseases (author's transl)]. Annales de pathologie, 1982, Volume: 2, Issue:2 Topics: Adult; Collagen; Connective Tissue; Humans; Male; Microscopy, Polarization; Penicillamine; Scleroder	1982
[Cholestatic jaundice induced by D-penicillamine and oral steroid contraceptive in progressive systemic sclerosis (author's transl)]. Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1982, Volume: 42, Issue:2-3 Topics: Adult; Alanine Transaminase; Bilirubin; Chlormadinone Acetate; Cholestasis, Intrahepatic; Contracept	1982
Does long-term treatment with D-penicillamine alter calcium and phosphorus metabolism in patients with systemic sclerosis? Acta dermato-venereologica, 1983, Volume: 63, Issue:5 Topics: Adult; Aged; Calcium; Female; Humans; Male; Middle Aged; Penicillamine; Phosphorus; Scleroderma, Sys	1983
Zinc and zinc-dependent enzymes in penicillamine-treated patients with generalized scleroderma. Acta dermato-venereologica, 1984, Volume: 64, Issue:5 Topics: Adult; Aged; Alkaline Phosphatase; Carbonic Anhydrases; Erythrocytes; Female; Granulocytes; Humans;	1984
Systemic sclerosis. The Journal of the Kansas Medical Society, 1984, Volume: 85, Issue:1 Topics: Adult; Captopril; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Penicillamine; Sclerod	1984
Changes in the growth and metabolism of cells cultured from normal, sclerotic and rheumatoid connective tissue brought about by D-penicillamine and by sodium salicylate. The Journal of investigative dermatology, 1980, Volume: 74, Issue:6 Topics: Adult; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Fibroblasts; Glycosaminoglycans; Human	1980
[Collagen metabolites in the urine in patients with generalized scleroderma]. Ugeskrift for laeger, 1984, May-28, Volume: 146, Issue:22 Topics: Adult; Aged; Amino Acids; Collagen; Female; Glutamine; Humans; Male; Middle Aged; Penicillamine; Scl	1984
[Prognosis and treatment of scleroderma]. Annales de medecine interne, 1984, Volume: 135, Issue:8 Topics: Adrenal Cortex Hormones; Autoantibodies; Colchicine; Humans; Immunosuppressive Agents; Penicillamine	1984
[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis]. Arquivos de neuro-psiquiatria, 1984, Volume: 42, Issue:4 Topics: Adult; Autoimmune Diseases; Female; Humans; Myasthenia Gravis; Neuromuscular Junction; Penicillamine	1984
Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro(SSA) antibody a possible marker of penicillamine-D intolerance. Annals of the rheumatic diseases, 1984, Volume: 43, Issue:2 Topics: Adult; Aged; Antigens; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Fem	1984
[Morphology and pathogenesis of penicillamine-induced nephropathy]. Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie, 1983, Volume: 128, Issue:1-2 Topics: Adult; Alveolitis, Extrinsic Allergic; Arthritis, Rheumatoid; Biopsy; Female; Glomerulonephritis; Hu	1983
The gastrointestinal manifestations of scleroderma: pathogenesis and management. Gastroenterology, 1980, Volume: 79, Issue:1 Topics: Action Potentials; Diagnosis, Differential; Digestive System; Gastrointestinal Diseases; Gastrointes	1980
Penicillamine and progressive systemic sclerosis. Annals of internal medicine, 1983, Volume: 98, Issue:5 Pt 1 Topics: Drug Evaluation; Humans; Penicillamine; Prospective Studies; Scleroderma, Systemic	1983
D-penicillamine treatment of progressive systemic sclerosis (scleroderma): a comparison of clinical and in vitro effects. The Journal of rheumatology, 1983, Volume: 10, Issue:2 Topics: Adult; Aged; Cells, Cultured; Female; Fibroblasts; Glycosaminoglycans; Humans; In Vitro Techniques;	1983
Historical perspectives on penicillamine. Journal of the Royal College of Physicians of London, 1980, Volume: 14, Issue:2 Topics: Animals; Chelating Agents; Chemical Phenomena; Chemistry; Hepatitis; Humans; Immunity; Lathyrism; Li	1980
[D-penicillamine in the treatment of progressive systemic sclerosis]. AMB : revista da Associacao Medica Brasileira, 1980, Volume: 26, Issue:6 Topics: Adolescent; Adult; Female; Follow-Up Studies; Humans; Middle Aged; Penicillamine; Scleroderma, Syste	1980
Hidden anti-nuclear antibodies in rheumatic diseases. Clinical and experimental immunology, 1980, Volume: 39, Issue:2 Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Collagen Diseases; Fluorescent Antibody Technique; H	1980
Successful treatment of far-advanced progressive systemic sclerosis by D-penicillamine. The Journal of allergy and clinical immunology, 1982, Volume: 69, Issue:3 Topics: Adolescent; Adult; Blood Volume; Collagen; Colonic Diseases; Electrocardiography; Female; Humans; In	1982
[Experience using d-penicillamine in systemic scleroderma]. Klinicheskaia meditsina, 1982, Volume: 60, Issue:1 Topics: Adult; Biopsy; Drug Evaluation; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Syste	1982
Treatment of generalized scleroderma with inhibitors of collagen synthesis. International journal of dermatology, 1982, Volume: 21, Issue:3 Topics: Catechin; Chlorpromazine; Collagen; Dextrothyroxine; Glutamine; Humans; Hydralazine; Levodopa; Penic	1982
D-Penicillamine therapy in progressive systemic sclerosis (scleroderma): a retrospective analysis. Annals of internal medicine, 1982, Volume: 97, Issue:5 Topics: Biopsy; Contracture; Female; Humans; Male; Middle Aged; Penicillamine; Retrospective Studies; Sclero	1982
[D-penicillamine-induced lipoid nephrosis in a patient with scleroderma]. Ryumachi. [Rheumatism], 1982, Volume: 22, Issue:5 Topics: Female; Humans; Kidney; Middle Aged; Nephrosis, Lipoid; Penicillamine; Scleroderma, Systemic	1982
[Progressive systemic sclerosis with gastrointestinal manifestations]. Ugeskrift for laeger, 1982, Sep-27, Volume: 144, Issue:39 Topics: Adult; Gastrointestinal Diseases; Glutamine; Humans; Male; Penicillamine; Scleroderma, Systemic	1982
[Pregnancy and rheumatic disease (author's transl)]. Ryumachi. [Rheumatism], 1981, Volume: 21, Issue:2 Topics: Arthritis, Rheumatoid; Female; Gold; Humans; Penicillamine; Pregnancy; Pregnancy Complications; Scle	1981
[Microcirculatory disorders in systemic scleroderma treated with d-penicillamine]. Klinicheskaia meditsina, 1981, Volume: 59, Issue:11 Topics: Adult; Capillary Permeability; Female; Humans; Male; Microcirculation; Muscles; Penicillamine; Scler	1981
Penicillamine-induced myasthenia gravis in progressive systemic sclerosis. Arthritis and rheumatism, 1980, Volume: 23, Issue:4 Topics: Adult; Female; Humans; Myasthenia Gravis; Penicillamine; Scleroderma, Systemic	1980
[Nephropathy in a patient with systemic scleroderma treated with D-penicillamine]. Terapevticheskii arkhiv, 1980, Volume: 52, Issue:4 Topics: Humans; Male; Middle Aged; Nephrotic Syndrome; Penicillamine; Scleroderma, Systemic	1980
[Scleroderma in the child. Treatment with colchicine]. La Nouvelle presse medicale, 1980, Oct-18, Volume: 9, Issue:38 Topics: Child; Colchicine; Female; Humans; Penicillamine; Scleroderma, Systemic	1980
Nodular scleroderma: focally increased tenascin expression differing from that in the surrounding scleroderma skin. The Journal of dermatology, 1995, Volume: 22, Issue:4 Topics: Adult; Biopsy; Cell Adhesion Molecules, Neuronal; Diagnosis, Differential; Extracellular Matrix Prot	1995
[Multifocal idiopathic fibrosis]. Problemy tuberkuleza, 1994, Issue:5 Topics: Adult; Diagnosis, Differential; Drug Therapy, Combination; Humans; Male; Penicillamine; Prednisolone	1994
The use of serologic markers for collagen synthesis and degradation in systemic sclerosis. Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:4 Topics: Biomarkers; Blister; Collagen; Collagen Type I; Cyclophosphamide; Cyclosporine; Exudates and Transud	1995
Breast gigantism due to D-penicillamine. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 1994, Volume: 45, Issue:2 Topics: Breast Diseases; Female; Gigantism; Humans; Middle Aged; Penicillamine; Scleroderma, Systemic	1994
Unilateral ptosis as an initial manifestation of D-penicillamine induced myasthenia gravis. The Journal of rheumatology, 1993, Volume: 20, Issue:9 Topics: Adult; Arthritis, Rheumatoid; Blepharoptosis; Female; Humans; Myasthenia Gravis; Penicillamine; Scle	1993
Toward rational treatment of scleroderma. Hospital practice (Office ed.), 1993, Sep-30, Volume: 28, Issue:9A Topics: Humans; Interferon-gamma; Penicillamine; Scleroderma, Systemic	1993
Therapy for childhood rheumatic diseases. Have we been doing enough? Arthritis and rheumatism, 1993, Volume: 36, Issue:1 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Child, Pr	1993
Chromosome abnormalities in peripheral lymphocytes from patients with progressive systemic sclerosis. Rheumatology international, 1993, Volume: 12, Issue:6 Topics: Adult; Aged; Asian People; Base Sequence; Cells, Cultured; Chromosome Aberrations; Chromosome Disord	1993
Childhood-onset scleroderma: is it different from adult-onset disease. Arthritis and rheumatism, 1996, Volume: 39, Issue:6 Topics: Adolescent; Adult; Age of Onset; Anti-Inflammatory Agents; Antirheumatic Agents; Autoantibodies; Chi	1996
Cystic lung disease in systemic sclerosis: a case report with high resolution computed tomography findings. Revue du rhumatisme (English ed.), 1996, Volume: 63, Issue:3 Topics: Adult; Antirheumatic Agents; Cysts; Female; Humans; Lung Diseases; Nifedipine; Penicillamine; Pulmon	1996
Pulmonary hypertension in systemic sclerosis: an analysis of 17 patients. British journal of rheumatology, 1996, Volume: 35, Issue:10 Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Cohort Studies; Demography; Dyspnea; Female;	1996
Intestinal pseudo-obstruction as an initial presentation of systemic sclerosis in two children. British journal of rheumatology, 1997, Volume: 36, Issue:2 Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Child, Preschool; Dermatologic Agents; F	1997
Organizing diffuse alveolar damage associated with progressive systemic sclerosis. Mayo Clinic proceedings, 1997, Volume: 72, Issue:7 Topics: Aged; Antirheumatic Agents; Biopsy; Female; Humans; Middle Aged; Pancytopenia; Penicillamine; Pulmon	1997
Transient acantholytic dermatosis (Grover's disease) in a patient with progressive systemic sclerosis treated with D-penicillamine. International journal of dermatology, 1997, Volume: 36, Issue:6 Topics: Acantholysis; Antirheumatic Agents; Chelating Agents; Female; Humans; Middle Aged; Penicillamine; Sc	1997
Scleroderma, D-penicillamine treatment, and progressive renal failure associated with positive antimyeloperoxidase antineutrophil cytoplasmic antibodies. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997, Volume: 30, Issue:2 Topics: Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Female; Glomerulonephritis; Humans; Middle A	1997
[A patient with systemic scleroderma showing improvement during long-term hemodialysis after renal crisis]. Ryumachi. [Rheumatism], 1997, Volume: 37, Issue:4 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antirheumatic Agents; Humans; Kidney Diseases; Male;	1997
Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis. Arthritis and rheumatism, 1998, Volume: 41, Issue:9 Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroid	1998
Postural changes, dysphagia, and systemic sclerosis. Annals of the rheumatic diseases, 1998, Volume: 57, Issue:6 Topics: Antirheumatic Agents; Deglutition Disorders; Diagnosis, Differential; Histocompatibility Testing; Hu	1998
[A case of myasthenia gravis caused by D-penicillamine therapy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1998, Dec-10, Volume: 87, Issue:12 Topics: Adult; Antirheumatic Agents; Female; Humans; Myasthenia Gravis; Penicillamine; Plasma Exchange; Scle	1998
[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D]. Presse medicale (Paris, France : 1983), 1999, Jan-16, Volume: 28, Issue:2 Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Autoimmune Diseases; Female; Glomerulonephritis; Human	1999
[Extra-capillary glomerulonephritis induced by D-penicillamine therapy]. Presse medicale (Paris, France : 1983), 1999, Apr-03, Volume: 28, Issue:13 Topics: Glomerulonephritis; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Systemic	1999
Correlates of the disability index of the health assessment questionnaire: a measure of functional impairment in systemic sclerosis. Arthritis and rheumatism, 1999, Volume: 42, Issue:11 Topics: Adolescent; Adult; Aged; Disability Evaluation; Female; Health Surveys; Humans; Logistic Models; Mal	1999
In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine. The Journal of rheumatology, 1999, Volume: 26, Issue:11 Topics: Aged; Anemia; Antirheumatic Agents; Colony-Forming Units Assay; Female; Hematopoiesis; Humans; Penic	1999
[D-penicillamine: an outdated cure for systemic scleroderma?]. La Revue de medecine interne, 1999, Volume: 20, Issue:12 Topics: Antirheumatic Agents; Humans; Penicillamine; Prognosis; Scleroderma, Systemic; Skin Diseases; Surviv	1999
Pemphigus vulgaris induced by D-penicillamine therapy in a patient with systemic sclerosis. Journal of the American Academy of Dermatology, 2000, Volume: 42, Issue:2 Pt 1 Topics: Aged; Antirheumatic Agents; Disease Progression; Female; Humans; Pemphigus; Penicillamine; Scleroder	2000
Skin thickness score as a predictor and correlate of outcome in systemic sclerosis: high-dose versus low-dose penicillamine trial. Arthritis and rheumatism, 2000, Volume: 43, Issue:11 Topics: Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Linear Models; Lo	2000
[Two cases of successfully treated multifocal fibrosis]. Terapevticheskii arkhiv, 2002, Volume: 74, Issue:5 Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Diagnosis, Differential; Drug Therapy, Combin	2002
Letter: Marrow aplasia and penicillamine. Lancet (London, England), 1976, Sep-25, Volume: 2, Issue:7987 Topics: Anemia, Aplastic; Arthritis, Rheumatoid; Bone Marrow; Female; Humans; Middle Aged; Penicillamine; Sc	1976
Treatment of generalized scleroderma: updated results. Acta dermato-venereologica, 1979, Volume: 59, Issue:5 Topics: Chlorpromazine; Collagen; Drug Evaluation; Glutamine; Glycosaminoglycans; Humans; Hydralazine; Levod	1979
Penicillamine therapy in systemic sclerosis. Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 3 Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Systemic	1977
Treatment of scleroderma heart by D-penicillamine. British heart journal, 1976, Volume: 38, Issue:8 Topics: Adult; Cardiomegaly; Cardiomyopathies; Exercise Test; Female; Heart Failure; Humans; Penicillamine;	1976
Scleroderma in childhood. Arthritis and rheumatism, 1977, Volume: 20, Issue:2 Suppl Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Immunosuppress	1977
Connective tissue changes in systemic sclerosis and the use of D-penicillamine. Agents and actions. Supplements, 1979, Issue:5 Topics: Collagen; Connective Tissue; Humans; Penicillamine; Scleroderma, Systemic	1979
[Drug therapy of various collagen diseases based on connective tissue metabolism--with special reference to systemic scleroderma]. Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology, 1977, Volume: 87, Issue:12 Topics: Adult; Connective Tissue; Drug Evaluation; Female; Humans; Male; Middle Aged; Penicillamine; Plant E	1977
Scleroderma with massive regional lymphadenopathy. Acta paediatrica Scandinavica, 1979, Volume: 68, Issue:4 Topics: Child, Preschool; Humans; Lymphatic Diseases; Male; Penicillamine; Scleroderma, Systemic	1979
[Treatment of scleroderma and dermatomyositis in childhood]. La Clinica terapeutica, 1978, Jan-31, Volume: 84, Issue:2 Topics: Adolescent; Age Factors; Aluminum Hydroxide; Anabolic Agents; Child; Cyclophosphamide; Dermatomyosit	1978
Taste dysfunction and changes in zinc and copper metabolism during penicillamine therapy for generalized scleroderma. Acta medica Scandinavica, 1978, Volume: 204, Issue:1-2 Topics: Adult; Aged; Arthritis, Rheumatoid; Copper; Female; Humans; Male; Metabolic Diseases; Middle Aged; P	1978
Scleroderma (progressive systemic sclerosis, PSS); pathophysiological, clinical and pharmacological aspects of the syndrome. Acta medica Academiae Scientiarum Hungaricae, 1978, Volume: 35, Issue:3-4 Topics: Cyclofenil; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Systemic; Skin	1978
(D)-penicillamine treatment in systemic sclerosis (scleroderma). Effect on nutritional capillary circulation. Scandinavian journal of rheumatology, 1977, Volume: 6, Issue:2 Topics: Adult; Aged; Capillaries; Capillary Permeability; Female; Humans; Male; Middle Aged; Penicillamine;	1977
[Effect of D-penicillamine in scleroderma complicating phenylketonuria]. Ceskoslovenska pediatrie, 1976, Volume: 31, Issue:6 Topics: Child, Preschool; Humans; Male; Penicillamine; Phenylketonurias; Scleroderma, Systemic	1976
[Treatment of interstitial pulmonary fibrosis with D-penicillamine in progressive scleroderma: a long-term study (author's transl)]. Wiener klinische Wochenschrift, 1976, Apr-30, Volume: 88, Issue:9 Topics: Aged; Drug Evaluation; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Age	1976
Scleroderma in childhood. Annals of the rheumatic diseases, 1976, Volume: 35, Issue:3 Topics: Adolescent; Age Factors; Arthritis, Juvenile; Bone Diseases; Child; Chlorambucil; Diagnosis, Differe	1976
[Clinical and prognostic significance of antinuclear factors during D-penicillamine treatment (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1975, Oct-24, Volume: 100, Issue:43 Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Humans; Kidney Diseases; Male; Middle Aged; P	1975
[Biosynthesis of collagen and mode of action of D-penicillamine (author's transl)]. Wiener klinische Wochenschrift, 1975, Jan-10, Volume: 87, Issue:1 Topics: Amino Acids; Animals; Aorta; Binding Sites; Cartilage; Collagen; Connective Tissue; Hepatitis; Human	1975
Cutaneous extensibility in health and disease. Rheumatology and rehabilitation, 1975, Volume: 14, Issue:2 Topics: Acromegaly; Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Collagen; Cutis Laxa; Ehlers-Da	1975
Renal involvement in progressive systemic sclerosis. Proceedings of the Royal Society of Medicine, 1975, Volume: 68, Issue:9 Topics: Acute Kidney Injury; Adult; Blood Pressure; Female; Humans; Penicillamine; Peritoneal Dialysis; Scle	1975
[Treatment of generalized scleroderma with connective tissue inhibitors]. Ugeskrift for laeger, 1976, May-24, Volume: 138, Issue:22 Topics: Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydral	1976
[Proteinuria in immunopathological diseases during long-term penicillamine therapy (author's transl)]. Casopis lekaru ceskych, 1976, May-07, Volume: 115, Issue:18 Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Penicillamine; Proteinuria; Scleroderma, Systemi	1976
Nodular scleroderma in systemic sclerosis under D-penicillamine therapy. The Journal of dermatology, 1992, Volume: 19, Issue:12 Topics: Adult; Female; Humans; Penicillamine; Scleroderma, Systemic; Skin	1992
Photochemotherapy in systemic sclerosis. The stage is set. Archives of dermatology, 1992, Volume: 128, Issue:3 Topics: Humans; Leukocytes; Methoxsalen; Penicillamine; Photochemotherapy; Scleroderma, Systemic; Ultraviole	1992
Serum levels of aminoterminal type III procollagen peptide and hyaluronan predict mortality in systemic sclerosis. Scandinavian journal of rheumatology, 1992, Volume: 21, Issue:1 Topics: Cyclofenil; Female; Humans; Hyaluronic Acid; Male; Penicillamine; Peptide Fragments; Procollagen; Pr	1992
[Therapeutic possibilities in systemic scleroderma]. Zeitschrift fur arztliche Fortbildung, 1992, Mar-10, Volume: 86, Issue:5 Topics: Antibodies, Antinuclear; Autoantibodies; Azathioprine; Combined Modality Therapy; Dose-Response Rela	1992
Progressive systemic sclerosis complicated with immune thrombocytopenia during D-penicillamine therapy. Internal medicine (Tokyo, Japan), 1992, Volume: 31, Issue:2 Topics: Blood Platelets; Female; Humans; Immunoglobulin G; Middle Aged; Penicillamine; Scleroderma, Systemic	1992
Why everything (or nothing) seems to work in the treatment of scleroderma. The Journal of rheumatology, 1992, Volume: 19, Issue:5 Topics: Humans; Penicillamine; Scleroderma, Systemic	1992
Vesicular lesions in a woman with progressive systemic sclerosis. Penicillamine-induced intradermal vesicles: an example of human lathyrism. Archives of dermatology, 1992, Volume: 128, Issue:7 Topics: Female; Humans; Lathyrism; Middle Aged; Penicillamine; Scleroderma, Systemic; Skin; Skin Diseases, V	1992
Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. The Journal of dermatology, 1992, Volume: 19, Issue:5 Topics: Female; Humans; Middle Aged; Penicillamine; Prednisolone; Recurrence; Scleroderma, Localized; Sclero	1992
Spontaneous and clastogen induced chromosomal breakage in scleroderma. The Journal of rheumatology, 1991, Volume: 18, Issue:6 Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Bleomycin; Cells, Cultured; Chromosome Aberrations; Chromosom	1991
D-penicillamine treatment in systemic sclerosis. The Journal of rheumatology, 1991, Volume: 18, Issue:10 Topics: Humans; Penicillamine; Scleroderma, Systemic	1991
Immunological alterations during photopheresis and D-penicillamine treatment of systemic sclerosis. Annals of the New York Academy of Sciences, 1991, Dec-30, Volume: 636 Topics: Female; Humans; Leukapheresis; Male; Penicillamine; PUVA Therapy; Scleroderma, Systemic; T-Lymphocyt	1991
Polymyositis due to D-penicillamine in a patient with systemic sclerosis. Clinical and experimental dermatology, 1991, Volume: 16, Issue:1 Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic	1991
Penicillamine in systemic sclerosis: a reappraisal. Clinical rheumatology, 1990, Volume: 9, Issue:4 Topics: Adult; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Localized; Scleroderma, System	1990
[Fever caused by penicillin. Description of a clinical case]. La Clinica terapeutica, 1990, Feb-15, Volume: 132, Issue:3 Topics: Female; Fever; Humans; Middle Aged; Penicillamine; Scleroderma, Systemic	1990
Lupus erythematosus-like eruption due to D-penicillamine in progressive systemic sclerosis. International journal of dermatology, 1990, Volume: 29, Issue:8 Topics: Drug Eruptions; Female; Humans; Lupus Erythematosus, Cutaneous; Middle Aged; Penicillamine; Sclerode	1990
The progress of oesophageal involvement in progressive systemic sclerosis during D-penicillamine treatment. Scandinavian journal of rheumatology, 1989, Volume: 18, Issue:3 Topics: Esophagitis; Esophagus; Female; Gastroesophageal Reflux; Humans; Male; Penicillamine; Peristalsis; P	1989
[Analysis of the distribution of class I HLA-antigens in patients with systemic scleroderma with regard to features of the clinical course of the disease and therapy with D-penicillamine]. Genetika, 1989, Volume: 25, Issue:6 Topics: Adolescent; Adult; Aged; Female; Gene Frequency; HLA-A Antigens; HLA-B Antigens; HLA-C Antigens; Hum	1989
The toxicity of D-penicillamine in systemic sclerosis. Annals of internal medicine, 1986, Volume: 104, Issue:5 Topics: Arthritis, Rheumatoid; Digestive System Diseases; Dose-Response Relationship, Drug; Drug Eruptions;	1986
[Effect of penicillin and D-penicillamine on beta-galactosidase activity in patients with progressive scleroderma]. Dermatologische Monatschrift, 1988, Volume: 174, Issue:11 Topics: beta-Galactosidase; Dose-Response Relationship, Drug; Galactosidases; Humans; Liver; Penicillamine;	1988
[Epidemiological study of systemic scleroderma in Tokyo based on application forms for financial aid for patients with intractable diseases]. Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology, 1988, Volume: 98, Issue:14 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Female; Humans; Male; Middle Aged; Penicillamine;	1988
Systemic sclerosis secondary to occupational exposure. The American journal of medicine, 1988, Volume: 85, Issue:1 Topics: Adult; Chemical Industry; Humans; Male; Middle Aged; Occupational Diseases; Penicillamine; Phenylene	1988
D-penicillamine induced crescentic glomerulonephritis: report and review of the literature. The Journal of rheumatology, 1987, Volume: 14, Issue:5 Topics: Biopsy; Female; Glomerulonephritis; Hemoptysis; Humans; Kidney Glomerulus; Microscopy, Electron; Mid	1987
Phenotype of peripheral blood lymphocytes in patients with progressive systemic sclerosis: activated T lymphocytes and the effect of D-penicillamine therapy. Clinical and experimental immunology, 1987, Volume: 69, Issue:2 Topics: Adult; Antibodies, Monoclonal; Antigens, Surface; Arthritis, Rheumatoid; Female; Humans; Lymphocyte	1987
[Pulmonary involvement in progressive systemic sclerosis]. Revista medica de Chile, 1986, Volume: 114, Issue:10 Topics: Humans; Hypertension, Pulmonary; Lung Diseases; Nifedipine; Penicillamine; Pulmonary Fibrosis; Scler	1986
Bioavailability of D-penicillamine in relation to gastrointestinal involvement of generalized scleroderma. Scandinavian journal of rheumatology, 1987, Volume: 16, Issue:2 Topics: Administration, Oral; Adult; Aged; Biological Availability; Capsules; Esophageal Diseases; Female; G	1987
[Cholestatic hepatitis: a rare complication of the treatment with D. penicillamine]. Annales de dermatologie et de venereologie, 1987, Volume: 114, Issue:3 Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Penicillam	1987
D-penicillamine therapy and interstitial lung disease in scleroderma. A long-term followup study. Arthritis and rheumatism, 1987, Volume: 30, Issue:6 Topics: Carbon Monoxide; Diffusion; Follow-Up Studies; Humans; Lung; Penicillamine; Pulmonary Fibrosis; Resp	1987
Scleroderma. Journal of the American Academy of Dermatology, 1987, Volume: 17, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Drug Therapy, Combination; Female; Glutamine; Hum	1987
[Penicillamine in the treatment of patients with systemic scleroderma]. Vrachebnoe delo, 1987, Issue:5 Topics: Adult; Ceruloplasmin; Copper; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Systemi	1987
[Treatment of systemic scleroderma with D-penicillamine. Results in 14 patients treated for more than a year]. Revue du rhumatisme et des maladies osteo-articulaires, 1986, Volume: 53, Issue:1 Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Syste	1986
[Long-term use of D-penicillamine in systemic scleroderma and rheumatoid arthritis]. Klinicheskaia meditsina, 1986, Volume: 64, Issue:6 Topics: Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Female; Humans; Male; Middle Ag	1986
Penicillamine-induced rapidly progressive glomerulonephritis in patients with progressive systemic sclerosis: successful treatment of two patients and a review of the literature. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1986, Volume: 8, Issue:3 Topics: Adolescent; Adult; Biopsy; Female; Glomerulonephritis; Humans; Kidney Glomerulus; Lupus Erythematosu	1986
Systemic sclerosis-like lesions during long-term penicillamine therapy for Wilson's disease. The British journal of dermatology, 1987, Volume: 116, Issue:1 Topics: Adolescent; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Scleroderma, Systemic	1987
Bioavailability of D-penicillamine in a patient with gastrointestinal progressive systemic sclerosis. Scandinavian journal of rheumatology, 1986, Volume: 15, Issue:1 Topics: Administration, Oral; Adult; Biological Availability; Enema; Fats; Feces; Gastrointestinal Diseases;	1986
Penicillamine-induced polymyositis. Scandinavian journal of rheumatology, 1985, Volume: 14, Issue:1 Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic	1985
The effect of D-penicillamine on pulmonary findings in systemic sclerosis. Arthritis and rheumatism, 1985, Volume: 28, Issue:8 Topics: Colchicine; Female; Humans; Lung; Male; Penicillamine; Pulmonary Diffusing Capacity; Regression Anal	1985
Pregnancy and progressive systemic sclerosis. Case report and review of the literature. Cleveland Clinic quarterly, 1985,Summer, Volume: 52, Issue:2 Topics: Adult; Blood Pressure; Colchicine; Female; Humans; Penicillamine; Prednisone; Pregnancy; Pregnancy C	1985
[Progressive systemic sclerosis with pancytopenia, polymyositis and complete heart block developing after D-penicillamine therapy: a case report]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1985, Volume: 74, Issue:7 Topics: Aged; Female; Heart Block; Humans; Myositis; Pancytopenia; Penicillamine; Scleroderma, Systemic	1985
Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. The Journal of rheumatology, 1985, Volume: 12, Issue:5 Topics: Aged; Breast; Danazol; Female; Humans; Hyperprolactinemia; Penicillamine; Scleroderma, Systemic	1985
[Treatment of generalized (progressive) scleroderma]. Deutsche medizinische Wochenschrift (1946), 1972, Dec-01, Volume: 97, Issue:48 Topics: Ammotherapy; Female; Glucocorticoids; Heparinoids; Humans; Hyaluronoglucosaminidase; Male; Ointments	1972
Biosynthesis and maturation of skin collagen in scleroderma, and effect of D-penicillamine. Lancet (London, England), 1974, Feb-09, Volume: 1, Issue:7850 Topics: Adolescent; Adult; Age Factors; Aged; Amino Acids; Animals; Biopsy; Collagen; Culture Techniques; Fe	1974
[Rheumatic and pararheumatic diseases. Problems of diagnosis and therapy]. Fortschritte der Medizin, 1973, Jul-19, Volume: 91, Issue:20 Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Collagen Diseases; Dermatomyositis; Humans; Lupus Eryt	1973
Effect of penicillamine on human collagen and its possible application to treatment of scleroderma. Lancet (London, England), 1966, Nov-05, Volume: 2, Issue:7471 Topics: Adult; Aged; Arthritis, Rheumatoid; Collagen; Cystinuria; Female; Hepatolenticular Degeneration; Hum	1966
Decreased taste sensitivity after D-penicillamine reversed by copper administration. Lancet (London, England), 1967, Dec-16, Volume: 2, Issue:7529 Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Ceruloplasmin; Child; Copper; Cystinuria; Female; He	1967
Nephropathy induced by D-penicillamine. Annals of internal medicine, 1968, Volume: 69, Issue:3 Topics: Adult; Arthritis, Rheumatoid; Complement System Proteins; Female; Fluorescent Antibody Technique; ga	1968
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma). Seminars in arthritis and rheumatism, 1973, Volume: 2, Issue:4 Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kyn	1973
Proceedings: Biosynthesis and maturation of skin collagen in scleroderma. Annals of the rheumatic diseases, 1974, Volume: 33, Issue:4 Topics: Biopsy; Collagen; Humans; Penicillamine; Protein Binding; Scleroderma, Systemic; Skin	1974
The actionof D-penicillamine on collagen in scleroderma and osteoarthrosis. Postgraduate medical journal, 1974, Volume: 50 Suppl 2 Topics: Arthritis, Rheumatoid; Collagen; Humans; In Vitro Techniques; Osteoarthritis; Penicillamine; Sclerod	1974
Two years of penicillamine for progressive systemic sclerosis: a case report. Postgraduate medical journal, 1974, Volume: 50 Suppl 2 Topics: Adolescent; Biopsy; Child; Female; Humans; Penicillamine; Scleroderma, Systemic	1974
Penicillamine for systemic sclerosis? Drug and therapeutics bulletin, 1974, Sep-13, Volume: 12, Issue:19 Topics: Humans; Penicillamine; Scleroderma, Systemic	1974
D-penicillamine in progressive scleroderma. Scandinavian journal of rheumatology, 1972, Volume: 1, Issue:3 Topics: Adult; Aged; Biopsy; Blood Proteins; Blood Sedimentation; Collagen; Female; Hemoglobins; Humans; Hyd	1972
Treatment of progressive systemic sclerosis (PSS) with penicillamine. Preliminary report of two cases. Acta medica Scandinavica, 1973, Volume: 193, Issue:5 Topics: Adult; Collagen; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Middle Aged; P	1973
Progressive systemic sclerosis (scleroderma). JAMA, 1973, Apr-30, Volume: 224, Issue:5 Suppl Topics: Adult; Aged; Calcinosis; Esophageal Diseases; Female; Heart Diseases; Humans; Intestinal Diseases; J	1973
[Investigations on the mode of action of D-penicillamine (Metalcaptase) in sclerodermia]. Munchener medizinische Wochenschrift (1950), 1973, Aug-03, Volume: 115, Issue:31 Topics: Adult; Birefringence; Child; Female; Humans; Male; Microscopy, Electron; Microscopy, Polarization; M	1973
Serial changes in scleroderma and idiopathic interstitial lung disease. Archives of internal medicine, 1973, Volume: 132, Issue:4 Topics: Adult; Aged; Arteries; Carbon Monoxide; Cyclophosphamide; Female; Humans; Lung Compliance; Male; Mer	1973
[Therapeutic effect of d-penicillamine in scleroderma]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1973, Aug-20, Volume: 28, Issue:34 Topics: Adolescent; Adult; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Humans; Male; Middle	1973
[Treatment of "collagen and autoimmune" diseases (author's transl)]. Wiener klinische Wochenschrift, 1973, Nov-23, Volume: 85, Issue:47 Topics: Adolescent; Adult; Aminobenzoates; Azathioprine; Chloroquine; Cyclophosphamide; Dermatomyositis; Dex	1973
[Penicillamine in the treatment of scleroderma]. Ceskoslovenska dermatologie, 1973, Volume: 48, Issue:6 Topics: Adult; Drug Evaluation; Female; Humans; Male; Middle Aged; Penicillamine; Proteinuria; Scleroderma,	1973
[Ultrastructural comparative study of the behavior of collagen tissue and elastic tissue during 3 pathological states (Marfans disease, scleroderma due to vitamin K-1 lathyrogenic effect of penicillamine)]. Annales de dermatologie et de syphiligraphie, 1973, Volume: 100, Issue:5-6 Topics: Collagen; Collagen Diseases; Connective Tissue; Culture Techniques; Elastic Tissue; Elastin; Fibrobl	1973
Monoclonal gammopathy penicillamine-induced polymyositis and systemic sclerosis. Archives of dermatology, 1974, Volume: 110, Issue:2 Topics: Aged; Biopsy; Humans; Hypergammaglobulinemia; Japan; Male; Myositis; Penicillamine; Prednisolone; Sc	1974
Progressive systemic sclerosis. Diagnosis at the age of 4 years. American journal of diseases of children (1960), 1972, Volume: 123, Issue:1 Topics: Alopecia; Biopsy; Child, Preschool; Ectropion; Female; Foot Deformities, Acquired; Hand Deformities,	1972
[Recent attempts at treatment of diffuse scleroderma]. Casopis lekaru ceskych, 1972, Volume: 111, Issue:10 Topics: Female; Humans; Male; Penicillamine; Scleroderma, Systemic	1972
[Allergic-toxic liver damage due to D-penicillamine]. Schweizerische medizinische Wochenschrift, 1972, Aug-26, Volume: 102, Issue:34 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver Functio	1972
[Studies on the solubility of skin collagen in scleroderma and the effect of D-penicillamine]. Archiv fur dermatologische Forschung, 1972, Volume: 243, Issue:4 Topics: Adult; Aged; Biopsy; Collagen; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Locali	1972
[Marked proteinuria in the course of penicillamine treatment of progressive systemic sclerosis]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1971, Nov-15, Volume: 26, Issue:46 Topics: Humans; Middle Aged; Penicillamine; Proteinuria; Scleroderma, Systemic	1971
Penicillamine for scleroderma. Archives of dermatology, 1968, Volume: 98, Issue:1 Topics: Animals; Drug Hypersensitivity; Feeding and Eating Disorders; Humans; Joint Diseases; Leukopenia; Pe	1968
[Treatment of progressive scleroderma with D-penicillamine (Metalcaptase)]. Munchener medizinische Wochenschrift (1950), 1969, Aug-01, Volume: 111, Issue:31 Topics: Adult; Collagen; Copper; Elasticity; Female; Humans; Middle Aged; Penicillamine; Scleroderma, System	1969
Treatment of systemic sclerosis with D-penicillamine. A new method of observing the effects of treatment. Annals of the rheumatic diseases, 1970, Volume: 29, Issue:2 Topics: Adult; Aged; Elasticity; Female; Humans; Male; Middle Aged; Penicillamine; Proteinuria; Scleroderma,	1970
Skin collagen in patients with scleroderma: biosynthesis and maturation in vitro, and the effect of D-penicillamine. Annals of clinical research, 1970, Volume: 2, Issue:3 Topics: Adult; Aged; Biopsy; Carbon Isotopes; Collagen; Female; Humans; Hydroxyproline; In Vitro Techniques;	1970
Management of scleroderma. Mayo Clinic proceedings, 1971, Volume: 46, Issue:2 Topics: Aminobenzoates; Aminocaproates; Anti-Inflammatory Agents; Dimethyl Sulfoxide; Environment; Hormones;	1971
Nephrotic syndrome induced by penicillamine. Canadian Medical Association journal, 1968, Mar-09, Volume: 98, Issue:10 Topics: Arthritis, Rheumatoid; Female; Humans; Middle Aged; Nephrotic Syndrome; Penicillamine; Scleroderma,	1968
Loss of taste during therapy with penicillamine. JAMA, 1968, Feb-05, Volume: 203, Issue:6 Topics: Adolescent; Adult; Cystinuria; Female; Food; Humans; Hydrochloric Acid; Male; Middle Aged; Penicilla	1968
[Collagen diseases. On clinical aspects and theapy of disseminated lupus erythematosus, progressive scleroderma and dermatomyositis]. Hippokrates, 1969, Aug-31, Volume: 40, Issue:16 Topics: Collagen Diseases; Dermatomyositis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic;	1969

penicillamine and Sclerosis, Systemic

Research Excerpts

Research

Studies (237)

Authors

Clinical Trials (4)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Gigante, A	1
Leodori, G	1
Pellicano, C	1
Villa, A	1
Rosato, E	1
Atzori, L	1
Ferreli, C	1
Agosta, D	1
Mou, M	1
Coni, P	1
Lachowicz, JI	1
Pilloni, L	1
Arroyo-Ávila, M	1
Vilá, LM	1
Chabra, IS	1
Grandinetti, LM	1
Bennett, JA	1
Clarke, JT	1
Ioffreda, MD	1
Adnan, ZA	1
Ouédraogo, DD	1
Palazzo, E	1
Nlomé-Nzé, M	1
Somogyi-Demerjian, N	1
Meyer, O	2
Amjadi, S	1
Maranian, P	1
Furst, DE	9
Clements, PJ	10
Wong, WK	7
Postlethwaite, AE	1
Khanna, PP	1
Khanna, D	1
Bian, H	1
Fan, YS	1
Lou, LH	1
Mao, BY	1
Shi, JY	1
Poulas, K	1
Koutsouraki, E	1
Kordas, G	1
Kokla, A	1
Tzartos, SJ	1
Quéméneur, T	1
Mouthon, L	3
Cacoub, P	1
Michon-Pasturel, U	1
Vanhille, P	2
Hatron, PY	1
Guillevin, L	2
Hachulla, E	1
Rosenkranz, ME	1
Lehman, TJ	1
Strand, V	1
DeMarco, PJ	1
Weisman, MH	2
Seibold, JR	6
Hurwitz, EL	4
Mayes, M	6
White, B	6
Wigley, F	6
Barr, W	6
Moreland, L	5
Medsger, TA	18
Steen, V	6
Martin, RW	5
Collier, D	6
Weinstein, A	6
Lally, E	6
Varga, J	8
Weiner, SR	4
Andrews, B	6
Abeles, M	6
Dourmishev, LA	1
Stomonjakova, SR	1
Dourmishev, AL	1
Derk, CT	1
Jimenez, SA	5
Jinnin, M	1
Ihn, H	2
Asano, Y	1
Yamane, K	3
Yazawa, N	1
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Skálová, A	1
Mayes, MD	1
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Rothfield, NF	1
Csuka, ME	1
Weisman, MD	1
Alekperov, RT	1
Avdeev, SN	1
Kotovskaia, MA	1
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García-Martín, F	1
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Miyamura, T	1
Idutsu, K	1
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Müller-Ladner, U	1
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Pieraggi, MT	1
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Weismann, K	2
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Jepsen, LV	1
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Priollet, P	1
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Priestley, GC	1
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Asboe-Hansen, G	8
Crickx, B	1
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Scaff, M	1
Cossermelli, W	1
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Giotaki, H	1
Maddison, PJ	1
Mavridis, AC	1
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Kang, B	1
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Heredia, R	1
Cha, E	1
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Krel', AA	1
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Alekberova, ZS	1
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Jegasothy, BV	2
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Lindberg, KA	3
Bailey, AJ	3
Scheiffarth, F	1
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Sjoerdsma, A	2
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Keiser, HR	2
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Scheinberg, IH	1
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