penicillamine has been researched along with Scleroderma, Localized in 47 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 56-year-old woman with generalized morphea was treated with penicillamine." | 5.26 | Pemphigus in a patient treated with penicillamine for generalized morphea. ( Davies, MG; Holt, P, 1976) |
| "The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma." | 2.82 | Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy. ( Gigante, A; Leodori, G; Pellicano, C; Rosato, E; Villa, A, 2022) |
| "Although the aetiology of systemic sclerosis is unknown, its prevalence has been reported to be increased in workers exposed to silica." | 2.39 | [Systemic sclerosis]. ( Gustafsson, R, 1994) |
| "None of the patients with morphea had a history of thyroid pathology and the thyroid screenings were within normal limits." | 2.38 | [Scleroderma and thyroid diseases]. ( Claudy, A; Mourier-Clavreul, MC; Rousset, H, 1989) |
| "Primary biliary cirrhosis is a disease of the small bile ducts with altered immunologic responsiveness often associated with various collagen diseases." | 2.36 | Primary biliary cirrhosis as a collagen disease. ( Schaffner, F, 1979) |
| "Generalised morphea (GM) is a subtype of localised scleroderma that usually manifests with bilateral involvement." | 1.56 | Unilateral generalized morphea: First case report in Taiwan. ( Hsu, T; Lee, LW; Lu, MC; Shyur, SD, 2020) |
| "Localized scleroderma is a chronic inflammatory condition confined to the skin." | 1.39 | Localized scleroderma: a clinical study at a single center in Korea. ( Kim, J; Kim, JW; Noh, JW, 2013) |
| "Localized disease manifests as patches (morphea) or bandlike (linear scleroderma) areas of skin thickening." | 1.35 | Diagnosis and treatment of scleroderma. ( Adnan, ZA, 2008) |
| "Congenital localized scleroderma is a rare and probably underestimated condition in neonates." | 1.33 | Congenital localized scleroderma. ( Da Dalt, L; de Oliveira, SK; Eichenfield, LF; Galea, P; Mazur-Zielinska, H; Punaro, MG; Ros, J; Vallongo, C; Zulian, F, 2006) |
| "All children who were referred for fasciitis were included in the study." | 1.28 | The fasciitis-morphea complex in children. ( Miller, JJ, 1992) |
| "A 45-year-old woman had recurrent morphea lesions over 10 times in 6 years." | 1.28 | Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. ( Mizutani, H; Mizutani, T; Okada, H; Shimizu, M; Tanaka, H, 1992) |
| "In all patients with diffuse systemic sclerosis there was objective improvement." | 1.28 | Penicillamine in systemic sclerosis: a reappraisal. ( Guindi, RT; Sattar, MA; Sugathan, TN, 1990) |
| "There is no accepted or proven treatment for localized scleroderma." | 1.28 | D-penicillamine in the treatment of localized scleroderma. ( Falanga, V; Medsger, TA, 1990) |
| "A 56-year-old woman with generalized morphea was treated with penicillamine." | 1.26 | Pemphigus in a patient treated with penicillamine for generalized morphea. ( Davies, MG; Holt, P, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (51.06) | 18.7374 |
| 1990's | 13 (27.66) | 18.2507 |
| 2000's | 6 (12.77) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 3 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Gigante, A | 1 |
| Leodori, G | 1 |
| Pellicano, C | 1 |
| Villa, A | 1 |
| Rosato, E | 1 |
| Atzori, L | 1 |
| Ferreli, C | 1 |
| Agosta, D | 1 |
| Mou, M | 1 |
| Coni, P | 1 |
| Lachowicz, JI | 1 |
| Pilloni, L | 1 |
| Lu, MC | 1 |
| Shyur, SD | 2 |
| Lee, LW | 1 |
| Hsu, T | 1 |
| Noh, JW | 1 |
| Kim, J | 1 |
| Kim, JW | 1 |
| Adnan, ZA | 1 |
| Cox, D | 1 |
| O' Regan, G | 1 |
| Collins, S | 1 |
| Byrne, A | 1 |
| Irvine, A | 1 |
| Watson, R | 1 |
| Dourmishev, LA | 1 |
| Stomonjakova, SR | 1 |
| Dourmishev, AL | 1 |
| Melani, L | 1 |
| Caproni, M | 1 |
| Cardinali, C | 1 |
| Antiga, E | 1 |
| Bernacchi, E | 1 |
| Schincaglia, E | 1 |
| Fabbri, P | 1 |
| Zulian, F | 1 |
| Vallongo, C | 1 |
| de Oliveira, SK | 1 |
| Punaro, MG | 1 |
| Ros, J | 1 |
| Mazur-Zielinska, H | 1 |
| Galea, P | 1 |
| Da Dalt, L | 1 |
| Eichenfield, LF | 1 |
| Coyle, HE | 1 |
| Chapman, RS | 1 |
| Bernstein, RM | 1 |
| Hall, MA | 1 |
| Gostelow, BE | 1 |
| Crickx, B | 1 |
| Belaich, S | 1 |
| Kesler, RW | 1 |
| McDonald, TD | 1 |
| Balasubramaniam, M | 1 |
| Saulsbury, FT | 1 |
| Chan, WC | 1 |
| Sy, LB | 1 |
| Lin, YN | 1 |
| Gustafsson, R | 1 |
| Kaur, S | 1 |
| Dhar, S | 1 |
| Kanwar, AJ | 1 |
| Farrington, ML | 1 |
| Haas, JE | 1 |
| Nazar-Stewart, V | 1 |
| Mellins, ED | 1 |
| Kato, Y | 1 |
| Naito, Y | 1 |
| Narita, Y | 1 |
| Kuzuhara, S | 1 |
| McGovern, TW | 1 |
| Bennion, SD | 1 |
| van Bergen, BH | 1 |
| van Dooren-Greebe, RJ | 1 |
| Fiselier, TJ | 1 |
| Koopman, RJ | 1 |
| Varga, J | 1 |
| Ponor, I | 1 |
| Tchebiner, JZ | 1 |
| Davies, MG | 1 |
| Holt, P | 1 |
| Kornreich, HK | 1 |
| King, KK | 1 |
| Bernstein, BH | 1 |
| Singsen, BH | 1 |
| Hanson, V | 1 |
| Schaffner, F | 1 |
| Ansell, BM | 2 |
| Davis, P | 1 |
| Bleehen, SS | 1 |
| Nasseh, GA | 1 |
| Bywaters, EG | 1 |
| Korting, GW | 1 |
| Miller, JJ | 1 |
| Mizutani, H | 1 |
| Tanaka, H | 1 |
| Okada, H | 1 |
| Mizutani, T | 1 |
| Shimizu, M | 1 |
| Sattar, MA | 1 |
| Guindi, RT | 1 |
| Sugathan, TN | 1 |
| Goldenstein-Schainberg, C | 1 |
| Pereira, RM | 1 |
| Gusukuma, MC | 1 |
| Messina, WC | 1 |
| Cossermelli, W | 1 |
| Falanga, V | 1 |
| Medsger, TA | 1 |
| Liddle, BJ | 1 |
| Mourier-Clavreul, MC | 1 |
| Rousset, H | 1 |
| Claudy, A | 1 |
| Woo, TY | 1 |
| Rasmussen, JE | 1 |
| Asboe-Hansen, G | 1 |
| Curley, RK | 1 |
| Macfarlane, AW | 1 |
| Evans, S | 1 |
| Woodrow, JC | 1 |
| Moynahan, EJ | 3 |
| Herbert, CM | 1 |
| Lindberg, KA | 1 |
| Jayson, MI | 1 |
| Bailey, AJ | 1 |
| Elmes, ME | 1 |
| Daróczy, J | 1 |
| Gyöngyvér, S | 1 |
| Kerl, H | 1 |
| Klein, G | 1 |
| Sandhofer, M | 1 |
| Zimmermann, BK | 1 |
| Balda, BR | 1 |
6 reviews available for penicillamine and Scleroderma, Localized
| Article | Year |
|---|---|
Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.
Topics: Acute Kidney Injury; Antibodies, Antineutrophil Cytoplasmic; Humans; Kidney; Penicillamine; Peroxida | 2022 |
[Systemic sclerosis].
Topics: Adjuvants, Immunologic; Adult; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Locali | 1994 |
Clinical trials for the treatment of systemic sclerosis/scleroderma.
Topics: Antirheumatic Agents; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Male; Penicillamin | 1999 |
Primary biliary cirrhosis as a collagen disease.
Topics: Adrenal Cortex Hormones; Antibodies; Antigen-Antibody Complex; Aspirin; Collagen Diseases; Complemen | 1979 |
D-penicillamine in the treatment of rheumatoid arthritis and progressive systemic sclerosis.
Topics: Animals; Arthritis, Rheumatoid; Chelating Agents; Collagen; Copper; Humans; Leukopenia; Nephrotic Sy | 1976 |
[Scleroderma and thyroid diseases].
Topics: Aged; Confidence Intervals; Female; Humans; Incidence; Male; Middle Aged; Penicillamine; Prospective | 1989 |
41 other studies available for penicillamine and Scleroderma, Localized
| Article | Year |
|---|---|
Generalized scleroderma-like induration associated with D-penicillamine elastosis perforans serpiginosa in Wilson's disease.
Topics: Hepatolenticular Degeneration; Humans; Penicillamine; Scleroderma, Localized; Scleroderma, Systemic; | 2023 |
Unilateral generalized morphea: First case report in Taiwan.
Topics: Administration, Oral; Administration, Topical; Child; Emollients; Female; Humans; Hyperpigmentation; | 2020 |
Localized scleroderma: a clinical study at a single center in Korea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antimalarials; Child; Colchicine; Female; Humans; Male; | 2013 |
Diagnosis and treatment of scleroderma.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Female; Humans; Immunosuppressive Agents; Male; Penic | 2008 |
Juvenile localised scleroderma: a retrospective review of response to systemic treatment.
Topics: Adolescent; Adolescent Medicine; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antirheumatic Ag | 2008 |
D-penicillamine induced polymyositis and morphea in a woman with Hashimoto thyroiditis.
Topics: Aged; Antirheumatic Agents; Female; Humans; Penicillamine; Polymyositis; Scleroderma, Localized; Scl | 2002 |
A case of nodular scleroderma.
Topics: Adult; Biopsy, Needle; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Immunohistochem | 2005 |
Congenital localized scleroderma.
Topics: Atrophy; Biopsy; Chelating Agents; Child, Preschool; Female; Follow-Up Studies; Humans; Immunosuppre | 2006 |
Eosinophilic fasciitis (Shulman syndrome) in association with morphoea and systemic sclerosis.
Topics: Eosinophils; Fascia; Humans; Inflammation; Male; Middle Aged; Penicillamine; Scleroderma, Localized; | 1980 |
Morphea-like reaction to D-penicillamine therapy.
Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Penicillamine; Scleroderma, Localized; | 1981 |
[Prognosis and treatment of scleroderma].
Topics: Adrenal Cortex Hormones; Autoantibodies; Colchicine; Humans; Immunosuppressive Agents; Penicillamine | 1984 |
Linear scleroderma in children.
Topics: Child; Female; Humans; Male; Penicillamine; Scleroderma, Localized | 1981 |
Juvenile scleroderma: report of a case.
Topics: Child; Drug Therapy, Combination; Humans; Male; Penicillamine; Prednisolone; Scleroderma, Localized; | 1995 |
Treatment of childhood linear morphea with D-penicillamine.
Topics: Child; Female; Humans; Penicillamine; Scleroderma, Localized; Treatment Failure | 1993 |
Eosinophilic fasciitis in children frequently progresses to scleroderma-like cutaneous fibrosis.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Eosinophilia; Fasciitis; Female; Fibrosis; Humans; Male | 1993 |
D-penicillamine-induced myasthenia gravis in a case of eosinophilic fasciitis.
Topics: Eosinophilia; Fasciitis; Female; Humans; Middle Aged; Myasthenia Gravis; Penicillamine; Scleroderma, | 1997 |
Diffuse blisters and erosions in a patient with limited scleroderma. Penicillamine-induced pemphigus foliaceus (PIPF).
Topics: Aged; Blister; Drug Eruptions; Female; Humans; Pemphigus; Penicillamine; Scleroderma, Localized | 1997 |
[D-penicillamine in treatment of scleroderma "en coup de sabre"].
Topics: Adolescent; Antirheumatic Agents; Follow-Up Studies; Forehead; Humans; Male; Penicillamine; Sclerode | 1997 |
Breast enlargement induced by D-penicillamine.
Topics: Breast; Chelating Agents; Female; Humans; Middle Aged; Penicillamine; Scleroderma, Localized | 2002 |
Pemphigus in a patient treated with penicillamine for generalized morphea.
Topics: Drug Eruptions; Female; Humans; Middle Aged; Pemphigus; Penicillamine; Scleroderma, Localized | 1976 |
Scleroderma in childhood.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Immunosuppress | 1977 |
[Treatment of scleroderma and dermatomyositis in childhood].
Topics: Adolescent; Age Factors; Aluminum Hydroxide; Anabolic Agents; Child; Cyclophosphamide; Dermatomyosit | 1978 |
Scleroderma in childhood.
Topics: Adolescent; Age Factors; Arthritis, Juvenile; Bone Diseases; Child; Chlorambucil; Diagnosis, Differe | 1976 |
[Letter: Therapy of generalized circumscribed scleroderma].
Topics: Humans; Penicillamine; Progestins; Scleroderma, Localized | 1975 |
The fasciitis-morphea complex in children.
Topics: Adolescent; Antibodies, Antinuclear; Biopsy; Blood Sedimentation; Child; Child, Preschool; Eosinophi | 1992 |
Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis.
Topics: Female; Humans; Middle Aged; Penicillamine; Prednisolone; Recurrence; Scleroderma, Localized; Sclero | 1992 |
Penicillamine in systemic sclerosis: a reappraisal.
Topics: Adult; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Localized; Scleroderma, System | 1990 |
Childhood linear scleroderma "en coup de sabre" with uveitis.
Topics: Autoantibodies; Azathioprine; Child; Diagnosis, Differential; Facial Hemiatrophy; Humans; Male; Peni | 1990 |
D-penicillamine in the treatment of localized scleroderma.
Topics: Dose-Response Relationship, Drug; Female; Humans; Male; Nephrotic Syndrome; Penicillamine; Proteinur | 1990 |
Development of morphoea in rheumatoid arthritis treated with penicillamine.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Penicillamine; Scleroderma, Localized | 1989 |
Disorders of transepidermal elimination. Part 1.
Topics: Adolescent; Adult; Aged; Cartilage Diseases; Child; Child, Preschool; Collagen Diseases; Down Syndro | 1985 |
Scleroderma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Drug Therapy, Combination; Female; Glutamine; Hum | 1987 |
The treatment of linear morphoea with D-penicillamine.
Topics: Adolescent; Adult; Female; Humans; Male; Penicillamine; Scleroderma, Localized | 1987 |
D(-)penicillamine in morphoea (localised scleroderma).
Topics: Arthritis, Rheumatoid; Humans; Penicillamine; Scleroderma, Localized | 1973 |
Biosynthesis and maturation of skin collagen in scleroderma, and effect of D-penicillamine.
Topics: Adolescent; Adult; Age Factors; Aged; Amino Acids; Animals; Biopsy; Collagen; Culture Techniques; Fe | 1974 |
Letter: Anti-inflammatory drugs and tissue copper.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Copper; Humans; Liver Cirrhosis; Penicillamine; Pro | 1974 |
Penicillamine in the treatment of morphoea and keloid in children.
Topics: Child; Female; Humans; Keloid; Male; Penicillamine; Scleroderma, Localized | 1974 |
[Investigations on the mode of action of D-penicillamine (Metalcaptase) in sclerodermia].
Topics: Adult; Birefringence; Child; Female; Humans; Male; Microscopy, Electron; Microscopy, Polarization; M | 1973 |
[Treatment of "collagen and autoimmune" diseases (author's transl)].
Topics: Adolescent; Adult; Aminobenzoates; Azathioprine; Chloroquine; Cyclophosphamide; Dermatomyositis; Dex | 1973 |
Morphoea (localized cutaneous scleroderma) treated with low-dosage penicillamine (4 cases, including coup de sabre).
Topics: Child; Child, Preschool; Collagen; Female; Humans; Male; Penicillamine; Pyridoxine; Scleroderma, Loc | 1973 |
[Studies on the solubility of skin collagen in scleroderma and the effect of D-penicillamine].
Topics: Adult; Aged; Biopsy; Collagen; Female; Humans; Male; Middle Aged; Penicillamine; Scleroderma, Locali | 1972 |