Page last updated: 2024-11-07

penicillamine and Scleroderma, Diffuse

penicillamine has been researched along with Scleroderma, Diffuse in 8 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Scleroderma, Diffuse: A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.

Research Excerpts

ExcerptRelevanceReference
"Eighty-four patients with diffuse cutaneous systemic sclerosis who had received D-penicillamine within 24 months of clinically detectable onset of skin sclerosis were randomly selected from the systemic sclerosis cohort followed at the Scleroderma Center of Thomas Jefferson University."7.74A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset. ( Derk, CT; Huaman, G; Jimenez, SA, 2008)
"In patients presenting with early diffuse scleroderma prognosis is variable."3.81The health assessment questionnaire (HAQ) is strongly predictive of good outcome in early diffuse scleroderma: results from an analysis of two randomized controlled trials in early diffuse scleroderma. ( Clements, PJ; Pope, JE; Sultan, N, 2004)
"Eighty-four patients with diffuse cutaneous systemic sclerosis who had received D-penicillamine within 24 months of clinically detectable onset of skin sclerosis were randomly selected from the systemic sclerosis cohort followed at the Scleroderma Center of Thomas Jefferson University."3.74A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset. ( Derk, CT; Huaman, G; Jimenez, SA, 2008)
"Stiff skin syndrome is a sclerodermalike disorder that presents in infancy or early childhood with rock-hard skin, limited joint mobility, and mild hypertrichosis in the absence of visceral or muscle involvement, immunologic abnormalities, or vascular hyperreactivity."2.44The stiff skin syndrome: case series, differential diagnosis of the stiff skin phenotype, and review of the literature. ( Connolly, MK; Frieden, IJ; Gilliam, AE; Liu, T; McCalmont, TH; Williams, ML, 2008)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (75.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, T1
McCalmont, TH1
Frieden, IJ1
Williams, ML1
Connolly, MK1
Gilliam, AE1
Tseng, CH1
Wong, WK3
Le, EN1
Wigley, FM1
Shah, AA1
Boin, F1
Hummers, LK1
Sultan, N1
Pope, JE1
Clements, PJ3
Santiago, M1
de Castro, DO1
Costa, CA1
Passos, ES1
Paixão, A1
Khanna, D1
Furst, DE2
Hays, RD1
Park, GS1
Seibold, JR1
Mayes, MD1
White, B1
Wigley, FF1
Weisman, M1
Barr, W1
Moreland, L1
Medsger, TA1
Steen, VD1
Martin, RW1
Collier, D1
Weinstein, A1
Lally, EV1
Varga, J1
Weiner, SR1
Andrews, B1
Abeles, M1
Streisand, JB1
Derk, CT1
Huaman, G1
Jimenez, SA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Physical Rehabilitation in Women With Scleroderma: Effects on Pulmonary Function, Lung Ultrasound, Muscle Function, Hand Functional, Functional Capacity, and Quality of Life[NCT05041868]104 participants (Anticipated)Interventional2021-10-15Recruiting
A Phase II, Double-blind, Randomized, Placebo-controlled Study to Investigate Pharmacokinetics (PK), Safety and Efficacy of Intravenous Factor XIII Treatment in Patients With Systemic Sclerosis[NCT02551042]Phase 226 participants (Anticipated)Interventional2015-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for penicillamine and Scleroderma, Diffuse

ArticleYear
The stiff skin syndrome: case series, differential diagnosis of the stiff skin phenotype, and review of the literature.
    Archives of dermatology, 2008, Volume: 144, Issue:10

    Topics: Age Distribution; Biopsy, Needle; Child; Child, Preschool; Disease Progression; Fascia; Female; Huma

2008
Long-term experience of mycophenolate mofetil for treatment of diffuse cutaneous systemic sclerosis.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:6

    Topics: Adult; Collagen Type I; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Male; Middl

2011
The health assessment questionnaire (HAQ) is strongly predictive of good outcome in early diffuse scleroderma: results from an analysis of two randomized controlled trials in early diffuse scleroderma.
    Rheumatology (Oxford, England), 2004, Volume: 43, Issue:4

    Topics: Dermatologic Agents; Disability Evaluation; Female; Health Status Indicators; Humans; Immunosuppress

2004

Trials

2 trials available for penicillamine and Scleroderma, Diffuse

ArticleYear
The health assessment questionnaire (HAQ) is strongly predictive of good outcome in early diffuse scleroderma: results from an analysis of two randomized controlled trials in early diffuse scleroderma.
    Rheumatology (Oxford, England), 2004, Volume: 43, Issue:4

    Topics: Dermatologic Agents; Disability Evaluation; Female; Health Status Indicators; Humans; Immunosuppress

2004
Minimally important difference in diffuse systemic sclerosis: results from the D-penicillamine study.
    Annals of the rheumatic diseases, 2006, Volume: 65, Issue:10

    Topics: Adult; Antirheumatic Agents; Disability Evaluation; Dose-Response Relationship, Drug; Female; Follow

2006

Other Studies

4 other studies available for penicillamine and Scleroderma, Diffuse

ArticleYear
Analysis of a composite endpoint with longitudinal and time-to-event data.
    Statistics in medicine, 2011, Apr-30, Volume: 30, Issue:9

    Topics: Computer Simulation; Data Interpretation, Statistical; Humans; Longitudinal Studies; Penicillamine;

2011
Keloidal scleroderma.
    Clinical rheumatology, 2004, Volume: 23, Issue:1

    Topics: Adult; Antirheumatic Agents; Azathioprine; Female; Humans; Keloid; Penicillamine; Scleroderma, Diffu

2004
Assessing disease progression using a composite endpoint.
    Statistical methods in medical research, 2007, Volume: 16, Issue:1

    Topics: Antirheumatic Agents; Data Interpretation, Statistical; Disease Progression; Endpoint Determination;

2007
A retrospective randomly selected cohort study of D-penicillamine treatment in rapidly progressive diffuse cutaneous systemic sclerosis of recent onset.
    The British journal of dermatology, 2008, Volume: 158, Issue:5

    Topics: Antirheumatic Agents; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle

2008