penicillamine has been researched along with Schizophrenia in 21 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melanosis observed in association with prolonged chlorpromazine therapy has become a serious problem in mental institutions." | 7.64 | THERAPY OF CHLORPROMAZINE MELANOSIS: A PRELIMINARY REPORT. ( BAKER, RA; GREINER, AC; NICOLSON, GA, 1964) |
| "In primary biliary cirrhosis there are increased skin pigmentation, hepatic fibrosis, elevated cholesterol and alkaline phosphatase levels, defective T lymphocytes and hyperactive B lymphocytes." | 5.26 | The pineal and regulation of fibrosis: pinealectomy as a model of primary biliary cirrhosis: roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes. ( Cunnane, SC; Horrobin, DF; Manku, MS, 1979) |
| "Melanosis observed in association with prolonged chlorpromazine therapy has become a serious problem in mental institutions." | 3.64 | THERAPY OF CHLORPROMAZINE MELANOSIS: A PRELIMINARY REPORT. ( BAKER, RA; GREINER, AC; NICOLSON, GA, 1964) |
| "The pseudosclerotic type of Wilson's disease, also known as the Westphal-Strümpell form, is distinguished by positional tremor, ataxia and dysarthria as the main symptoms." | 1.30 | [Schizophrenia-like symptoms in the Westphal-Strümpell variation of Wilson disease]. ( Landgraf, F; Müller, J; Trabert, W, 1998) |
| "In primary biliary cirrhosis there are increased skin pigmentation, hepatic fibrosis, elevated cholesterol and alkaline phosphatase levels, defective T lymphocytes and hyperactive B lymphocytes." | 1.26 | The pineal and regulation of fibrosis: pinealectomy as a model of primary biliary cirrhosis: roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes. ( Cunnane, SC; Horrobin, DF; Manku, MS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| WALSHE, JM | 1 |
| GREINER, AC | 4 |
| NICOLSON, GA | 3 |
| BAKER, RA | 2 |
| Hoffer, A | 1 |
| Osmond, H | 1 |
| Srinivas, K | 1 |
| Sinha, S | 1 |
| Taly, AB | 1 |
| Prashanth, LK | 1 |
| Arunodaya, GR | 1 |
| Janardhana Reddy, YC | 1 |
| Khanna, S | 1 |
| Helmchen, H | 1 |
| Hippius, H | 1 |
| Hoffmann, I | 1 |
| Selbach, H | 1 |
| Bowman, MB | 1 |
| Lewis, MS | 1 |
| Vitorovic, S | 1 |
| Lieina, M | 1 |
| Müller, J | 1 |
| Landgraf, F | 1 |
| Trabert, W | 1 |
| Cunnane, SC | 1 |
| Manku, MS | 1 |
| Horrobin, DF | 1 |
| McFarlane, WJ | 1 |
| Vaĭnshteĭn, IA | 2 |
| Brooker, BK | 1 |
| Papeschi, R | 1 |
| Murray, L | 1 |
| Affleck, JW | 1 |
| Cooper, AJ | 1 |
| Forrest, AD | 1 |
| Smythies, JR | 1 |
| Zealley, AK | 1 |
| Mattke, DJ | 1 |
| Adler, M | 1 |
| Mathalone, MB | 1 |
| Grener, AC | 1 |
| Gibbard, BA | 1 |
| Lehmann, HE | 1 |
| Hollister, LE | 1 |
| Moore, FF | 1 |
| Forrest, F | 1 |
| Bennett, JL | 1 |
4 trials available for penicillamine and Schizophrenia
| Article | Year |
|---|---|
Effect of penicillamine on schizophrenic patients.
Topics: Adult; Clinical Trials as Topic; Copper; Diet Therapy; Humans; Male; Melanosis; Penicillamine; Place | 1966 |
Negative results of a trial of penicillamine in chronic schizophrenia.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Humans; Male; Middle Aged; Penicillamine; Placebos | 1968 |
Penicillamine and schizophrenia--a clinical trial.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Middle | 1969 |
Mode of action of D-penicillamine in chronic schizophrenia.
Topics: Adult; Catecholamines; Chronic Disease; Clinical Trials as Topic; Dopamine; Electrophoresis; Female; | 1971 |
17 other studies available for penicillamine and Schizophrenia
| Article | Year |
|---|---|
ENDOGENOUS COPPER CLEARANCE IN WILSON'S DISEASE: A STUDY OF THE MODE OF ACTION OF PENICILLAMINE.
Topics: Adolescent; Blood; Body Fluids; Ceruloplasmin; Child; Copper; Hepatolenticular Degeneration; Humans; | 1964 |
THERAPY OF CHLORPROMAZINE MELANOSIS: A PRELIMINARY REPORT.
Topics: Body Fluids; Chlorpromazine; Copper; Darkness; Drug Therapy; Eye Diseases; Histocytochemistry; Hospi | 1964 |
TREATMENT OF SCHIZOPHRENIA WITH NICOTINIC ACID. A TEN YEAR FOLLOW-UP.
Topics: Adolescent; Biomedical Research; Drug Therapy; Electroconvulsive Therapy; Follow-Up Studies; Hospita | 1964 |
Dominant psychiatric manifestations in Wilson's disease: a diagnostic and therapeutic challenge!
Topics: Adolescent; Adult; Chelating Agents; Cohort Studies; Copper; Depressive Disorder; Female; Follow-Up | 2008 |
[D-penicillamine in schizophrenia--treatment].
Topics: Adult; Female; Humans; Male; Penicillamine; Schizophrenia | 1967 |
The copper hypothesis of schizophrenia: a review.
Topics: Ceruloplasmin; Copper; Dopamine; Hepatolenticular Degeneration; Humans; Melanins; Penicillamine; Sch | 1982 |
Wilson's disease and mental disturbances.
Topics: Adult; Copper; Diagnosis, Differential; Female; Hepatolenticular Degeneration; Humans; Male; Neuroco | 1996 |
[Schizophrenia-like symptoms in the Westphal-Strümpell variation of Wilson disease].
Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Biperiden | 1998 |
The pineal and regulation of fibrosis: pinealectomy as a model of primary biliary cirrhosis: roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes.
Topics: Animals; Colchicine; Glucocorticoids; Humans; Liver Cirrhosis, Biliary; Melatonin; Models, Biologica | 1979 |
Schizophrenia-melanosis: cause or side-effect?
Topics: Adult; Copper; Diet Therapy; Female; Humans; Male; Melanins; Melanosis; Mononuclear Phagocyte System | 1965 |
[Copper and glutathione metabolism in chronic schizophrenic patients and changes under the influence of complex-formers].
Topics: Ceruloplasmin; Chelating Agents; Chronic Disease; Copper; Glutathione; Humans; Penicillamine; Schizo | 1973 |
[Unithiol and D-penicillamine as psychic energizers and corrective agents in treatment with neuroleptics].
Topics: Adult; Antidepressive Agents; Chelating Agents; Female; Humans; Penicillamine; Schizophrenia; Sulfhy | 1972 |
Schizophrenia and the pineal gland.
Topics: Adult; Chlorpromazine; Copper; Eye Manifestations; Female; Glucagon; Humans; Male; Melanosis; Middle | 1970 |
Ocular effects of phenothiazine derivatives and reversibility.
Topics: Accommodation, Ocular; Animals; Cats; Chlorpromazine; Cornea; Eye Diseases; Female; Fundus Oculi; Hu | 1968 |
Schizophrenia melanosis. Iatrogenic--congenital defect?
Topics: Animals; Anura; Copper; Diet; Female; Humans; Male; Melanins; Melanosis; Melatonin; Models, Biologic | 1968 |
Therapy of Phenothiazine-produced skin pigmentation: a preliminary report.
Topics: Ascorbic Acid; Chlorpromazine; Female; Humans; Penicillamine; Pigmentation Disorders; Schizophrenia | 1966 |
Antipyridoxine effect of D-penicillamine in schizophrenic men.
Topics: Adult; Ceruloplasmin; Copper; Fluorometry; Humans; Male; Middle Aged; Penicillamine; Pyridoxine; Sch | 1966 |