penicillamine has been researched along with Rheumatoid Nodule in 11 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The sera of 40 patients with severe progressive rheumatoid arthritis were examined for the presence of soluble immune complexes before penicillamine therapy was started, and again after treatment for a mean period of 14-4 months." | 7.65 | Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis. ( Ansell, BM; Barraclough, D; Holborow, EJ; Mohammed, I, 1975) |
| "Accelerated nodulosis is a recognized complication of methotrexate (MTX) therapy in rheumatoid arthritis (RA)." | 3.70 | Successful treatment of methotrexate induced nodulosis with D-penicillamine. ( Dash, S; Seibold, JR; Tiku, ML, 1999) |
| "The sera of 40 patients with severe progressive rheumatoid arthritis were examined for the presence of soluble immune complexes before penicillamine therapy was started, and again after treatment for a mean period of 14-4 months." | 3.65 | Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis. ( Ansell, BM; Barraclough, D; Holborow, EJ; Mohammed, I, 1975) |
| "Rheumatoid nodules have been associated with a poor long-term prognosis." | 1.28 | Rheumatoid nodules do not predict response to treatment with slow-acting anti-rheumatic drugs. ( Hall, GM; Huskisson, EC; Scott, DL; Studnicke, A, 1991) |
| "While rheumatoid arthritis is characteristically an indolent disease, failure to recognize its urgent complications can cause significant morbidity and mortality." | 1.27 | Emergencies in rheumatoid arthritis. ( Weiner, SR, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, AJ | 1 |
| Wooley, P | 1 |
| Panayi, GS | 1 |
| Batchelor, JR | 1 |
| Weiner, SR | 1 |
| Gaskin, G | 1 |
| Thompson, EM | 1 |
| Pusey, CD | 1 |
| Dash, S | 1 |
| Seibold, JR | 1 |
| Tiku, ML | 1 |
| Mohammed, I | 1 |
| Barraclough, D | 1 |
| Holborow, EJ | 1 |
| Ansell, BM | 1 |
| Hall, GM | 1 |
| Studnicke, A | 1 |
| Huskisson, EC | 3 |
| Scott, DL | 1 |
| McCarty, DJ | 1 |
| Yousem, SA | 1 |
| Colby, TV | 1 |
| Carrington, CB | 1 |
| Gibson, TJ | 2 |
| Balme, HW | 2 |
| Berry, H | 2 |
| Burry, HC | 2 |
| Grahame, R | 2 |
| Hart, FD | 2 |
| Henderson, DR | 2 |
| Wojtulewski, JA | 2 |
2 trials available for penicillamine and Rheumatoid Nodule
| Article | Year |
|---|---|
Trial comparing D-penicillamine and gold in rheumatoid arthritis. Preliminary report.
Topics: Agglutination Tests; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Feeding a | 1974 |
Proceedings: Penicillamine or gold for rheumatoid arthritis? Multicentre trial using 'blind' observers. The first six months.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Female; Gold; Humans; Male; Pa | 1974 |
9 other studies available for penicillamine and Rheumatoid Nodule
| Article | Year |
|---|---|
HLA DR antigens and disease expression in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Histocompatibility Antigens Class II; HLA-DR | 1984 |
Emergencies in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Carpal Tunnel Syndrome; Cerv | 1984 |
Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Antibodies, Antineutrophil Cytoplasmic; Antirheuma | 1995 |
Successful treatment of methotrexate induced nodulosis with D-penicillamine.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Penici | 1999 |
Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Antinuclear; Antigen-Antibody Complex; Arthritis, Rheumatoid; Blood Sedimen | 1975 |
Rheumatoid nodules do not predict response to treatment with slow-acting anti-rheumatic drugs.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Forecasting; Humans; Male; | 1991 |
Complete reversal of rheumatoid nodulosis.
Topics: Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Middle Aged; Penicillamine; Pyridoxine; R | 1991 |
HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research.
Topics: Aged; Arthritis, Rheumatoid; Female; Gold; HLA-D Antigens; HLA-DR Antigens; HLA-DR1 Antigen; HLA-DR4 | 1986 |
Lung biopsy in rheumatoid arthritis.
Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; Female; Gold; Humans; Lung; Lung Diseases; M | 1985 |