penicillamine has been researched along with Pregnancy in 150 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism." | 7.74 | Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease. ( Berkowitz, D; Curiel, B; Hanukoglu, A; Levine, A; Lorberboym, M; Sack, J, 2008) |
| "A case of successful pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate is presented." | 7.69 | Pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate. A case report and review of the literature. ( Hartard, C; Kunze, K, 1994) |
| "The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate." | 7.67 | D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984) |
| " A regimen of d-penicillamine was started at this time and continued, although irregularly for the 10 months prior to her 9th week of pregnancy." | 7.67 | Pregnancy and penicillamine treatment in a patient with Wilson's disease. ( Komatsu, K; Morimoto, I; Ninomiya, H; Satho, M, 1986) |
| "The action of D-penicillamine on collagen can cause undesired side-effects in the treatment of cystinuria and Wilson's disease, it is on the other hand essential to the therapy of rheumatoid arthritis and scleroderma." | 7.66 | D-penicillamine in pregnancy--to ban or not to ban? ( Endres, W, 1981) |
| "The mother we present is a Wilson's disease patient who had been compliant with D-penicillamine for the preceding 13 years." | 5.32 | Transient fetal myelosuppressive effect of D-penicillamine when used in pregnancy. ( Akisu, M; Aydogdu, S; Kultursay, N; Ozgenc, F; Yagci, RV; Yalaz, M, 2003) |
| "In this report, we describe a case of Wilson's disease with pancytopenia and liver cirrhosis for over 4 years, without any specific treatment." | 5.28 | Successful pregnancy after D-penicillamine therapy in a patient with Wilson's disease. ( Chu, NS; Huang, CC; Huang, HY; Soong, YK, 1991) |
| "After reviewing the history of the discovery of the action of D-penicillamine in rheumatoid arthritis, the authors define the practical modalities for the management of treatment based on their own experience and on the data from the literature." | 4.77 | [Penicillamine in 1985]. ( Camus, JP; Koeger, AC; Laveant, C; Leca, AP, 1986) |
| " D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced." | 4.77 | Antirheumatic medication in pregnancy. ( Brooks, PM; Needs, CJ, 1985) |
| " The first pregnant woman had a 16-year history of WD, stopped taking penicillamine 1 year before pregnancy." | 4.31 | Wilson disease in pregnancy: A case series. ( Chen, Q; Wei, H; Xiong, X; Zhao, Z; Zhou, X; Zhu, Y, 2023) |
| "She was at 38 weeks and 4 days of gestation with a 15-year history of WD, controlled with penicillamine in the past and replaced by zinc preparations from three months before pregnancy." | 3.88 | Anesthetic management of cesarean delivery for a parturient with Wilson's disease: A case report. ( Jiang, X; Lin, X; Wan, Y, 2018) |
| "Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism." | 3.74 | Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease. ( Berkowitz, D; Curiel, B; Hanukoglu, A; Levine, A; Lorberboym, M; Sack, J, 2008) |
| "We report a chromosomally normal infant boy with congenital diffuse cutis laxa, severe micrognathia, contractures of all limbs, and central nervous system abnormalities including agenesis of the corpus callosum, born to a woman taking D-penicillamine (DP) for Wilson disease (WD) throughout her pregnancy." | 3.72 | Infant with severe penicillamine embryopathy born to a woman with Wilson disease. ( Hogge, WA; McPherson, E; Pinter, R, 2004) |
| "A case of successful pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate is presented." | 3.69 | Pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate. A case report and review of the literature. ( Hartard, C; Kunze, K, 1994) |
| "The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate." | 3.67 | D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984) |
| " A regimen of d-penicillamine was started at this time and continued, although irregularly for the 10 months prior to her 9th week of pregnancy." | 3.67 | Pregnancy and penicillamine treatment in a patient with Wilson's disease. ( Komatsu, K; Morimoto, I; Ninomiya, H; Satho, M, 1986) |
| "D-penicillamine, added to a low copper diet fed through pregnancy or given by gavage to pregnant rts which were on a copper-deficient or a normal diet produced fetal resorptions and malformations." | 3.66 | Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat. ( Hess, RA; Kilburn, KH, 1982) |
| "46 pregnancies in patients with cystinuria treated with a high fluid intake alone or in combination with D-penicillamine resulted in 41 normal births." | 3.66 | Pregnancy and cystinuria. ( Gregory, MC; Mansell, MA, 1983) |
| "The action of D-penicillamine on collagen can cause undesired side-effects in the treatment of cystinuria and Wilson's disease, it is on the other hand essential to the therapy of rheumatoid arthritis and scleroderma." | 3.66 | D-penicillamine in pregnancy--to ban or not to ban? ( Endres, W, 1981) |
| " During treatment with the basic drugs: gold, D-penicillamine and chloroquine, pregnancy should be avoided." | 3.65 | [Problems of rheumatic therapy in pregnancy (author's transl)]. ( Bischof, P, 1976) |
| "The treatment of Wilson's disease has changed considerably in recent times, from the use of penicillamine (Cuprimine, Merck) for all stages and types of disease, to the use of three other anticopper drugs at appropriate times for appropriate patients." | 2.43 | Novel therapeutic approaches to the treatment of Wilson's disease. ( Brewer, GJ, 2006) |
| "Wilson's disease is an inherited copper toxicosis caused by defective putative copper transporting ATPase in the liver." | 2.42 | [Wilson's disease and its pharmacological treatment]. ( Hayashi, H; Suzuki, R; Wakusawa, S, 2004) |
| "Wilson's disease is an inherited disorder of copper accumulation." | 2.39 | Practical recommendations and new therapies for Wilson's disease. ( Brewer, GJ, 1995) |
| "Certain features of Wilson's disease (WD) in Asia have been found to be different from those in other continents." | 2.38 | Geographic variations in Wilson's disease. ( Chu, NS; Hung, TP, 1993) |
| "If untreated, Wilson's disease is fatal." | 2.38 | Wilson's disease. ( Colón, VF; Woods, SE, 1989) |
| "This article presents a case report of Wilson's disease in pregnancy and a review of this entity during gestation." | 2.36 | Hepatolenticular degeneration (Wilson's disease) and pregnancy. A review and report of a case. ( Peyser, MR; Streifler, M; Toaff, ME; Toaff, R, 1977) |
| "Red cell aplasia developed in a case of Wilson's disease following an increase in D-penicillamine dosage after 14 years' treatment." | 2.35 | Red cell aplasia following prolonged D-penicillamine therapy. ( Gollan, JL; Hoffbrand, AV; Hussein, S; Sherlock, S, 1976) |
| "Spontaneous abortion was observed in 8 (30." | 1.72 | Pregnancy Outcomes in Wilson's Disease Women: Single-Center Case Series. ( Abreu, ES; Cançado, GGL; Couto, CA; Faria, LC; Ferrari, TCA; Mussi, MCL; Nardelli, MJ; Osório, FMF; Santos, BC, 2022) |
| "The mother we present is a Wilson's disease patient who had been compliant with D-penicillamine for the preceding 13 years." | 1.32 | Transient fetal myelosuppressive effect of D-penicillamine when used in pregnancy. ( Akisu, M; Aydogdu, S; Kultursay, N; Ozgenc, F; Yagci, RV; Yalaz, M, 2003) |
| "Wilson's disease is an autosomal recessive disorder of copper metabolism characterized mainly by liver cirrhosis and neurological disorders." | 1.31 | Wilson's disease in pregnancy: five successful consecutive pregnancies of the same woman. ( Bashiri, A; Erez, O; Furman, B; Holcberg, G; Mazor, M; Wiznitzer, A, 2001) |
| "Patients with Wilson's disease contemplating pregnancy should have their hepatic function and copper status assessed." | 1.29 | Wilson's disease in pregnancy. ( Goulding, P; Hawthorne, B; Maresh, M; Nunns, D, 1995) |
| "Wilson's Disease is an inherited disorder of copper metabolism." | 1.29 | [Wilson's disease: a review apropos of a clinical experience in 16 patients]. ( Alarcón, T; Brinck, P; González, M; Miranda, M; Roessler, JL; Troncoso Sch, M; Villagra, R, 1995) |
| "A patient with untreated Wilson's disease showed the possibility of fetal liver damage and copper accumulation in the placenta by this disease." | 1.29 | Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease. ( Anai, T; Inoue, I; Matsui, N; Miyakawa, I; Oga, M; Yoshimatsu, J, 1993) |
| "Adenosine diphosphate was used as the aggregating agent." | 1.28 | Nitric oxide and prostacyclin inhibit fetal platelet aggregation: a response similar to that observed in adults. ( Chaudhuri, G; Ignarro, LJ; Runge, A; Varela, AF, 1992) |
| "In this report, we describe a case of Wilson's disease with pancytopenia and liver cirrhosis for over 4 years, without any specific treatment." | 1.28 | Successful pregnancy after D-penicillamine therapy in a patient with Wilson's disease. ( Chu, NS; Huang, CC; Huang, HY; Soong, YK, 1991) |
| "She was diagnosed as having Wilson's disease at 12 years of age, at which time she started taking D-penicillamine." | 1.28 | Fulminant hepatic failure during perinatal period in a pregnant woman with Wilson's disease. ( Ikematsu, H; Inaba, S; Ishibashi, H; Kudo, J; Maeda, K; Niho, Y; Shimono, N; Shirahama, M; Yamasaki, K, 1991) |
| "Pregnancy in patients with Wilson's disease can be successfully managed." | 1.27 | Successful pregnancy in Wilson's disease: a case report and review of the literature. ( Biller, J; Brazis, PW; Swiontoniowski, M, 1985) |
| "Untreated Wilson's disease usually causes infertility or abortion, as a result of increased intrauterine copper level." | 1.27 | [Teratogenic risk during treatment of Wilson disease]. ( Mathieu, M; Piussan, C, 1985) |
| "The effect of pregnancy has been studied in 10 mothers with Wilson's disease." | 1.26 | Pregnancy in Wilson's disease. ( Walshe, JM, 1977) |
| "Twenty patients with Wilson's disease in whom severe penicillamine intolerance developed have been managed with the orally active chelating agent trientine dihydrochloride (trien)." | 1.26 | Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride. ( Walshe, JM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 94 (62.67) | 18.7374 |
| 1990's | 22 (14.67) | 18.2507 |
| 2000's | 25 (16.67) | 29.6817 |
| 2010's | 5 (3.33) | 24.3611 |
| 2020's | 4 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Xiong, X | 1 |
| Wei, H | 1 |
| Zhu, Y | 1 |
| Zhou, X | 1 |
| Zhao, Z | 1 |
| Chen, Q | 1 |
| Li, S | 1 |
| Bai, Y | 1 |
| Meng, J | 1 |
| Wang, Q | 1 |
| Tian, X | 1 |
| Li, M | 1 |
| Zeng, X | 1 |
| Zhao, J | 1 |
| Hu, C | 1 |
| Roseira, J | 1 |
| Lopes, R | 1 |
| Silva, MJ | 1 |
| Vieira, AM | 1 |
| Sampaio, M | 1 |
| Calinas, F | 1 |
| Mussi, MCL | 1 |
| Nardelli, MJ | 1 |
| Santos, BC | 1 |
| Abreu, ES | 1 |
| Osório, FMF | 1 |
| Cançado, GGL | 1 |
| Ferrari, TCA | 1 |
| Faria, LC | 1 |
| Couto, CA | 1 |
| Wan, Y | 1 |
| Jiang, X | 1 |
| Lin, X | 1 |
| Mordaunt, CE | 1 |
| Shibata, NM | 2 |
| Kieffer, DA | 2 |
| Czlonkowska, A | 1 |
| Litwin, T | 1 |
| Weiss, KH | 1 |
| Gotthardt, DN | 1 |
| Olson, K | 2 |
| Wei, D | 1 |
| Cooper, S | 1 |
| Wan, YY | 1 |
| Ali, MR | 1 |
| LaSalle, JM | 2 |
| Medici, V | 2 |
| Dathe, K | 1 |
| Beck, E | 1 |
| Schaefer, C | 1 |
| Chima, H | 1 |
| Kim, K | 1 |
| Canovas, A | 1 |
| Medrano, JF | 1 |
| Islas-Trejo, AD | 1 |
| Kharbanda, KK | 1 |
| Su, RJ | 1 |
| Islam, MS | 1 |
| Syed, R | 1 |
| Keen, CL | 7 |
| Miller, AY | 1 |
| Rutledge, JC | 1 |
| Halsted, CH | 1 |
| Khan, FA | 1 |
| Chenier, TS | 1 |
| Murrant, CL | 1 |
| Foster, RA | 1 |
| Hewson, J | 1 |
| Scholtz, EL | 1 |
| Hanukoglu, A | 1 |
| Curiel, B | 1 |
| Berkowitz, D | 1 |
| Levine, A | 1 |
| Sack, J | 1 |
| Lorberboym, M | 1 |
| Rush, T | 1 |
| Hjelmhaug, J | 1 |
| Lobner, D | 1 |
| Carey, JC | 1 |
| Martinez, L | 1 |
| Balken, E | 1 |
| Leen-Mitchell, M | 1 |
| Robertson, J | 1 |
| Linke, A | 1 |
| Li, W | 1 |
| Huang, H | 1 |
| Wang, Z | 1 |
| Hintze, TH | 1 |
| Konduri, GG | 1 |
| Mattei, J | 1 |
| Ryselis, S | 1 |
| Abdrachmanovas, O | 1 |
| Vitkuviene, B | 1 |
| Naginiene, R | 1 |
| Pérez-Aguilar, F | 1 |
| Galli, C | 1 |
| Vassiliev, I | 1 |
| Lagutina, I | 1 |
| Galli, A | 2 |
| Lazzari, G | 1 |
| Yalaz, M | 1 |
| Aydogdu, S | 1 |
| Ozgenc, F | 1 |
| Akisu, M | 1 |
| Kultursay, N | 1 |
| Yagci, RV | 1 |
| Pinter, R | 1 |
| Hogge, WA | 1 |
| McPherson, E | 1 |
| Hayashi, H | 1 |
| Suzuki, R | 1 |
| Wakusawa, S | 1 |
| Brewer, GJ | 4 |
| Llansola, M | 1 |
| Erceg, S | 1 |
| Monfort, P | 1 |
| Montoliu, C | 1 |
| Felipo, V | 1 |
| Lakshminrusimha, S | 1 |
| Wiseman, D | 1 |
| Black, SM | 1 |
| Russell, JA | 1 |
| Gugino, SF | 1 |
| Oishi, P | 1 |
| Steinhorn, RH | 1 |
| Fineman, JR | 1 |
| Conde, PA | 1 |
| Herrera, C | 1 |
| Trasorras, VL | 1 |
| Giuliano, SM | 1 |
| Director, A | 1 |
| Miragaya, MH | 1 |
| Chaves, MG | 1 |
| Sarchi, MI | 1 |
| Stivale, D | 1 |
| Quintans, C | 1 |
| Agüero, A | 1 |
| Rutter, B | 1 |
| Pasqualini, S | 1 |
| Nakamura, K | 1 |
| Saeki, S | 1 |
| Walshe, JM | 3 |
| Kilburn, KH | 1 |
| Hess, RA | 1 |
| Harpey, JP | 1 |
| Jaudon, MC | 1 |
| Clavel, JP | 1 |
| Darbois, Y | 1 |
| Gregory, MC | 1 |
| Mansell, MA | 1 |
| McKercher, HG | 2 |
| Derewlany, LO | 2 |
| Radde, IC | 2 |
| Myint, B | 1 |
| Lönnerdal, B | 4 |
| Hurley, LS | 5 |
| Mark-Savage, P | 3 |
| Cohen, NL | 1 |
| Kean, WF | 1 |
| Bellamy, N | 1 |
| Lock, CJ | 1 |
| Adachi, J | 1 |
| Lien, DC | 1 |
| Todoruk, DN | 1 |
| Rajani, HR | 1 |
| Cook, DA | 1 |
| Herbert, FA | 1 |
| Gerster, JC | 1 |
| Irino, M | 1 |
| Sanada, H | 1 |
| Tashiro, S | 1 |
| Yasuhira, K | 1 |
| Takeda, T | 1 |
| Thew, DC | 1 |
| Stewart, IM | 1 |
| Endres, W | 1 |
| Lodemann, E | 1 |
| Tojo, T | 1 |
| Pigrau Serrallach, C | 1 |
| Pahissa Berga, A | 1 |
| Clotet Sala, B | 1 |
| Guardia Massó, J | 1 |
| Wannag, A | 2 |
| Aaseth, J | 2 |
| Nunns, D | 1 |
| Hawthorne, B | 1 |
| Goulding, P | 1 |
| Maresh, M | 1 |
| Yeowell, HN | 1 |
| Marshall, MK | 1 |
| Walker, LC | 1 |
| Ha, V | 1 |
| Pinnell, SR | 1 |
| Hartard, C | 1 |
| Kunze, K | 1 |
| Hull, AD | 2 |
| Longo, LD | 2 |
| Long, DM | 2 |
| Pearce, WJ | 2 |
| Oga, M | 1 |
| Matsui, N | 1 |
| Anai, T | 1 |
| Yoshimatsu, J | 1 |
| Inoue, I | 1 |
| Miyakawa, I | 1 |
| Chu, NS | 2 |
| Hung, TP | 1 |
| Miranda, M | 1 |
| Brinck, P | 1 |
| Roessler, JL | 1 |
| Troncoso Sch, M | 1 |
| González, M | 1 |
| Alarcón, T | 1 |
| Villagra, R | 1 |
| Okere, CO | 1 |
| Kaba, H | 1 |
| Takahashi, S | 1 |
| Higuchi, T | 1 |
| González, C | 1 |
| Cruz, MA | 1 |
| Gallardo, V | 1 |
| Miguel, P | 1 |
| Carrasco, G | 1 |
| Martínez-Frías, ML | 1 |
| Rodríguez-Pinilla, E | 1 |
| Bermejo, E | 1 |
| Blanco, M | 1 |
| Word, RA | 1 |
| Cornwell, TL | 1 |
| Hennan, JK | 1 |
| Diamond, J | 1 |
| Mustafa, MS | 1 |
| Shamina, AH | 1 |
| Hlinst'ák, K | 1 |
| Borovský, M | 1 |
| Hlinst'áková, S | 1 |
| Langevin, PB | 1 |
| Katovich, MJ | 1 |
| Wood, CE | 1 |
| James, CF | 1 |
| Langevin, SO | 1 |
| Sternlieb, I | 2 |
| Buhimschi, IA | 2 |
| Kramer, WB | 1 |
| Buhimschi, CS | 1 |
| Thompson, LP | 2 |
| Weiner, CP | 2 |
| Honold, J | 1 |
| Pusser, NL | 1 |
| Nathan, L | 1 |
| Chaudhuri, G | 2 |
| Ignarro, LJ | 2 |
| Sherman, MP | 1 |
| Castilla-Higuero, L | 1 |
| Romero-Gomez, M | 1 |
| Suarez, E | 1 |
| Castro, M | 1 |
| San Martin-Clark, O | 1 |
| Aguan, K | 1 |
| Schilsky, ML | 1 |
| Zhang, XQ | 1 |
| Kwek, K | 1 |
| Read, MA | 1 |
| Donoghue, JF | 1 |
| Walters, WA | 1 |
| Furman, B | 1 |
| Bashiri, A | 1 |
| Wiznitzer, A | 1 |
| Erez, O | 1 |
| Holcberg, G | 1 |
| Mazor, M | 1 |
| Buxton, IL | 1 |
| Kaiser, RA | 1 |
| Malmquist, NA | 1 |
| Tichenor, S | 1 |
| Feist, D | 1 |
| Arbisser, AI | 1 |
| Scott, CI | 1 |
| Howell, BR | 1 |
| Lyle, WH | 1 |
| Linares, A | 1 |
| Zarranz, JJ | 1 |
| Rodriguez-Alarcon, J | 1 |
| Diaz-Perez, JL | 1 |
| Huskisson, EC | 1 |
| Bischof, P | 2 |
| Kaiser, H | 1 |
| Rudkowski, Z | 1 |
| Toaff, R | 1 |
| Toaff, ME | 1 |
| Peyser, MR | 1 |
| Streifler, M | 1 |
| Stephens, S | 1 |
| Harkness, RA | 1 |
| Cockle, SM | 1 |
| Dickson, ER | 1 |
| Fleming, CR | 1 |
| Ludwig, J | 1 |
| Chiancone, FM | 1 |
| Fukuda, K | 1 |
| Ishii, A | 1 |
| Matsue, Y | 1 |
| Funaki, K | 1 |
| Hoshiai, H | 1 |
| Maeda, S | 1 |
| Wiley, MJ | 1 |
| Joneja, MG | 1 |
| McClain, RM | 1 |
| Siekierka, JJ | 1 |
| Gollan, JL | 1 |
| Hussein, S | 1 |
| Hoffbrand, AV | 1 |
| Sherlock, S | 1 |
| Norseth, T | 1 |
| Solomon, L | 1 |
| Abrams, G | 1 |
| Dinner, M | 1 |
| Berman, L | 1 |
| Corcoran, R | 1 |
| Castles, WJ | 1 |
| Milazzo, S | 1 |
| Marecek, Z | 1 |
| Graf, M | 1 |
| Lakatos, L | 3 |
| Kövér, B | 3 |
| Oroszlán, G | 1 |
| Vekerdy, Z | 2 |
| Vekerdy, S | 1 |
| Dvorácsek, E | 2 |
| Olhagen, B | 1 |
| Merker, HJ | 1 |
| Franke, L | 1 |
| Günther, T | 1 |
| Scheinberg, IH | 1 |
| Albukerk, JN | 2 |
| Varela, AF | 1 |
| Runge, A | 1 |
| Rousseaux, CG | 1 |
| MacNabb, LG | 1 |
| Soong, YK | 1 |
| Huang, HY | 1 |
| Huang, CC | 1 |
| Chin, RK | 1 |
| Shimono, N | 1 |
| Ishibashi, H | 1 |
| Ikematsu, H | 1 |
| Kudo, J | 1 |
| Shirahama, M | 1 |
| Inaba, S | 1 |
| Maeda, K | 1 |
| Yamasaki, K | 1 |
| Niho, Y | 1 |
| Dupont, P | 1 |
| Irion, O | 1 |
| Béguin, F | 1 |
| Woods, SE | 1 |
| Colón, VF | 1 |
| Yuzbasiyan-Gurkan, V | 2 |
| Dubick, MA | 1 |
| Rucker, RB | 1 |
| Lewis, JH | 1 |
| Weingold, AB | 1 |
| Miehle, W | 1 |
| Byron, MA | 1 |
| Shekhtman, MM | 1 |
| Koridze, RS | 1 |
| Young, AB | 1 |
| Berkow, R | 1 |
| Camus, JP | 1 |
| Koeger, AC | 1 |
| Laveant, C | 1 |
| Leca, AP | 1 |
| Morimoto, I | 1 |
| Ninomiya, H | 1 |
| Komatsu, K | 1 |
| Satho, M | 1 |
| Rosa, FW | 1 |
| Chan, WY | 2 |
| Hruby, VJ | 1 |
| Rockway, TW | 1 |
| Hlavacek, J | 1 |
| Ostensen, M | 1 |
| Husby, G | 1 |
| Needs, CJ | 1 |
| Brooks, PM | 1 |
| Schardein, JL | 1 |
| Scarpinato, L | 1 |
| Mackenzie, AH | 1 |
| Biller, J | 1 |
| Swiontoniowski, M | 1 |
| Brazis, PW | 1 |
| Piussan, C | 1 |
| Mathieu, M | 1 |
| Mjolnerod, OK | 1 |
| Dommerud, SA | 1 |
| Rasmussen, K | 2 |
| Gjeruldsen, ST | 1 |
| Laver, M | 1 |
| Fairley, KF | 1 |
| Axelsson, H | 1 |
| Johansson, BG | 1 |
| Rymo, L | 1 |
| Reinken, L | 1 |
| Lamperti, AA | 2 |
| Printz, RH | 2 |
| Bonventre, MV | 1 |
| Stähler, E | 1 |
| Stähler, F | 1 |
| Sturm, G | 1 |
| Nestor, JJ | 1 |
| Ferger, MF | 1 |
| Du Vigneaud, V | 1 |
| Trux, F | 1 |
| Haley, TJ | 1 |
| Steffek, AJ | 2 |
| Verrusio, AC | 1 |
| Watkins, CA | 1 |
| Snyder, RD | 1 |
| Pierce, PE | 1 |
| Thompson, JF | 1 |
| Likosky, WH | 1 |
| Nickey, LN | 1 |
| Barthel, WF | 1 |
| Hinman, AR | 1 |
| Uitto, J | 1 |
| Deiss, A | 1 |
| Lee, GR | 1 |
| Cartwright, GE | 1 |
| Terashima, T | 1 |
| Stivers, FE | 2 |
| Steffer, AJ | 1 |
| Yarington, CT | 2 |
| Wenzl, H | 1 |
| Kludas, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease[NCT01472874] | 8 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | g/dL (Mean) |
|---|---|
| Once a Day Trientine | 0.52 |
(NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | g/dL (Mean) |
|---|---|
| Once a Day Trientine | 0.54 |
Alanine transaminase (NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | U/L (Mean) |
|---|---|
| Once a Day Trientine | 50.89 |
Alanine transaminase (NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | U/L (Mean) |
|---|---|
| Once a Day Trientine | 41.38 |
(NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | mcg/24h (Mean) |
|---|---|
| Once a Day Trientine | 0.52 |
(NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | mcg/24h (Mean) |
|---|---|
| Once a Day Trientine | 0.54 |
(NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | mcg/24hr (Mean) |
|---|---|
| Once a Day Trientine | 313.4 |
(NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | mcg/24hr (Mean) |
|---|---|
| Once a Day Trientine | 287.9 |
The International Normalized Ratio (INR) is a standard way to describe the time it takes for blood to clot; an INR range of 0.8 to 1.2 is considered normal for a healthy person who is not using oral anticoagulant therapy (NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | international normalized ratio (Mean) |
|---|---|
| Once a Day Trientine | 1.05 |
The International Normalized Ratio (INR) is a standard way to describe the time it takes for blood to clot; an INR range of 0.8 to 1.2 is considered normal for a healthy person who is not using oral anticoagulant therapy (NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | international normalized ratio (Mean) |
|---|---|
| Once a Day Trientine | 0.99 |
(NCT01472874)
Timeframe: Months 1,2,3,6,9,12 (mean)
| Intervention | mcg/24hr (Mean) |
|---|---|
| Once a Day Trientine | 2214 |
(NCT01472874)
Timeframe: Pre Treatment (mean)
| Intervention | mcg/24hr (Mean) |
|---|---|
| Once a Day Trientine | 1959 |
24 reviews available for penicillamine and Pregnancy
| Article | Year |
|---|---|
Determination of human teratogenicity by the astute clinician method: review of illustrative agents and a proposal of guidelines.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Antirheumatic Agents; Congenital Abnormalities; Evid | 2009 |
[Wilson's disease: physiopathological, clinical and therapeutic considerations].
Topics: Adenosine Triphosphatases; Adolescent; Adult; Basal Ganglia Diseases; Brain; Cation Transport Protei | 2003 |
[Wilson's disease and its pharmacological treatment].
Topics: Adenosine Triphosphatases; Biomarkers; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; C | 2004 |
Novel therapeutic approaches to the treatment of Wilson's disease.
Topics: Chelating Agents; Child; Child, Preschool; Clinical Trials as Topic; Copper; Female; Hepatolenticula | 2006 |
[Which anti-inflammatory agents should be used in rheumatology?].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anticoagulants; Arthritis, Rheumatoid; Drug Syner | 1981 |
Geographic variations in Wilson's disease.
Topics: Adolescent; Adult; Brain Diseases, Metabolic; Carcinoma, Hepatocellular; China; Comorbidity; Consang | 1993 |
Practical recommendations and new therapies for Wilson's disease.
Topics: Chelating Agents; Copper; Female; Hepatolenticular Degeneration; Humans; Liver; Metallothionein; Mol | 1995 |
Wilson's disease and pregnancy.
Topics: Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy | 2000 |
Treatment of Wilson's disease: what are the relative roles of penicillamine, trientine, and zinc supplementation?
Topics: Adenosine Triphosphatases; Chelating Agents; Drug Therapy, Combination; Female; Hepatolenticular Deg | 2001 |
[Lead microintoxication in children as an element of "industrial pediatrics"].
Topics: Age Factors; Air Pollutants; Chelating Agents; Child; Environmental Exposure; Female; Humans; Lead P | 1977 |
Hepatolenticular degeneration (Wilson's disease) and pregnancy. A review and report of a case.
Topics: Adolescent; Adult; Animals; Ceruloplasmin; Copper; Estrogens; Female; Fertility; Hepatolenticular De | 1977 |
Primary biliary cirrhosis.
Topics: Adult; Aged; Antigen-Antibody Complex; Copper; Esophageal and Gastric Varices; Female; Humans; Liver | 1979 |
Red cell aplasia following prolonged D-penicillamine therapy.
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow; Bone Marrow Cells; Chelating Agents; Child; Child, | 1976 |
Wilson's disease.
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Pregnancy | 1989 |
Wilson's disease: an update, with emphasis on new approaches to treatment.
Topics: Copper; Female; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Pregnancy; Trienti | 1989 |
The use of gastrointestinal drugs during pregnancy and lactation.
Topics: Adrenal Cortex Hormones; Animals; Antidiarrheals; Antiemetics; Cathartics; Diuretics; Female; Gastro | 1985 |
[Current aspects of D-penicillamine and pregnancy].
Topics: Abnormalities, Drug-Induced; Arthritis, Rheumatoid; Cystinuria; Female; Hepatolenticular Degeneratio | 1988 |
Treatment of Wilson's disease.
Topics: Copper; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; T | 1987 |
[Penicillamine in 1985].
Topics: Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Drug Tolerance; Female; | 1986 |
Antirheumatic drug treatment during pregnancy and lactation.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Azathioprine; Chloroquine; Cyc | 1985 |
Antirheumatic medication in pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplas | 1985 |
Current status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticonvulsants; Antineoplastic Agents; Coumarin | 1985 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
Saturnism, pediatric and adult lead poisoning.
Topics: Adult; Central Nervous System Diseases; Chicago; Child; Child, Preschool; Edetic Acid; Environmental | 1971 |
126 other studies available for penicillamine and Pregnancy
| Article | Year |
|---|---|
Wilson disease in pregnancy: A case series.
Topics: Abortion, Spontaneous; Child; Copper; Female; Hepatolenticular Degeneration; Humans; Penicillamine; | 2023 |
Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients.
Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; East Asian People; Female; Humans; Immunogl | 2023 |
Gynecological history to diagnosis and pregnancy outcomes in diagnosed Wilson's disease patients under therapy - A bicentric matched-control cohort study.
Topics: Cohort Studies; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Pregnancy; Pregn | 2022 |
Pregnancy Outcomes in Wilson's Disease Women: Single-Center Case Series.
Topics: Abortion, Spontaneous; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Preg | 2022 |
Anesthetic management of cesarean delivery for a parturient with Wilson's disease: A case report.
Topics: Adult; Anesthetics, General; Cesarean Section; Chelating Agents; Female; Hepatolenticular Degenerati | 2018 |
Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease.
Topics: Animals; Chelating Agents; Choline; Copper; Copper-Transporting ATPases; Disease Models, Animal; DNA | 2018 |
Pregnancy outcome after chelation therapy in Wilson disease. Evaluation of the German Embryotox Database.
Topics: Adult; Chelating Agents; Chelation Therapy; Copper; Databases, Factual; Female; Germany; Hepatolenti | 2016 |
Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.
Topics: Animals; Choline; Copper; Dietary Supplements; Disease Models, Animal; DNA Methylation; Epigenomics; | 2016 |
Dose-dependent inhibition of uterine contractility by nitric oxide: A potential mechanism underlying persistent breeding-induced endometritis in the mare.
Topics: Animals; Dose-Response Relationship, Drug; Endometritis; Female; Horse Diseases; Horses; Myometrium; | 2017 |
Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.
Topics: Adolescent; Chelating Agents; Child; Female; Goiter; Hepatolenticular Degeneration; Humans; Hypothyr | 2008 |
Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture.
Topics: Animals; Brain Chemistry; Cell Death; Cells, Cultured; Cerebral Cortex; Chelating Agents; Drug Syner | 2009 |
Role of cardiac eNOS expression during pregnancy in the coupling of myocardial oxygen consumption to cardiac work.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; | 2002 |
Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Animals, Newborn; Female; Labor, Obstetric; Lung; Ni | 2002 |
[Poisoning by chromium and its long lasting detoxication].
Topics: Chelating Agents; Chromium; Ditiocarb; Female; Humans; Infant, Newborn; Male; Occupational Diseases; | 2002 |
Bovine embryo development following ICSI: effect of activation, sperm capacitation and pre-treatment with dithiothreitol.
Topics: Animals; Cattle; Cycloheximide; Dithiothreitol; Embryo, Mammalian; Embryonic and Fetal Development; | 2003 |
Transient fetal myelosuppressive effect of D-penicillamine when used in pregnancy.
Topics: Chelating Agents; Female; Fetal Diseases; Hepatolenticular Degeneration; Humans; Infant, Newborn; Le | 2003 |
Infant with severe penicillamine embryopathy born to a woman with Wilson disease.
Topics: Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Cutis Laxa; Female; Fetal Diseases; Fetus; | 2004 |
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relat | 2007 |
The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Calcimycin; Catalase; Female; Ionop | 2007 |
In vitro production of llama (Lama glama) embryos by IVF and ICSI with fresh semen.
Topics: Adenine; Animals; Antioxidants; Argentina; Camelids, New World; Ejaculation; Electric Stimulation; E | 2008 |
Preventive effect of penicillamine on the brain defect of fetal rat poisoned transplacentally with methyl mercury.
Topics: Animals; Brain; Female; Fetus; Injections, Intramuscular; Male; Maternal-Fetal Exchange; Mercury Poi | 1967 |
Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride.
Topics: Adolescent; Adult; Brain; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Pen | 1982 |
Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Dose-Response Relationship, Drug; Female; Fetal Death; | 1982 |
Cutis laxa and low serum zinc after antenatal exposure to penicillamine.
Topics: Adult; Cutis Laxa; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Penicillamine; Pregnanc | 1983 |
Pregnancy and cystinuria.
Topics: Birth Weight; Cystinuria; Female; Follow-Up Studies; Genetic Counseling; Humans; Penicillamine; Preg | 1983 |
Placental calcium and phosphorus transfer in the guinea pig: lack of effect of modulators of Ca-ATPase and alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Antipyrine; Calcium; Calcium-Transporting ATPases; Ethacrynic Acid; F | 1983 |
Placental transfer of calcium (Ca) and phosphorus (Pi) in the guinea pig: lack of correlation with placental Ca-ATPase and alkaline phosphatase (AP) activities.
Topics: Alkaline Phosphatase; Animals; Calcium; Calcium-Transporting ATPases; Ethacrynic Acid; Female; Furos | 1983 |
D-penicillamine-induced cleft palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Maxilla; Mice; Mice, Inbred Strains; Ost | 1984 |
Drug-induced copper deficiency: a model for copper deficiency teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Humans; Penicillamine; Pregnancy; Teratogens; | 1983 |
Teratogenic effects of D-penicillamine in rats: relation to copper deficiency.
Topics: Animals; Copper; Diet; Female; Fetus; Gestational Age; Metals; Penicillamine; Placenta; Pregnancy; R | 1983 |
Molecular localization of copper and zinc in rat fetal liver in dietary and drug-induced copper deficiency.
Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Gel; Copper; Ethylenediamines; Female; Liver; | 1984 |
Bio-inorganic effects of D-penicillamine in children and in the elderly.
Topics: Abnormalities, Drug-Induced; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Cystinuria; Fe | 1984 |
Reduction by copper supplementation of teratogenic effects of D-penicillamine.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Fetus; Food, Fortified; Liver; Male; Manganese | 1983 |
Accidental inhalation of mercury vapour: respiratory and toxicologic consequences.
Topics: Accidents; Adult; Child; Female; Gold; Hot Temperature; Humans; Infant; Male; Maternal-Fetal Exchang | 1983 |
Teratogenesis and low copper status resulting from D-penicillamine in rats.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Penicillamine; Pregnancy; Rats; Rats, Inbred S | 1982 |
D-penicillamine toxicity in mice. III. pathological study of offspring of penicillamine-fed pregnant and lactating mice.
Topics: Animal Population Groups; Animals; Animals, Suckling; Aortic Rupture; Female; Lactation; Mice; Penic | 1982 |
D penicillamine and breast enlargement.
Topics: Adult; Breast; Female; Galactorrhea; Humans; Hypertrophy; Lactation Disorders; Penicillamine; Pregna | 1980 |
D-penicillamine in pregnancy--to ban or not to ban?
Topics: Arthritis, Rheumatoid; Connective Tissue Diseases; Cystinuria; Female; Hepatolenticular Degeneration | 1981 |
Transport of D- and L-penicillamine by mammalian cells.
Topics: Amino Acids; Animals; Biological Transport; Embryo, Mammalian; Female; Humans; Kinetics; L Cells; Ma | 1981 |
[Pregnancy and rheumatic disease (author's transl)].
Topics: Arthritis, Rheumatoid; Female; Gold; Humans; Penicillamine; Pregnancy; Pregnancy Complications; Scle | 1981 |
[Wilson's disease: seven cases with hepatic onset (author's transl)].
Topics: Adolescent; Adult; Child; Copper; Female; Hepatitis; Hepatolenticular Degeneration; Humans; Liver; L | 1981 |
The effect of immediate and delayed treatment with 2,3-dimercaptopropane-1-sulphonate on the distribution and toxicity of inorganic mercury in mice and in foetal and adult rats.
Topics: Animals; Brain; Chelating Agents; Dimercaprol; Extraembryonic Membranes; Feces; Female; Fetus; Kidne | 1980 |
Wilson's disease in pregnancy.
Topics: Adolescent; Copper; Female; Hepatolenticular Degeneration; Humans; Liver; Male; Penicillamine; Pregn | 1995 |
Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders.
Topics: Aminopropionitrile; Ascorbic Acid; Bleomycin; Cell Line; Collagen; Connective Tissue Diseases; DNA P | 1994 |
Pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate. A case report and review of the literature.
Topics: Adult; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Complicati | 1994 |
Pregnancy alters cerebrovascular adaptation to high-altitude hypoxia.
Topics: Adaptation, Physiological; Altitude; Animals; Blood Vessels; Calcimycin; Cerebrovascular Circulation | 1994 |
Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease.
Topics: Adult; Ceruloplasmin; Copper; Female; Fetal Diseases; Fetus; Hepatolenticular Degeneration; Humans; | 1993 |
[Wilson's disease: a review apropos of a clinical experience in 16 patients].
Topics: Adolescent; Adult; Central Nervous System Diseases; Ceruloplasmin; Child; Child, Preschool; Copper; | 1995 |
Intrabulbar infusions of (+/-)S-nitroso-N-acetylpenicillamine and L-arginine induce functional plasticity in the accessory olfactory bulb of female mice.
Topics: Animals; Arginine; Female; Hemoglobins; Learning; Memory; Mice; Mice, Inbred BALB C; Microinjections | 1996 |
Relative potency of nitrovasodilators on human placental vessels from normal and preeclamptic pregnancies.
Topics: Analysis of Variance; Arteries; Dose-Response Relationship, Drug; Female; Humans; Muscle, Smooth, Va | 1997 |
Prenatal exposure to penicillamine and oral clefts: case report.
Topics: Adult; Chelating Agents; Cleft Lip; Cleft Palate; Female; Hepatolenticular Degeneration; Humans; Inf | 1998 |
Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Down | 1998 |
Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increases in tissue levels of cyclic GMP.
Topics: Animals; Arginine; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fema | 1998 |
Five successful deliveries following 9 consecutive spontaneous abortions in a patient with Wilson disease.
Topics: Abortion, Habitual; Adult; Ceruloplasmin; Chelating Agents; Copper; Delivery, Obstetric; Female; Hep | 1998 |
[Pregnancy, labor and early puerperium in a patient with Wilson's disease].
Topics: Adult; Chelating Agents; Female; Foot Deformities, Congenital; Hepatolenticular Degeneration; Humans | 1999 |
The effect of nitroglycerin on the gravid uterus in sheep and rabbits.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Compliance; Female; Heart Rate; In Vitro Techniqu | 2000 |
Reduction-oxidation (redox) state regulation of matrix metalloproteinase activity in human fetal membranes.
Topics: Acetylcysteine; Cesarean Section; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; E | 2000 |
Production and excretion of nitrate by human newborn infants: neonates are not little adults.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Luminescent Measurements; Nitrates; Nitri | 2000 |
Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatolenticular Degeneration; | 2000 |
Differential alterations in responsiveness in particulate and soluble guanylate cyclases in pregnant guinea pig myometrium.
Topics: Animals; Female; Guanylate Cyclase; Guinea Pigs; Isoenzymes; Myometrium; Natriuretic Agents; Nitric | 2000 |
Effects of nitrovasodilators on the human fetal-placental circulation in vitro.
Topics: Adolescent; Adult; Antioxidants; Arteries; Chorion; Cysteine; Female; Fetus; Gestational Age; Glutat | 2001 |
Wilson's disease in pregnancy: five successful consecutive pregnancies of the same woman.
Topics: Alanine Transaminase; Apgar Score; Aspartate Aminotransferases; Chelating Agents; Female; Gestationa | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gu | 2001 |
[Studies on juvenile chronic hepatitis].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Autoantibodies; Autoimmune Diseases; Azathioprine | 1975 |
Letter: Mannosidosis and maternal penicillamine therapy.
Topics: Carbohydrate Metabolism, Inborn Errors; Disaccharidases; Female; Hepatolenticular Degeneration; Huma | 1976 |
Penicillamine in pregnancy.
Topics: Drug Evaluation; Female; Humans; Penicillamine; Pregnancy; Pregnancy Complications | 1978 |
Reversible cutis laxa due to maternal D-penicillamine treatment.
Topics: Cutis Laxa; Female; Fetus; Hepatolenticular Degeneration; Humans; Infant, Newborn; Infant, Newborn, | 1979 |
Congenital cutis laxa and maternal D-penicillamine.
Topics: Cutis Laxa; Female; Fetus; Humans; Infant, Newborn; Penicillamine; Pregnancy | 1979 |
Clinical evaluation of novel anti-rheumatic drugs.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Drug Evaluation; Female; Humans; Levamisole; Penicillami | 1977 |
[Problems of rheumatism therapy in pregnant women].
Topics: Abortion, Spontaneous; Chloroquine; Female; Gold; Humans; Hyperbilirubinemia; Indomethacin; Penicill | 1978 |
Lactoperoxidase activity in guinea-pig milk and saliva: correlation in milk of lactoperoxidase with bactericidal activity against Escherichia coli.
Topics: Animals; Escherichia coli Infections; Female; Guinea Pigs; Iron; Lactation; Lactoperoxidase; Milk; P | 1979 |
[Urinary xanthurenic acid levels].
Topics: Age Factors; Aged; Alcoholism; Arthritis, Rheumatoid; Child; Contraceptives, Oral; Diabetes Mellitus | 1978 |
Pregnancy and delivery in penicillamine treated patients with Wilson's disease.
Topics: Adult; Copper; Female; Hepatolenticular Degeneration; Humans; Labor, Obstetric; Liver; Maternal-Feta | 1977 |
Neural tube lesions in the offspring of hamsters given single oral doses of lathyrogens early in gestation.
Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Animals; Brain; Cricetinae; Female; F | 1978 |
The effects of various chelating agents on the teratogenicity of lead nitrate in rats.
Topics: Animals; Chelating Agents; Dicarboxylic Acids; Edetic Acid; Female; Fetus; Hydrocephalus; Imino Acid | 1975 |
The effect of N-acetylated DL-penicillamine and DL-homocysteine thiolactone on the mercury distribution in adult rats, rat foetuses and macaca monkeys after exposure to methyl mercuric chloride.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Fetus; Haplorhini; Homocysteine; Kidney; L | 1976 |
[Problems of rheumatic therapy in pregnancy (author's transl)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Chloroquine; Female; Fetal Diseases | 1976 |
Neonatal abnormalities associated with D-penicillamine treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Fetus; Humans; Infant, Newborn; P | 1977 |
Penicillamine therapy and teratogenesis.
Topics: Abnormalities, Drug-Induced; Cystinuria; Female; Humans; Infant, Newborn; Penicillamine; Pregnancy; | 1977 |
Pregnancy in Wilson's disease.
Topics: Ceruloplasmin; Copper; Female; Fetal Blood; Hepatolenticular Degeneration; Humans; Penicillamine; Pr | 1977 |
The treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Child; Chloroquine; Female; Gold; Humans; Hydroxychl | 1977 |
Letter: Pregnancy in penicillamine-treated patients with Wilson's disease.
Topics: Female; Hepatolenticular Degeneration; Humans; Maternal-Fetal Exchange; Penicillamine; Pregnancy; Pr | 1976 |
D-penicillamine therapy in ABO hemolytic disease of the newborn infant.
Topics: ABO Blood-Group System; Age Factors; Bilirubin; Erythroblastosis, Fetal; Exchange Transfusion, Whole | 1976 |
D-penicillamine therapy of neonatal jaundice: comparison with phototherapy.
Topics: Administration, Oral; Copper; Female; Humans; Immunosuppression Therapy; Infant, Newborn; Infant, Pr | 1976 |
[Immunosuppressive treatment of rheumatologic diseases].
Topics: Arthritis; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Immunity, Cellular; Immunosuppres | 1976 |
The effect of D-penicillamine of the skeletal development of rat foetuses.
Topics: Abnormalities, Drug-Induced; Animals; Apatites; Bone and Bones; Bone Development; Collagen; Extracel | 1975 |
[Penicillamine D therapy of hemolytic disease of newborn and neonatal hyperbilirubinemia].
Topics: Erythroblastosis, Fetal; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice, Neonatal; Pe | 1975 |
Pregnancy in penicillamine-treated patients with Wilson's disease.
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Infant, Newborn; Male; Penicillami | 1975 |
Letter: The pregnant woman with Wilson's disease.
Topics: Female; Fetus; Hepatolenticular Degeneration; Humans; Maternal-Fetal Exchange; Penicillamine; Pregna | 1976 |
Nitric oxide and prostacyclin inhibit fetal platelet aggregation: a response similar to that observed in adults.
Topics: Adenosine Diphosphate; Blood Platelets; Epinephrine; Epoprostenol; Female; Fetal Blood; Humans; Nitr | 1992 |
Oral administration of D-penicillamine causes neonatal mortality without morphological defects in CD-1 mice.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Animals, Newborn; Body Weight; Dose-Resp | 1992 |
Successful pregnancy after D-penicillamine therapy in a patient with Wilson's disease.
Topics: Adult; Female; Hepatolenticular Degeneration; Humans; Infant, Newborn; Penicillamine; Pregnancy | 1991 |
Pregnancy-induced changes in ovine cerebrovascular reactivity and composition.
Topics: Animals; Body Water; Calcimycin; Cerebrovascular Circulation; Female; Muscle Contraction; Muscle, Sm | 1991 |
Pregnancy and Wilson's disease.
Topics: Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Complications; Su | 1991 |
Fulminant hepatic failure during perinatal period in a pregnant woman with Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Female; Hepatolenticular Degeneration; Humans; Liver; Liver Diseases; Peni | 1991 |
Pregnancy in a patient with treated Wilson's disease: a case report.
Topics: Adult; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Complicati | 1990 |
Elastin metabolism during perinatal lung development in the copper-deficient rat.
Topics: Animals; Animals, Newborn; Collagen; Copper; Elastin; Female; Liver; Lung; Penicillamine; Pregnancy; | 1985 |
Treatment of rheumatic diseases.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Breast Feeding; | 1987 |
[Hepatocerebral dystrophy in pregnancy].
Topics: Adult; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Complicati | 1988 |
Wilson's disease in The Merck Manual: corrections.
Topics: Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Zinc | 1988 |
Pregnancy and penicillamine treatment in a patient with Wilson's disease.
Topics: Adult; Ceruloplasmin; Female; Hepatolenticular Degeneration; Humans; Infant, Newborn; Male; Penicill | 1986 |
Teratogen update: penicillamine.
Topics: Abnormalities, Drug-Induced; Animals; Collagen; Copper; Cutis Laxa; Female; Hepatolenticular Degener | 1986 |
Design of oxytocin antagonists with prolonged action: potential tocolytic agents for the treatment of preterm labor.
Topics: Alkylation; Animals; Female; Obstetric Labor, Premature; Oxytocin; Penicillamine; Pregnancy; Rats; R | 1986 |
Pregnancy and progressive systemic sclerosis. Case report and review of the literature.
Topics: Adult; Blood Pressure; Colchicine; Female; Humans; Penicillamine; Prednisone; Pregnancy; Pregnancy C | 1985 |
Successful pregnancy in Wilson's disease: a case report and review of the literature.
Topics: Adult; Ceruloplasmin; Copper; Diet; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pr | 1985 |
[Teratogenic risk during treatment of Wilson disease].
Topics: Adult; Congenital Abnormalities; Copper; Female; Fetus; Hepatolenticular Degeneration; Humans; Infan | 1985 |
Congenital connective-tissue defect probably due to D-penicillamine treatment in pregnancy.
Topics: Collagen Diseases; Connective Tissue; Cystinuria; Elasticity; Female; Humans; Infant, Newborn; Infan | 1971 |
D-penicillamine treatment in pregnancy.
Topics: Adult; Cystinuria; Female; Humans; Penicillamine; Pregnancy; Pregnancy Complications | 1971 |
Isolation of immunoglobulin A (IgA) from human colostrum.
Topics: Alkylation; Amino Acids; Aspartic Acid; Buffers; Chromatography, Gel; Colostrum; Cysteine; Electroph | 1966 |
Localization, accumulation, and toxic effects of mercuric chloride on the reproductive axis of the female hamster.
Topics: Animals; Autoradiography; Cerebral Cortex; Chlorides; Cricetinae; Estrus; Female; Hypothalamus; Inje | 1974 |
Sweet peas, copper, pregnancy, and pills: effects on aorta.
Topics: Animals; Aortic Diseases; Collagen; Contraceptives, Oral; Copper; Deficiency Diseases; Estrogens; Fe | 1974 |
[Pregnancy in a case of Wilson's copper metabolism disorder].
Topics: Amenorrhea; Female; Hepatolenticular Degeneration; Humans; Infertility; Male; Penicillamine; Pregnan | 1972 |
Wilson's disease and pregnancy. A case report.
Topics: Abortion, Spontaneous; Adult; Ascites; Autopsy; Ceruloplasmin; Copper; Diet Therapy; Female; Fetus; | 1973 |
Effects of mercuric chloride on the reproductive cycle of the female hamster.
Topics: Animals; Chlorides; Corpus Luteum; Cricetinae; Estrus; Female; Hypothalamus; Luteinizing Hormone; Me | 1973 |
Inhibition of oxytocic responses to oxytocin in pregnant rats by (1-L-penicillamine)oxytocin and (1-beta-mercapto-beta, beta-diethylpropionic acid)oxytocin.
Topics: Animals; Diethylpropion; Female; Oxytocin; Penicillamine; Pregnancy; Pregnancy, Animal; Rats; Transd | 1974 |
[Treatment of chronic hepatitis].
Topics: Azathioprine; Chronic Disease; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Female; Hepati | 1974 |
Cleft palate in rodents after maternal treatment with various lathyrogenic agents.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animal Feed; Animals; Cleft Palate; Female; Nitrile | 1972 |
The involuntary movements of chronic mercury poisoning.
Topics: Adolescent; Adult; Ataxia; Child; Dimercaprol; Female; Fetal Diseases; Humans; Infant, Newborn; Infa | 1972 |
Alkyl mercury poisoning in humans. Report of an outbreak.
Topics: Adolescent; Adult; Amniocentesis; Animal Feed; Ataxia; Cerebellum; Child; Child, Preschool; Coma; Di | 1972 |
Effect of D-penicillamine on collagen biosynthesis in organ culture.
Topics: Animals; Bone and Bones; Carbon Isotopes; Collagen; Culture Media; Depression, Chemical; Dialysis; F | 1969 |
Hemolytic anemia in Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Copper; Erythrocytes; Female; Glucosephosphate Dehydrogenase; Glutathione; | 1970 |
[Copper salts on the induction of pseudopregnancy and its toxicity in rat, with special reference to the action of D-penicillamine].
Topics: Animals; Copper; Female; Injections, Intravenous; Penicillamine; Pregnancy; Pseudopregnancy; Radiois | 1970 |
The effect of lathyrogens on developing mid-facial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Diet; Female; Jaw Abnormalities; Lathyrism | 1970 |
[Therapeutic problems during D-penicillamine treatment of patients with cystine calculi].
Topics: Adolescent; Adult; Albuminuria; Copper; Cystine; Cystinuria; Female; Humans; Kidney Calculi; Penicil | 1970 |
The effect of lathyrogens on developing midfacial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Cleft Palate; Diet; Face; Femal | 1971 |
Observations during treatment of cystinuria with D-penicillamine.
Topics: Adult; Collagen Diseases; Cystinuria; Female; Humans; Lupus Erythematosus, Systemic; Male; Nephrotic | 1971 |