Page last updated: 2024-11-07

penicillamine and Poisoning

penicillamine has been researched along with Poisoning in 34 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.

Research Excerpts

ExcerptRelevanceReference
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."7.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."3.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
" Before dosing with D-penicillamine, the median 24 h urinary bismuth output was 55 micrograms 24 h-1 (range 17-156 micrograms 24 h-1) and following dosing with D-penicillamine the median 24 h urinary bismuth output was 53 micrograms 24 h-1 (range 12-156 micrograms 24 h-1)."1.28D-penicillamine does not increase urinary bismuth excretion in patients treated with tripotassium dicitrato bismuthate. ( Nwokolo, CU; Pounder, RE, 1990)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199019 (55.88)18.7374
1990's7 (20.59)18.2507
2000's4 (11.76)29.6817
2010's3 (8.82)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Shankar, JA1
Kaur, A1
Tyagi, L1
Selvam, S1
Hans, R1
Pannu, AK1
Aaseth, J2
Skaug, MA1
Cao, Y1
Andersen, O1
Lee, YR1
Kang, MH1
Park, HM1
Montes, S1
Pérez-Barrón, G1
Rubio-Osornio, M1
Ríos, C3
Diaz-Ruíz, A1
Altagracia-Martínez, M1
Monroy-Noyola, A3
Ryselis, S1
Abdrachmanovas, O1
Vitkuviene, B1
Naginiene, R1
Faure, A1
Mathon, L1
Poupelin, JC1
Allaouchiche, B1
Chassard, D1
Cornish, J1
Angelos, J1
Puschner, B1
Miller, G1
George, L1
Cullen, NM1
Wolf, LR1
St Clair, D1
Heaven, R1
Duncan, M1
Vukelja, SJ1
Barroso-Moguel, R1
Villeda-Hernández, J1
Méndez-Armenta, M1
Roden, R1
Fraser-Moodie, A1
Hantson, P1
Lievens, M1
Mahieu, P1
Takeda, T1
Yukioka, T1
Shimazaki, S1
Mofenson, HC1
Greensher, J1
Prescott, LF1
Sutherland, GR1
Park, J1
Smith, IJ1
Proudfoot, AT1
Lodemann, E1
Jones, MM1
Pratt, TH1
Gabard, B1
Kuruvilla, A1
Bergeson, PS1
Done, AK1
Nwokolo, CU1
Pounder, RE1
Vale, JA1
Meredith, TJ1
Anghinah, A1
Canelas, HM1
Bastos de Jorge, F1
Forti, F1
Kjeldsberg, CR1
Ward, HP1
Strubelt, O1
Siegers, CP1
Schütt, A1
Ogawa, E1
Suzuki, S1
Tsuzuki, H1
Wirth, W1
Chisolm, JJ1
Lehnert, G1
Eschstruth, R1
Szadkowski, D1
Schaller, KH1
Kanbayashi, K1
Salmon, MA1
Wright, T1
Klein, R1
Brubaker, P1

Reviews

5 reviews available for penicillamine and Poisoning

ArticleYear
Chelation in metal intoxication--Principles and paradigms.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 31

    Topics: Administration, Oral; Antidotes; Benzoates; Chelating Agents; Deferasirox; Deferiprone; Deferoxamine

2015
Pediatric arsenic ingestion.
    The American journal of emergency medicine, 1995, Volume: 13, Issue:4

    Topics: Arsenates; Chelating Agents; Dimercaprol; Drug Therapy, Combination; Female; Humans; Infant; Penicil

1995
Arsenic intoxication presenting with macrocytosis and peripheral neuropathy, without anemia.
    Acta haematologica, 1994, Volume: 92, Issue:3

    Topics: Aged; Arsenic Poisoning; Chronic Disease; Erythrocytes, Abnormal; Humans; Insecticides; Male; Penici

1994
Therapeutic chelating agents.
    Journal of chemical education, 1976, Volume: 53, Issue:6

    Topics: Chelating Agents; Deferoxamine; Dimercaprol; Edetic Acid; Humans; Metallothionein; Metals; Penicilla

1976
Antidotal therapy: pharmacokinetic aspects.
    Developments in toxicology and environmental science, 1986, Volume: 12

    Topics: Administration, Oral; Antidotes; Deferoxamine; Dimercaprol; Hot Temperature; Humans; Injections, Int

1986

Trials

1 trial available for penicillamine and Poisoning

ArticleYear
Letter: Cysteamine for paracetamol overdosage.
    Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864

    Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch

1974

Other Studies

28 other studies available for penicillamine and Poisoning

ArticleYear
Severe copper sulphate poisoning: A case rescued with plasmapheresis.
    Tropical doctor, 2023, Volume: 53, Issue:2

    Topics: Copper; Copper Sulfate; Humans; Penicillamine; Plasmapheresis; Poisoning; Sulfates

2023
Treatment of zinc toxicosis in a dog with chelation using d-penicillamine.
    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2016, Volume: 26, Issue:6

    Topics: Animals; Chelating Agents; Diagnosis, Differential; Dog Diseases; Dogs; Female; Foreign Bodies; Peni

2016
Additive effect of DL-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats.
    Environmental toxicology and pharmacology, 2011, Volume: 32, Issue:3

    Topics: Animals; Antidotes; Brain; Chelating Agents; Drug Synergism; Ferrocyanides; Male; Penicillamine; Poi

2011
[Poisoning by chromium and its long lasting detoxication].
    Medicina (Kaunas, Lithuania), 2002, Volume: 38, Issue:8

    Topics: Chelating Agents; Chromium; Ditiocarb; Female; Humans; Infant, Newborn; Male; Occupational Diseases;

2002
[Acute cupric sulfate intoxication: pathophysiology and therapy about a case report].
    Annales francaises d'anesthesie et de reanimation, 2003, Volume: 22, Issue:6

    Topics: Adult; Chelating Agents; Copper Sulfate; Erythrocyte Transfusion; Hemolysis; Humans; Intellectual Di

2003
Copper toxicosis in a dairy goat herd.
    Journal of the American Veterinary Medical Association, 2007, Aug-15, Volume: 231, Issue:4

    Topics: Animal Feed; Animals; Antidotes; Copper; Female; Goat Diseases; Goats; Liver; Molybdenum; Penicillam

2007
Combined D-penicillamine and prussian blue as antidotal treatment against thallotoxicosis in rats: evaluation of cerebellar lesions.
    Toxicology, 1994, Mar-25, Volume: 89, Issue:1

    Topics: Animals; Antidotes; Drug Therapy, Combination; Ferrocyanides; Male; Organometallic Compounds; Penici

1994
Self-injection with mercury.
    Injury, 1993, Volume: 24, Issue:3

    Topics: Adult; Forearm; Humans; Injections; Lung; Male; Mercury Poisoning; Penicillamine; Poisoning; Radiogr

1993
Accidental ingestion of a zinc and copper sulfate preparation.
    Journal of toxicology. Clinical toxicology, 1996, Volume: 34, Issue:6

    Topics: Aged; Aged, 80 and over; Cardiovascular System; Chelating Agents; Copper Sulfate; Digestive System;

1996
Cupric sulfate intoxication with rhabdomyolysis, treated with chelating agents and blood purification.
    Internal medicine (Tokyo, Japan), 2000, Volume: 39, Issue:3

    Topics: Acute Disease; Adolescent; Chelating Agents; Copper Sulfate; Dimercaprol; Drug Therapy, Combination;

2000
Controversies in the prevention and treatment of poisonings.
    Pediatric annals, 1977, Volume: 6, Issue:11

    Topics: Accident Prevention; Antidotes; Aspirin; Chelating Agents; Child; Cobalt; Cyanides; Drug Labeling; D

1977
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury;

1976
[D-Penacillamine. From constituent of penicillins to significant drug].
    Die Naturwissenschaften, 1979, Volume: 66, Issue:9

    Topics: Arthritis, Rheumatoid; Cystinuria; Hepatitis; Hepatolenticular Degeneration; Humans; Multiple Sclero

1979
Improvement of oral chelation treatment of methyl mercury poisoning in rats.
    Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:2

    Topics: Administration, Oral; Animals; Chelating Agents; Dimercaprol; Homocysteine; Lactones; Male; Methylme

1976
Arsenic poisoning in childhood. An unusual case report with special notes on therapy with penicillamine.
    Clinical toxicology, 1975, Volume: 8, Issue:5

    Topics: Adolescent; Arsenic Poisoning; Child; Humans; Male; Penicillamine; Poisoning

1975
D-penicillamine and prussian blue as antidotes against thallium intoxication in rats.
    Toxicology, 1992, Volume: 74, Issue:1

    Topics: Animals; Antidotes; Brain; Drug Therapy, Combination; Ferrocyanides; Lethal Dose 50; Male; Penicilla

1992
D-penicillamine does not increase urinary bismuth excretion in patients treated with tripotassium dicitrato bismuthate.
    British journal of clinical pharmacology, 1990, Volume: 30, Issue:4

    Topics: Aged; Antacids; Bismuth; Chelating Agents; Humans; Middle Aged; Organometallic Compounds; Penicillam

1990
[Arsenical peripheral polyneuropathy: treatment with penicillamine. Determination of inorganic arsenic in peripheral nerve, blood and urine].
    Arquivos de neuro-psiquiatria, 1974, Volume: 32, Issue:3

    Topics: Arsenic; Arsenic Poisoning; Capsules; Drug Evaluation; Humans; Penicillamine; Peripheral Nerves; Poi

1974
Leukemia in arsenic poisoning.
    Annals of internal medicine, 1972, Volume: 77, Issue:6

    Topics: Aged; Anemia, Aplastic; Arsenic; Arsenic Poisoning; Autopsy; Biopsy; Bone Marrow Cells; Cytarabine;

1972
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
    Archives of toxicology, 1974, Volume: 33, Issue:1

    Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami

1974
[Recent advance in the therapy of metal poisoning with complexing agents].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1972, May-10, Volume: 12, Issue:13

    Topics: Arsenic Poisoning; Carbon Isotopes; Chelating Agents; Deferoxamine; Dimercaprol; Edetic Acid; Humans

1972
Radiopharmacological studies on the cadmium poisoning.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:3

    Topics: Animals; Antidotes; Bone and Bones; Cadmium; Cadmium Poisoning; Chelating Agents; Chlorides; Edetic

1972
[Possible side-effects of antidotal therapy].
    Archiv fur Toxikologie, 1968, Volume: 24, Issue:1

    Topics: Antidotes; Atropine; Chelating Agents; Cyanides; Deferoxamine; Dimercaprol; Edetic Acid; Humans; Hyd

1968
Poisoning due to heavy metals.
    Pediatric clinics of North America, 1970, Volume: 17, Issue:3

    Topics: Arsenic Poisoning; Cadmium Poisoning; Chelating Agents; Child; Child, Preschool; Copper; Deferoxamin

1970
[Prevention of occupational heavy metal poisoning using D-penicillamine].
    Die Medizinische Welt, 1970, Feb-28, Volume: 9

    Topics: Adult; Humans; Male; Metallurgy; Metals; Minerals; Occupational Diseases; Penicillamine; Poisoning;

1970
[Measurement of urinary thallium by atomic absorption spectrophotometry and the effect of penicillamine on thallotoxicosis].
    Igaku to seibutsugaku. Medicine and biology, 1970, Jun-10, Volume: 80, Issue:6

    Topics: Humans; Male; Methods; Middle Aged; Penicillamine; Poisoning; Spectrophotometry; Thallium

1970
Chronic copper poisoning presenting as pink disease.
    Archives of disease in childhood, 1971, Volume: 46, Issue:245

    Topics: Acrodynia; Chronic Disease; Copper; Diagnosis, Differential; Humans; Infant; Male; Penicillamine; Po

1971
Mercury vs. zinc poisoning.
    The New England journal of medicine, 1971, Sep-16, Volume: 285, Issue:12

    Topics: Adolescent; Animals; Diagnosis, Differential; Humans; Mercury Poisoning; Mice; Penicillamine; Poison

1971