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penicillamine and Nervous System Disorders

penicillamine has been researched along with Nervous System Disorders in 29 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"The occurrence of a neurologic syndrome that severely impaired a child's usual daily activities and his health-related quality of life after the institution of penicillamine therapy."7.69Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation. ( Iorio, R; Pensati, P; Porzio, S; Vajro, P; Vegnente, A, 1997)
"The occurrence of a neurologic syndrome that severely impaired a child's usual daily activities and his health-related quality of life after the institution of penicillamine therapy."3.69Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation. ( Iorio, R; Pensati, P; Porzio, S; Vajro, P; Vegnente, A, 1997)
"A case of acute lead poisoning due to intravenous injection of lead acetate is reported."3.67Acute lead intoxication due to intravenous injection. ( Doss, M; Pfeil, CH; Sixel-Dietrich, F; Solcher, H, 1985)
"Wilson's disease is a rare autosomal recessive disease of copper accumulation and copper toxicity, due to mutations in the ATP7B gene, which leads to a failure of copper excretion in the bile."2.43Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment. ( Brewer, GJ, 2005)
"Wilson disease is an autosomal recessive disease that produces a copper accumulation in many organs, initially in the liver, progressing to liver cirrhosis, and in the brain, with different neurologic symptoms."1.38[Diagnosis and care of Wilson disease with neurological revelation]. ( Bost, M; Broussolle, E; Brunet, AS; Des Portes, V; Lachaux, A; Lion-François, L; Wagner, S, 2012)
"The progression of Wilson disease (WD), a disorder of copper metabolism, can be arrested by chelation therapy."1.32Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease. ( Davie, CA; Lees, AJ; MacManus, D; Miller, DH; Miszkiel, KA; Page, RA; Schapira, AH; Walshe, JM, 2004)
"Wilson disease is an inborn error of copper metabolism that has neurological and hepatic manifestations."1.30[Neuroradiological findings in 2 cases of Wilson disease with neurological involvement]. ( Badilla, L; Barrios, A; Bravo, E; Gajewski, C; Miranda, M; Troncoso, M; Villagra, R, 1998)
"To report a case of presymptomatic Wilson's disease in a patient who became severely neurologically disabled after treatment with penicillamine and to discuss alternative initial therapy for such patients."1.29Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine. ( Brewer, GJ; Turkay, A; Yuzbaziyan-Gurkan, V, 1994)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199011 (37.93)18.7374
1990's10 (34.48)18.2507
2000's2 (6.90)29.6817
2010's5 (17.24)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Antos, A1
Członkowska, A1
Smolinski, L1
Bembenek, J1
Przybyłkowski, A1
Skowrońska, M1
Kurkowska-Jastrzębska, I1
Litwin, T1
Ranjan, A1
Kalita, J1
Kumar, V1
Misra, UK1
Dubbioso, R1
Ranucci, G1
Esposito, M1
Di Dato, F1
Topa, A1
Quarantelli, M1
Matarazzo, M1
Santoro, L1
Manganelli, F1
Iorio, R2
Lowette, KF1
Desmet, K1
Witters, P1
Laleman, W1
Verslype, C1
Nevens, F1
Fevery, J1
Cassiman, DM1
Wagner, S1
Brunet, AS1
Bost, M1
Lachaux, A1
Broussolle, E1
Des Portes, V1
Lion-François, L1
Noureen, N1
Rana, MT1
Page, RA1
Davie, CA1
MacManus, D1
Miszkiel, KA1
Walshe, JM1
Miller, DH1
Lees, AJ1
Schapira, AH1
Brewer, GJ2
Ede, RJ1
Mowat, AP1
Sánchez Rodríguez, A1
González Macías, J1
Díez Jarilla, JL1
Suquia Múgica, B1
de Portugal Alvarez, J1
Pool, KD1
Feit, H1
Kirkpatrick, J1
Gilsanz, V1
Scheinberg, IH1
Sternlieb, I1
Gross, PM1
Weaver, DF1
Bowers, RJ1
Nag, S1
Ho, LT1
Pang, JJ1
Espinosa, FJ1
Turkay, A1
Yuzbaziyan-Gurkan, V1
Mason, AL1
Marsh, W1
Alpers, DH1
Porzio, S1
Vajro, P1
Pensati, P1
Vegnente, A1
Troncoso, M1
Badilla, L1
Bravo, E1
Miranda, M1
Gajewski, C1
Barrios, A1
Villagra, R1
Zimmer, L1
Carter, DE2
Zimmer, LJ1
Shmidt, EV1
Tkachev, RA1
Markova, ED1
Kher, A1
Bharucha, BA1
Kumta, NB1
Yamamoto, M1
Akiyama, C1
Aikawa, H1
Tandan, R1
Bradley, WG1
Fillyaw, MJ1
Glass, JD1
Reich, SG1
DeLong, MR1
Sixel-Dietrich, F1
Doss, M1
Pfeil, CH1
Solcher, H1
Cumings, JN1
Levine, GB1
Mills, PE1
Epstein, WV1
Goldberg, A1
Beattie, AD1

Reviews

4 reviews available for penicillamine and Nervous System Disorders

ArticleYear
Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:10

    Topics: Copper; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Trientine

2023
Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.
    CNS drugs, 2005, Volume: 19, Issue:3

    Topics: Behavior; Chelating Agents; Enzyme Inhibitors; Hepatolenticular Degeneration; Humans; Molybdenum; Ne

2005
[Wilson's disease. II].
    Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 62, Issue:2

    Topics: Adolescent; Bone Diseases; Ceruloplasmin; Child; Copper; Eye Diseases; Female; Hematologic Diseases;

1982
[Role of lead in medicine].
    Recenti progressi in medicina, 1974, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Aged; Air Pollution; Anemia; Cardiovascular Diseases; Child; Child, Preschool; Ed

1974

Other Studies

25 other studies available for penicillamine and Nervous System Disorders

ArticleYear
MRI and oxidative stress markers in neurological worsening of Wilson disease following penicillamine.
    Neurotoxicology, 2015, Volume: 49

    Topics: Adult; Antidotes; Child; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Ne

2015
Subclinical neurological involvement does not develop if Wilson's disease is treated early.
    Parkinsonism & related disorders, 2016, Volume: 24

    Topics: Adenosine Triphosphatases; Adolescent; Adult; Analysis of Variance; Brain; Cation Transport Proteins

2016
Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine.
    European journal of gastroenterology & hepatology, 2010, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Che

2010
[Diagnosis and care of Wilson disease with neurological revelation].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2012, Volume: 19, Issue:3

    Topics: Adolescent; Brain; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liver Transplant

2012
Neurological Wilson disease in children: a three years experience from Multan.
    JPMA. The Journal of the Pakistan Medical Association, 2011, Volume: 61, Issue:8

    Topics: Adolescent; Age Distribution; Age of Onset; Astringents; Chelating Agents; Child; Child, Preschool;

2011
Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Chelation Therapy; Copper; Dipeptides;

2004
Wilson's disease: a 1984 perspective.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Adolescent; Adult; Bone and Bones; Ceruloplasmin; Child; Child, Preschool; Copper; Diagnosis, Differ

1984
Penicillamine-induced neuropathy in rheumatoid arthritis.
    Annals of internal medicine, 1981, Volume: 95, Issue:4

    Topics: Arthritis, Rheumatoid; Female; Humans; Middle Aged; Nervous System Diseases; Neural Conduction; Peni

1981
[Evolution, clinical aspects, treatment of poisoning by denatured rapeseed oil].
    Anales de la Real Academia Nacional de Medicina, 1981, Volume: 98, Issue:4

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Balneology; Cardiovascular Diseases; Child; Fatty

1981
Treatment of the neurologic manifestations of Wilson's disease.
    Archives of neurology, 1995, Volume: 52, Issue:4

    Topics: Dimercaprol; Hepatolenticular Degeneration; Humans; Molybdenum; Nervous System Diseases; Penicillami

1995
Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor.
    Neuropharmacology, 1994, Volume: 33, Issue:7

    Topics: Acid-Base Equilibrium; Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; G

1994
Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine.
    Archives of neurology, 1994, Volume: 51, Issue:3

    Topics: Adult; Hepatolenticular Degeneration; Humans; Male; Nervous System Diseases; Penicillamine

1994
Intractable neurological Wilson's disease treated with orthotopic liver transplantation.
    Digestive diseases and sciences, 1993, Volume: 38, Issue:9

    Topics: Adult; Hepatolenticular Degeneration; Humans; Liver Transplantation; Male; Nervous System Diseases;

1993
Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation.
    Archives of neurology, 1997, Volume: 54, Issue:9

    Topics: Child; Hepatolenticular Degeneration; Humans; Liver Diseases; Male; Nervous System Diseases; Penicil

1997
[Neuroradiological findings in 2 cases of Wilson disease with neurological involvement].
    Revista medica de Chile, 1998, Volume: 126, Issue:1

    Topics: Adolescent; Child; Female; Hepatolenticular Degeneration; Humans; Male; Nervous System Diseases; Pen

1998
Effects of complexing treatment administered with the onset of methyl mercury neurotoxic signs.
    Toxicology and applied pharmacology, 1979, Volume: 51, Issue:1

    Topics: Animals; Body Weight; Chelating Agents; Dimercaprol; Female; Glucuronidase; Mercury; Methylmercury C

1979
The efficacy of 2,3-dimercaptopropanol and D-penicillamine on methyl mercury induced neurological signs and weight loss.
    Life sciences, 1978, Sep-11, Volume: 23, Issue:10

    Topics: Animals; Body Weight; Dimercaprol; Female; Methylmercury Compounds; Nervous System Diseases; Penicil

1978
[Key problems of clinical neurogenetics].
    Vestnik Akademii meditsinskikh nauk SSSR, 1976, Issue:7

    Topics: Diagnosis, Differential; Drug Evaluation; Genetic Diseases, Inborn; Humans; Levodopa; Nervous System

1976
Wilson's disease: initial worsening of neurologic syndrome with penicillamine therapy.
    Indian pediatrics, 1992, Volume: 29, Issue:7

    Topics: Child; Female; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Syndro

1992
D-penicillamine-induced copper deficiency in suckling mice: neurological abnormalities and brain mitochondrial enzyme activities.
    Brain research. Developmental brain research, 1990, Aug-01, Volume: 55, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Copper; Disease Models, Animal; Electron Transport Complex IV; His

1990
Giant axonal neuropathy: studies with sulfhydryl donor compounds.
    Journal of the neurological sciences, 1990, Volume: 95, Issue:2

    Topics: Adolescent; Cells, Cultured; Female; Fibroblasts; Humans; Nervous System Diseases; Penicillamine; Su

1990
Wilson's disease. Development of neurological disease after beginning penicillamine therapy.
    Archives of neurology, 1990, Volume: 47, Issue:5

    Topics: Adult; Behavior; Brain; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Ner

1990
Acute lead intoxication due to intravenous injection.
    Human toxicology, 1985, Volume: 4, Issue:3

    Topics: Adult; Dithiothreitol; Electroencephalography; Heme; Humans; Injections, Intravenous; Lead; Lead Poi

1985
Inborn errors of metabolism in neurology (Wilson's disease, Refsum's disease and lipidoses).
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:3

    Topics: Adolescent; Adult; Cerebral Cortex; Ceruloplasmin; Cholesterol; Copper; Dimercaprol; Fatty Acids; Fe

1971
Circulating LgG globulin anti-LgG globulin complex in a patient with carcinoma of the lung and severe neuromyopathy.
    The Journal of laboratory and clinical medicine, 1967, Volume: 69, Issue:5

    Topics: Aged; Arteritis; Autoantibodies; Blood Proteins; Carcinoma, Squamous Cell; Chromatography, Gel; gamm

1967