penicillamine has been researched along with Nervous System Disorders in 29 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The occurrence of a neurologic syndrome that severely impaired a child's usual daily activities and his health-related quality of life after the institution of penicillamine therapy." | 7.69 | Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation. ( Iorio, R; Pensati, P; Porzio, S; Vajro, P; Vegnente, A, 1997) |
| "The occurrence of a neurologic syndrome that severely impaired a child's usual daily activities and his health-related quality of life after the institution of penicillamine therapy." | 3.69 | Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation. ( Iorio, R; Pensati, P; Porzio, S; Vajro, P; Vegnente, A, 1997) |
| "A case of acute lead poisoning due to intravenous injection of lead acetate is reported." | 3.67 | Acute lead intoxication due to intravenous injection. ( Doss, M; Pfeil, CH; Sixel-Dietrich, F; Solcher, H, 1985) |
| "Wilson's disease is a rare autosomal recessive disease of copper accumulation and copper toxicity, due to mutations in the ATP7B gene, which leads to a failure of copper excretion in the bile." | 2.43 | Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment. ( Brewer, GJ, 2005) |
| "Wilson disease is an autosomal recessive disease that produces a copper accumulation in many organs, initially in the liver, progressing to liver cirrhosis, and in the brain, with different neurologic symptoms." | 1.38 | [Diagnosis and care of Wilson disease with neurological revelation]. ( Bost, M; Broussolle, E; Brunet, AS; Des Portes, V; Lachaux, A; Lion-François, L; Wagner, S, 2012) |
| "The progression of Wilson disease (WD), a disorder of copper metabolism, can be arrested by chelation therapy." | 1.32 | Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease. ( Davie, CA; Lees, AJ; MacManus, D; Miller, DH; Miszkiel, KA; Page, RA; Schapira, AH; Walshe, JM, 2004) |
| "Wilson disease is an inborn error of copper metabolism that has neurological and hepatic manifestations." | 1.30 | [Neuroradiological findings in 2 cases of Wilson disease with neurological involvement]. ( Badilla, L; Barrios, A; Bravo, E; Gajewski, C; Miranda, M; Troncoso, M; Villagra, R, 1998) |
| "To report a case of presymptomatic Wilson's disease in a patient who became severely neurologically disabled after treatment with penicillamine and to discuss alternative initial therapy for such patients." | 1.29 | Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine. ( Brewer, GJ; Turkay, A; Yuzbaziyan-Gurkan, V, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 10 (34.48) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Antos, A | 1 |
| Członkowska, A | 1 |
| Smolinski, L | 1 |
| Bembenek, J | 1 |
| Przybyłkowski, A | 1 |
| Skowrońska, M | 1 |
| Kurkowska-Jastrzębska, I | 1 |
| Litwin, T | 1 |
| Ranjan, A | 1 |
| Kalita, J | 1 |
| Kumar, V | 1 |
| Misra, UK | 1 |
| Dubbioso, R | 1 |
| Ranucci, G | 1 |
| Esposito, M | 1 |
| Di Dato, F | 1 |
| Topa, A | 1 |
| Quarantelli, M | 1 |
| Matarazzo, M | 1 |
| Santoro, L | 1 |
| Manganelli, F | 1 |
| Iorio, R | 2 |
| Lowette, KF | 1 |
| Desmet, K | 1 |
| Witters, P | 1 |
| Laleman, W | 1 |
| Verslype, C | 1 |
| Nevens, F | 1 |
| Fevery, J | 1 |
| Cassiman, DM | 1 |
| Wagner, S | 1 |
| Brunet, AS | 1 |
| Bost, M | 1 |
| Lachaux, A | 1 |
| Broussolle, E | 1 |
| Des Portes, V | 1 |
| Lion-François, L | 1 |
| Noureen, N | 1 |
| Rana, MT | 1 |
| Page, RA | 1 |
| Davie, CA | 1 |
| MacManus, D | 1 |
| Miszkiel, KA | 1 |
| Walshe, JM | 1 |
| Miller, DH | 1 |
| Lees, AJ | 1 |
| Schapira, AH | 1 |
| Brewer, GJ | 2 |
| Ede, RJ | 1 |
| Mowat, AP | 1 |
| Sánchez Rodríguez, A | 1 |
| González Macías, J | 1 |
| Díez Jarilla, JL | 1 |
| Suquia Múgica, B | 1 |
| de Portugal Alvarez, J | 1 |
| Pool, KD | 1 |
| Feit, H | 1 |
| Kirkpatrick, J | 1 |
| Gilsanz, V | 1 |
| Scheinberg, IH | 1 |
| Sternlieb, I | 1 |
| Gross, PM | 1 |
| Weaver, DF | 1 |
| Bowers, RJ | 1 |
| Nag, S | 1 |
| Ho, LT | 1 |
| Pang, JJ | 1 |
| Espinosa, FJ | 1 |
| Turkay, A | 1 |
| Yuzbaziyan-Gurkan, V | 1 |
| Mason, AL | 1 |
| Marsh, W | 1 |
| Alpers, DH | 1 |
| Porzio, S | 1 |
| Vajro, P | 1 |
| Pensati, P | 1 |
| Vegnente, A | 1 |
| Troncoso, M | 1 |
| Badilla, L | 1 |
| Bravo, E | 1 |
| Miranda, M | 1 |
| Gajewski, C | 1 |
| Barrios, A | 1 |
| Villagra, R | 1 |
| Zimmer, L | 1 |
| Carter, DE | 2 |
| Zimmer, LJ | 1 |
| Shmidt, EV | 1 |
| Tkachev, RA | 1 |
| Markova, ED | 1 |
| Kher, A | 1 |
| Bharucha, BA | 1 |
| Kumta, NB | 1 |
| Yamamoto, M | 1 |
| Akiyama, C | 1 |
| Aikawa, H | 1 |
| Tandan, R | 1 |
| Bradley, WG | 1 |
| Fillyaw, MJ | 1 |
| Glass, JD | 1 |
| Reich, SG | 1 |
| DeLong, MR | 1 |
| Sixel-Dietrich, F | 1 |
| Doss, M | 1 |
| Pfeil, CH | 1 |
| Solcher, H | 1 |
| Cumings, JN | 1 |
| Levine, GB | 1 |
| Mills, PE | 1 |
| Epstein, WV | 1 |
| Goldberg, A | 1 |
| Beattie, AD | 1 |
4 reviews available for penicillamine and Nervous System Disorders
| Article | Year |
|---|---|
Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.
Topics: Copper; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Trientine | 2023 |
Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.
Topics: Behavior; Chelating Agents; Enzyme Inhibitors; Hepatolenticular Degeneration; Humans; Molybdenum; Ne | 2005 |
[Wilson's disease. II].
Topics: Adolescent; Bone Diseases; Ceruloplasmin; Child; Copper; Eye Diseases; Female; Hematologic Diseases; | 1982 |
[Role of lead in medicine].
Topics: Adolescent; Adult; Aged; Air Pollution; Anemia; Cardiovascular Diseases; Child; Child, Preschool; Ed | 1974 |
25 other studies available for penicillamine and Nervous System Disorders
| Article | Year |
|---|---|
MRI and oxidative stress markers in neurological worsening of Wilson disease following penicillamine.
Topics: Adult; Antidotes; Child; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Ne | 2015 |
Subclinical neurological involvement does not develop if Wilson's disease is treated early.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Analysis of Variance; Brain; Cation Transport Proteins | 2016 |
Wilson's disease: long-term follow-up of a cohort of 24 patients treated with D-penicillamine.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Che | 2010 |
[Diagnosis and care of Wilson disease with neurological revelation].
Topics: Adolescent; Brain; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liver Transplant | 2012 |
Neurological Wilson disease in children: a three years experience from Multan.
Topics: Adolescent; Age Distribution; Age of Onset; Astringents; Chelating Agents; Child; Child, Preschool; | 2011 |
Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Chelation Therapy; Copper; Dipeptides; | 2004 |
Wilson's disease: a 1984 perspective.
Topics: Adolescent; Adult; Bone and Bones; Ceruloplasmin; Child; Child, Preschool; Copper; Diagnosis, Differ | 1984 |
Penicillamine-induced neuropathy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Middle Aged; Nervous System Diseases; Neural Conduction; Peni | 1981 |
[Evolution, clinical aspects, treatment of poisoning by denatured rapeseed oil].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Balneology; Cardiovascular Diseases; Child; Fatty | 1981 |
Treatment of the neurologic manifestations of Wilson's disease.
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans; Molybdenum; Nervous System Diseases; Penicillami | 1995 |
Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor.
Topics: Acid-Base Equilibrium; Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; G | 1994 |
Development of neurologic symptoms in a patient with asymptomatic Wilson's disease treated with penicillamine.
Topics: Adult; Hepatolenticular Degeneration; Humans; Male; Nervous System Diseases; Penicillamine | 1994 |
Intractable neurological Wilson's disease treated with orthotopic liver transplantation.
Topics: Adult; Hepatolenticular Degeneration; Humans; Liver Transplantation; Male; Nervous System Diseases; | 1993 |
Penicillamine-related neurologic syndrome in a child affected by Wilson disease with hepatic presentation.
Topics: Child; Hepatolenticular Degeneration; Humans; Liver Diseases; Male; Nervous System Diseases; Penicil | 1997 |
[Neuroradiological findings in 2 cases of Wilson disease with neurological involvement].
Topics: Adolescent; Child; Female; Hepatolenticular Degeneration; Humans; Male; Nervous System Diseases; Pen | 1998 |
Effects of complexing treatment administered with the onset of methyl mercury neurotoxic signs.
Topics: Animals; Body Weight; Chelating Agents; Dimercaprol; Female; Glucuronidase; Mercury; Methylmercury C | 1979 |
The efficacy of 2,3-dimercaptopropanol and D-penicillamine on methyl mercury induced neurological signs and weight loss.
Topics: Animals; Body Weight; Dimercaprol; Female; Methylmercury Compounds; Nervous System Diseases; Penicil | 1978 |
[Key problems of clinical neurogenetics].
Topics: Diagnosis, Differential; Drug Evaluation; Genetic Diseases, Inborn; Humans; Levodopa; Nervous System | 1976 |
Wilson's disease: initial worsening of neurologic syndrome with penicillamine therapy.
Topics: Child; Female; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Syndro | 1992 |
D-penicillamine-induced copper deficiency in suckling mice: neurological abnormalities and brain mitochondrial enzyme activities.
Topics: Animals; Animals, Newborn; Brain; Copper; Disease Models, Animal; Electron Transport Complex IV; His | 1990 |
Giant axonal neuropathy: studies with sulfhydryl donor compounds.
Topics: Adolescent; Cells, Cultured; Female; Fibroblasts; Humans; Nervous System Diseases; Penicillamine; Su | 1990 |
Wilson's disease. Development of neurological disease after beginning penicillamine therapy.
Topics: Adult; Behavior; Brain; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Ner | 1990 |
Acute lead intoxication due to intravenous injection.
Topics: Adult; Dithiothreitol; Electroencephalography; Heme; Humans; Injections, Intravenous; Lead; Lead Poi | 1985 |
Inborn errors of metabolism in neurology (Wilson's disease, Refsum's disease and lipidoses).
Topics: Adolescent; Adult; Cerebral Cortex; Ceruloplasmin; Cholesterol; Copper; Dimercaprol; Fatty Acids; Fe | 1971 |
Circulating LgG globulin anti-LgG globulin complex in a patient with carcinoma of the lung and severe neuromyopathy.
Topics: Aged; Arteritis; Autoantibodies; Blood Proteins; Carcinoma, Squamous Cell; Chromatography, Gel; gamm | 1967 |