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penicillamine and Muscle Relaxation

penicillamine has been researched along with Muscle Relaxation in 44 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
" Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn)."1.43Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome. ( Gasheva, O; Muthuchamy, M; Zawieja, DC; Zawieja, SD, 2016)
" Copper is a catalyst for the generation of H2O2 in the presence of homocysteine and in the presence of copper, H2O2 undergoes reactions resulting in the generation of O2*-, which reacts with NO to produce peroxynitrite (ONOO-), thereby reducing the bioavailability of NO and impairing NO-mediated relaxation of CC."1.33Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit. ( Angelini, G; Jeremy, J; Koupparis, AJ; Persad, R; Shukla, N, 2006)
" Vitamin C inhibited relaxation to GTN but potentiated relaxations to NP and SNAP, causing a parallel shift to a lower concentration range of the log dose-response curve by approximately one log unit at the highest dose."1.31Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors. ( Chowienczyk, PJ; de Saram, K; Khokher, S; McNeill, KL; Ritter, JM, 2002)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19904 (9.09)18.7374
1990's31 (70.45)18.2507
2000's8 (18.18)29.6817
2010's1 (2.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zawieja, SD1
Gasheva, O1
Zawieja, DC1
Muthuchamy, M1
Che, Y1
Rand, MJ2
Li, CG2
Hamrouni, AM1
Gudka, N1
Broadley, KJ1
Koupparis, AJ1
Jeremy, J1
Angelini, G1
Persad, R1
Shukla, N1
Matsuda, NM1
Lemos, MC1
Feitosa, RL1
Edwards, JC1
Ignarro, LJ4
Hyman, AL1
Kadowitz, PJ2
Burke, TM1
Wood, KS1
Wolin, MS1
Kojda, G1
Beck, JK1
Meyer, W1
Noack, E1
Kannan, MS1
Johnson, DE1
Buga, GM2
Griscavage, JM1
Rogers, NE1
Bialecki, RA1
Stinson-Fisher, C1
Iversen, HH1
Gustafsson, LE1
Leone, AM1
Wiklund, NP1
Marks, GS2
McLaughlin, BE2
Jimmo, SL1
Poklewska-Koziell, M1
Brien, JF2
Nakatsu, K2
Irie, K1
Sadeghi-Hashjin, G1
Henricks, PA1
Folkerts, G1
Verheyen, AK1
van der Linde, HJ1
Nijkamp, FP1
De la Lande, IS1
Stafford, I1
Horowitz, JD2
Al-Sa'doni, HH1
Megson, IL1
Bisland, S1
Butler, AR1
Flitney, FW1
Carrier, GO1
Fuchs, LC1
Winecoff, AP1
Giulumian, AD1
White, RE1
Word, RA1
Cornwell, TL1
Hernández, M1
Elmedal, B1
Mulvany, MJ3
Simonsen, U3
Hennan, JK1
Diamond, J1
Plane, F1
Wiley, KE1
Jeremy, JY1
Cohen, RA1
Garland, CJ1
Grieve, DJ1
Avella, MA1
Botham, KM1
Elliott, J1
White, R2
Hiley, CR2
Guilmard, C1
Auguet, M1
Chabrier, PE1
Smith, TK1
McCarron, SL1
Ekblad, E1
Ekelund, M1
Sundler, F1
Wadsworth, RM1
Buus, NH2
Hussain, AS1
Crispino, NH1
Hjoberg, J1
Högman, M1
Hedenstierna, G1
Pilegaard, HK1
Buxton, IL1
Kaiser, RA1
Malmquist, NA1
Tichenor, S1
de Saram, K1
McNeill, KL1
Khokher, S1
Ritter, JM1
Chowienczyk, PJ1
Moon, A1
Bush, PA1
Aronson, WJ1
Rajfer, J1
Zhou, HL1
Torphy, TJ1
Hull, AD1
Long, DM1
Longo, LD1
Pearce, WJ1
Bauer, JA1
Fung, HL3
Kowaluk, EA2
Yeates, RA1
Schmid, M1
Leitold, M1
Henry, PJ1
Drummer, OH1

Other Studies

44 other studies available for penicillamine and Muscle Relaxation

ArticleYear
Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome.
    American journal of physiology. Heart and circulatory physiology, 2016, Feb-01, Volume: 310, Issue:3

    Topics: Animals; Antioxidants; Cyclic N-Oxides; Endothelium, Lymphatic; Enzyme Inhibitors; Male; Metabolic S

2016
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
    European journal of pharmacology, 2003, Feb-21, Volume: 462, Issue:1-3

    Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, D

2003
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Res

2006
Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit.
    BJU international, 2006, Volume: 98, Issue:2

    Topics: Animals; Chelating Agents; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascu

2006
The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter.
    Fundamental & clinical pharmacology, 2008, Volume: 22, Issue:3

    Topics: Aminoquinolines; Animals; Cyclic GMP; Cysteamine; Electric Stimulation; Esophageal Sphincter, Lower;

2008
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:1

    Topics: Animals; Cattle; Cyclic GMP; Female; In Vitro Techniques; Mercaptoethanol; Muscle Relaxation; Muscle

1984
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:3

    Topics: Acetylcholine; Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endotheliu

1984
Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Animals; Arginine; Cysteine; Dinoprost; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques;

1994
Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels.
    Life sciences, 1995, Volume: 56, Issue:25

    Topics: Aminoquinolines; Animals; Calcium; Charybdotoxin; Electric Stimulation; Guanylate Cyclase; Isoproter

1995
Negative feedback regulation of endothelial cell function by nitric oxide.
    Circulation research, 1993, Volume: 73, Issue:5

    Topics: Amino Acid Oxidoreductases; Animals; Aorta; Cattle; Cells, Cultured; Endothelium, Vascular; Feedback

1993
KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle.
    The American journal of physiology, 1995, Volume: 268, Issue:1 Pt 1

    Topics: Animals; Calcium; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation

1995
Smooth muscle relaxing effects of NO, nitrosothiols and a nerve-induced relaxing factor released in guinea-pig colon.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Animals; Colon; Cysteine; Electric Stimulation; Female; Guinea Pigs; Half-Life; Hydroxylamine; Hydro

1994
Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols in rat aorta and anococcygeus muscle.
    European journal of pharmacology, 1993, Sep-14, Volume: 241, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Coenzyme A; Cysteine; Glutathione; Hemoglobins; Hydroxocobalamin; In Vitro

1993
Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:11

    Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Luminescent Measurements; Male; Molsidomine; Muscle R

1995
[Nitric oxide donors and endogenous nitric oxide induced relaxation in isolated rat duodenum].
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 1995, Volume: 31, Issue:6

    Topics: Animals; Benzoates; Duodenum; Imidazoles; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smoo

1995
Bovine tracheal responsiveness in vitro: role of the epithelium and nitric oxide.
    The European respiratory journal, 1996, Volume: 9, Issue:11

    Topics: Animals; Cattle; Dinoprostone; Epithelium; Female; Histamine; In Vitro Techniques; Male; Muscle Cont

1996
Heterogeneity of glyceryl trinitrate response in isolated bovine coronary arteries.
    European journal of pharmacology, 1996, Dec-27, Volume: 318, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Cattle; Cor

1996
Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols.
    British journal of pharmacology, 1997, Volume: 121, Issue:6

    Topics: Animals; Chelating Agents; Copper; Glutathione; In Vitro Techniques; Male; Muscle Relaxation; Muscle

1997
Nitrovasodilators relax mesenteric microvessels by cGMP-induced stimulation of Ca-activated K channels.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; In Vitro Techniques; Kin

1997
Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy.
    The American journal of physiology, 1998, Volume: 274, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Down

1998
Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175.
    British journal of pharmacology, 1998, Volume: 123, Issue:5

    Topics: Albuterol; Aminoquinolines; Animals; Apamin; Bronchi; Bronchodilator Agents; Cattle; Charybdotoxin;

1998
Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increases in tissue levels of cyclic GMP.
    British journal of pharmacology, 1998, Volume: 123, Issue:5

    Topics: Animals; Arginine; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fema

1998
Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery.
    British journal of pharmacology, 1998, Volume: 123, Issue:7

    Topics: Acetylcholine; Animals; Apamin; Calcimycin; Carotid Arteries; Cell Membrane; Cyclic GMP; Glyburide;

1998
Effects of chylomicrons and chylomicron remnants on endothelium-dependent relaxation of rat aorta.
    European journal of pharmacology, 1998, May-08, Volume: 348, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Aorta; Calcimycin; Carbachol; Chylomicrons; Dose-Response Relations

1998
Modulation of relaxation to levcromakalim by S-nitroso-N-acetylpenicillamine (SNAP) and 8-bromo cyclic GMP in the rat isolated mesenteric artery.
    British journal of pharmacology, 1998, Volume: 124, Issue:6

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cromakalim; In Vitro Techniques; Male; Mesenteric A

1998
Comparison between endothelial and neuronal nitric oxide pathways in rat aorta and gastric fundus.
    Nitric oxide : biology and chemistry, 1998, Volume: 2, Issue:3

    Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro

1998
Nitric oxide modulates cholinergic reflex pathways to the longitudinal and circular muscle in the isolated guinea-pig distal colon.
    The Journal of physiology, 1998, Nov-01, Volume: 512 ( Pt 3)

    Topics: Animals; Autonomic Pathways; Colon; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Guin

1998
The actions of the cannabinoid receptor antagonist, SR 141716A, in the rat isolated mesenteric artery.
    British journal of pharmacology, 1998, Volume: 125, Issue:4

    Topics: Animals; Benzimidazoles; Calcium; Cannabinoids; Carbachol; Cromakalim; Dose-Response Relationship, D

1998
Relaxant responses of VIP and PACAP in rat ileum: receptors and adaptive supersensitivity.
    Annals of the New York Academy of Sciences, 1998, Dec-11, Volume: 865

    Topics: Animals; Colforsin; Ganglia, Autonomic; Ileum; In Vitro Techniques; Isometric Contraction; Muscle Re

1998
In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery.
    The Journal of physiology, 1999, Apr-01, Volume: 516 ( Pt 1)

    Topics: Acetylcholine; Animals; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Mesente

1999
Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Animals; Biotransformation; Cattle; In Vitro Techniques; Luminescent Measurements; Muscle Relaxation

1999
Hyperosmolarity reduces the relaxing potency of nitric oxide donors in guinea-pig trachea.
    British journal of pharmacology, 1999, Volume: 127, Issue:2

    Topics: Animals; Carbachol; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniqu

1999
Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries.
    British journal of pharmacology, 2000, Volume: 129, Issue:1

    Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Arteries; Cytochrome P-450 Enzyme System; Endot

2000
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gu

2001
Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors.
    British journal of pharmacology, 2002, Volume: 135, Issue:4

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Ascorbic Acid; Drug Interactions; Endothelium, Vascular; In

2002
Influence of nitric oxide signalling pathways on pre-contracted human detrusor smooth muscle in vitro.
    BJU international, 2002, Volume: 89, Issue:9

    Topics: Dose-Response Relationship, Drug; Evoked Potentials; Humans; Muscle Contraction; Muscle Relaxation;

2002
Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
    The Journal of urology, 1992, Volume: 147, Issue:6

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Electric Stimulation; Humans; In Vitro Tec

1992
Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Drug Synergism; Female; Guanylate Cy

1991
Chronic hypoxia alters ovine cerebrovascular reactivity and composition.
    Proceedings of the Western Pharmacology Society, 1991, Volume: 34

    Topics: Animals; Cerebrovascular Circulation; Chronic Disease; Endothelium, Vascular; Hypoxia; In Vitro Tech

1991
Chemical stabilization of a vasoactive S-nitrosothiol with cyclodextrins without loss of pharmacologic activity.
    Pharmaceutical research, 1991, Volume: 8, Issue:10

    Topics: Animals; Aorta, Thoracic; Cyclodextrins; Drug Stability; Half-Life; In Vitro Techniques; Male; Molec

1991
Dissociation of nitrovasodilator-induced relaxation from cyclic GMP levels during in vitro nitrate tolerance.
    European journal of pharmacology, 1990, Jan-25, Volume: 176, Issue:1

    Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Male; Muscle Relaxation;

1990
Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: Animals; Aorta; Cattle; Cells, Cultured; Coronary Vessels; Glutathione; Kinetics; Mercaptoethanol; M

1990
Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase.
    Biochemical pharmacology, 1989, Jun-01, Volume: 38, Issue:11

    Topics: Animals; Aorta; Glutathione; Glutathione Transferase; In Vitro Techniques; Muscle Relaxation; Nitrog

1989
S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators.
    British journal of pharmacology, 1989, Volume: 98, Issue:3

    Topics: Acetylcysteine; Animals; Ascorbic Acid; Cattle; Chromatography, High Pressure Liquid; Coronary Vesse

1989