penicillamine has been researched along with Muscle Relaxation in 44 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn)." | 1.43 | Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome. ( Gasheva, O; Muthuchamy, M; Zawieja, DC; Zawieja, SD, 2016) |
| " Copper is a catalyst for the generation of H2O2 in the presence of homocysteine and in the presence of copper, H2O2 undergoes reactions resulting in the generation of O2*-, which reacts with NO to produce peroxynitrite (ONOO-), thereby reducing the bioavailability of NO and impairing NO-mediated relaxation of CC." | 1.33 | Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit. ( Angelini, G; Jeremy, J; Koupparis, AJ; Persad, R; Shukla, N, 2006) |
| " Vitamin C inhibited relaxation to GTN but potentiated relaxations to NP and SNAP, causing a parallel shift to a lower concentration range of the log dose-response curve by approximately one log unit at the highest dose." | 1.31 | Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors. ( Chowienczyk, PJ; de Saram, K; Khokher, S; McNeill, KL; Ritter, JM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.09) | 18.7374 |
| 1990's | 31 (70.45) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zawieja, SD | 1 |
| Gasheva, O | 1 |
| Zawieja, DC | 1 |
| Muthuchamy, M | 1 |
| Che, Y | 1 |
| Rand, MJ | 2 |
| Li, CG | 2 |
| Hamrouni, AM | 1 |
| Gudka, N | 1 |
| Broadley, KJ | 1 |
| Koupparis, AJ | 1 |
| Jeremy, J | 1 |
| Angelini, G | 1 |
| Persad, R | 1 |
| Shukla, N | 1 |
| Matsuda, NM | 1 |
| Lemos, MC | 1 |
| Feitosa, RL | 1 |
| Edwards, JC | 1 |
| Ignarro, LJ | 4 |
| Hyman, AL | 1 |
| Kadowitz, PJ | 2 |
| Burke, TM | 1 |
| Wood, KS | 1 |
| Wolin, MS | 1 |
| Kojda, G | 1 |
| Beck, JK | 1 |
| Meyer, W | 1 |
| Noack, E | 1 |
| Kannan, MS | 1 |
| Johnson, DE | 1 |
| Buga, GM | 2 |
| Griscavage, JM | 1 |
| Rogers, NE | 1 |
| Bialecki, RA | 1 |
| Stinson-Fisher, C | 1 |
| Iversen, HH | 1 |
| Gustafsson, LE | 1 |
| Leone, AM | 1 |
| Wiklund, NP | 1 |
| Marks, GS | 2 |
| McLaughlin, BE | 2 |
| Jimmo, SL | 1 |
| Poklewska-Koziell, M | 1 |
| Brien, JF | 2 |
| Nakatsu, K | 2 |
| Irie, K | 1 |
| Sadeghi-Hashjin, G | 1 |
| Henricks, PA | 1 |
| Folkerts, G | 1 |
| Verheyen, AK | 1 |
| van der Linde, HJ | 1 |
| Nijkamp, FP | 1 |
| De la Lande, IS | 1 |
| Stafford, I | 1 |
| Horowitz, JD | 2 |
| Al-Sa'doni, HH | 1 |
| Megson, IL | 1 |
| Bisland, S | 1 |
| Butler, AR | 1 |
| Flitney, FW | 1 |
| Carrier, GO | 1 |
| Fuchs, LC | 1 |
| Winecoff, AP | 1 |
| Giulumian, AD | 1 |
| White, RE | 1 |
| Word, RA | 1 |
| Cornwell, TL | 1 |
| Hernández, M | 1 |
| Elmedal, B | 1 |
| Mulvany, MJ | 3 |
| Simonsen, U | 3 |
| Hennan, JK | 1 |
| Diamond, J | 1 |
| Plane, F | 1 |
| Wiley, KE | 1 |
| Jeremy, JY | 1 |
| Cohen, RA | 1 |
| Garland, CJ | 1 |
| Grieve, DJ | 1 |
| Avella, MA | 1 |
| Botham, KM | 1 |
| Elliott, J | 1 |
| White, R | 2 |
| Hiley, CR | 2 |
| Guilmard, C | 1 |
| Auguet, M | 1 |
| Chabrier, PE | 1 |
| Smith, TK | 1 |
| McCarron, SL | 1 |
| Ekblad, E | 1 |
| Ekelund, M | 1 |
| Sundler, F | 1 |
| Wadsworth, RM | 1 |
| Buus, NH | 2 |
| Hussain, AS | 1 |
| Crispino, NH | 1 |
| Hjoberg, J | 1 |
| Högman, M | 1 |
| Hedenstierna, G | 1 |
| Pilegaard, HK | 1 |
| Buxton, IL | 1 |
| Kaiser, RA | 1 |
| Malmquist, NA | 1 |
| Tichenor, S | 1 |
| de Saram, K | 1 |
| McNeill, KL | 1 |
| Khokher, S | 1 |
| Ritter, JM | 1 |
| Chowienczyk, PJ | 1 |
| Moon, A | 1 |
| Bush, PA | 1 |
| Aronson, WJ | 1 |
| Rajfer, J | 1 |
| Zhou, HL | 1 |
| Torphy, TJ | 1 |
| Hull, AD | 1 |
| Long, DM | 1 |
| Longo, LD | 1 |
| Pearce, WJ | 1 |
| Bauer, JA | 1 |
| Fung, HL | 3 |
| Kowaluk, EA | 2 |
| Yeates, RA | 1 |
| Schmid, M | 1 |
| Leitold, M | 1 |
| Henry, PJ | 1 |
| Drummer, OH | 1 |
44 other studies available for penicillamine and Muscle Relaxation
| Article | Year |
|---|---|
Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Endothelium, Lymphatic; Enzyme Inhibitors; Male; Metabolic S | 2016 |
Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle.
Topics: Animals; Aorta; Azoles; Copper; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, D | 2003 |
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Res | 2006 |
Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit.
Topics: Animals; Chelating Agents; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascu | 2006 |
The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter.
Topics: Aminoquinolines; Animals; Cyclic GMP; Cysteamine; Electric Stimulation; Esophageal Sphincter, Lower; | 2008 |
Relaxation of intrapulmonary artery and vein by nitrogen oxide-containing vasodilators and cyclic GMP.
Topics: Animals; Cattle; Cyclic GMP; Female; In Vitro Techniques; Mercaptoethanol; Muscle Relaxation; Muscle | 1984 |
Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.
Topics: Acetylcholine; Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endotheliu | 1984 |
Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium.
Topics: Animals; Arginine; Cysteine; Dinoprost; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques; | 1994 |
Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels.
Topics: Aminoquinolines; Animals; Calcium; Charybdotoxin; Electric Stimulation; Guanylate Cyclase; Isoproter | 1995 |
Negative feedback regulation of endothelial cell function by nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Cattle; Cells, Cultured; Endothelium, Vascular; Feedback | 1993 |
KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle.
Topics: Animals; Calcium; Cyclic GMP; Guinea Pigs; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation | 1995 |
Smooth muscle relaxing effects of NO, nitrosothiols and a nerve-induced relaxing factor released in guinea-pig colon.
Topics: Animals; Colon; Cysteine; Electric Stimulation; Female; Guinea Pigs; Half-Life; Hydroxylamine; Hydro | 1994 |
Differential effects of hydroxocobalamin on relaxations induced by nitrosothiols in rat aorta and anococcygeus muscle.
Topics: Animals; Aorta, Thoracic; Coenzyme A; Cysteine; Glutathione; Hemoglobins; Hydroxocobalamin; In Vitro | 1993 |
Time-dependent increase in nitric oxide formation concurrent with vasodilation induced by sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine but not by glyceryl trinitrate.
Topics: Animals; Aorta, Thoracic; In Vitro Techniques; Luminescent Measurements; Male; Molsidomine; Muscle R | 1995 |
[Nitric oxide donors and endogenous nitric oxide induced relaxation in isolated rat duodenum].
Topics: Animals; Benzoates; Duodenum; Imidazoles; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smoo | 1995 |
Bovine tracheal responsiveness in vitro: role of the epithelium and nitric oxide.
Topics: Animals; Cattle; Dinoprostone; Epithelium; Female; Histamine; In Vitro Techniques; Male; Muscle Cont | 1996 |
Heterogeneity of glyceryl trinitrate response in isolated bovine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Cattle; Cor | 1996 |
Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols.
Topics: Animals; Chelating Agents; Copper; Glutathione; In Vitro Techniques; Male; Muscle Relaxation; Muscle | 1997 |
Nitrovasodilators relax mesenteric microvessels by cGMP-induced stimulation of Ca-activated K channels.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; In Vitro Techniques; Kin | 1997 |
Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Down | 1998 |
Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175.
Topics: Albuterol; Aminoquinolines; Animals; Apamin; Bronchi; Bronchodilator Agents; Cattle; Charybdotoxin; | 1998 |
Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increases in tissue levels of cyclic GMP.
Topics: Animals; Arginine; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fema | 1998 |
Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery.
Topics: Acetylcholine; Animals; Apamin; Calcimycin; Carotid Arteries; Cell Membrane; Cyclic GMP; Glyburide; | 1998 |
Effects of chylomicrons and chylomicron remnants on endothelium-dependent relaxation of rat aorta.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcimycin; Carbachol; Chylomicrons; Dose-Response Relations | 1998 |
Modulation of relaxation to levcromakalim by S-nitroso-N-acetylpenicillamine (SNAP) and 8-bromo cyclic GMP in the rat isolated mesenteric artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cromakalim; In Vitro Techniques; Male; Mesenteric A | 1998 |
Comparison between endothelial and neuronal nitric oxide pathways in rat aorta and gastric fundus.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro | 1998 |
Nitric oxide modulates cholinergic reflex pathways to the longitudinal and circular muscle in the isolated guinea-pig distal colon.
Topics: Animals; Autonomic Pathways; Colon; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Guin | 1998 |
The actions of the cannabinoid receptor antagonist, SR 141716A, in the rat isolated mesenteric artery.
Topics: Animals; Benzimidazoles; Calcium; Cannabinoids; Carbachol; Cromakalim; Dose-Response Relationship, D | 1998 |
Relaxant responses of VIP and PACAP in rat ileum: receptors and adaptive supersensitivity.
Topics: Animals; Colforsin; Ganglia, Autonomic; Ileum; In Vitro Techniques; Isometric Contraction; Muscle Re | 1998 |
In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Mesente | 1999 |
Glyceryl trinitrate-induced vasodilation is inhibited by ultraviolet irradiation despite enhanced nitric oxide generation: evidence for formation of a nitric oxide conjugate.
Topics: Animals; Biotransformation; Cattle; In Vitro Techniques; Luminescent Measurements; Muscle Relaxation | 1999 |
Hyperosmolarity reduces the relaxing potency of nitric oxide donors in guinea-pig trachea.
Topics: Animals; Carbachol; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniqu | 1999 |
Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Arteries; Cytochrome P-450 Enzyme System; Endot | 2000 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gu | 2001 |
Divergent effects of vitamin C on relaxations of rabbit aortic rings to acetylcholine and NO-donors.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Ascorbic Acid; Drug Interactions; Endothelium, Vascular; In | 2002 |
Influence of nitric oxide signalling pathways on pre-contracted human detrusor smooth muscle in vitro.
Topics: Dose-Response Relationship, Drug; Evoked Potentials; Humans; Muscle Contraction; Muscle Relaxation; | 2002 |
Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Electric Stimulation; Humans; In Vitro Tec | 1992 |
Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Drug Synergism; Female; Guanylate Cy | 1991 |
Chronic hypoxia alters ovine cerebrovascular reactivity and composition.
Topics: Animals; Cerebrovascular Circulation; Chronic Disease; Endothelium, Vascular; Hypoxia; In Vitro Tech | 1991 |
Chemical stabilization of a vasoactive S-nitrosothiol with cyclodextrins without loss of pharmacologic activity.
Topics: Animals; Aorta, Thoracic; Cyclodextrins; Drug Stability; Half-Life; In Vitro Techniques; Male; Molec | 1991 |
Dissociation of nitrovasodilator-induced relaxation from cyclic GMP levels during in vitro nitrate tolerance.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Male; Muscle Relaxation; | 1990 |
Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Coronary Vessels; Glutathione; Kinetics; Mercaptoethanol; M | 1990 |
Antagonism of glycerol trinitrate activity by an inhibitor of glutathione S-transferase.
Topics: Animals; Aorta; Glutathione; Glutathione Transferase; In Vitro Techniques; Muscle Relaxation; Nitrog | 1989 |
S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Cattle; Chromatography, High Pressure Liquid; Coronary Vesse | 1989 |