penicillamine has been researched along with Melanoma in 12 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the role of nitric oxide (NO) in the expression of interleukin-8 (IL-8) in the human melanoma cell line, G361." | 3.69 | Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. ( Andrew, PJ; Harant, H; Lindley, IJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brozyna, AA | 1 |
| VanMiddlesworth, L | 1 |
| Slominski, AT | 1 |
| Qiao, S | 1 |
| Cabello, CM | 1 |
| Lamore, SD | 1 |
| Lesson, JL | 1 |
| Wondrak, GT | 1 |
| de Groot-Besseling, RR | 1 |
| Ruers, TJ | 1 |
| Lamers-Elemans, IL | 1 |
| Maass, CN | 1 |
| de Waal, RM | 1 |
| Westphal, JR | 1 |
| Touraine, R | 1 |
| Revuz, J | 1 |
| Dubertret, L | 1 |
| de Prost, Y | 1 |
| Guillaume, JC | 1 |
| Andrew, PJ | 1 |
| Harant, H | 1 |
| Lindley, IJ | 1 |
| Steigleder, GK | 1 |
| Zygulska-Mach, H | 1 |
| Maciejewski, Z | 1 |
| Lukiewicz, S | 1 |
| Iwasiów, B | 1 |
| Link, E | 1 |
| Birkmayer, GD | 1 |
| Balda, BR | 1 |
| Duke, PS | 1 |
| Hourani, BT | 2 |
| Demopoulos, HB | 2 |
| Jensen, OA | 1 |
| Egeberg, J | 1 |
| Edmund, J | 1 |
| Prabhakaran, K | 1 |
| Harris, EB | 1 |
| Kirchheimer, WF | 1 |
1 trial available for penicillamine and Melanoma
| Article | Year |
|---|---|
Clinical trials on chemical radiosensitization of malignant melanoma of the choroid.
Topics: Adult; Aged; Choroid Neoplasms; Clinical Trials as Topic; Edetic Acid; Female; Humans; Male; Melanom | 1979 |
11 other studies available for penicillamine and Melanoma
| Article | Year |
|---|---|
Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy.
Topics: Cell Line, Tumor; Cell Survival; Humans; Melanins; Melanoma; Melanoma, Amelanotic; Penicillamine; Ph | 2008 |
D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Endoplasmic Reticulum Chaperone | 2012 |
Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators.
Topics: Angiostatins; Animals; Antineoplastic Combined Chemotherapy Protocols; Humans; In Vitro Techniques; | 2006 |
[Present status of dermatology].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Drug Eruptions; Female; Humans; Leg Ulcer; Lit | 1980 |
Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level.
Topics: Base Sequence; Binding Sites; CCAAT-Enhancer-Binding Proteins; Cell Line; DNA Primers; DNA-Binding P | 1995 |
[Adverse effects of drugs on the skin--significance, survey and prospects].
Topics: Adrenergic beta-Antagonists; Allergens; Alopecia; Bleomycin; Drug Eruptions; Humans; Melanoma; Metho | 1978 |
[Nucleic acid and protein synthesis in hamster melanoma under the action of drugs. II. In vivo studies of protein synthesis in hamster melanoma following treatment with proflavin, chloramphenicol and D-penicillamine].
Topics: Acridines; Animals; Cell Nucleus; Chloramphenicol; Cricetinae; Melanoma; Mitochondria; Neoplasm Prot | 1970 |
Study of S91 mouse melanomas by electron paramagnetic resonance (EPR) spectroscopy and tissue culture. II. Effects of penicillamine on EPR signals and on growth in vitro.
Topics: Animals; Chromatography, Paper; Copper; Culture Techniques; Dihydroxyphenylalanine; Electron Spin Re | 1967 |
Effect on growth and structure of transplantable malignant melanomas of the Syrian golden hamster (Mesocricetus auratus) by depletion of phenylalanine and tyrosine in the diet and by inhibition of tyrosinase. Brief report.
Topics: Animals; Catechol Oxidase; Copper; Cricetinae; Cytoplasmic Granules; Diet; Genitalia; Hair; Melanocy | 1974 |
Inhibition of S-91 mouse melanoma metastases and growth by D-penicillamine.
Topics: Animals; Catechol Oxidase; Copper; Cysteine; Melanoma; Mice; Neoplasm Metastasis; Penicillamine; Tyr | 1969 |
Effect of inhibitors on phenoloxidase of Mycobacterium leprae.
Topics: Antimetabolites; Basidiomycota; Carbamates; Catechol Oxidase; Dihydroxyphenylalanine; Enzyme Repress | 1969 |