Page last updated: 2024-11-07

penicillamine and MS (Multiple Sclerosis)

penicillamine has been researched along with MS (Multiple Sclerosis) in 8 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"Twenty-three patients with the chronic progressive or intermittent relapsing form of multiple sclerosis (MS) were treated with d-penicillamine over a period from 6 weeks to 12 months."9.04Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study. ( Cendrowski, W; Czlonkowska, A, 1976)
"A pilot study of the effect of D-penicillamine in multiple sclerosis (MS) was undertaken because of D-penicillamine's activity against RNA neurotropic viruses, because it is effective against the auto-immune disease, rheumatoid arthritis, and because both viruses and autoimmunity have been implicated in multiple sclerosis."7.66Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis. ( Alba, A; Berger, AR; Rudez, A; Seelig, MS; Tarlau, M, 1978)
"It has been suggested that lead may be a cause of multiple sclerosis, but confirmation of this hypothesis is difficult to obtain as lead is so widely present both in the environment and in many human tissues."7.65Lead and multiple sclerosis. ( , 1976)
"Twenty-three patients with the chronic progressive or intermittent relapsing form of multiple sclerosis (MS) were treated with d-penicillamine over a period from 6 weeks to 12 months."5.04Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study. ( Cendrowski, W; Czlonkowska, A, 1976)
"A pilot study of the effect of D-penicillamine in multiple sclerosis (MS) was undertaken because of D-penicillamine's activity against RNA neurotropic viruses, because it is effective against the auto-immune disease, rheumatoid arthritis, and because both viruses and autoimmunity have been implicated in multiple sclerosis."3.66Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis. ( Alba, A; Berger, AR; Rudez, A; Seelig, MS; Tarlau, M, 1978)
"It has been suggested that lead may be a cause of multiple sclerosis, but confirmation of this hypothesis is difficult to obtain as lead is so widely present both in the environment and in many human tissues."3.65Lead and multiple sclerosis. ( , 1976)
"The diagnosis of MS preceded that of Wilson's disease and was relatively mild in course."2.82Rare co-occurrence of multiple sclerosis and Wilson's disease - case report. ( Despotov, K; Klivényi, P; Nagy, I; Pálvölgyi, A; Rajda, C; Vécsei, L, 2022)
"Multiple sclerosis is a chronic inflammatory disease of the CNS leading to focal destruction of myelin, still the earliest changes that lead to lesion formation are not known."1.32Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. ( Graumann, U; Reynolds, R; Schaeren-Wiemers, N; Steck, AJ, 2003)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Despotov, K1
Klivényi, P1
Nagy, I1
Pálvölgyi, A1
Vécsei, L1
Rajda, C1
Graumann, U1
Reynolds, R1
Steck, AJ1
Schaeren-Wiemers, N1
Norga, K1
Paemen, L1
Masure, S1
Dillen, C1
Heremans, H1
Billiau, A1
Carton, H2
Cuzner, L1
Olsson, T1
Van Damme, J1
Dubois, B1
D'Hooghe, MB1
De Lepeleire, K1
Ketelaer, P1
Opdenakker, G1
Lodemann, E1
Seelig, MS1
Alba, A1
Berger, AR1
Rudez, A1
Tarlau, M1
Cendrowski, W1
Czlonkowska, A1

Reviews

1 review available for penicillamine and MS (Multiple Sclerosis)

ArticleYear
Rare co-occurrence of multiple sclerosis and Wilson's disease - case report.
    BMC neurology, 2022, May-16, Volume: 22, Issue:1

    Topics: Copper; Hepatolenticular Degeneration; Humans; Multiple Sclerosis; Penicillamine; Quality of Life

2022

Trials

2 trials available for penicillamine and MS (Multiple Sclerosis)

ArticleYear
Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis.
    Multiple sclerosis (Houndmills, Basingstoke, England), 1998, Volume: 4, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Double-Blind Method; Drug Therapy, Combination;

1998
Penicillamine in multiple sclerosis. Therapeutic trial and design of uncontrolled pilot drug study.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3

    Topics: Adult; Ageusia; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Dyspepsia; Erythema; Fem

1976

Other Studies

5 other studies available for penicillamine and MS (Multiple Sclerosis)

ArticleYear
Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult.
    Brain pathology (Zurich, Switzerland), 2003, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aurora Kinases; Bl

2003
Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:12

    Topics: Acute Disease; Animals; Blotting, Northern; Chronic Disease; Collagenases; Encephalomyelitis, Autoim

1995
[D-Penacillamine. From constituent of penicillins to significant drug].
    Die Naturwissenschaften, 1979, Volume: 66, Issue:9

    Topics: Arthritis, Rheumatoid; Cystinuria; Hepatitis; Hepatolenticular Degeneration; Humans; Multiple Sclero

1979
Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:2

    Topics: Adult; Autoimmune Diseases; Brain; Dose-Response Relationship, Drug; Female; Humans; Magnesium; Male

1978
Lead and multiple sclerosis.
    The Journal of the Royal College of General Practitioners, 1976, Volume: 26, Issue:169

    Topics: Female; Humans; Lead; Lead Poisoning; Male; Multiple Sclerosis; Penicillamine

1976