Page last updated: 2024-11-07

penicillamine and Liver Failure, Acute

penicillamine has been researched along with Liver Failure, Acute in 9 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.

Research Excerpts

ExcerptRelevanceReference
"Consideration of a diagnosis of Wilson disease is still the critical factor in testing for and establishing disease diagnosis."2.55Wilson Disease: Diagnosis, Treatment, and Follow-up. ( Schilsky, ML, 2017)
"Four patients presented with acute liver failure, four with persistently elevated liver function tests, and two with decompensated cirrhosis; none had neurological manifestations."1.48Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre. ( Ferenci, P; Fraga, M; Giostra, E; Hiroz, P; Moradpour, D; Saldarriaga, J; Sempoux, C; Vieira Barbosa, J, 2018)
"We conclude that Wilson's disease may be a good indication for LTX for both neurological manifestation with stable liver function and hepatic manifestation with cirrhosis or acute liver failure."1.30Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease. ( Bechstein, WO; Becker, M; Luck, W; Mueller, AR; Neuhaus, P; Neuhaus, R; Platz, KP; Schuelke, M; Schumacher, G; Steinmüller, T, 1997)
"In child B acute liver failure developed despite initiation of treatment."1.30Treatment of copper associated liver disease in childhood. ( Kardoff, R; Melter, M; Rodeck, B, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Proost, R1
Cassiman, D1
Levtchenko, E1
Morava-Kozicz, E1
Neirynck, J1
Witters, P1
Schilsky, ML1
Damsgaard, J1
Larsen, FS1
Ytting, H1
Vieira Barbosa, J1
Fraga, M1
Saldarriaga, J1
Hiroz, P1
Giostra, E1
Sempoux, C1
Ferenci, P1
Moradpour, D1
Oosthuizen, NM1
Rodríguez Fariña, E1
Tremosa Llurba, G1
Xiol Quingles, X1
Lores Obradors, A1
Castellote Alonso, J1
Gornals Soler, JB1
López Núñez, C1
Schumacher, G1
Platz, KP1
Mueller, AR1
Neuhaus, R1
Steinmüller, T1
Bechstein, WO1
Becker, M1
Luck, W1
Schuelke, M1
Neuhaus, P1
Rodeck, B1
Kardoff, R1
Melter, M1
Takahashi, A1
Suzuki, T1
Shishido, S1
Tojo, J1
Ito, O1
Kazuta, Y1
Watanabe, H1
Ishikawa, H1
Ohira, H1
Obara, K1
Kasukawa, R1

Reviews

2 reviews available for penicillamine and Liver Failure, Acute

ArticleYear
Fulminant Wilson Disease in Children: Recovery After Plasma Exchange Without Transplantation.
    Journal of pediatric gastroenterology and nutrition, 2020, Volume: 71, Issue:6

    Topics: Adolescent; Child; Female; Hepatolenticular Degeneration; Humans; Liver Failure, Acute; Liver Transp

2020
Wilson Disease: Diagnosis, Treatment, and Follow-up.
    Clinics in liver disease, 2017, Volume: 21, Issue:4

    Topics: Aftercare; Biopsy; Ceruloplasmin; Chelating Agents; Copper; Copper-Transporting ATPases; Disease Man

2017

Other Studies

7 other studies available for penicillamine and Liver Failure, Acute

ArticleYear
Reversal of Acute Liver Failure Due to Wilson Disease by a Regimen of High-Volume Plasma Exchange and Penicillamine.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:4

    Topics: Adult; Chelating Agents; Hepatolenticular Degeneration; Humans; Liver Failure, Acute; Male; Penicill

2019
Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.
    Swiss medical weekly, 2018, 12-17, Volume: 148

    Topics: Adult; Chelating Agents; Copper; Copper-Transporting ATPases; Female; Hepatolenticular Degeneration;

2018
Undetectable serum alkaline phosphatase activity in a patient with fulminant hepatic failure and hemolytic anemia.
    Clinical chemistry, 2011, Volume: 57, Issue:3

    Topics: Adult; Alkaline Phosphatase; Anemia, Hemolytic; Chelating Agents; Copper; Diagnosis, Differential; F

2011
D-penicillamine and plasmapheresis in acute liver failure secondary to Wilson's disease.
    Revista espanola de enfermedades digestivas, 2003, Volume: 95, Issue:1

    Topics: Adult; Anemia, Hemolytic; Biopsy; Ceruloplasmin; Chelating Agents; Copper; Female; Follow-Up Studies

2003
Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease.
    Clinical transplantation, 1997, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Anemia, Hemolytic; Ataxia; Chelating Agents; Deglutition Disorders; Dysarthria; D

1997
Treatment of copper associated liver disease in childhood.
    European journal of medical research, 1999, Jun-28, Volume: 4, Issue:6

    Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Drinking; Germany; Humans; Infant;

1999
[Two recovery cases of Wilson's disease initiated with severe hemolysis and acute hepatic failure].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2000, Volume: 97, Issue:6

    Topics: Adolescent; Anemia, Hemolytic; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Live

2000