penicillamine has been researched along with Liver Failure, Acute in 9 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Consideration of a diagnosis of Wilson disease is still the critical factor in testing for and establishing disease diagnosis." | 2.55 | Wilson Disease: Diagnosis, Treatment, and Follow-up. ( Schilsky, ML, 2017) |
| "Four patients presented with acute liver failure, four with persistently elevated liver function tests, and two with decompensated cirrhosis; none had neurological manifestations." | 1.48 | Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre. ( Ferenci, P; Fraga, M; Giostra, E; Hiroz, P; Moradpour, D; Saldarriaga, J; Sempoux, C; Vieira Barbosa, J, 2018) |
| "We conclude that Wilson's disease may be a good indication for LTX for both neurological manifestation with stable liver function and hepatic manifestation with cirrhosis or acute liver failure." | 1.30 | Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease. ( Bechstein, WO; Becker, M; Luck, W; Mueller, AR; Neuhaus, P; Neuhaus, R; Platz, KP; Schuelke, M; Schumacher, G; Steinmüller, T, 1997) |
| "In child B acute liver failure developed despite initiation of treatment." | 1.30 | Treatment of copper associated liver disease in childhood. ( Kardoff, R; Melter, M; Rodeck, B, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Proost, R | 1 |
| Cassiman, D | 1 |
| Levtchenko, E | 1 |
| Morava-Kozicz, E | 1 |
| Neirynck, J | 1 |
| Witters, P | 1 |
| Schilsky, ML | 1 |
| Damsgaard, J | 1 |
| Larsen, FS | 1 |
| Ytting, H | 1 |
| Vieira Barbosa, J | 1 |
| Fraga, M | 1 |
| Saldarriaga, J | 1 |
| Hiroz, P | 1 |
| Giostra, E | 1 |
| Sempoux, C | 1 |
| Ferenci, P | 1 |
| Moradpour, D | 1 |
| Oosthuizen, NM | 1 |
| Rodríguez Fariña, E | 1 |
| Tremosa Llurba, G | 1 |
| Xiol Quingles, X | 1 |
| Lores Obradors, A | 1 |
| Castellote Alonso, J | 1 |
| Gornals Soler, JB | 1 |
| López Núñez, C | 1 |
| Schumacher, G | 1 |
| Platz, KP | 1 |
| Mueller, AR | 1 |
| Neuhaus, R | 1 |
| Steinmüller, T | 1 |
| Bechstein, WO | 1 |
| Becker, M | 1 |
| Luck, W | 1 |
| Schuelke, M | 1 |
| Neuhaus, P | 1 |
| Rodeck, B | 1 |
| Kardoff, R | 1 |
| Melter, M | 1 |
| Takahashi, A | 1 |
| Suzuki, T | 1 |
| Shishido, S | 1 |
| Tojo, J | 1 |
| Ito, O | 1 |
| Kazuta, Y | 1 |
| Watanabe, H | 1 |
| Ishikawa, H | 1 |
| Ohira, H | 1 |
| Obara, K | 1 |
| Kasukawa, R | 1 |
2 reviews available for penicillamine and Liver Failure, Acute
| Article | Year |
|---|---|
Fulminant Wilson Disease in Children: Recovery After Plasma Exchange Without Transplantation.
Topics: Adolescent; Child; Female; Hepatolenticular Degeneration; Humans; Liver Failure, Acute; Liver Transp | 2020 |
Wilson Disease: Diagnosis, Treatment, and Follow-up.
Topics: Aftercare; Biopsy; Ceruloplasmin; Chelating Agents; Copper; Copper-Transporting ATPases; Disease Man | 2017 |
7 other studies available for penicillamine and Liver Failure, Acute
| Article | Year |
|---|---|
Reversal of Acute Liver Failure Due to Wilson Disease by a Regimen of High-Volume Plasma Exchange and Penicillamine.
Topics: Adult; Chelating Agents; Hepatolenticular Degeneration; Humans; Liver Failure, Acute; Male; Penicill | 2019 |
Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.
Topics: Adult; Chelating Agents; Copper; Copper-Transporting ATPases; Female; Hepatolenticular Degeneration; | 2018 |
Undetectable serum alkaline phosphatase activity in a patient with fulminant hepatic failure and hemolytic anemia.
Topics: Adult; Alkaline Phosphatase; Anemia, Hemolytic; Chelating Agents; Copper; Diagnosis, Differential; F | 2011 |
D-penicillamine and plasmapheresis in acute liver failure secondary to Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Biopsy; Ceruloplasmin; Chelating Agents; Copper; Female; Follow-Up Studies | 2003 |
Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease.
Topics: Adolescent; Adult; Anemia, Hemolytic; Ataxia; Chelating Agents; Deglutition Disorders; Dysarthria; D | 1997 |
Treatment of copper associated liver disease in childhood.
Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Drinking; Germany; Humans; Infant; | 1999 |
[Two recovery cases of Wilson's disease initiated with severe hemolysis and acute hepatic failure].
Topics: Adolescent; Anemia, Hemolytic; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Live | 2000 |