penicillamine has been researched along with Liver Cirrhosis in 114 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 9.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| "To report a case of early-decompensated liver cirrhosis secondary to discontinuation of penicillamine therapy in a patient with Wilson's disease." | 7.74 | Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease. ( Awaisu, A; Aziz, NA; Ghazali, R; Hassan, Y; Ping, CC, 2007) |
| "Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC." | 6.69 | Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis. ( Angulo, P; Batts, KP; Dickson, ER; Jorgensen, RA; Lindor, KD; Therneau, TM, 1999) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 6.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 5.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 5.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| "Controlled trial of D-penicillamine was carried out with low dosis in 10 patients with chronic persistent hepatitis, 11 patients with chronic aggressive hepatitis and 7 patients with liver cirrhosis." | 5.05 | Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases. ( Imura, H; Ito, K; Miyamura, M; Nakano, H; Ohnishi, S; Sugiyama, T; Yamamoto, Y, 1980) |
| "To report a case of early-decompensated liver cirrhosis secondary to discontinuation of penicillamine therapy in a patient with Wilson's disease." | 3.74 | Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease. ( Awaisu, A; Aziz, NA; Ghazali, R; Hassan, Y; Ping, CC, 2007) |
| "Cyclic GMP (cGMP) concentration is increased in plasma of patients with liver cirrhosis." | 3.73 | Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. ( Del Olmo, JA; Felipo, V; Kosenko, E; Montoliu, C; Rodrigo, JM; Serra, MA, 2005) |
| "Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC." | 2.69 | Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis. ( Angulo, P; Batts, KP; Dickson, ER; Jorgensen, RA; Lindor, KD; Therneau, TM, 1999) |
| "Most patients with Wilson disease become symptomatic between the ages of 6 and 15." | 2.41 | [Rare, but important chronic liver diseases]. ( Maier, KP, 2002) |
| "According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 2.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
| "The mortality of liver cirrhosis has doubled during the past two decades and is still increasing in most of the European countries." | 2.36 | [Liver fibrosis. 2]. ( Hahn, EG; Martini, GA; Ott, U, 1980) |
| "The patient was diagnosed with liver cirrhosis 6 years prior based on outside hospital ultrasound and liver biopsy." | 1.72 | Wilson's disease: neuropsychiatric presentation and delayed diagnosis. ( Alick-Lindstrom, S; Deme, P; Sheffield, A, 2022) |
| "Four patients presented with acute liver failure, four with persistently elevated liver function tests, and two with decompensated cirrhosis; none had neurological manifestations." | 1.48 | Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre. ( Ferenci, P; Fraga, M; Giostra, E; Hiroz, P; Moradpour, D; Saldarriaga, J; Sempoux, C; Vieira Barbosa, J, 2018) |
| "Sixty patients with liver fibrosis induced by hepatolenticular degeneration were randomly divided into two groups, a penicillamine group and a BMSCs plus penicillamine group, with 30 patients in each." | 1.46 | A clinical study of bone mesenchymal stem cells for the treatment of hepatic fibrosis induced by hepatolenticular degeneration. ( Zhang, D, 2017) |
| "Wilson disease is a disorder of copper metabolism characterized by copper overload." | 1.35 | Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease. ( Bahador, A; Dehghani, M; Dehghani, SM; Geramizadeh, B; Kakaei, F; Kazemi, K; Malek-Hosseini, SA; Nikeghbalian, S; Reza Nejatollahi, SM; Salahi, H, 2008) |
| "Evaluation of minimal hepatic encephalopathy (MHE) in cirrhotic patients would have prognostic value." | 1.34 | Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. ( del Olmo, JA; Felipo, V; Ferrandez, A; Montoliu, C; Piedrafita, B; Rodrigo, JM; Serra, MA, 2007) |
| "A case of a patient is reported in whom Wilson's disease presented in debut with a picture of decompensated liver cirrhosis and immune thrombocytopania complicated by recurrent hemorrhagic syndrome." | 1.32 | [Wilson's disease and secondary copper hemochromatoses in hematological practice]. ( Levina, AA; Lukina, EA; Solov'eva, TI; Sysoeva, EP; Vorob'ev, AI, 2004) |
| "We conclude that Wilson's disease may be a good indication for LTX for both neurological manifestation with stable liver function and hepatic manifestation with cirrhosis or acute liver failure." | 1.30 | Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease. ( Bechstein, WO; Becker, M; Luck, W; Mueller, AR; Neuhaus, P; Neuhaus, R; Platz, KP; Schuelke, M; Schumacher, G; Steinmüller, T, 1997) |
| "Major depressive disorder was the first clinical manifestation at the age of 38 years." | 1.30 | Psychiatric symptoms as late onset of Wilson's disease: neuroradiological findings, clinical features and treatment. ( Bergamasco, B; Crasto, S; Keller, R; Lagget, M; Torta, R, 1999) |
| "A patient with untreated Wilson's disease showed the possibility of fetal liver damage and copper accumulation in the placenta by this disease." | 1.29 | Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease. ( Anai, T; Inoue, I; Matsui, N; Miyakawa, I; Oga, M; Yoshimatsu, J, 1993) |
| "The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 1.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
| "Twenty of 320 patients with Wilson's disease initially presented with chemical and laboratory features of chronic active hepatitis, confirmed histologically in 17." | 1.28 | Prognosis of Wilsonian chronic active hepatitis. ( Scheinberg, IH; Schilsky, ML; Sternlieb, I, 1991) |
| "Oral zinc therapy in Wilson's Disease may be regarded as an alternative to D-Penicillamine treatment when this drug has to be discontinued because of side effects." | 1.27 | [Oral zinc in Wilson disease--an alternative to D-penicillamine]. ( Dormeyer, HH; Hütteroth, T; Keidl, E; Manns, M; Meyer zum Büschenfelde, KH; Ramadori, G, 1985) |
| "During childhood, Wilson's disease becomes manifest mostly in the hepatic form." | 1.26 | [Morbus Wilson--pathogenesis, diagnosis, therapy, and course (author's transl)]. ( Helwig, H; Werner, JP, 1977) |
| "Thus, since Wilson's disease may present with chronic active hepatitis or cirrhosis with a normal ESR and without ocular or neurologic signs, it may be a more common cause of liver disease in young people than has been appreciated." | 1.26 | Wilson's disease: a common liver disorder? ( Barr, R; Hyslop, PS; Sass-Kortsak, A; Thompson, WG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (64.04) | 18.7374 |
| 1990's | 17 (14.91) | 18.2507 |
| 2000's | 11 (9.65) | 29.6817 |
| 2010's | 12 (10.53) | 24.3611 |
| 2020's | 1 (0.88) | 2.80 |
| Authors | Studies |
|---|---|
| Deme, P | 1 |
| Sheffield, A | 1 |
| Alick-Lindstrom, S | 1 |
| Vieira Barbosa, J | 1 |
| Fraga, M | 1 |
| Saldarriaga, J | 1 |
| Hiroz, P | 1 |
| Giostra, E | 1 |
| Sempoux, C | 1 |
| Ferenci, P | 1 |
| Moradpour, D | 1 |
| Gerosa, C | 1 |
| Fanni, D | 2 |
| Congiu, T | 1 |
| Piras, M | 1 |
| Cau, F | 1 |
| Moi, M | 1 |
| Faa, G | 2 |
| Idrissi, ML | 1 |
| Babakhoya, A | 1 |
| Khabbache, K | 1 |
| Souilmi, F | 1 |
| Benmiloud, S | 1 |
| Abourrazak, S | 1 |
| Chaouki, S | 1 |
| Atmani, S | 1 |
| Bouharrou, A | 1 |
| Hida, M | 1 |
| Mareček, Z | 1 |
| Brůha, R | 1 |
| Fieten, H | 2 |
| Penning, LC | 1 |
| Leegwater, PA | 2 |
| Rothuizen, J | 2 |
| Zhang, D | 1 |
| Kazemi, K | 1 |
| Geramizadeh, B | 1 |
| Nikeghbalian, S | 1 |
| Salahi, H | 1 |
| Bahador, A | 1 |
| Reza Nejatollahi, SM | 1 |
| Dehghani, SM | 1 |
| Dehghani, M | 1 |
| Kakaei, F | 1 |
| Malek-Hosseini, SA | 1 |
| Seo, JY | 1 |
| Kim, SY | 1 |
| Choi, WC | 1 |
| Cocco, GA | 1 |
| Loudianos, G | 2 |
| Pes, GM | 1 |
| Tolu, F | 1 |
| Lepori, MB | 2 |
| Barrocu, M | 1 |
| Sechi, GP | 1 |
| Cope-Yokoyama, S | 1 |
| Finegold, MJ | 2 |
| Sturniolo, GC | 1 |
| Kim, K | 1 |
| Mescoli, C | 1 |
| Rugge, M | 1 |
| Medici, V | 1 |
| Roy, DN | 1 |
| Sen, G | 1 |
| Chowdhury, KD | 1 |
| Biswas, T | 1 |
| Gucev, ZS | 1 |
| Pop-Jordanova, N | 1 |
| Calovska, V | 1 |
| Tasic, V | 1 |
| Slavevska, N | 1 |
| Laban, N | 1 |
| Noli, MC | 1 |
| Moores, A | 1 |
| Fox, S | 1 |
| Lang, A | 1 |
| Hirschfield, GM | 1 |
| Sini, M | 1 |
| Sorbello, O | 1 |
| Sanna, F | 1 |
| Battolu, F | 1 |
| Civolani, A | 1 |
| Demelia, L | 1 |
| Dirksen, K | 1 |
| van den Ingh, TS | 1 |
| Winter, EA | 1 |
| Watson, AL | 1 |
| Maier, KP | 1 |
| Rakhimova, OIu | 1 |
| Rozina, TP | 1 |
| Ignatova, TM | 1 |
| STERNLIEB, I | 3 |
| Mandrekar, SJ | 1 |
| Mandrekar, JN | 1 |
| Vorob'ev, AI | 1 |
| Lukina, EA | 1 |
| Sysoeva, EP | 1 |
| Levina, AA | 1 |
| Solov'eva, TI | 1 |
| Montoliu, C | 2 |
| Kosenko, E | 1 |
| Del Olmo, JA | 2 |
| Serra, MA | 2 |
| Rodrigo, JM | 2 |
| Felipo, V | 2 |
| Piedrafita, B | 1 |
| Ferrandez, A | 1 |
| Ping, CC | 1 |
| Hassan, Y | 1 |
| Aziz, NA | 1 |
| Ghazali, R | 1 |
| Awaisu, A | 1 |
| Hauftová, D | 1 |
| Hartl, J | 1 |
| Slavícek, J | 1 |
| Valach, V | 1 |
| Fialová, J | 1 |
| Pojerová, M | 1 |
| Hahn, EG | 1 |
| Ott, U | 1 |
| Martini, GA | 1 |
| Paumgartner, G | 1 |
| Ferraccioli, GF | 1 |
| Baldini, A | 1 |
| Ambanelli, U | 1 |
| Berg, PA | 1 |
| Marcus, SN | 1 |
| Chadwick, D | 1 |
| Walker, RJ | 1 |
| Nakano, H | 1 |
| Ohnishi, S | 1 |
| Sugiyama, T | 1 |
| Miyamura, M | 1 |
| Imura, H | 1 |
| Yamamoto, Y | 1 |
| Ito, K | 1 |
| Weinzierl, M | 1 |
| Kruis, W | 1 |
| Eisenburg, J | 2 |
| Mörl, M | 3 |
| Thierman-Duffaud, D | 1 |
| Lévy, VG | 1 |
| Pigrau Serrallach, C | 1 |
| Pahissa Berga, A | 1 |
| Clotet Sala, B | 1 |
| Guardia Massó, J | 1 |
| Gichev, IuP | 1 |
| Bakulina, LF | 1 |
| Pradhan, AM | 3 |
| Bhave, SA | 3 |
| Joshi, VV | 1 |
| Bavdekar, AR | 2 |
| Pandit, AN | 3 |
| Tanner, MS | 6 |
| Horslen, SP | 1 |
| Lyon, TD | 1 |
| Fell, GS | 1 |
| Lowry, MF | 1 |
| Oga, M | 1 |
| Matsui, N | 1 |
| Anai, T | 1 |
| Yoshimatsu, J | 1 |
| Inoue, I | 1 |
| Miyakawa, I | 1 |
| Schumacher, G | 1 |
| Platz, KP | 1 |
| Mueller, AR | 1 |
| Neuhaus, R | 1 |
| Steinmüller, T | 1 |
| Bechstein, WO | 1 |
| Becker, M | 1 |
| Luck, W | 1 |
| Schuelke, M | 1 |
| Neuhaus, P | 1 |
| Angulo, P | 2 |
| Batts, KP | 2 |
| Therneau, TM | 2 |
| Jorgensen, RA | 1 |
| Dickson, ER | 1 |
| Lindor, KD | 2 |
| Larson, DR | 1 |
| LaRusso, NF | 1 |
| Keller, R | 1 |
| Torta, R | 1 |
| Lagget, M | 1 |
| Crasto, S | 1 |
| Bergamasco, B | 1 |
| Svegliati-Baroni, G | 1 |
| Saccomanno, S | 1 |
| van Goor, H | 1 |
| Jansen, P | 1 |
| Benedetti, A | 1 |
| Moshage, H | 1 |
| Kuntz, HD | 1 |
| May, B | 1 |
| Ulmer, WT | 1 |
| Mezey, E | 1 |
| Potter, JJ | 1 |
| Iber, FL | 2 |
| Maddrey, WC | 1 |
| Wallnöfer, H | 1 |
| Jackson, DS | 1 |
| Friedrich, K | 1 |
| Henning, H | 1 |
| Nisman, RM | 1 |
| Ganderson, AP | 1 |
| Vlahcevic, ZR | 1 |
| Gregory, DH | 1 |
| Talke, H | 1 |
| Werner, JP | 1 |
| Helwig, H | 1 |
| Thaler, H | 1 |
| Szepesi, T | 1 |
| Szepesi, G | 1 |
| Pusch, JH | 1 |
| Ullmann, W | 1 |
| Gabriel, L | 1 |
| Thompson, WG | 1 |
| Hyslop, PS | 1 |
| Barr, R | 1 |
| Sass-Kortsak, A | 1 |
| Davcev, P | 1 |
| Vanovski, B | 1 |
| Bidikov, V | 1 |
| Moritz, AJ | 1 |
| Bielawski, W | 1 |
| Kaszewska-Jablońska, I | 1 |
| Górski, M | 1 |
| Adamson, M | 1 |
| Reiner, B | 1 |
| Olson, JL | 1 |
| Goodman, Z | 1 |
| Plotnick, L | 1 |
| Bernardini, I | 1 |
| Gahl, WA | 1 |
| Schaff, Z | 2 |
| Lapis, K | 2 |
| Szende, B | 2 |
| Jeney, A | 2 |
| Gergely, P | 2 |
| Simon, K | 2 |
| Divald, A | 2 |
| Timár, F | 2 |
| Major, J | 2 |
| Singh, S | 2 |
| Kohli, V | 1 |
| Johnson, PJ | 1 |
| Williams, R | 1 |
| Schilsky, ML | 1 |
| Scheinberg, IH | 1 |
| Bhusnurmath, SR | 1 |
| Walia, BN | 1 |
| Parkash, D | 1 |
| Radotra, BD | 1 |
| Nath, R | 1 |
| Gonzales Cabello, R | 1 |
| Walshe, JM | 1 |
| Dixon, AK | 1 |
| Barrow, L | 1 |
| Tarantino, G | 1 |
| Guardascione, AM | 1 |
| Rossi, A | 1 |
| Carandente, B | 1 |
| Ciccarelli, AF | 1 |
| De Michele, NG | 1 |
| De Rosa, G | 1 |
| Pannain, M | 1 |
| Camus, JP | 1 |
| Koeger, AC | 1 |
| Last, JA | 1 |
| Manghani, DK | 1 |
| Dastur, DK | 1 |
| Ramadori, G | 1 |
| Keidl, E | 1 |
| Hütteroth, T | 1 |
| Dormeyer, HH | 1 |
| Manns, M | 1 |
| Meyer zum Büschenfelde, KH | 1 |
| Elmes, ME | 1 |
| Levi, AJ | 1 |
| Sherlock, S | 2 |
| Scheuer, PJ | 1 |
| Cumings, JN | 1 |
| Smallwood, RA | 1 |
| Williams, HA | 1 |
| Rosenoer, VM | 1 |
| Danks, DM | 1 |
| Stevens, BJ | 1 |
| Alexander, M | 2 |
| Wille, G | 1 |
| Wildhirt, E | 1 |
| Henrich, M | 1 |
| Bannaski, H | 1 |
| Furrer, HU | 1 |
| Tönz, O | 1 |
| Scheiffarth, F | 1 |
| Lössner, J | 1 |
| Eichner, B | 1 |
| Bachmann, H | 1 |
| Biesold, D | 1 |
| Günther, K | 1 |
| Thomas, M | 1 |
| Schnack, H | 2 |
| Resnick, RH | 1 |
| Boitnott, J | 1 |
| Makopour, H | 1 |
| Cerda, JJ | 1 |
| Markoff, N | 1 |
| Gros, H | 1 |
| Zwirner, K | 1 |
| Herzog, W | 1 |
| Lynch, RE | 1 |
| Lee, GR | 1 |
| Cartwright, GE | 1 |
| Albukerk, JN | 1 |
| Grasedyck, K | 1 |
| Jarstorff, G | 1 |
| Trux, F | 1 |
| Hansen, HJ | 1 |
| Andersen, OS | 2 |
| Blattner, RJ | 1 |
| Bickel, H | 1 |
| Becker, K | 1 |
| Falkmer, S | 1 |
| Samuelson, G | 1 |
| Sjölin, S | 1 |
| Brailski, C | 1 |
| Kolarski, V | 1 |
| Krastev, I | 1 |
| Leu, ML | 1 |
| Strickland, GT | 2 |
| Gutman, RA | 1 |
| Lange, J | 1 |
| Schumacher, K | 1 |
| Witscher, HP | 1 |
| Slovis, TL | 1 |
| Dubois, RS | 1 |
| Rodgerson, DO | 1 |
| Silverman, A | 1 |
| O'Reilly, S | 1 |
| Weber, PM | 1 |
| Beckner, WM | 1 |
| Shipley, L | 1 |
| Boudin, G | 1 |
| Pépin, B | 1 |
| Milhaud, M | 1 |
| Jérome, H | 1 |
| Pacilly, A | 1 |
| Hansen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Security of Bezafibrate in Patients With Primary Biliary Cirrhosis Without Biochemical Response to Ursodeoxycholic Acid: A Randomized, Double-blind, Placebo-controlled Trial[NCT02937012] | Phase 3 | 34 participants (Anticipated) | Interventional | 2016-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for penicillamine and Liver Cirrhosis
| Article | Year |
|---|---|
Liver pathology in Wilson's disease: From copper overload to cirrhosis.
Topics: Copper; Copper-Transporting ATPases; Epigenesis, Genetic; Hepatolenticular Degeneration; Humans; Liv | 2019 |
[Wilson's disease in the child: apropos of 20 cases].
Topics: Adolescent; Anemia, Hemolytic; Ceruloplasmin; Chelation Therapy; Child; Child, Preschool; Consanguin | 2013 |
[Wilsons disease].
Topics: Adenosine Triphosphatases; Adult; Cation Transport Proteins; Chelating Agents; Copper; Copper-Transp | 2013 |
[Rare, but important chronic liver diseases].
Topics: Adolescent; Adult; Biopsy; Ceruloplasmin; Chelating Agents; Child; Chronic Disease; Copper; Diabetes | 2002 |
[Liver fibrosis. 2].
Topics: Acetylglucosaminidase; Aminopropionitrile; Animals; Collagen; Connective Tissue; Female; Fibroblasts | 1980 |
[Therapy of liver cirrhosis].
Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colchicine; Hepatitis; Humans; Liver Cirrhos | 1983 |
[Clinical aspects and immunology of chronic active autoimmune hepatitis and primary biliary cirrhosis].
Topics: Adrenal Cortex Hormones; Autoantibodies; Azathioprine; Chronic Disease; Hepatitis; Humans; Liver Cir | 1982 |
[Typical risks in the treatment of acute and chronic liver diseases].
Topics: Androgens; Ascites; Cholestyramine Resin; Cimetidine; Disseminated Intravascular Coagulation; Diuret | 1982 |
Role of copper in Indian childhood cirrhosis.
Topics: Chelating Agents; Child, Preschool; Copper; Diet; Humans; India; Infant; Liver Cirrhosis; Penicillam | 1998 |
Possible modification of scar tissue by biochemical methods.
Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Cortisone; Humans; Hydroxylysine; Hydroxyproline; L | 1979 |
[Long-term treatment of chronic hepatitis and liver cirrhosis].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Chronic Disease; Diagnosis, Differential; Diet Therapy; Di | 1975 |
The development of cirrhosis in Wilson's disease.
Topics: Ceruloplasmin; Copper; Cornea; Cytosol; Hepatolenticular Degeneration; Humans; Liver; Liver Cirrhosi | 1975 |
D-penicillamine.
Topics: Child; Hepatolenticular Degeneration; Humans; India; Liver Cirrhosis; Penicillamine | 1991 |
[The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Topics: Animals; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Penici | 1990 |
[D-penicillamine and collagen].
Topics: Aminopropionitrile; Arthritis, Rheumatoid; Autoantibodies; Bronchi; Cicatrix; Collagen; Collagen Dis | 1986 |
Changes in the collagen pathway in fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Collagen; Connective Tissue Diseases; Cross-Linking R | 1985 |
Wilson's disease and copper metabolism--a review.
Topics: Brain; Ceruloplasmin; Child; Copper; Cornea; Hepatolenticular Degeneration; Humans; India; Kidney; L | 1985 |
[Long-term therapy of liver diseases].
Topics: Aged; Anabolic Agents; Chronic Disease; Cortisone; Diet Therapy; Fatty Liver; Female; Fluorouracil; | 1972 |
[Hepatolenticular degeneration. Wilson's disease].
Topics: Age Factors; Ceruloplasmin; Copper; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicill | 1969 |
[Wilson's disease (hepatolenticular degeneration)].
Topics: Adolescent; Adult; Biopsy; Brain; Ceruloplasmin; Child; Copper; Dimercaprol; Edetic Acid; Hepatolent | 1966 |
6 trials available for penicillamine and Liver Cirrhosis
| Article | Year |
|---|---|
Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Clinical Trials as To | 1980 |
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.
Topics: Biopsy; Copper; Female; Fibrosis; Humans; India; Infant; Inflammation; Liver; Liver Cirrhosis; Male; | 1995 |
Long term survival in Indian childhood cirrhosis treated with D-penicillamine.
Topics: Chelating Agents; Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Humans; India; Infan | 1996 |
Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis.
Topics: Adult; Aged; Cholagogues and Choleretics; Disease Progression; Female; Humans; Liver Cirrhosis; Live | 1999 |
Clinical trials of penicillamine in Indian childhood cirrhosis.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; India; Inf | 1987 |
Preliminary observations of d-penicillamine therapy in acute alcoholic liver disease.
Topics: Acute Disease; Adult; Albumins; Alcoholism; Biopsy; Clinical Trials as Topic; Female; Globulins; Hep | 1974 |
88 other studies available for penicillamine and Liver Cirrhosis
| Article | Year |
|---|---|
Wilson's disease: neuropsychiatric presentation and delayed diagnosis.
Topics: Ataxia; Delayed Diagnosis; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicilla | 2022 |
Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.
Topics: Adult; Chelating Agents; Copper; Copper-Transporting ATPases; Female; Hepatolenticular Degeneration; | 2018 |
New canine models of copper toxicosis: diagnosis, treatment, and genetics.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chromosome Deletion; Copper; Disease Models, Animal; | 2014 |
A clinical study of bone mesenchymal stem cells for the treatment of hepatic fibrosis induced by hepatolenticular degeneration.
Topics: Adult; Biomarkers; Case-Control Studies; Cells, Cultured; Chelating Agents; Combined Modality Therap | 2017 |
Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease.
Topics: Adolescent; Adult; Chelating Agents; Child; Child, Preschool; Copper; Disease Progression; Female; H | 2008 |
Education and imaging. Hepatobiliary and pancreatic: hypersensitivity pneumonitis induced by penicillamine.
Topics: Alveolitis, Extrinsic Allergic; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liv | 2009 |
"Acquired" hepatocerebral degeneration in a patient heterozygote carrier for a novel mutation in ATP7B gene.
Topics: Adenosine Triphosphatases; Adult; Amino Acid Substitution; Basal Ganglia; Cation Transport Proteins; | 2009 |
Wilson disease: histopathological correlations with treatment on follow-up liver biopsies.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Biopsy; Chelating | 2010 |
Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Caspases; Copper; Di | 2011 |
Acute Gallbladder Hydrops and Arthritis: unusual initial manifestations of Wilson's Disease (WD): Case Report.
Topics: Adenosine Triphosphatases; Arthritis; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Ch | 2011 |
Wilson disease: Canadian perspectives on presentation and outcomes from an adult ambulatory setting.
Topics: Adolescent; Adult; Ambulatory Care; Biopsy; Brain Diseases; Canada; Chelating Agents; Child; Female; | 2012 |
Histologic evolution and long-term outcome of Wilson's disease: results of a single-center experience.
Topics: Adolescent; Adult; Biopsy; Chelating Agents; Chi-Square Distribution; Child; Child, Preschool; Disea | 2013 |
D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.
Topics: Animals; Copper; Dog Diseases; Dogs; Female; Genetic Predisposition to Disease; Liver Cirrhosis; Mal | 2013 |
[Nephrolithiasis as an initial clinical manifestation of Wilson-Konovalov disease].
Topics: Adolescent; Adult; Chelating Agents; Diagnosis, Differential; Female; Hepatolenticular Degeneration; | 2003 |
WILSON'S DISEASE AS A GASTROENTEROLOGIC PROBLEM.
Topics: Copper; Diet; Diet Therapy; Dimercaprol; Gastroenterology; Genetics, Medical; Hepatolenticular Degen | 1964 |
Are our data symmetric?
Topics: Biometry; Chelating Agents; Cholesterol; Data Interpretation, Statistical; Humans; Liver Cirrhosis; | 2003 |
[Wilson's disease and secondary copper hemochromatoses in hematological practice].
Topics: Adult; Chelating Agents; Copper; Diagnosis, Differential; Drug Administration Schedule; Hemochromato | 2004 |
Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis.
Topics: Adult; Aged; Ascites; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; Hum | 2005 |
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients.
Topics: Adult; Aged; Case-Control Studies; Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Hepatic | 2007 |
Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease.
Topics: Adult; Chelating Agents; Fatal Outcome; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhos | 2007 |
[Hepatic changes in the neurological form of Wilson's disease].
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; Penicillami | 1967 |
[Reactive SH-groups in clinical practice. Methodological notes].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Citrates; Darkness; Diabetes Mellitus; | 1981 |
D-penicillamine-induced myasthenia gravis in primary biliary cirrhosis.
Topics: Autoantibodies; Electromyography; Female; Humans; Liver Cirrhosis; Middle Aged; Myasthenia Gravis; P | 1984 |
[Myasthenia syndrome in D-penicillamine therapy in primary biliary cirrhosis].
Topics: Adult; Copper; Female; Humans; Liver; Liver Cirrhosis; Myasthenia Gravis; Penicillamine | 1981 |
[Main characteristics of the treatment of liver cirrhosis].
Topics: Adolescent; Adult; Ascites; Bed Rest; Bloodletting; Child; Child, Preschool; Cholestyramine Resin; D | 1981 |
[Copper metabolism: ultimate therapeutic implications in cholestasis].
Topics: Cholestasis; Copper; Hepatolenticular Degeneration; Humans; Liver; Liver Cirrhosis; Penicillamine | 1981 |
[Wilson's disease: seven cases with hepatic onset (author's transl)].
Topics: Adolescent; Adult; Child; Copper; Female; Hepatitis; Hepatolenticular Degeneration; Humans; Liver; L | 1981 |
[Study of the in vitro effect of hydrocortisone and D-penicillamine on the liver of patients with chronic hepatitis and liver cirrhosis].
Topics: Chronic Disease; Drug Evaluation, Preclinical; Glucocorticoids; Hepatitis; Humans; Hydrocortisone; L | 1980 |
Copper associated childhood cirrhosis.
Topics: Bangladesh; Child, Preschool; Copper; Humans; Isotopes; Liver; Liver Cirrhosis; Male; Penicillamine; | 1994 |
Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease.
Topics: Adult; Ceruloplasmin; Copper; Female; Fetal Diseases; Fetus; Hepatolenticular Degeneration; Humans; | 1993 |
Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease.
Topics: Adolescent; Adult; Anemia, Hemolytic; Ataxia; Chelating Agents; Deglutition Disorders; Dysarthria; D | 1997 |
Time course of histological progression in primary sclerosing cholangitis.
Topics: Adolescent; Adult; Aged; Biopsy; Cholagogues and Choleretics; Cholangitis, Sclerosing; Disease Progr | 1999 |
Psychiatric symptoms as late onset of Wilson's disease: neuroradiological findings, clinical features and treatment.
Topics: Adult; Age of Onset; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases; Biopsy; Bipolar D | 1999 |
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
Topics: Animals; Ascorbic Acid; Cell Division; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; | 2001 |
[Wilson's disease or liver cirrhosis of a different etiology].
Topics: Adolescent; Ceruloplasmin; Copper; Corneal Diseases; Diagnosis, Differential; Female; Hepatolenticul | 1979 |
Hepatic collagen proline hydroxylase activity in alcoholic hepatitis: effect of d-penicillamine.
Topics: Adult; Aged; Aspartate Aminotransferases; Collagen; Fatty Liver; Female; Glycosaminoglycans; Hepatit | 1979 |
[Fundamental aspects of diagnosis and therapy of chronic hepatitis and cirrhosis].
Topics: Adult; Antibodies, Antinuclear; Austria; Chemical and Drug Induced Liver Injury; Female; Hepatitis; | 1977 |
[Spontaneous and DL-penicillamine-induced renal copper excretion in liver diseases (author's transl)].
Topics: Copper; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Penicillamine | 1979 |
Acute viral hepatitis with bridging hepatic necrosis. An overview.
Topics: Adrenal Cortex Hormones; Biopsy; Hepatitis, Viral, Human; Humans; Liver; Liver Cirrhosis; Necrosis; | 1979 |
[Treatment of liver cirrhosis and its complications].
Topics: Ascites; Azathioprine; Barbiturates; Hemochromatosis; Hepatic Encephalopathy; Hepatolenticular Degen | 1979 |
[Morbus Wilson--pathogenesis, diagnosis, therapy, and course (author's transl)].
Topics: Age Factors; Ceruloplasmin; Child; Copper; Hemolysis; Hepatolenticular Degeneration; Humans; Liver C | 1977 |
[Results of treatment of chronic hepatitis (author's transl)].
Topics: Adolescent; Adult; Aged; Aspartate Aminotransferases; Azathioprine; Child; Child, Preschool; Chronic | 1978 |
[Liver cirrhosis caused by genetic defects].
Topics: Adult; Bloodletting; Hemochromatosis; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; | 1977 |
[Therapy and prognosis of chronic hepatitis].
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chronic Disease; Drug Therapy, Combination; Hepatitis, | 1977 |
Wilson's disease: a common liver disorder?
Topics: Adolescent; Adult; Aspartate Aminotransferases; Blood Sedimentation; Ceruloplasmin; Child; Copper; E | 1977 |
[Therapeutic procedures in chronic hepatitis and liver cirrhosis].
Topics: Adrenal Cortex Hormones; Chronic Disease; Female; Hepatitis; Humans; Immunosuppressive Agents; Liver | 1976 |
[Biosynthesis of collagen and mode of action of D-penicillamine (author's transl)].
Topics: Amino Acids; Animals; Aorta; Binding Sites; Cartilage; Collagen; Connective Tissue; Hepatitis; Human | 1975 |
[Results of controlled therapeutic trials of D-penicillamine in chronic hepatitis].
Topics: Adolescent; Adult; Aged; Chronic Disease; Drug Evaluation; Female; Hepatitis; Humans; Liver Cirrhosi | 1976 |
Indian childhood cirrhosis in an American child.
Topics: Copper; Humans; Infant; Liver Cirrhosis; Male; Penicillamine | 1992 |
The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Connective Tissue; Liver; Liver Cirrhosis; Male; Microscopy | 1991 |
Excellent prognosis in Wilsonian chronic active hepatitis: new data or an article of faith?
Topics: Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicillamine; Prognosis | 1991 |
Prognosis of Wilsonian chronic active hepatitis.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Child; Copper; Fema | 1991 |
Successful treatment of Indian childhood cirrhosis.
Topics: Child, Preschool; Copper; Humans; India; Infant; Liver; Liver Cirrhosis; Penicillamine | 1991 |
Sequential histopathologic alterations in Indian childhood cirrhosis treated with d-penicillamine.
Topics: Copper; Female; Humans; India; Infant; Liver; Liver Cirrhosis; Male; Penicillamine | 1991 |
Dangers of non-compliance in Wilson's disease.
Topics: Acute Disease; Adolescent; Ascites; Brain Chemistry; Copper; Female; Follow-Up Studies; Hepatolentic | 1986 |
Penicillamine in Indian childhood cirrhosis.
Topics: Child; Copper; Drug Evaluation; Humans; India; Liver Cirrhosis; Penicillamine | 1987 |
D-penicillamine in patients with postnecrotic liver cirrhosis.
Topics: Female; Humans; Liver Cirrhosis; Male; Middle Aged; Penicillamine | 1988 |
[Oral zinc in Wilson disease--an alternative to D-penicillamine].
Topics: Administration, Oral; Adult; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Liver Function | 1985 |
Letter: Anti-inflammatory drugs and tissue copper.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Copper; Humans; Liver Cirrhosis; Penicillamine; Pro | 1974 |
Presymptomatic Wilson's disease.
Topics: Adolescent; Adult; Biopsy; Ceruloplasmin; Child; Child, Preschool; Copper; Fatty Liver; Hepatolentic | 1967 |
Liver-copper levels in liver disease: studies using neutron activation analysis.
Topics: Activation Analysis; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Cholest | 1968 |
Diagnosis of Wilson's disease in children with liver disease. A report of two families.
Topics: Adolescent; Adult; Brain; Ceruloplasmin; Child; Copper; Diagnosis, Differential; Eye Manifestations; | 1969 |
[D-penicillamine therapy in liver diseases. Preliminary results in 44 cases].
Topics: Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Leukopenia; Liver Cirrhosis; Liver Diseases | 1974 |
[Penicillamine therapy of chronic liver diseases].
Topics: Azathioprine; Chronic Disease; Drug Hypersensitivity; Female; Glucocorticoids; Hepatitis; Humans; Li | 1974 |
D-penicillamine in reconstructice surgery of the biliary tract.
Topics: Biliary Tract Surgical Procedures; Cholestasis; Chronic Disease; Hepatitis; Liver Cirrhosis; Liver C | 1974 |
[Long-term treatment of chronic aggressive hepatitis and liver cirrhosis using immunosuppressive agents].
Topics: Adrenal Cortex Hormones; Alanine Transaminase; Aspartate Aminotransferases; Azathioprine; Chronic Di | 1974 |
[Acute hemolysis in morbus Wilson (author's transl)].
Topics: Adolescent; Adult; Anemia, Hemolytic; Ascites; Bilirubin; Blood Coagulation Tests; Blood Protein Ele | 1974 |
[Immunoprevention and immunosuppression of chronic inflammatory liver diseases].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chronic Disease; Drug Therapy, Combination; Hepatiti | 1974 |
[Nature of course and rehabilitation in the clinical stage of Wilson's disease].
Topics: Adolescent; Adult; Age Factors; Basal Ganglia Diseases; Child; Child, Preschool; Diagnosis, Differen | 1974 |
[Toward a control of collagen metabolism].
Topics: Animals; Collagen; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Metabolism; Penicil | 1974 |
Treatment of active chronic hepatitis and active cirrhosis with penicillamine.
Topics: Azathioprine; Hepatitis; Humans; Liver Cirrhosis; Penicillamine | 1974 |
[Mesenchyma-suppressing therapy of chronic aggressive hepatitis].
Topics: Adolescent; Adult; Aged; Biopsy; Chronic Disease; Drug Hypersensitivity; Exanthema; Female; Gingival | 1972 |
Penicillamine-induced cupriuria in normal subjects and in patients with active liver disease.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aspartate Aminotransferases; Bilirubin; Cerulo | 1973 |
Wilson's disease and pregnancy. A case report.
Topics: Abortion, Spontaneous; Adult; Ascites; Autopsy; Ceruloplasmin; Copper; Diet Therapy; Female; Fetus; | 1973 |
[Effect of D-penicillamine on the collagen metabolism].
Topics: Animals; Anti-Inflammatory Agents; Collagen; Connective Tissue; Disease Models, Animal; Liver; Liver | 1974 |
[Treatment of chronic hepatitis].
Topics: Azathioprine; Chronic Disease; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Female; Hepati | 1974 |
Hemolytic anemia associated with Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Ascites; Child; Copper; Cornea; Diet Therapy; Dimercaprol; Edetic Acid; Fe | 1967 |
[Long term and permanent therapy of chronic hepatitis].
Topics: Autoimmune Diseases; Chronic Disease; Cortisone; Cyclophosphamide; Female; Hepatitis; Hepatitis A; H | 1970 |
[Therapy of active cirrhosis with penicillamine].
Topics: Acute Disease; Biopsy; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Penicillamine | 1971 |
[Therapy of the chronic aggressive hepatitis with D-penicillamine].
Topics: Adult; Aged; Biopsy; Chronic Disease; Female; Hepatitis; Humans; Liver; Liver Cirrhosis; Male; Middl | 1971 |
Penicillamine-induced normalization of clinical signs, and liver morphology and histochemistry in a case of Wilson's disease.
Topics: Ceruloplasmin; Child; Copper; Female; Hepatolenticular Degeneration; Histocytochemistry; Humans; Liv | 1970 |
[Studies of the hepatolenticular degeneration and results of its continuous therapy].
Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Blood Proteins; Chronic Disease; Depressi | 1970 |
Renal function in Wilson's disease: response to penicillamine therapy.
Topics: Adolescent; Adult; Aminohippuric Acids; Ammonium Chloride; Calcium; Dehydration; Female; Follow-Up S | 1970 |
[The treatment of chronic aggressive hepatitis with D-penicillamine].
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Copper; Female; | 1971 |
The varied manifestations of Wilson's disease.
Topics: Adolescent; Anemia, Hemolytic; Ascites; Ceruloplasmin; Child; Copper; Diseases in Twins; Eye Manifes | 1971 |
Abnormalities of the physiology of copper in Wilson's disease. I. The whole-body turnover of copper.
Topics: Adolescent; Adult; Ascites; California; Ceruloplasmin; Child; Copper; Female; Hepatolenticular Degen | 1971 |
[Anatomo-clinical study of a case of Wilson's disease treated with chelating agents for 5 years].
Topics: Acute Kidney Injury; Adult; Basal Ganglia; Chelating Agents; Female; Globus Pallidus; Hepatolenticul | 1968 |
[Hepatolenticular degeneration, Wilson's disease. A characteristics case with remission under penicillamine therapy].
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicillamine; Ti | 1969 |