penicillamine has been researched along with Liver Cirrhosis in 114 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Excerpt | Relevance | Reference |
---|---|---|
"Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 9.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
"To report a case of early-decompensated liver cirrhosis secondary to discontinuation of penicillamine therapy in a patient with Wilson's disease." | 7.74 | Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease. ( Awaisu, A; Aziz, NA; Ghazali, R; Hassan, Y; Ping, CC, 2007) |
"Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC." | 6.69 | Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis. ( Angulo, P; Batts, KP; Dickson, ER; Jorgensen, RA; Lindor, KD; Therneau, TM, 1999) |
"According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 6.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
"The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 5.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
"Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 5.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
"Controlled trial of D-penicillamine was carried out with low dosis in 10 patients with chronic persistent hepatitis, 11 patients with chronic aggressive hepatitis and 7 patients with liver cirrhosis." | 5.05 | Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases. ( Imura, H; Ito, K; Miyamura, M; Nakano, H; Ohnishi, S; Sugiyama, T; Yamamoto, Y, 1980) |
"To report a case of early-decompensated liver cirrhosis secondary to discontinuation of penicillamine therapy in a patient with Wilson's disease." | 3.74 | Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease. ( Awaisu, A; Aziz, NA; Ghazali, R; Hassan, Y; Ping, CC, 2007) |
"Cyclic GMP (cGMP) concentration is increased in plasma of patients with liver cirrhosis." | 3.73 | Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. ( Del Olmo, JA; Felipo, V; Kosenko, E; Montoliu, C; Rodrigo, JM; Serra, MA, 2005) |
"Ursodeoxycholic acid (UDCA) is a beneficial medical therapy for patients with PBC." | 2.69 | Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis. ( Angulo, P; Batts, KP; Dickson, ER; Jorgensen, RA; Lindor, KD; Therneau, TM, 1999) |
"Most patients with Wilson disease become symptomatic between the ages of 6 and 15." | 2.41 | [Rare, but important chronic liver diseases]. ( Maier, KP, 2002) |
"According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful." | 2.38 | [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4]. ( Divald, A; Gergely, P; Gonzales Cabello, R; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1990) |
"The mortality of liver cirrhosis has doubled during the past two decades and is still increasing in most of the European countries." | 2.36 | [Liver fibrosis. 2]. ( Hahn, EG; Martini, GA; Ott, U, 1980) |
"The patient was diagnosed with liver cirrhosis 6 years prior based on outside hospital ultrasound and liver biopsy." | 1.72 | Wilson's disease: neuropsychiatric presentation and delayed diagnosis. ( Alick-Lindstrom, S; Deme, P; Sheffield, A, 2022) |
"Four patients presented with acute liver failure, four with persistently elevated liver function tests, and two with decompensated cirrhosis; none had neurological manifestations." | 1.48 | Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre. ( Ferenci, P; Fraga, M; Giostra, E; Hiroz, P; Moradpour, D; Saldarriaga, J; Sempoux, C; Vieira Barbosa, J, 2018) |
"Sixty patients with liver fibrosis induced by hepatolenticular degeneration were randomly divided into two groups, a penicillamine group and a BMSCs plus penicillamine group, with 30 patients in each." | 1.46 | A clinical study of bone mesenchymal stem cells for the treatment of hepatic fibrosis induced by hepatolenticular degeneration. ( Zhang, D, 2017) |
"Wilson disease is a disorder of copper metabolism characterized by copper overload." | 1.35 | Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease. ( Bahador, A; Dehghani, M; Dehghani, SM; Geramizadeh, B; Kakaei, F; Kazemi, K; Malek-Hosseini, SA; Nikeghbalian, S; Reza Nejatollahi, SM; Salahi, H, 2008) |
"Evaluation of minimal hepatic encephalopathy (MHE) in cirrhotic patients would have prognostic value." | 1.34 | Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. ( del Olmo, JA; Felipo, V; Ferrandez, A; Montoliu, C; Piedrafita, B; Rodrigo, JM; Serra, MA, 2007) |
"A case of a patient is reported in whom Wilson's disease presented in debut with a picture of decompensated liver cirrhosis and immune thrombocytopania complicated by recurrent hemorrhagic syndrome." | 1.32 | [Wilson's disease and secondary copper hemochromatoses in hematological practice]. ( Levina, AA; Lukina, EA; Solov'eva, TI; Sysoeva, EP; Vorob'ev, AI, 2004) |
"We conclude that Wilson's disease may be a good indication for LTX for both neurological manifestation with stable liver function and hepatic manifestation with cirrhosis or acute liver failure." | 1.30 | Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease. ( Bechstein, WO; Becker, M; Luck, W; Mueller, AR; Neuhaus, P; Neuhaus, R; Platz, KP; Schuelke, M; Schumacher, G; Steinmüller, T, 1997) |
"Major depressive disorder was the first clinical manifestation at the age of 38 years." | 1.30 | Psychiatric symptoms as late onset of Wilson's disease: neuroradiological findings, clinical features and treatment. ( Bergamasco, B; Crasto, S; Keller, R; Lagget, M; Torta, R, 1999) |
"A patient with untreated Wilson's disease showed the possibility of fetal liver damage and copper accumulation in the placenta by this disease." | 1.29 | Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease. ( Anai, T; Inoue, I; Matsui, N; Miyakawa, I; Oga, M; Yoshimatsu, J, 1993) |
"The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied." | 1.28 | The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. ( Divald, A; Gergely, P; Jeney, A; Lapis, K; Major, J; Schaff, Z; Simon, K; Szende, B; Timár, F, 1991) |
"Twenty of 320 patients with Wilson's disease initially presented with chemical and laboratory features of chronic active hepatitis, confirmed histologically in 17." | 1.28 | Prognosis of Wilsonian chronic active hepatitis. ( Scheinberg, IH; Schilsky, ML; Sternlieb, I, 1991) |
"Oral zinc therapy in Wilson's Disease may be regarded as an alternative to D-Penicillamine treatment when this drug has to be discontinued because of side effects." | 1.27 | [Oral zinc in Wilson disease--an alternative to D-penicillamine]. ( Dormeyer, HH; Hütteroth, T; Keidl, E; Manns, M; Meyer zum Büschenfelde, KH; Ramadori, G, 1985) |
"During childhood, Wilson's disease becomes manifest mostly in the hepatic form." | 1.26 | [Morbus Wilson--pathogenesis, diagnosis, therapy, and course (author's transl)]. ( Helwig, H; Werner, JP, 1977) |
"Thus, since Wilson's disease may present with chronic active hepatitis or cirrhosis with a normal ESR and without ocular or neurologic signs, it may be a more common cause of liver disease in young people than has been appreciated." | 1.26 | Wilson's disease: a common liver disorder? ( Barr, R; Hyslop, PS; Sass-Kortsak, A; Thompson, WG, 1977) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 73 (64.04) | 18.7374 |
1990's | 17 (14.91) | 18.2507 |
2000's | 11 (9.65) | 29.6817 |
2010's | 12 (10.53) | 24.3611 |
2020's | 1 (0.88) | 2.80 |
Authors | Studies |
---|---|
Deme, P | 1 |
Sheffield, A | 1 |
Alick-Lindstrom, S | 1 |
Vieira Barbosa, J | 1 |
Fraga, M | 1 |
Saldarriaga, J | 1 |
Hiroz, P | 1 |
Giostra, E | 1 |
Sempoux, C | 1 |
Ferenci, P | 1 |
Moradpour, D | 1 |
Gerosa, C | 1 |
Fanni, D | 2 |
Congiu, T | 1 |
Piras, M | 1 |
Cau, F | 1 |
Moi, M | 1 |
Faa, G | 2 |
Idrissi, ML | 1 |
Babakhoya, A | 1 |
Khabbache, K | 1 |
Souilmi, F | 1 |
Benmiloud, S | 1 |
Abourrazak, S | 1 |
Chaouki, S | 1 |
Atmani, S | 1 |
Bouharrou, A | 1 |
Hida, M | 1 |
Mareček, Z | 1 |
Brůha, R | 1 |
Fieten, H | 2 |
Penning, LC | 1 |
Leegwater, PA | 2 |
Rothuizen, J | 2 |
Zhang, D | 1 |
Kazemi, K | 1 |
Geramizadeh, B | 1 |
Nikeghbalian, S | 1 |
Salahi, H | 1 |
Bahador, A | 1 |
Reza Nejatollahi, SM | 1 |
Dehghani, SM | 1 |
Dehghani, M | 1 |
Kakaei, F | 1 |
Malek-Hosseini, SA | 1 |
Seo, JY | 1 |
Kim, SY | 1 |
Choi, WC | 1 |
Cocco, GA | 1 |
Loudianos, G | 2 |
Pes, GM | 1 |
Tolu, F | 1 |
Lepori, MB | 2 |
Barrocu, M | 1 |
Sechi, GP | 1 |
Cope-Yokoyama, S | 1 |
Finegold, MJ | 2 |
Sturniolo, GC | 1 |
Kim, K | 1 |
Mescoli, C | 1 |
Rugge, M | 1 |
Medici, V | 1 |
Roy, DN | 1 |
Sen, G | 1 |
Chowdhury, KD | 1 |
Biswas, T | 1 |
Gucev, ZS | 1 |
Pop-Jordanova, N | 1 |
Calovska, V | 1 |
Tasic, V | 1 |
Slavevska, N | 1 |
Laban, N | 1 |
Noli, MC | 1 |
Moores, A | 1 |
Fox, S | 1 |
Lang, A | 1 |
Hirschfield, GM | 1 |
Sini, M | 1 |
Sorbello, O | 1 |
Sanna, F | 1 |
Battolu, F | 1 |
Civolani, A | 1 |
Demelia, L | 1 |
Dirksen, K | 1 |
van den Ingh, TS | 1 |
Winter, EA | 1 |
Watson, AL | 1 |
Maier, KP | 1 |
Rakhimova, OIu | 1 |
Rozina, TP | 1 |
Ignatova, TM | 1 |
STERNLIEB, I | 3 |
Mandrekar, SJ | 1 |
Mandrekar, JN | 1 |
Vorob'ev, AI | 1 |
Lukina, EA | 1 |
Sysoeva, EP | 1 |
Levina, AA | 1 |
Solov'eva, TI | 1 |
Montoliu, C | 2 |
Kosenko, E | 1 |
Del Olmo, JA | 2 |
Serra, MA | 2 |
Rodrigo, JM | 2 |
Felipo, V | 2 |
Piedrafita, B | 1 |
Ferrandez, A | 1 |
Ping, CC | 1 |
Hassan, Y | 1 |
Aziz, NA | 1 |
Ghazali, R | 1 |
Awaisu, A | 1 |
Hauftová, D | 1 |
Hartl, J | 1 |
Slavícek, J | 1 |
Valach, V | 1 |
Fialová, J | 1 |
Pojerová, M | 1 |
Hahn, EG | 1 |
Ott, U | 1 |
Martini, GA | 1 |
Paumgartner, G | 1 |
Ferraccioli, GF | 1 |
Baldini, A | 1 |
Ambanelli, U | 1 |
Berg, PA | 1 |
Marcus, SN | 1 |
Chadwick, D | 1 |
Walker, RJ | 1 |
Nakano, H | 1 |
Ohnishi, S | 1 |
Sugiyama, T | 1 |
Miyamura, M | 1 |
Imura, H | 1 |
Yamamoto, Y | 1 |
Ito, K | 1 |
Weinzierl, M | 1 |
Kruis, W | 1 |
Eisenburg, J | 2 |
Mörl, M | 3 |
Thierman-Duffaud, D | 1 |
Lévy, VG | 1 |
Pigrau Serrallach, C | 1 |
Pahissa Berga, A | 1 |
Clotet Sala, B | 1 |
Guardia Massó, J | 1 |
Gichev, IuP | 1 |
Bakulina, LF | 1 |
Pradhan, AM | 3 |
Bhave, SA | 3 |
Joshi, VV | 1 |
Bavdekar, AR | 2 |
Pandit, AN | 3 |
Tanner, MS | 6 |
Horslen, SP | 1 |
Lyon, TD | 1 |
Fell, GS | 1 |
Lowry, MF | 1 |
Oga, M | 1 |
Matsui, N | 1 |
Anai, T | 1 |
Yoshimatsu, J | 1 |
Inoue, I | 1 |
Miyakawa, I | 1 |
Schumacher, G | 1 |
Platz, KP | 1 |
Mueller, AR | 1 |
Neuhaus, R | 1 |
Steinmüller, T | 1 |
Bechstein, WO | 1 |
Becker, M | 1 |
Luck, W | 1 |
Schuelke, M | 1 |
Neuhaus, P | 1 |
Angulo, P | 2 |
Batts, KP | 2 |
Therneau, TM | 2 |
Jorgensen, RA | 1 |
Dickson, ER | 1 |
Lindor, KD | 2 |
Larson, DR | 1 |
LaRusso, NF | 1 |
Keller, R | 1 |
Torta, R | 1 |
Lagget, M | 1 |
Crasto, S | 1 |
Bergamasco, B | 1 |
Svegliati-Baroni, G | 1 |
Saccomanno, S | 1 |
van Goor, H | 1 |
Jansen, P | 1 |
Benedetti, A | 1 |
Moshage, H | 1 |
Kuntz, HD | 1 |
May, B | 1 |
Ulmer, WT | 1 |
Mezey, E | 1 |
Potter, JJ | 1 |
Iber, FL | 2 |
Maddrey, WC | 1 |
Wallnöfer, H | 1 |
Jackson, DS | 1 |
Friedrich, K | 1 |
Henning, H | 1 |
Nisman, RM | 1 |
Ganderson, AP | 1 |
Vlahcevic, ZR | 1 |
Gregory, DH | 1 |
Talke, H | 1 |
Werner, JP | 1 |
Helwig, H | 1 |
Thaler, H | 1 |
Szepesi, T | 1 |
Szepesi, G | 1 |
Pusch, JH | 1 |
Ullmann, W | 1 |
Gabriel, L | 1 |
Thompson, WG | 1 |
Hyslop, PS | 1 |
Barr, R | 1 |
Sass-Kortsak, A | 1 |
Davcev, P | 1 |
Vanovski, B | 1 |
Bidikov, V | 1 |
Moritz, AJ | 1 |
Bielawski, W | 1 |
Kaszewska-Jablońska, I | 1 |
Górski, M | 1 |
Adamson, M | 1 |
Reiner, B | 1 |
Olson, JL | 1 |
Goodman, Z | 1 |
Plotnick, L | 1 |
Bernardini, I | 1 |
Gahl, WA | 1 |
Schaff, Z | 2 |
Lapis, K | 2 |
Szende, B | 2 |
Jeney, A | 2 |
Gergely, P | 2 |
Simon, K | 2 |
Divald, A | 2 |
Timár, F | 2 |
Major, J | 2 |
Singh, S | 2 |
Kohli, V | 1 |
Johnson, PJ | 1 |
Williams, R | 1 |
Schilsky, ML | 1 |
Scheinberg, IH | 1 |
Bhusnurmath, SR | 1 |
Walia, BN | 1 |
Parkash, D | 1 |
Radotra, BD | 1 |
Nath, R | 1 |
Gonzales Cabello, R | 1 |
Walshe, JM | 1 |
Dixon, AK | 1 |
Barrow, L | 1 |
Tarantino, G | 1 |
Guardascione, AM | 1 |
Rossi, A | 1 |
Carandente, B | 1 |
Ciccarelli, AF | 1 |
De Michele, NG | 1 |
De Rosa, G | 1 |
Pannain, M | 1 |
Camus, JP | 1 |
Koeger, AC | 1 |
Last, JA | 1 |
Manghani, DK | 1 |
Dastur, DK | 1 |
Ramadori, G | 1 |
Keidl, E | 1 |
Hütteroth, T | 1 |
Dormeyer, HH | 1 |
Manns, M | 1 |
Meyer zum Büschenfelde, KH | 1 |
Elmes, ME | 1 |
Levi, AJ | 1 |
Sherlock, S | 2 |
Scheuer, PJ | 1 |
Cumings, JN | 1 |
Smallwood, RA | 1 |
Williams, HA | 1 |
Rosenoer, VM | 1 |
Danks, DM | 1 |
Stevens, BJ | 1 |
Alexander, M | 2 |
Wille, G | 1 |
Wildhirt, E | 1 |
Henrich, M | 1 |
Bannaski, H | 1 |
Furrer, HU | 1 |
Tönz, O | 1 |
Scheiffarth, F | 1 |
Lössner, J | 1 |
Eichner, B | 1 |
Bachmann, H | 1 |
Biesold, D | 1 |
Günther, K | 1 |
Thomas, M | 1 |
Schnack, H | 2 |
Resnick, RH | 1 |
Boitnott, J | 1 |
Makopour, H | 1 |
Cerda, JJ | 1 |
Markoff, N | 1 |
Gros, H | 1 |
Zwirner, K | 1 |
Herzog, W | 1 |
Lynch, RE | 1 |
Lee, GR | 1 |
Cartwright, GE | 1 |
Albukerk, JN | 1 |
Grasedyck, K | 1 |
Jarstorff, G | 1 |
Trux, F | 1 |
Hansen, HJ | 1 |
Andersen, OS | 2 |
Blattner, RJ | 1 |
Bickel, H | 1 |
Becker, K | 1 |
Falkmer, S | 1 |
Samuelson, G | 1 |
Sjölin, S | 1 |
Brailski, C | 1 |
Kolarski, V | 1 |
Krastev, I | 1 |
Leu, ML | 1 |
Strickland, GT | 2 |
Gutman, RA | 1 |
Lange, J | 1 |
Schumacher, K | 1 |
Witscher, HP | 1 |
Slovis, TL | 1 |
Dubois, RS | 1 |
Rodgerson, DO | 1 |
Silverman, A | 1 |
O'Reilly, S | 1 |
Weber, PM | 1 |
Beckner, WM | 1 |
Shipley, L | 1 |
Boudin, G | 1 |
Pépin, B | 1 |
Milhaud, M | 1 |
Jérome, H | 1 |
Pacilly, A | 1 |
Hansen, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Efficacy and Security of Bezafibrate in Patients With Primary Biliary Cirrhosis Without Biochemical Response to Ursodeoxycholic Acid: A Randomized, Double-blind, Placebo-controlled Trial[NCT02937012] | Phase 3 | 34 participants (Anticipated) | Interventional | 2016-10-31 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
20 reviews available for penicillamine and Liver Cirrhosis
Article | Year |
---|---|
Liver pathology in Wilson's disease: From copper overload to cirrhosis.
Topics: Copper; Copper-Transporting ATPases; Epigenesis, Genetic; Hepatolenticular Degeneration; Humans; Liv | 2019 |
[Wilson's disease in the child: apropos of 20 cases].
Topics: Adolescent; Anemia, Hemolytic; Ceruloplasmin; Chelation Therapy; Child; Child, Preschool; Consanguin | 2013 |
[Wilsons disease].
Topics: Adenosine Triphosphatases; Adult; Cation Transport Proteins; Chelating Agents; Copper; Copper-Transp | 2013 |
[Rare, but important chronic liver diseases].
Topics: Adolescent; Adult; Biopsy; Ceruloplasmin; Chelating Agents; Child; Chronic Disease; Copper; Diabetes | 2002 |
[Liver fibrosis. 2].
Topics: Acetylglucosaminidase; Aminopropionitrile; Animals; Collagen; Connective Tissue; Female; Fibroblasts | 1980 |
[Therapy of liver cirrhosis].
Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colchicine; Hepatitis; Humans; Liver Cirrhos | 1983 |
[Clinical aspects and immunology of chronic active autoimmune hepatitis and primary biliary cirrhosis].
Topics: Adrenal Cortex Hormones; Autoantibodies; Azathioprine; Chronic Disease; Hepatitis; Humans; Liver Cir | 1982 |
[Typical risks in the treatment of acute and chronic liver diseases].
Topics: Androgens; Ascites; Cholestyramine Resin; Cimetidine; Disseminated Intravascular Coagulation; Diuret | 1982 |
Role of copper in Indian childhood cirrhosis.
Topics: Chelating Agents; Child, Preschool; Copper; Diet; Humans; India; Infant; Liver Cirrhosis; Penicillam | 1998 |
Possible modification of scar tissue by biochemical methods.
Topics: Aminopropionitrile; Animals; Cicatrix; Collagen; Cortisone; Humans; Hydroxylysine; Hydroxyproline; L | 1979 |
[Long-term treatment of chronic hepatitis and liver cirrhosis].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Chronic Disease; Diagnosis, Differential; Diet Therapy; Di | 1975 |
The development of cirrhosis in Wilson's disease.
Topics: Ceruloplasmin; Copper; Cornea; Cytosol; Hepatolenticular Degeneration; Humans; Liver; Liver Cirrhosi | 1975 |
D-penicillamine.
Topics: Child; Hepatolenticular Degeneration; Humans; India; Liver Cirrhosis; Penicillamine | 1991 |
[The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Topics: Animals; Carbon Tetrachloride; Humans; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Penici | 1990 |
[D-penicillamine and collagen].
Topics: Aminopropionitrile; Arthritis, Rheumatoid; Autoantibodies; Bronchi; Cicatrix; Collagen; Collagen Dis | 1986 |
Changes in the collagen pathway in fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Collagen; Connective Tissue Diseases; Cross-Linking R | 1985 |
Wilson's disease and copper metabolism--a review.
Topics: Brain; Ceruloplasmin; Child; Copper; Cornea; Hepatolenticular Degeneration; Humans; India; Kidney; L | 1985 |
[Long-term therapy of liver diseases].
Topics: Aged; Anabolic Agents; Chronic Disease; Cortisone; Diet Therapy; Fatty Liver; Female; Fluorouracil; | 1972 |
[Hepatolenticular degeneration. Wilson's disease].
Topics: Age Factors; Ceruloplasmin; Copper; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicill | 1969 |
[Wilson's disease (hepatolenticular degeneration)].
Topics: Adolescent; Adult; Biopsy; Brain; Ceruloplasmin; Child; Copper; Dimercaprol; Edetic Acid; Hepatolent | 1966 |
6 trials available for penicillamine and Liver Cirrhosis
Article | Year |
---|---|
Controlled trial of D-penicillamine with low dosis in the treatment of chronic liver diseases.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Clinical Trials as To | 1980 |
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.
Topics: Biopsy; Copper; Female; Fibrosis; Humans; India; Infant; Inflammation; Liver; Liver Cirrhosis; Male; | 1995 |
Long term survival in Indian childhood cirrhosis treated with D-penicillamine.
Topics: Chelating Agents; Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Humans; India; Infan | 1996 |
Long-term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis.
Topics: Adult; Aged; Cholagogues and Choleretics; Disease Progression; Female; Humans; Liver Cirrhosis; Live | 1999 |
Clinical trials of penicillamine in Indian childhood cirrhosis.
Topics: Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; India; Inf | 1987 |
Preliminary observations of d-penicillamine therapy in acute alcoholic liver disease.
Topics: Acute Disease; Adult; Albumins; Alcoholism; Biopsy; Clinical Trials as Topic; Female; Globulins; Hep | 1974 |
88 other studies available for penicillamine and Liver Cirrhosis
Article | Year |
---|---|
Wilson's disease: neuropsychiatric presentation and delayed diagnosis.
Topics: Ataxia; Delayed Diagnosis; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicilla | 2022 |
Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.
Topics: Adult; Chelating Agents; Copper; Copper-Transporting ATPases; Female; Hepatolenticular Degeneration; | 2018 |
New canine models of copper toxicosis: diagnosis, treatment, and genetics.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chromosome Deletion; Copper; Disease Models, Animal; | 2014 |
A clinical study of bone mesenchymal stem cells for the treatment of hepatic fibrosis induced by hepatolenticular degeneration.
Topics: Adult; Biomarkers; Case-Control Studies; Cells, Cultured; Chelating Agents; Combined Modality Therap | 2017 |
Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease.
Topics: Adolescent; Adult; Chelating Agents; Child; Child, Preschool; Copper; Disease Progression; Female; H | 2008 |
Education and imaging. Hepatobiliary and pancreatic: hypersensitivity pneumonitis induced by penicillamine.
Topics: Alveolitis, Extrinsic Allergic; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liv | 2009 |
"Acquired" hepatocerebral degeneration in a patient heterozygote carrier for a novel mutation in ATP7B gene.
Topics: Adenosine Triphosphatases; Adult; Amino Acid Substitution; Basal Ganglia; Cation Transport Proteins; | 2009 |
Wilson disease: histopathological correlations with treatment on follow-up liver biopsies.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Biopsy; Chelating | 2010 |
Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Caspases; Copper; Di | 2011 |
Acute Gallbladder Hydrops and Arthritis: unusual initial manifestations of Wilson's Disease (WD): Case Report.
Topics: Adenosine Triphosphatases; Arthritis; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Ch | 2011 |
Wilson disease: Canadian perspectives on presentation and outcomes from an adult ambulatory setting.
Topics: Adolescent; Adult; Ambulatory Care; Biopsy; Brain Diseases; Canada; Chelating Agents; Child; Female; | 2012 |
Histologic evolution and long-term outcome of Wilson's disease: results of a single-center experience.
Topics: Adolescent; Adult; Biopsy; Chelating Agents; Chi-Square Distribution; Child; Child, Preschool; Disea | 2013 |
D-penicillamine treatment of copper-associated hepatitis in Labrador retrievers.
Topics: Animals; Copper; Dog Diseases; Dogs; Female; Genetic Predisposition to Disease; Liver Cirrhosis; Mal | 2013 |
[Nephrolithiasis as an initial clinical manifestation of Wilson-Konovalov disease].
Topics: Adolescent; Adult; Chelating Agents; Diagnosis, Differential; Female; Hepatolenticular Degeneration; | 2003 |
WILSON'S DISEASE AS A GASTROENTEROLOGIC PROBLEM.
Topics: Copper; Diet; Diet Therapy; Dimercaprol; Gastroenterology; Genetics, Medical; Hepatolenticular Degen | 1964 |
Are our data symmetric?
Topics: Biometry; Chelating Agents; Cholesterol; Data Interpretation, Statistical; Humans; Liver Cirrhosis; | 2003 |
[Wilson's disease and secondary copper hemochromatoses in hematological practice].
Topics: Adult; Chelating Agents; Copper; Diagnosis, Differential; Drug Administration Schedule; Hemochromato | 2004 |
Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis.
Topics: Adult; Aged; Ascites; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Guanylate Cyclase; Hum | 2005 |
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients.
Topics: Adult; Aged; Case-Control Studies; Cyclic GMP; Enzyme Activation; Female; Guanylate Cyclase; Hepatic | 2007 |
Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease.
Topics: Adult; Chelating Agents; Fatal Outcome; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhos | 2007 |
[Hepatic changes in the neurological form of Wilson's disease].
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; Penicillami | 1967 |
[Reactive SH-groups in clinical practice. Methodological notes].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Citrates; Darkness; Diabetes Mellitus; | 1981 |
D-penicillamine-induced myasthenia gravis in primary biliary cirrhosis.
Topics: Autoantibodies; Electromyography; Female; Humans; Liver Cirrhosis; Middle Aged; Myasthenia Gravis; P | 1984 |
[Myasthenia syndrome in D-penicillamine therapy in primary biliary cirrhosis].
Topics: Adult; Copper; Female; Humans; Liver; Liver Cirrhosis; Myasthenia Gravis; Penicillamine | 1981 |
[Main characteristics of the treatment of liver cirrhosis].
Topics: Adolescent; Adult; Ascites; Bed Rest; Bloodletting; Child; Child, Preschool; Cholestyramine Resin; D | 1981 |
[Copper metabolism: ultimate therapeutic implications in cholestasis].
Topics: Cholestasis; Copper; Hepatolenticular Degeneration; Humans; Liver; Liver Cirrhosis; Penicillamine | 1981 |
[Wilson's disease: seven cases with hepatic onset (author's transl)].
Topics: Adolescent; Adult; Child; Copper; Female; Hepatitis; Hepatolenticular Degeneration; Humans; Liver; L | 1981 |
[Study of the in vitro effect of hydrocortisone and D-penicillamine on the liver of patients with chronic hepatitis and liver cirrhosis].
Topics: Chronic Disease; Drug Evaluation, Preclinical; Glucocorticoids; Hepatitis; Humans; Hydrocortisone; L | 1980 |
Copper associated childhood cirrhosis.
Topics: Bangladesh; Child, Preschool; Copper; Humans; Isotopes; Liver; Liver Cirrhosis; Male; Penicillamine; | 1994 |
Copper disposition of the fetus and placenta in a patient with untreated Wilson's disease.
Topics: Adult; Ceruloplasmin; Copper; Female; Fetal Diseases; Fetus; Hepatolenticular Degeneration; Humans; | 1993 |
Liver transplantation: treatment of choice for hepatic and neurological manifestation of Wilson's disease.
Topics: Adolescent; Adult; Anemia, Hemolytic; Ataxia; Chelating Agents; Deglutition Disorders; Dysarthria; D | 1997 |
Time course of histological progression in primary sclerosing cholangitis.
Topics: Adolescent; Adult; Aged; Biopsy; Cholagogues and Choleretics; Cholangitis, Sclerosing; Disease Progr | 1999 |
Psychiatric symptoms as late onset of Wilson's disease: neuroradiological findings, clinical features and treatment.
Topics: Adult; Age of Onset; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases; Biopsy; Bipolar D | 1999 |
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
Topics: Animals; Ascorbic Acid; Cell Division; Cells, Cultured; Dimethylnitrosamine; Disease Models, Animal; | 2001 |
[Wilson's disease or liver cirrhosis of a different etiology].
Topics: Adolescent; Ceruloplasmin; Copper; Corneal Diseases; Diagnosis, Differential; Female; Hepatolenticul | 1979 |
Hepatic collagen proline hydroxylase activity in alcoholic hepatitis: effect of d-penicillamine.
Topics: Adult; Aged; Aspartate Aminotransferases; Collagen; Fatty Liver; Female; Glycosaminoglycans; Hepatit | 1979 |
[Fundamental aspects of diagnosis and therapy of chronic hepatitis and cirrhosis].
Topics: Adult; Antibodies, Antinuclear; Austria; Chemical and Drug Induced Liver Injury; Female; Hepatitis; | 1977 |
[Spontaneous and DL-penicillamine-induced renal copper excretion in liver diseases (author's transl)].
Topics: Copper; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Penicillamine | 1979 |
Acute viral hepatitis with bridging hepatic necrosis. An overview.
Topics: Adrenal Cortex Hormones; Biopsy; Hepatitis, Viral, Human; Humans; Liver; Liver Cirrhosis; Necrosis; | 1979 |
[Treatment of liver cirrhosis and its complications].
Topics: Ascites; Azathioprine; Barbiturates; Hemochromatosis; Hepatic Encephalopathy; Hepatolenticular Degen | 1979 |
[Morbus Wilson--pathogenesis, diagnosis, therapy, and course (author's transl)].
Topics: Age Factors; Ceruloplasmin; Child; Copper; Hemolysis; Hepatolenticular Degeneration; Humans; Liver C | 1977 |
[Results of treatment of chronic hepatitis (author's transl)].
Topics: Adolescent; Adult; Aged; Aspartate Aminotransferases; Azathioprine; Child; Child, Preschool; Chronic | 1978 |
[Liver cirrhosis caused by genetic defects].
Topics: Adult; Bloodletting; Hemochromatosis; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; | 1977 |
[Therapy and prognosis of chronic hepatitis].
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chronic Disease; Drug Therapy, Combination; Hepatitis, | 1977 |
Wilson's disease: a common liver disorder?
Topics: Adolescent; Adult; Aspartate Aminotransferases; Blood Sedimentation; Ceruloplasmin; Child; Copper; E | 1977 |
[Therapeutic procedures in chronic hepatitis and liver cirrhosis].
Topics: Adrenal Cortex Hormones; Chronic Disease; Female; Hepatitis; Humans; Immunosuppressive Agents; Liver | 1976 |
[Biosynthesis of collagen and mode of action of D-penicillamine (author's transl)].
Topics: Amino Acids; Animals; Aorta; Binding Sites; Cartilage; Collagen; Connective Tissue; Hepatitis; Human | 1975 |
[Results of controlled therapeutic trials of D-penicillamine in chronic hepatitis].
Topics: Adolescent; Adult; Aged; Chronic Disease; Drug Evaluation; Female; Hepatitis; Humans; Liver Cirrhosi | 1976 |
Indian childhood cirrhosis in an American child.
Topics: Copper; Humans; Infant; Liver Cirrhosis; Male; Penicillamine | 1992 |
The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Collagen; Connective Tissue; Liver; Liver Cirrhosis; Male; Microscopy | 1991 |
Excellent prognosis in Wilsonian chronic active hepatitis: new data or an article of faith?
Topics: Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicillamine; Prognosis | 1991 |
Prognosis of Wilsonian chronic active hepatitis.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Child; Copper; Fema | 1991 |
Successful treatment of Indian childhood cirrhosis.
Topics: Child, Preschool; Copper; Humans; India; Infant; Liver; Liver Cirrhosis; Penicillamine | 1991 |
Sequential histopathologic alterations in Indian childhood cirrhosis treated with d-penicillamine.
Topics: Copper; Female; Humans; India; Infant; Liver; Liver Cirrhosis; Male; Penicillamine | 1991 |
Dangers of non-compliance in Wilson's disease.
Topics: Acute Disease; Adolescent; Ascites; Brain Chemistry; Copper; Female; Follow-Up Studies; Hepatolentic | 1986 |
Penicillamine in Indian childhood cirrhosis.
Topics: Child; Copper; Drug Evaluation; Humans; India; Liver Cirrhosis; Penicillamine | 1987 |
D-penicillamine in patients with postnecrotic liver cirrhosis.
Topics: Female; Humans; Liver Cirrhosis; Male; Middle Aged; Penicillamine | 1988 |
[Oral zinc in Wilson disease--an alternative to D-penicillamine].
Topics: Administration, Oral; Adult; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Liver Function | 1985 |
Letter: Anti-inflammatory drugs and tissue copper.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Copper; Humans; Liver Cirrhosis; Penicillamine; Pro | 1974 |
Presymptomatic Wilson's disease.
Topics: Adolescent; Adult; Biopsy; Ceruloplasmin; Child; Child, Preschool; Copper; Fatty Liver; Hepatolentic | 1967 |
Liver-copper levels in liver disease: studies using neutron activation analysis.
Topics: Activation Analysis; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Cholest | 1968 |
Diagnosis of Wilson's disease in children with liver disease. A report of two families.
Topics: Adolescent; Adult; Brain; Ceruloplasmin; Child; Copper; Diagnosis, Differential; Eye Manifestations; | 1969 |
[D-penicillamine therapy in liver diseases. Preliminary results in 44 cases].
Topics: Adult; Aged; Chronic Disease; Female; Hepatitis; Humans; Leukopenia; Liver Cirrhosis; Liver Diseases | 1974 |
[Penicillamine therapy of chronic liver diseases].
Topics: Azathioprine; Chronic Disease; Drug Hypersensitivity; Female; Glucocorticoids; Hepatitis; Humans; Li | 1974 |
D-penicillamine in reconstructice surgery of the biliary tract.
Topics: Biliary Tract Surgical Procedures; Cholestasis; Chronic Disease; Hepatitis; Liver Cirrhosis; Liver C | 1974 |
[Long-term treatment of chronic aggressive hepatitis and liver cirrhosis using immunosuppressive agents].
Topics: Adrenal Cortex Hormones; Alanine Transaminase; Aspartate Aminotransferases; Azathioprine; Chronic Di | 1974 |
[Acute hemolysis in morbus Wilson (author's transl)].
Topics: Adolescent; Adult; Anemia, Hemolytic; Ascites; Bilirubin; Blood Coagulation Tests; Blood Protein Ele | 1974 |
[Immunoprevention and immunosuppression of chronic inflammatory liver diseases].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Chronic Disease; Drug Therapy, Combination; Hepatiti | 1974 |
[Nature of course and rehabilitation in the clinical stage of Wilson's disease].
Topics: Adolescent; Adult; Age Factors; Basal Ganglia Diseases; Child; Child, Preschool; Diagnosis, Differen | 1974 |
[Toward a control of collagen metabolism].
Topics: Animals; Collagen; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Metabolism; Penicil | 1974 |
Treatment of active chronic hepatitis and active cirrhosis with penicillamine.
Topics: Azathioprine; Hepatitis; Humans; Liver Cirrhosis; Penicillamine | 1974 |
[Mesenchyma-suppressing therapy of chronic aggressive hepatitis].
Topics: Adolescent; Adult; Aged; Biopsy; Chronic Disease; Drug Hypersensitivity; Exanthema; Female; Gingival | 1972 |
Penicillamine-induced cupriuria in normal subjects and in patients with active liver disease.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aspartate Aminotransferases; Bilirubin; Cerulo | 1973 |
Wilson's disease and pregnancy. A case report.
Topics: Abortion, Spontaneous; Adult; Ascites; Autopsy; Ceruloplasmin; Copper; Diet Therapy; Female; Fetus; | 1973 |
[Effect of D-penicillamine on the collagen metabolism].
Topics: Animals; Anti-Inflammatory Agents; Collagen; Connective Tissue; Disease Models, Animal; Liver; Liver | 1974 |
[Treatment of chronic hepatitis].
Topics: Azathioprine; Chronic Disease; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Female; Hepati | 1974 |
Hemolytic anemia associated with Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Ascites; Child; Copper; Cornea; Diet Therapy; Dimercaprol; Edetic Acid; Fe | 1967 |
[Long term and permanent therapy of chronic hepatitis].
Topics: Autoimmune Diseases; Chronic Disease; Cortisone; Cyclophosphamide; Female; Hepatitis; Hepatitis A; H | 1970 |
[Therapy of active cirrhosis with penicillamine].
Topics: Acute Disease; Biopsy; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Penicillamine | 1971 |
[Therapy of the chronic aggressive hepatitis with D-penicillamine].
Topics: Adult; Aged; Biopsy; Chronic Disease; Female; Hepatitis; Humans; Liver; Liver Cirrhosis; Male; Middl | 1971 |
Penicillamine-induced normalization of clinical signs, and liver morphology and histochemistry in a case of Wilson's disease.
Topics: Ceruloplasmin; Child; Copper; Female; Hepatolenticular Degeneration; Histocytochemistry; Humans; Liv | 1970 |
[Studies of the hepatolenticular degeneration and results of its continuous therapy].
Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Blood Proteins; Chronic Disease; Depressi | 1970 |
Renal function in Wilson's disease: response to penicillamine therapy.
Topics: Adolescent; Adult; Aminohippuric Acids; Ammonium Chloride; Calcium; Dehydration; Female; Follow-Up S | 1970 |
[The treatment of chronic aggressive hepatitis with D-penicillamine].
Topics: Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Copper; Female; | 1971 |
The varied manifestations of Wilson's disease.
Topics: Adolescent; Anemia, Hemolytic; Ascites; Ceruloplasmin; Child; Copper; Diseases in Twins; Eye Manifes | 1971 |
Abnormalities of the physiology of copper in Wilson's disease. I. The whole-body turnover of copper.
Topics: Adolescent; Adult; Ascites; California; Ceruloplasmin; Child; Copper; Female; Hepatolenticular Degen | 1971 |
[Anatomo-clinical study of a case of Wilson's disease treated with chelating agents for 5 years].
Topics: Acute Kidney Injury; Adult; Basal Ganglia; Chelating Agents; Female; Globus Pallidus; Hepatolenticul | 1968 |
[Hepatolenticular degeneration, Wilson's disease. A characteristics case with remission under penicillamine therapy].
Topics: Adolescent; Adult; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicillamine; Ti | 1969 |