penicillamine has been researched along with Lathyrism in 38 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Lathyrism: A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have attempted to alter collagen metabolism in young squirrel monkeys by inducing lathyrism with D-penicillamine to weaken scar tissue." | 7.66 | Peripheral nerve regeneration in primates during D-penicillamine-induced lathyrism. ( Bucko, CD; Grabb, WC; Joynt, RL, 1981) |
| "A 2 1/4 year-old boy was treated for cystinuria and urolithiasis with high fluid intake, sodium bicarbonate, and D-penicillamine, over a period of 5 3/4 years, unauthorized interruptions and prescribed pauses included." | 7.66 | Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria. ( Gitzelmann, R; Otten, A; Steinmann, B, 1979) |
| " Ten patients with massive keloids, resistant to conventional therapy by excision, grafting, and/or intralesional injection of steroids, have been treated by excising the keloid, grafting the defect, inducing lathyrism with Beta aminopropionitrile fumurate or penicillamine and administering colchicine." | 3.66 | Pharmacologic control of surface scarring in human beings. ( Peacock, EE, 1981) |
| "A 2 1/4 year-old boy was treated for cystinuria and urolithiasis with high fluid intake, sodium bicarbonate, and D-penicillamine, over a period of 5 3/4 years, unauthorized interruptions and prescribed pauses included." | 3.66 | Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria. ( Gitzelmann, R; Otten, A; Steinmann, B, 1979) |
| " Possible roles of the lysosomal collagenolytic enzyme system in experimental lathyrism in rats given penicillamine, and in erosion of cartilage in rheumatoid arthritis, are considered." | 3.65 | Effects of lysosomal collagenolytic enzymes, anti-inflammatory drugs and other substances on some properties of insoluble collagen. ( Anderson, AJ, 1969) |
| "Experimental lathyrism was induced by feeding newborn chicks a diet containing 0." | 1.27 | Alterations of elastin fibrogenesis by inhibition of the formation of desmosine crosslinks. Comparison between the effect of beta-aminopropionitrile (beta-APN) and penicillamine. ( Contri, MB; Fornieri, C; Mori, G; Quaglino, D; Ronchetti, IP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (89.47) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dayan, D | 1 |
| Shoshan, S | 2 |
| Fernandes, L | 1 |
| Berry, H | 1 |
| Hamilton, E | 1 |
| Peacock, EE | 3 |
| Deyl, Z | 1 |
| Adam, M | 1 |
| Macek, K | 1 |
| Bucko, CD | 1 |
| Joynt, RL | 1 |
| Grabb, WC | 1 |
| Gehanno, P | 1 |
| Guedon, C | 1 |
| Taverne, AA | 2 |
| Mentzer, RK | 1 |
| Smith, ND | 1 |
| Pöch, G | 1 |
| Dawson, DA | 1 |
| Finkelstein, S | 1 |
| Siegel, RC | 1 |
| Arbisser, AI | 1 |
| Scott, CI | 1 |
| Howell, BR | 1 |
| Steinmann, B | 1 |
| Otten, A | 1 |
| Gitzelmann, R | 1 |
| Gabler, W | 1 |
| Brachmann, J | 1 |
| Dörfler, HP | 1 |
| Schmidt, W | 1 |
| Friedrich, L | 1 |
| Wuppermann, D | 1 |
| Zimmermann, F | 1 |
| Godar, JM | 1 |
| Norins, AL | 1 |
| van Doorn, K | 1 |
| de Man, B | 1 |
| Hendriks, T | 1 |
| Tinker, D | 1 |
| Rucker, RB | 1 |
| Ronchetti, IP | 1 |
| Contri, MB | 1 |
| Fornieri, C | 1 |
| Quaglino, D | 1 |
| Mori, G | 1 |
| Lemmens, IG | 1 |
| Tonino, GJ | 1 |
| Katz, R | 1 |
| Nimni, ME | 3 |
| Deshmukh, K | 2 |
| Gerth, N | 1 |
| Bonventre, MV | 1 |
| Raab, W | 1 |
| Speer, DP | 1 |
| Chvapil, M | 1 |
| Brendel, K | 1 |
| Eyre, DR | 1 |
| Harkness, RD | 1 |
| Lukens, LN | 1 |
| Schiffmann, E | 1 |
| Martin, GR | 3 |
| Stivers, FE | 2 |
| Steffer, AJ | 1 |
| Yarington, CT | 2 |
| Haney, A | 1 |
| Steffek, AJ | 1 |
| Pinnell, SR | 1 |
| Miller, EJ | 2 |
| Keiser, HR | 1 |
| Henkin, RI | 1 |
| Kare, M | 1 |
| Jacobus, D | 1 |
| Grenan, M | 1 |
| Wagner, B | 1 |
| Margolis, C | 1 |
| Jaffe, I | 1 |
| Anderson, AJ | 1 |
| Mecca, CE | 1 |
| Piez, KA | 1 |
2 reviews available for penicillamine and Lathyrism
| Article | Year |
|---|---|
Lysyl oxidase.
Topics: Amino Acid Oxidoreductases; Aneurysm; Animals; Chickens; Collagen; Copper; Cutis Laxa; Dogs; Ehlers- | 1979 |
Role of selected nutrients in synthesis, accumulation, and chemical modification of connective tissue proteins.
Topics: Aminopropionitrile; Animals; Ascorbic Acid; Collagen; Connective Tissue; Copper; Cross-Linking Reage | 1985 |
36 other studies available for penicillamine and Lathyrism
| Article | Year |
|---|---|
The response of periodontal ligament and mandibular joint to the collagen-crosslink inhibitor penicillamine in the rat.
Topics: Aminopropionitrile; Animals; Collagen; Lathyrism; Penicillamine; Periodontal Ligament; Rats; Temporo | 1981 |
Historical perspectives on penicillamine.
Topics: Animals; Chelating Agents; Chemical Phenomena; Chemistry; Hepatitis; Humans; Immunity; Lathyrism; Li | 1980 |
Pharmacologic control of surface scarring in human beings.
Topics: Adolescent; Adult; Aged; Aminopropionitrile; Child; Cicatrix; Colchicine; Drug Administration Schedu | 1981 |
3-Hydroxypyridinium cross-links in lathyritic tissues.
Topics: Amino Acids; Aminopropionitrile; Animals; Chemical Phenomena; Chemistry; Collagen; Elastin; Hydrazin | 1981 |
Peripheral nerve regeneration in primates during D-penicillamine-induced lathyrism.
Topics: Action Potentials; Animals; Evoked Potentials; Lathyrism; Nerve Regeneration; Neural Conduction; Pen | 1981 |
Inhibition of experimental esophageal lye strictures by penicillamine.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Lathyrism; Lye; Pen | 1981 |
Collagen responsible for tooth eruption? A study of the eruption of rat incisors.
Topics: Aminoacetonitrile; Aminopropionitrile; Animals; Body Weight; Collagen; Female; Lathyrism; Penicillam | 1993 |
Combined osteolathyric effects of beta-aminopropionitrile and penicillamine on Xenopus embryos: statistical comparison with dose-addition and independence.
Topics: Aminopropionitrile; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Fem | 1999 |
Lysyl oxidase: a pituitary hormone-dependent enzyme.
Topics: Amino Acid Oxidoreductases; Animals; Chick Embryo; Collagen; Hypophysectomy; Lathyrism; Male; Penici | 1976 |
Letter: Mannosidosis and maternal penicillamine therapy.
Topics: Carbohydrate Metabolism, Inborn Errors; Disaccharidases; Female; Hepatolenticular Degeneration; Huma | 1976 |
Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria.
Topics: Atrophy; Bicarbonates; Bone and Bones; Bone Diseases; Child, Preschool; Cystinuria; Drug Eruptions; | 1979 |
[Action mechanism of various teratogenic lathyrogens].
Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Aminopropionitrile; Animals; Chemical | 1977 |
Influence of D-penicillamine and beta-aminopropionitril on the metamorphosis of Rana temporaria.
Topics: Aminopropionitrile; Animals; Bone Development; Dose-Response Relationship, Drug; Larva; Lathyrism; M | 1976 |
Vesicular lesions in a woman with progressive systemic sclerosis. Penicillamine-induced intradermal vesicles: an example of human lathyrism.
Topics: Female; Humans; Lathyrism; Middle Aged; Penicillamine; Scleroderma, Systemic; Skin; Skin Diseases, V | 1992 |
The effects of lathyrogens on intestinal anastomoses in the rat.
Topics: Aminopropionitrile; Anastomosis, Surgical; Animals; Collagen; Intestinal Mucosa; Intestines; Lathyri | 1990 |
Alterations of elastin fibrogenesis by inhibition of the formation of desmosine crosslinks. Comparison between the effect of beta-aminopropionitrile (beta-APN) and penicillamine.
Topics: Amino Acids; Aminopropionitrile; Animals; Aorta; Chickens; Cross-Linking Reagents; Desmosine; Elasti | 1985 |
Lathyrogens and the role of collagen in the eruption of rat incisors.
Topics: Aminoacetonitrile; Aminopropionitrile; Animals; Collagen; Female; Lathyrism; Penicillamine; Periodon | 1986 |
Penicillamine-induced skin lesions. A possible example of human lathyrism.
Topics: Adult; Cysts; Drug Eruptions; Hepatolenticular Degeneration; Humans; Lathyrism; Male; Penicillamine | 1967 |
Collagen defect induced by penicillamine.
Topics: Aldehydes; Animals; Collagen; Collagen Diseases; Lathyrism; Penicillamine; Rats; Skin | 1972 |
Sweet peas, copper, pregnancy, and pills: effects on aorta.
Topics: Animals; Aortic Diseases; Collagen; Contraceptives, Oral; Copper; Deficiency Diseases; Estrogens; Fe | 1974 |
[Urinary hydroxyproline excretion in rheumatic conditions and under antirheumatic treatment].
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Animals; Arthritis; Aspirin; Drug Interactions; Glu | 1973 |
Use of large-molecular-weight compounds to produce local lathyrism in healing wounds.
Topics: Aminopropionitrile; Animals; Chick Embryo; Cicatrix; Disease Models, Animal; Lathyrism; Penicillamin | 1973 |
Collagen defects in genetic disorders of connective tissue.
Topics: Aminopropionitrile; Chemical Phenomena; Chemistry; Collagen; Ehlers-Danlos Syndrome; Homocystinuria; | 1974 |
Cross links in collagen and the mechanical properties of connective tissues.
Topics: Collagen; Connective Tissue; Dentistry; Lathyrism; Penicillamine | 1970 |
The formation of collagen alpha chains in the absence of proline hydroxylation.
Topics: Age Factors; Animals; Buffers; Carbon Isotopes; Chick Embryo; Chromatography, Gel; Chromatography, I | 1970 |
Spontaneous generation of cross-links in aldehyde-containing collagen.
Topics: Aldehydes; Amino Acids; Animal Feed; Animals; Chromatography; Collagen; Lathyrism; Lysine; Penicilla | 1970 |
The effect of lathyrogens on developing mid-facial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Diet; Female; Jaw Abnormalities; Lathyrism | 1970 |
Physical and biochemical effects of simultaneous administration of multiple lathyrogenic agents.
Topics: Animals; Cicatrix; Collagen; Lathyrism; Nitriles; Penicillamine; Rats; Stimulation, Chemical; Wound | 1970 |
The effect of lathyrogens on developing midfacial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Cleft Palate; Diet; Face; Femal | 1971 |
Desmosine biosynthesis: nature of inhibition by D-penicillamine.
Topics: Adipates; Amino Acids; Aminopropionitrile; Animals; Aorta; Chick Embryo; Collagen; Connective Tissue | 1968 |
Reversal by copper of the lathyrogenic action of D-penicillamine.
Topics: Animals; Body Weight; Collagen; Copper; Creatinine; Hydroxyproline; Lathyrism; Male; Monoamine Oxida | 1968 |
Osteolathyrogenic effect of penicillamine.
Topics: Animals; Bone and Bones; Connective Tissue; Diet; Epiphyses; Female; Lathyrism; Mice; Penicillamine; | 1969 |
A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. II. Functional groups involved in the interaction process.
Topics: Aldehydes; Amino Acids; Aminopropionitrile; Animals; Chemical Phenomena; Chemistry; Collagen; Dialys | 1969 |
Effects of lysosomal collagenolytic enzymes, anti-inflammatory drugs and other substances on some properties of insoluble collagen.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cathepsins; Collagen; Copper; Cysteine; Hy | 1969 |
The biosynthesis of elastin cross-links. The effect of copper deficiency and a lathyrogen.
Topics: Amino Acids; Aminopropionitrile; Animals; Aorta; Chick Embryo; Copper; Culture Techniques; Cyanides; | 1965 |
Accumulation of a collagen precursor in the skin of penicillamine-treated rats.
Topics: Aminopropionitrile; Animals; Collagen; In Vitro Techniques; Lathyrism; Penicillamine; Proline; Rats; | 1965 |