penicillamine and Kidney Calculi studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.

Research Excerpts

Excerpt	Relevance	Reference
"A 2 1/4 year-old boy was treated for cystinuria and urolithiasis with high fluid intake, sodium bicarbonate, and D-penicillamine, over a period of 5 3/4 years, unauthorized interruptions and prescribed pauses included."	7.66	Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria. ( Gitzelmann, R; Otten, A; Steinmann, B, 1979)
"Bilateral staghorn renal calculi in a 7-year-old girl with cystinuria were dissolved over a period of 6 months, using a high fluid intake, urinary alkalinisation, and D-penicillamine."	3.66	Dissolution of bilateral staghorn cystine renal calculi. ( Van Dugteren, GR; Wiggelinkhuizen, J, 1979)
"A 2 1/4 year-old boy was treated for cystinuria and urolithiasis with high fluid intake, sodium bicarbonate, and D-penicillamine, over a period of 5 3/4 years, unauthorized interruptions and prescribed pauses included."	3.66	Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria. ( Gitzelmann, R; Otten, A; Steinmann, B, 1979)
"Cystinuria is the most common monogenic nephrolithiasis disorder."	2.72	[Cystinuria]. ( Courbebaisse, M; Daudon, M; Defazio, J; Dousseaux, MP; Knebelmann, B; Prot-Bertoye, C; Tostivint, I; Traxer, O, 2021)
"Cystinuria is a hereditary disorder caused by a defect in the apical membrane transport system for cystine and dibasic amino acids in renal proximal tubules and intestine, resulting in recurrent urolithiasis."	1.34	Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies. ( Aranda, J; Clèries, R; Colell, G; Espino, M; Feliubadaló, L; Font-Llitjós, M; Frey, IM; Mañas, S; Nunes, V; Palacín, M; Palomo, S; Puertas, S; Visa, J, 2007)
"Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign."	1.29	Hypercalciuria and nephrocalcinosis, a feature of Wilson's disease. ( Forster, I; Hoppe, B; Leumann, E; Neuhaus, T; Superti-Furga, A, 1993)
"Cystinuria is a rare cause of renal calculi, accounting for about 1 percent of cases."	1.28	Management of cystine nephrolithiasis by endourologic methods and shock-wave lithotripsy. ( Castaneda-Zuniga, W; Hernandez-Graulau, JM; Hulbert, JC; Hunter, D, 1989)
"Cystinuria is measured by automatic analyser chromatography."	1.27	[Results of long-term treatment of cystine lithiasis with D-penicillamine]. ( Bec, P; Lacombe, JL; Malha, F; Pujo, JM, 1984)
"Cystinuria is a complex hereditary disorder characterized by excessive urinary excretion of cystine."	1.27	Management of the patient with cystinuria. ( Pahira, JJ, 1987)
"Significant progress of nephrolithiasis and nephrocalcinosis was observed in 80% of patients with permanent hypomagnesemia and in 4% of patients with normalization of serum magnesium level."	1.27	Prognosis of urolithiasis and nephrocalcinosis in hypomagnesemia. ( Karlíková, L; Revúsová, V; Suchánek, B; Zvara, V, 1985)
"The treatment of nephrolithiasis depends mainly on the type of stone present."	1.26	[Recent advances in the treatment of nephrolithiasis (author's transl)]. ( Frohmüller, H, 1979)
"A patient with Wilson's disease presented at the age of 41 with a neurological defect and gross osteomalacia secondary to a defect of renal tubular reabsorption."	1.25	Effect of treatment on renal function in severe osteomalacia due to Wilson's disease. ( Monro, P, 1970)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (83.05)	18.7374
1990's	4 (6.78)	18.2507
2000's	5 (8.47)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (1.69)	2.80

Authors	Studies
Prot-Bertoye, C	1
Daudon, M	2
Tostivint, I	1
Dousseaux, MP	1
Defazio, J	1
Traxer, O	1
Knebelmann, B	1
Courbebaisse, M	1
Roest, MA	1
Ratnavel, R	1
Rakhimova, OIu	1
Rozina, TP	1
Ignatova, TM	1
CRAWHALL, JC	1
SCOWEN, EF	1
WATTS, RW	1
YENDT, ER	1
MCDONALD, JE	1
HENNEMAN, PH	1
Knoll, T	1
Janitzky, V	1
Michel, MS	1
Alken, P	1
Köhrmann, KU	1
Font-Llitjós, M	1
Feliubadaló, L	1
Espino, M	1
Clèries, R	1
Mañas, S	1
Frey, IM	1
Puertas, S	1
Colell, G	1
Palomo, S	1
Aranda, J	1
Visa, J	1
Palacín, M	1
Nunes, V	1
Bec, P	1
Lacombe, JL	1
Malha, F	1
Pujo, JM	1
Coe, FL	1
Favus, MJ	1
Kokot, F	1
Viville, C	1
de Petriconi, R	1
Stark, H	1
Savir, A	1
Preminger, GM	1
Hoppe, B	1
Neuhaus, T	1
Superti-Furga, A	1
Forster, I	1
Leumann, E	1
Pierides, AM	1
Deltas, CC	1
Barbey, F	1
Joly, D	1
Rieu, P	1
N'Guessau, K	1
Jungers, P	1
Van Dugteren, GR	1
Wiggelinkhuizen, J	1
Frohmüller, H	1
Lichte, H	1
Hör, G	1
Steinmann, B	1
Otten, A	1
Gitzelmann, R	1
Taylor, A	1
Davis, G	1
Halpern, S	1
Ashburn, W	1
Terhorst, B	1
Drago, JR	1
Rohner, TJ	1
Sanford, EJ	1
Dore, B	1
Irani, J	1
Marroncle, M	1
Aubert, J	1
Hernandez-Graulau, JM	1
Castaneda-Zuniga, W	1
Hunter, D	1
Hulbert, JC	1
Singh, A	1
Marshall, FF	1
Chang, R	1
Pak, CY	1
Fuller, C	1
Sakhaee, K	1
Zerwekh, JE	1
Adams, BV	1
Pahira, JJ	1
Revúsová, V	1
Zvara, V	1
Karlíková, L	1
Suchánek, B	1
Alken, CE	1
Thomas, WC	1
Kallistratos, G	2
Malorny, G	1
Oliver, L	1
Liberman, AU	1
De Vries, A	1
Kozal, H	1
Czekalski, S	1
Rzymski, K	1
Ozog, LS	1
Tomskey, GC	1
King, JS	1
Wainer, A	1
Timmermann, A	1
Fenner, O	1
Smith, LH	1
Lurie, A	1
Harada, T	1
Takahashi, Y	1
Kato, T	1
Monro, P	1
Drach, GW	1
Smith, MJ	1
Boyce, WH	1
Fawcett, NP	1
Nyhan, WL	1
Vergis, JG	1
Walker, BR	1
Deutz, H	1
Wenzl, H	1
Kludas, M	1
Thomas, J	1
Steg, A	1
Aboulker, P	1
Lange, J	1
Freund, K	1
Büechl, H	1
Bischops, G	1
Dodinval, P	1
Willems, C	1
Boström, H	1
Wojnarowski, M	1
Rowecka-Trzebicka, K	1
Kuźnik, Z	1
Solga, U	1
Precht, K	1
Hutchison, AG	1
Kollwitz, AA	1
Zoratto, E	1
Cocuzza, S	1
Dworschak, W	1
Haschek, H	1
Lotz, M	1
Bartter, FC	1

Article	Year
[Cystinuria]. Nephrologie & therapeutique, 2021, Volume: 17S Topics: Cystine; Cystinuria; Humans; Kidney Calculi; Penicillamine; Tiopronin	2021
[Cystinuria - Cystine Stones: Recommendations for Diagnosis, Therapy and Follow-up]. Aktuelle Urologie, 2003, Volume: 34, Issue:2 Topics: Adult; Age Factors; Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Captopril; Chelating Ag	2003
Treatment of renal calculi. Advances in internal medicine, 1980, Volume: 26 Topics: Acidosis, Renal Tubular; Allopurinol; Benzothiadiazines; Calcium; Calcium, Dietary; Cystinuria; Diur	1980
Is there a need for medical evaluation and treatment of nephrolithiasis in the "age of lithotripsy"? Seminars in urology, 1994, Volume: 12, Issue:1 Topics: Antacids; Benzothiadiazines; Calcium; Cation Exchange Resins; Cellulose; Citrates; Citric Acid; Cyst	1994
Symposium on renal lithiasis. Medical aspects of renal calculous disease. Treatment and prophylaxis. The Urologic clinics of North America, 1974, Volume: 1, Issue:2 Topics: Acidosis, Renal Tubular; Allopurinol; Anti-Bacterial Agents; Bacterial Infections; Cystinuria; Diet;	1974

Article	Year
Elastosis perforans serpiginosa of the penis. BJU international, 2003, Volume: 91, Issue:4 Topics: Adult; Chelating Agents; Connective Tissue Diseases; Cystinuria; Elastic Tissue; Humans; Kidney Calc	2003
[Nephrolithiasis as an initial clinical manifestation of Wilson-Konovalov disease]. Terapevticheskii arkhiv, 2003, Volume: 75, Issue:6 Topics: Adolescent; Adult; Chelating Agents; Diagnosis, Differential; Female; Hepatolenticular Degeneration;	2003
FURTHER OBSERVATIONS ON USE OF D-PENICILLAMINE IN CYSTINURIA. British medical journal, 1964, May-30, Volume: 1, Issue:5395 Topics: Adolescent; Body Fluids; Child; Chromatography; Cystinuria; Humans; Kidney Calculi; Penicillamine; U	1964
DRUGS USED IN THE MANAGEMENT OF RENAL CALCULI. Canadian Medical Association journal, 1965, Aug-14, Volume: 93 Topics: Alkalies; Antacids; Citrates; Drug Therapy; Humans; Hyaluronoglucosaminidase; Inositol; Kidney Calcu	1965
STONE DISSOLUTION IN VIVO AND CONTROL OF CYSTINURIA WITH D-PENICILLAMINE. The New England journal of medicine, 1965, Sep-09, Volume: 273 Topics: Alkaline Phosphatase; Blood Sedimentation; Cystinuria; Drug Therapy; Eosinophilia; Humans; Kidney Ca	1965
Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies. American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:3 Topics: Amino Acid Transport Systems, Basic; Animals; Body Weight; Cystinuria; Disease Models, Animal; Kidne	2007
[Results of long-term treatment of cystine lithiasis with D-penicillamine]. Nephrologie, 1984, Volume: 5, Issue:5 Topics: Adult; Age Factors; Child, Preschool; Cystine; Cystinuria; Female; Humans; Kidney Calculi; Male; Mid	1984
[Use of immunosuppresive agents in the treatment of kidney diseases. Drug therapy of uremia and kidney calculi]. Przeglad lekarski, 1982, Volume: 39, Issue:7 Topics: Allopurinol; Azathioprine; Benzothiadiazines; Cyclophosphamide; Diuretics; Glucocorticoids; Humans;	1982
[Cystinuria, cystine lithiasis and D. penicillamine (author's transl)]. Journal d'urologie, 1980, Volume: 86, Issue:1 Topics: Adolescent; Adult; Alkaline Phosphatase; Child; Child, Preschool; Cystinuria; Humans; Infant; Infant	1980
Dissolution of cystine calculi by pelviocaliceal irrigation with D-penicillamine. The Journal of urology, 1980, Volume: 124, Issue:6 Topics: Adolescent; Cystine; Cystinuria; Female; Humans; Kidney Calculi; Patient Compliance; Penicillamine;	1980
Hypercalciuria and nephrocalcinosis, a feature of Wilson's disease. Nephron, 1993, Volume: 65, Issue:3 Topics: Adolescent; Calcium; Hematuria; Hepatolenticular Degeneration; Humans; Kidney Calculi; Male; Nephroc	1993
Clinical aspects of cystinuria. Contributions to nephrology, 1997, Volume: 122 Topics: Adolescent; Adult; Chelating Agents; Child; Child, Preschool; Cystine; Cystinuria; Diet; Female; Hum	1997
[Medical treatment of cystinuria: evaluation of long-term results in 30 patients]. Presse medicale (Paris, France : 1983), 2000, Mar-18, Volume: 29, Issue:10 Topics: Adolescent; Adult; Age of Onset; Analysis of Variance; Biomarkers; Case-Control Studies; Creatinine;	2000
Dissolution of bilateral staghorn cystine renal calculi. Archives of disease in childhood, 1979, Volume: 54, Issue:10 Topics: Child; Cystinuria; Female; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Penici	1979
[Recent advances in the treatment of nephrolithiasis (author's transl)]. Aktuelle Gerontologie, 1979, Volume: 9, Issue:12 Topics: Calcium; Cystine; Fluid Therapy; Humans; Kidney Calculi; Methods; Penicillamine; Uric Acid	1979
[Renal scintigraphy with 99mTc-penicillamine]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1975, Volume: 122, Issue:2 Topics: Chlormerodrin; Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney; Kidney Calculi; Kidney Disea	1975
Skin and bone lesions (dermato-osteolathyrism), possible side effects of D-penicillamine treatment, in a boy with cystinuria. Helvetica paediatrica acta, 1979, Volume: 34, Issue:3 Topics: Atrophy; Bicarbonates; Bone and Bones; Bone Diseases; Child, Preschool; Cystinuria; Drug Eruptions;	1979
99mtechnetium penicillamine: a renal cortical scanning agent. The Journal of urology, 1977, Volume: 117, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Child; Drug Evaluation; Evaluation Studies as Topic; Female; Humans; Hy	1977
[Possibilities of drug prevention of calculi]. Hippokrates, 1977, Volume: 48, Issue:2 Topics: Allopurinol; Aluminum Hydroxide; Benzbromarone; Humans; Kidney Calculi; Penicillamine	1977
Cystinuria. Pennsylvania medicine, 1976, Volume: 79, Issue:4 Topics: Adult; Cystinuria; Female; Humans; Kidney Calculi; Male; Middle Aged; Penicillamine; Radiography	1976
Cystinuria. The Medical journal of Australia, 1976, Nov-20, Volume: 2, Issue:21 Topics: Child; Child, Preschool; Cystinuria; Humans; Infant, Newborn; Kidney Calculi; Penicillamine	1976
[Cystinic lithiasis. Current aspects of the urologic treatment]. Journal d'urologie, 1990, Volume: 96, Issue:5 Topics: Adult; Aged; Cystinuria; Female; Humans; Kidney Calculi; Lithotripsy; Male; Middle Aged; Nephrostomy	1990
Management of cystine nephrolithiasis by endourologic methods and shock-wave lithotripsy. Urology, 1989, Volume: 34, Issue:3 Topics: Adult; Cystinuria; Female; Fluid Therapy; Humans; Kidney Calculi; Lithotripsy; Male; Middle Aged; Ne	1989
Cystine calculi: clinical management and in vitro observations. Urology, 1988, Volume: 31, Issue:3 Topics: Acetylcysteine; Adult; Ascorbic Acid; Bicarbonates; Cystine; Cystinuria; Female; Homozygote; Humans;	1988
Management of the patient with cystinuria. The Urologic clinics of North America, 1987, Volume: 14, Issue:2 Topics: Adult; Alkalies; Child; Cystinuria; Dietary Proteins; Female; Fluid Therapy; Humans; Kidney Calculi;	1987
Prognosis of urolithiasis and nephrocalcinosis in hypomagnesemia. Czechoslovak medicine, 1985, Volume: 8, Issue:4 Topics: Adolescent; Adult; Aged; Allopurinol; Cation Exchange Resins; Cellulose; Child; Child, Preschool; Ci	1985
[Conservative management of kidney calculi]. Wiener klinische Wochenschrift, 1967, Sep-08, Volume: 79, Issue:36 Topics: Analgesics; Calcium; Diphosphates; Humans; Kidney Calculi; Penicillamine; Phosphorus	1967
[Experimental studies on the chemical dissolution of cystine stones]. Arzneimittel-Forschung, 1972, Volume: 22, Issue:9 Topics: Animals; Cysteamine; Cysteine; Cystine; Disulfides; Dithiothreitol; Glutathione; Glycine; Isomerism;	1972
[Prevention and dissolution of cystine stones by D-penicillinamine]. Harefuah, 1973, Jan-01, Volume: 84, Issue:1 Topics: Adult; Cystinuria; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Kidney Calculi; Male; M	1973
[Cuprenil Polfa (D-penicillamine) in treatment of cystinuria]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1973, Volume: 28, Issue:39 Topics: Adolescent; Adult; Cystinuria; Female; Humans; Kidney Calculi; Penicillamine	1973
Diagnosis and treatment of cystinuria. Urology, 1974, Volume: 3, Issue:2 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Bicarbonates; Biological Transport; Colorin	1974
Cystinuria with hyperuricemia and methioninuria. Biochemical study of a case. The American journal of medicine, 1967, Volume: 43, Issue:1 Topics: Adult; Amino Acids; Cystinuria; Female; Homocysteine; Humans; Kidney Calculi; Methionine; Penicillam	1967
[Indications for the conservative chemical dissolution of kidney stones]. Munchener medizinische Wochenschrift (1950), 1969, Aug-29, Volume: 111, Issue:35 Topics: Edetic Acid; Female; Glycine; Humans; Ion Exchange Resins; Kidney Calculi; Lactates; Methods; Middle	1969
Nephrolithiasis. Current concepts in pathogenesis and management. Postgraduate medicine, 1972, Volume: 52, Issue:3 Topics: Acidosis, Renal Tubular; Citrates; Cystinuria; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentrati	1972
[Conservative treatment of nephrolithiasis]. Harefuah, 1972, Jul-16, Volume: 83, Issue:2 Topics: Alkalies; Allopurinol; Calculi; Citrates; Diuresis; Humans; Ion Exchange Resins; Kidney Calculi; Pen	1972
[Cases of cystinuria with urinary tract stones in sisters]. Hinyokika kiyo. Acta urologica Japonica, 1971, Volume: 17, Issue:9 Topics: Adolescent; Adult; Amino Acids; Cystinuria; Female; Humans; Kidney Calculi; Penicillamine; Urinary B	1971
Effect of treatment on renal function in severe osteomalacia due to Wilson's disease. Journal of clinical pathology, 1970, Volume: 23, Issue:6 Topics: Adult; Alkaline Phosphatase; Amino Acids; Ergocalciferols; Fanconi Syndrome; Hepatolenticular Degene	1970
Medical therapy of renal calculi. The Journal of urology, 1970, Volume: 104, Issue:5 Topics: Allopurinol; Calcium; Creatinine; Cystinuria; Diuresis; Humans; Kidney; Kidney Calculi; Magnesium; M	1970
Cystinuria and dermatomyositis. Clinical pediatrics, 1970, Volume: 9, Issue:12 Topics: Adolescent; Amino Acids; Chromatography, Paper; Cystinuria; Dermatomyositis; Electromyography; Femal	1970
Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report. Nephron, 1970, Volume: 7, Issue:6 Topics: Adult; Allopurinol; Cystine; Cystinuria; Female; Glycine; Humans; Kidney Calculi; Penicillamine; Uri	1970
[Preoperative diagnosis and postoperative treatment of cystine calculi]. Zeitschrift fur Urologie und Nephrologie, 1970, Volume: 63, Issue:12 Topics: Adult; Cystine; Cystinuria; Diet Therapy; Female; Humans; Hydrogen-Ion Concentration; Kidney Calculi	1970
[Therapeutic problems during D-penicillamine treatment of patients with cystine calculi]. Munchener medizinische Wochenschrift (1950), 1970, Nov-27, Volume: 112, Issue:48 Topics: Adolescent; Adult; Albuminuria; Copper; Cystine; Cystinuria; Female; Humans; Kidney Calculi; Penicil	1970
[Medical treatment of uric lithiasis and cystinic lithiasis]. Annales de chirurgie, 1967, Volume: 21, Issue:25 Topics: Bicarbonates; Citrates; Diet Therapy; Humans; Kidney Calculi; Penicillamine; Potassium; Tromethamine	1967
[The treatment of cystinuria with D-penicillamine together with a contribution on the determination of cystine in urine]. Arzneimittel-Forschung, 1967, Volume: 17, Issue:7 Topics: Adult; Cystinuria; Homozygote; Humans; Hydronephrosis; Kidney Calculi; Male; Methods; Penicillamine;	1967
[Observation and treatment of 2 cases of cystinuria with recurring lithiasis. Trial of D-pencillamine]. Journal d'urologie et de nephrologie, 1968, Volume: 74, Issue:3 Topics: Adolescent; Adult; Arginine; Chromatography, Paper; Chronic Disease; Cystinuria; Female; Humans; Kid	1968
[Experiences with penicillamine therapy for cystinuria]. Lakartidningen, 1968, Jun-04, Volume: 65 Topics: Adolescent; Adult; Cystinuria; Female; Humans; Kidney Calculi; Male; Middle Aged; Penicillamine; Rad	1968
[Cystinuria in the light of studies of twins]. Pediatria polska, 1968, Volume: 43, Issue:12 Topics: Cystinuria; Diseases in Twins; Female; Humans; Infant; Kidney Calculi; Penicillamine	1968
[Conservative therapy and prophylaxis of kidney calculi diseases]. Das Deutsche Gesundheitswesen, 1968, Dec-27, Volume: 23, Issue:52 Topics: Alkalies; Anti-Bacterial Agents; Diet Therapy; Humans; Kidney Calculi; Penicillamine; Pyridoxine	1968
Cystine stones treated by surgery and D-penicillamine. Proceedings of the Royal Society of Medicine, 1968, Volume: 61, Issue:11 Part 1 Topics: Adolescent; Cystine; Cystinuria; England; Follow-Up Studies; Humans; Kidney Calculi; Male; Penicilla	1968
[Therapy of calculi of the upper urinary tract]. Der Landarzt, 1968, Oct-10, Volume: 44, Issue:28 Topics: Acetates; Acids; Alkalies; Allopurinol; Citrates; Humans; Kidney Calculi; Penicillamine; Ureteral Ca	1968
[On a case of cystine renal calculosis]. Minerva pediatrica, 1968, Oct-13, Volume: 21, Issue:29 Topics: Child, Preschool; Cystinosis; Humans; Kidney Calculi; Male; Penicillamine; Radiography	1968
[Conservative treatment of kidney calculi]. Medizinische Klinik, 1969, Feb-14, Volume: 64, Issue:7 Topics: Allopurinol; Calcium; Calcium Phosphates; Chemical Phenomena; Chemistry; Citrates; Cystine; Diagnosi	1969
Stone dissolution with D-penicillamine in cystinuria. British medical journal, 1965, Dec-11, Volume: 2, Issue:5475 Topics: Adolescent; Adult; Cystinuria; Female; Humans; Kidney Calculi; Male; Penicillamine; Urinary Bladder	1965

penicillamine and Kidney Calculi

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