penicillamine has been researched along with Innate Inflammatory Response in 42 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 9.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| " D-penicillamine, a drug effective in the proliferative synovitis of rheumatoid arthritis, was evaluated in a rabbit model of hemarthroses-induced arthritis and in four hemophiliacs with chronic synovitis." | 7.67 | Treatment of hemophilic arthritis with D-penicillamine: a preliminary report. ( Corrigan, JJ; Damiano, ML; Gall, EP; Jeter, M; Kolba, KS; Meredith, K; Trombley, J, 1985) |
| "Levamisole potentiated paw oedema induced by carrageenan in the rat whereas penicillamine was without effect." | 7.66 | Effects of levamisole and D-penicillamine in rat paw oedema induced by carrageenan and by kaolin. ( Tranter, BC; West, GB, 1979) |
| "The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment." | 7.65 | The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma. ( Bock, G; Paulini, K; Sonntag, W, 1977) |
| "The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment." | 7.65 | The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma. ( Bock, G; Paulini, K; Sonntag, W, 1977) |
| "Serial liver biopsy changes have been reviewed in 30 patients with Indian childhood cirrhosis (ICC) who were randomly allocated to receive treatment with penicillamine in a dose of 20 mg/kg/day, 10 of whom also received prednisolone, and five receiving placebo." | 5.08 | Reversal of Indian childhood cirrhosis by D-penicillamine therapy. ( Bavdekar, AR; Bhave, SA; Joshi, VV; Pandit, AN; Pradhan, AM; Tanner, MS, 1995) |
| " D-penicillamine, a drug effective in the proliferative synovitis of rheumatoid arthritis, was evaluated in a rabbit model of hemarthroses-induced arthritis and in four hemophiliacs with chronic synovitis." | 3.67 | Treatment of hemophilic arthritis with D-penicillamine: a preliminary report. ( Corrigan, JJ; Damiano, ML; Gall, EP; Jeter, M; Kolba, KS; Meredith, K; Trombley, J, 1985) |
| "D-penicillamine was found to have a pro-inflammatory effect when given to rats during the formation of carrageenan air pouch granulomas or simple air cavity linings." | 3.66 | The effects of D-penicillamine on non-immune responses to tissue injury. ( Edwards, JC; Sedgwick, AD; Willoughby, DA, 1983) |
| "Levamisole potentiated paw oedema induced by carrageenan in the rat whereas penicillamine was without effect." | 3.66 | Effects of levamisole and D-penicillamine in rat paw oedema induced by carrageenan and by kaolin. ( Tranter, BC; West, GB, 1979) |
| "The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment." | 3.65 | The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma. ( Bock, G; Paulini, K; Sonntag, W, 1977) |
| "The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment." | 3.65 | The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma. ( Bock, G; Paulini, K; Sonntag, W, 1977) |
| "Some of the implications are that Alzheimer's disease and other diseases of neurodegeneration and fibrotic, inflammatory, and autoimmune diseases may be treatable by lowering the availability of free copper." | 2.44 | The risks of free copper in the body and the development of useful anticopper drugs. ( Brewer, GJ, 2008) |
| "Inflammation was induced in the six-day air pouch either with the non-immune irritant carrageenan or the immune irritant Bordetella pertussis." | 1.27 | The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats. ( Al-Duaij, AY; Sedgwick, AD; Willoughby, DA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (76.19) | 18.7374 |
| 1990's | 3 (7.14) | 18.2507 |
| 2000's | 5 (11.90) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brewer, GJ | 2 |
| Daoussis, D | 1 |
| Panoulas, VF | 1 |
| John, H | 1 |
| Toms, TE | 1 |
| Antonopoulos, I | 1 |
| Treharne, G | 1 |
| Nightingale, P | 1 |
| Douglas, KM | 1 |
| Kitas, GD | 1 |
| Medici, V | 1 |
| Shibata, NM | 1 |
| Kharbanda, KK | 1 |
| LaSalle, JM | 1 |
| Woods, R | 1 |
| Liu, S | 1 |
| Engelberg, JA | 1 |
| Devaraj, S | 1 |
| Török, NJ | 1 |
| Jiang, JX | 1 |
| Havel, PJ | 1 |
| Lönnerdal, B | 1 |
| Kim, K | 1 |
| Halsted, CH | 1 |
| Bar-Shai, M | 1 |
| Hasnis, E | 1 |
| Wiener-Megnazi, Z | 1 |
| Reznick, AZ | 1 |
| Bailey, KR | 1 |
| Sheffner, AL | 1 |
| Coyle, HE | 1 |
| Chapman, RS | 1 |
| Nakagawa, H | 2 |
| Binderup, L | 1 |
| Bramm, E | 2 |
| Arrigoni-Martelli, E | 1 |
| Sedgwick, AD | 3 |
| Edwards, JC | 1 |
| Willoughby, DA | 3 |
| Panayi, GS | 1 |
| Wooley, PH | 1 |
| Griffin, J | 1 |
| Batchelor, JR | 1 |
| Welsh, K | 1 |
| Gibson, TJ | 1 |
| Meacock, SC | 1 |
| Swann, BP | 1 |
| Dawson, W | 1 |
| Multz, CV | 1 |
| Capasso, F | 1 |
| Mascolo, N | 1 |
| Autore, G | 1 |
| Pradhan, AM | 1 |
| Bhave, SA | 1 |
| Joshi, VV | 1 |
| Bavdekar, AR | 1 |
| Pandit, AN | 1 |
| Tanner, MS | 1 |
| Hantson, P | 1 |
| Lievens, M | 1 |
| Mahieu, P | 1 |
| Murphy, HS | 1 |
| Warner, RL | 1 |
| Bakopoulos, N | 1 |
| Dame, MK | 1 |
| Varani, J | 1 |
| Ward, PA | 1 |
| Wheeler, MA | 1 |
| Yoon, JH | 1 |
| Olsson, LE | 1 |
| Weiss, RM | 1 |
| Yamamoto, M | 1 |
| Hara, H | 1 |
| Adachi, T | 1 |
| Vapaatalo, H | 1 |
| Parantainen, J | 1 |
| Lindén, IB | 1 |
| Ohkoshi, K | 1 |
| Tsurufuji, S | 1 |
| Tranter, BC | 1 |
| West, GB | 2 |
| Epler, GR | 1 |
| Snider, GL | 1 |
| Gaensler, EA | 1 |
| Cathcart, ES | 1 |
| FitzGerald, MX | 1 |
| Carrington, CB | 1 |
| Paulini, K | 2 |
| Bock, G | 2 |
| Sonntag, W | 2 |
| Clarke, AK | 1 |
| Vernon-Roberts, B | 2 |
| Currey, HL | 1 |
| Arrigoni-Martelld, E | 1 |
| Whitehouse, MW | 3 |
| Ercoli, N | 1 |
| Sánchez, A | 1 |
| McLure, M | 1 |
| Junker, P | 1 |
| Al-Duaij, AY | 2 |
| Kaschak, TJ | 1 |
| Edworthy, S | 1 |
| Cleland, LG | 1 |
| Connolly, KM | 1 |
| Stecher, VJ | 1 |
| Danis, E | 1 |
| Pruden, DJ | 1 |
| LaBrie, T | 1 |
| Beveridge, SJ | 1 |
| Garrett, IR | 1 |
| Brooks, PM | 1 |
| Hiroi, J | 1 |
| Ohara, K | 1 |
| Fujitsu, T | 1 |
| Hirai, O | 1 |
| Satoh, S | 1 |
| Ochi, T | 1 |
| Senoh, H | 1 |
| Mori, J | 1 |
| Kikuchi, H | 1 |
| Cashin, CH | 1 |
| Lewis, EJ | 1 |
| Burden, T | 1 |
| Corrigan, JJ | 1 |
| Kolba, KS | 1 |
| Gall, EP | 1 |
| Trombley, J | 1 |
| Damiano, ML | 1 |
| Meredith, K | 1 |
| Jeter, M | 1 |
| Behrend, T | 1 |
| Thomas, G | 1 |
| Mörsdorf, K | 1 |
| Knippertz, T | 1 |
| Rausch, KD | 1 |
| Domenjoz, R | 1 |
6 reviews available for penicillamine and Innate Inflammatory Response
| Article | Year |
|---|---|
The risks of free copper in the body and the development of useful anticopper drugs.
Topics: Alzheimer Disease; Angiogenesis Inhibitors; Autoimmunity; Copper; Fibrosis; Hepatolenticular Degener | 2008 |
Anticopper therapy against cancer and diseases of inflammation and fibrosis.
Topics: Animals; Copper; Fibrosis; Humans; Inflammation; Molybdenum; Neoplasms; Neovascularization, Patholog | 2005 |
[Regulation of chronic proliferative inflammation by anti-inflammatory drugs (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Collagen; Disease Models, Animal; Granulation Tissue | 1982 |
The dynamics and possible roles of metal complexes in inflammation.
Topics: Chemotaxis; Collagen; Copper; Humans; Immunity; In Vitro Techniques; Inflammation; Iron; Manganese; | 1981 |
D-penicillamine effects on inflammatory and normal connective tissues in rats. Studies on collagen, glycosaminoglycans and nucleic acids with particular reference to antirheumatoid therapy.
Topics: Animals; Collagen; Connective Tissue; Connective Tissue Diseases; DNA; Glycosaminoglycans; Inflammat | 1985 |
Pharmacologic management of inflammatory joint disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antimetabolites; Arthritis; Gold; Gout; Huma | 1988 |
1 trial available for penicillamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.
Topics: Biopsy; Copper; Female; Fibrosis; Humans; India; Infant; Inflammation; Liver; Liver Cirrhosis; Male; | 1995 |
35 other studies available for penicillamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation.
Topics: Aged; Albuminuria; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; | 2011 |
Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
Topics: Adenosylhomocysteinase; Animals; Betaine; Copper; Disease Models, Animal; DNA (Cytosine-5-)-Methyltr | 2013 |
The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Inflammation; Lymphocytes; Molsidomine; NF-kappa B; Nic | 2006 |
The reduction of experimentally induced inflammation by sulfhydryl compounds.
Topics: Acetylcysteine; Animals; Dexamethasone; Drug Synergism; Hydrocortisone; Inflammation; Male; Methioni | 1967 |
Eosinophilic fasciitis (Shulman syndrome) in association with morphoea and systemic sclerosis.
Topics: Eosinophils; Fascia; Humans; Inflammation; Male; Middle Aged; Penicillamine; Scleroderma, Localized; | 1980 |
The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Chronic Disease; Concanavalin A; Female; Go | 1982 |
The effects of D-penicillamine on non-immune responses to tissue injury.
Topics: Animals; Carrageenan; Cell Movement; Dexamethasone; Granuloma; Inflammation; Male; Penicillamine; Ra | 1983 |
HLA antigens in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Gold; HLA Antigens; Humans; Inflammation; Major Histocompatibility Complex; P | 1980 |
Cholestatic hepatitis caused by penicillamine.
Topics: Arthritis, Rheumatoid; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Cholestasis | 1981 |
The effects of levamisole and D-penicillamine on some inflammatory models in vivo and on PG production in vitro.
Topics: Animals; Disease Models, Animal; Edema; In Vitro Techniques; Indomethacin; Inflammation; Leukocytes; | 1981 |
Accidental ingestion of a zinc and copper sulfate preparation.
Topics: Aged; Aged, 80 and over; Cardiovascular System; Chelating Agents; Copper Sulfate; Digestive System; | 1996 |
Endothelial cell determinants of susceptibility to neutrophil-mediated killing.
Topics: Animals; Catalase; Cells, Cultured; E-Selectin; Endothelium, Vascular; Fluorescent Dyes; Free Radica | 1999 |
Cyclooxygenase-2 protein and prostaglandin E(2) production are up-regulated in a rat bladder inflammation model.
Topics: Administration, Intravesical; Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cycloo | 2001 |
Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface.
Topics: Animals; Cattle; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vasc | 2001 |
Penicillamine and prostaglandin biosynthesis.
Topics: Animals; Humans; Inflammation; Kidney Medulla; Microsomes; Penicillamine; Prostaglandin-Endoperoxide | 1979 |
Selective inhibition of collagen synthesis by D-penicillamine in carrageenin-induced inflammation in rats.
Topics: Animals; Carrageenan; Collagen; Ferrous Compounds; Hydroxylation; Inflammation; Male; Penicillamine; | 1979 |
Effects of levamisole and D-penicillamine in rat paw oedema induced by carrageenan and by kaolin.
Topics: Animals; Carrageenan; Edema; Female; Inflammation; Kaolin; Levamisole; Male; Penicillamine; Rats | 1979 |
Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine.
Topics: Adult; Arthritis, Rheumatoid; Bronchitis; Collagen Diseases; Eosinophils; Fascia; Female; Humans; In | 1979 |
The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.
Topics: Animals; Body Weight; Cell Division; Collagen; DNA; Exudates and Transudates; Fibroblasts; Inflammat | 1977 |
The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.
Topics: Animals; Body Weight; Cell Division; Collagen; DNA; Granuloma; Inflammation; Male; Penicillamine; Ra | 1977 |
Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Biological Assay; Cyclophosphamide; Female | 1975 |
Investigations on the influence of cyclophosphamide, gold sodium thiomalate and D-penicillamine on nystatin oedema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Cyclophosphamide; Disease Models, Animal; Female; Gold | 1975 |
Ambivalent role of copper in inflammatory disorders.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Copper; Humans; Inflammation; Irritants; P | 1976 |
[Experimental studies on the anti-inflammatory action of penicillamines].
Topics: Animals; Anti-Inflammatory Agents; Drug Evaluation; Inflammation; Penicillamine; Rats | 1976 |
The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats.
Topics: Animals; Anti-Inflammatory Agents; Bordetella pertussis; Carrageenan; Dexamethasone; Disease Models, | 1986 |
Reactive oxygen species and drug therapy for inflammatory diseases.
Topics: Anti-Inflammatory Agents; Antioxidants; Ceruloplasmin; Free Radicals; Humans; Inflammation; Lipid Pe | 1985 |
Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying antirheumatic drugs.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experi | 1988 |
Studies on the effects of non-steroidal and disease modifying agents on cartilage soft tissue interaction in vivo.
Topics: Animals; Anti-Inflammatory Agents; Cartilage; Dexamethasone; Indomethacin; Inflammation; Levamisole; | 1986 |
Biodistribution of 64Cu in inflamed rats following administration of two anti-inflammatory copper complexes.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Copper; Edema; Granuloma; I | 1985 |
[The anti-inflammatory effect of auranofin].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Auranofin; Aurothiogluco | 1985 |
The development of screening tests for D-penicillamine-like antirheumatic activity based on in vivo interactions with copper.
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Copper; Drug Interactions; Extremities; Fema | 1985 |
Treatment of hemophilic arthritis with D-penicillamine: a preliminary report.
Topics: Animals; Arthritis; Hemarthrosis; Hemophilia A; Humans; Inflammation; Penicillamine; Platelet Aggreg | 1985 |
[What is assured in the treatment of chronic inflammatory joint disease?].
Topics: Chloroquine; Chronic Disease; Gold; Humans; Immunosuppressive Agents; Inflammation; Joint Diseases; | 1972 |
Amino acids and inflammation.
Topics: Amino Acids; Animals; Carrageenan; Cysteine; Dextrans; Dose-Response Relationship, Drug; Esters; Fre | 1973 |
Studies on the antiphlogistic activity of cytostatics.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Carrageenan; Chloramphenicol; Cyclophosphamide; | 1972 |