penicillamine has been researched along with Idiopathic Inflammatory Myopathies in 40 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1979 and 1990 we have seen 8 patients (7 females) with rheumatoid arthritis (RA) who developed a neuro-muscular involvement while on D-penicillamine (D." | 8.78 | [Neuromuscular complications of D-penicillamine in rheumatoid arthritis]. ( Bouchet, F; Bussière, JL; Dubost, JJ; Kemeny, JL; Lhopitaux, R; Sauvezie, B; Soubrier, M, 1992) |
| "D-penicillamine, an agent still used in the treatment of rheumatoid arthritis (RA) may produce inflammatory myopathy or myositis." | 7.69 | D-penicillamine-induced myositis in rheumatoid arthritis. ( Chappel, R; Willems, J, 1996) |
| "Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear." | 7.68 | Polymyositis complicating D-penicillamine treatment. ( Asherson, RA; Aydintug, AO; Cervera, R; D'Cruz, D; Hughes, GR; Khamashta, MA; Ramírez, G, 1991) |
| "Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis." | 7.67 | Penicillamine-induced polymyositis with complete heart block. ( Christensen, PD; Sørensen, KE, 1989) |
| "Eight Australian cases of D-penicillamine induced polymyositis/dermatomyositis (PM/DM) are reported." | 7.67 | Penicillamine induced polymyositis and dermatomyositis. ( Carroll, GJ; Dawkins, RL; Garlepp, MJ; Peter, JB; Will, RK, 1987) |
| "Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis." | 7.67 | D-penicillamine-induced polymyositis in patients with rheumatoid arthritis. ( Miyamoto, T; Ogita, T; Okudaira, H; Takahashi, K; Yoshinoya, S; Yoshizawa, H, 1986) |
| "Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis." | 7.67 | Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis. ( De Bruyère, M; Devogelaer, JP; Huaux, JP; Isaac, G; Nagant de Deuxchaisnes, C; Noël, H, 1985) |
| "Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis." | 7.66 | Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis. ( Essigman, WK, 1982) |
| "Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years." | 7.66 | [Is myositis in chronic polyarthritis using d-penicillamine drug-induced?]. ( Bussmann, HU; Jerusalem, F; Schlumpf, U, 1981) |
| "Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described." | 7.66 | Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. ( Doyle, DR; McCurley, TL; Sergent, JS, 1983) |
| "Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine." | 7.66 | Penicillamine-induced polymyositis-dermatomyositis. ( Halberg, P; Højgaard, K; Lyon, BB; Petersen, J; Ullman, S, 1978) |
| "Between 1979 and 1990 we have seen 8 patients (7 females) with rheumatoid arthritis (RA) who developed a neuro-muscular involvement while on D-penicillamine (D." | 4.78 | [Neuromuscular complications of D-penicillamine in rheumatoid arthritis]. ( Bouchet, F; Bussière, JL; Dubost, JJ; Kemeny, JL; Lhopitaux, R; Sauvezie, B; Soubrier, M, 1992) |
| "D-penicillamine, an agent still used in the treatment of rheumatoid arthritis (RA) may produce inflammatory myopathy or myositis." | 3.69 | D-penicillamine-induced myositis in rheumatoid arthritis. ( Chappel, R; Willems, J, 1996) |
| "Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear." | 3.68 | Polymyositis complicating D-penicillamine treatment. ( Asherson, RA; Aydintug, AO; Cervera, R; D'Cruz, D; Hughes, GR; Khamashta, MA; Ramírez, G, 1991) |
| "Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis." | 3.67 | Penicillamine-induced polymyositis with complete heart block. ( Christensen, PD; Sørensen, KE, 1989) |
| "Eight Australian cases of D-penicillamine induced polymyositis/dermatomyositis (PM/DM) are reported." | 3.67 | Penicillamine induced polymyositis and dermatomyositis. ( Carroll, GJ; Dawkins, RL; Garlepp, MJ; Peter, JB; Will, RK, 1987) |
| "Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis." | 3.67 | D-penicillamine-induced polymyositis in patients with rheumatoid arthritis. ( Miyamoto, T; Ogita, T; Okudaira, H; Takahashi, K; Yoshinoya, S; Yoshizawa, H, 1986) |
| "Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis." | 3.67 | Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis. ( De Bruyère, M; Devogelaer, JP; Huaux, JP; Isaac, G; Nagant de Deuxchaisnes, C; Noël, H, 1985) |
| "Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis." | 3.66 | Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis. ( Essigman, WK, 1982) |
| "Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years." | 3.66 | [Is myositis in chronic polyarthritis using d-penicillamine drug-induced?]. ( Bussmann, HU; Jerusalem, F; Schlumpf, U, 1981) |
| "Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described." | 3.66 | Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. ( Doyle, DR; McCurley, TL; Sergent, JS, 1983) |
| "Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine." | 3.66 | Penicillamine-induced polymyositis-dermatomyositis. ( Halberg, P; Højgaard, K; Lyon, BB; Petersen, J; Ullman, S, 1978) |
| " A patient and his young sister were shown to be suffering from spinal muscular atrophy with superimposed, excessive proliferative activity of fibroblasts, and in these cases a beneficial effect of penicillamine was demonstrated." | 3.65 | The syndrome of myosclerosis. ( Bradley, WG; Gardner-Medwin, D; Hudgson, P; Walton, JN, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (80.00) | 18.7374 |
| 1990's | 7 (17.50) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Essigman, WK | 1 |
| Swartz, MO | 1 |
| Silver, RM | 1 |
| Schlumpf, U | 1 |
| Bussmann, HU | 1 |
| Jerusalem, F | 1 |
| Doyle, DR | 1 |
| McCurley, TL | 1 |
| Sergent, JS | 1 |
| Willson, RA | 1 |
| McVicker, JH | 1 |
| Lava, NS | 1 |
| Mittag, TW | 1 |
| Ringel, SP | 1 |
| Wouters, JM | 1 |
| Van de Putte, LB | 1 |
| Renier, WO | 1 |
| Joosten, EM | 1 |
| Caspi, D | 1 |
| Fishel, R | 1 |
| Varon, M | 1 |
| Yona, E | 1 |
| Baratz, M | 1 |
| Yaron, M | 1 |
| Brousson, A | 2 |
| Pélissier, J | 1 |
| Lepeu, G | 1 |
| Pages, M | 2 |
| Huttel, JM | 1 |
| Blotman, F | 1 |
| Bertrand, A | 1 |
| Simon, L | 1 |
| Major, GA | 1 |
| Fischer, RG | 1 |
| Pennebaker, JB | 1 |
| Ostensen, M | 1 |
| Husby, G | 1 |
| Aarli, J | 1 |
| Marty-Double, C | 1 |
| Pagès, AM | 1 |
| Pellissier, J | 1 |
| Garlepp, MJ | 2 |
| Chappel, R | 1 |
| Willems, J | 1 |
| Horinouchi, H | 1 |
| Kumamoto, T | 1 |
| Petersen, J | 1 |
| Halberg, P | 1 |
| Højgaard, K | 1 |
| Lyon, BB | 1 |
| Ullman, S | 1 |
| Machtey, I | 1 |
| Cucher, BG | 2 |
| Goldman, AL | 2 |
| Dubost, JJ | 1 |
| Soubrier, M | 1 |
| Bouchet, F | 1 |
| Kemeny, JL | 1 |
| Lhopitaux, R | 1 |
| Bussière, JL | 1 |
| Sauvezie, B | 1 |
| Aydintug, AO | 1 |
| Cervera, R | 1 |
| D'Cruz, D | 1 |
| Ramírez, G | 1 |
| Asherson, RA | 1 |
| Khamashta, MA | 1 |
| Hughes, GR | 1 |
| Jimenez-Balderas, FJ | 1 |
| Rangel, J | 1 |
| Mintz, G | 1 |
| Santos, JC | 1 |
| Velasco, JA | 1 |
| Taneja, V | 1 |
| Mehra, N | 1 |
| Singh, YN | 1 |
| Kumar, A | 1 |
| Malaviya, A | 1 |
| Singh, RR | 1 |
| Christensen, PD | 1 |
| Sørensen, KE | 1 |
| Muirden, KD | 1 |
| Meyer, O | 1 |
| Smiley, JD | 1 |
| Moore, SE | 1 |
| Matsumura, T | 2 |
| Yuhara, T | 1 |
| Yamane, K | 2 |
| Kono, I | 2 |
| Kabashima, T | 2 |
| Kashiwagi, H | 2 |
| Masson, CJ | 1 |
| Ménard, HA | 1 |
| Audran, M | 1 |
| Renier, JC | 1 |
| Lussier, A | 1 |
| Myhal, DM | 1 |
| Carroll, GJ | 1 |
| Will, RK | 1 |
| Peter, JB | 1 |
| Dawkins, RL | 1 |
| Takahashi, K | 1 |
| Ogita, T | 1 |
| Okudaira, H | 1 |
| Yoshinoya, S | 1 |
| Yoshizawa, H | 1 |
| Miyamoto, T | 1 |
| Leden, I | 1 |
| Libelius, R | 1 |
| Devogelaer, JP | 1 |
| Isaac, G | 1 |
| Noël, H | 1 |
| De Bruyère, M | 1 |
| Huaux, JP | 1 |
| Nagant de Deuxchaisnes, C | 1 |
| Sakurai, T | 1 |
| Yamaguchi, I | 1 |
| Schraeder, PL | 1 |
| Peters, HA | 1 |
| Dahl, DS | 1 |
| Golding, DN | 1 |
| Bettendorf, U | 1 |
| Neuhaus, R | 1 |
| Bradley, WG | 1 |
| Hudgson, P | 1 |
| Gardner-Medwin, D | 1 |
| Walton, JN | 1 |
| Nishikai, M | 1 |
| Funatsu, Y | 1 |
| Homma, M | 1 |
5 reviews available for penicillamine and Idiopathic Inflammatory Myopathies
| Article | Year |
|---|---|
Immunogenetics of inflammatory myopathies.
Topics: Autoantibodies; Complement System Proteins; Humans; Myositis; Penicillamine | 1993 |
[Toxin-induced inflammatory myopathy].
Topics: Anti-Arrhythmia Agents; Antirheumatic Agents; Humans; Myositis; Penicillamine; Procainamide; Toxins, | 2001 |
[Neuromuscular complications of D-penicillamine in rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Female; Graves Disease; Humans; Male; Middle Aged; Myasthenia Gravis; M | 1992 |
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T | 1986 |
Molecular mechanisms of autoimmunity.
Topics: Antibodies, Antinuclear; Autoantibodies; Autoimmune Diseases; B-Lymphocytes; DNA; Humans; Immunoglob | 1988 |
1 trial available for penicillamine and Idiopathic Inflammatory Myopathies
| Article | Year |
|---|---|
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T | 1986 |
35 other studies available for penicillamine and Idiopathic Inflammatory Myopathies
| Article | Year |
|---|---|
Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Humans; Lupus Erythematosus, Systemic; Male; Myastheni | 1982 |
D-penicillamine induced polymyositis in juvenile chronic arthritis: report of a case.
Topics: Adolescent; Arthritis, Juvenile; Humans; Male; Myositis; Penicillamine | 1984 |
[Is myositis in chronic polyarthritis using d-penicillamine drug-induced?].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gold Sod | 1981 |
Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Heart Block; Humans; Middle Aged; Myocarditis; Myositis; Penicillamin | 1983 |
Therapeutic quandary: asymptomatic primary biliary cirrhosis associated with polymyositis.
Topics: Alkaline Phosphatase; Female; Histocompatibility Antigens Class II; Humans; Liver Cirrhosis, Biliary | 1981 |
D-penicillamine-induced neuromuscular disease in guinea pigs.
Topics: Action Potentials; Animals; Autoantibodies; Disease Models, Animal; Electromyography; Extremities; F | 1982 |
D-penicillamine-induced polymyositis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Myositis; Penicillamine | 1982 |
Multisystem presentation of eosinophilic fasciitis.
Topics: Adult; Ankle Joint; Azathioprine; Blood Sedimentation; Bone Marrow Examination; Elbow Joint; Eosinop | 1982 |
[Polymyositis induced by D-penicillamine].
Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Musc | 1981 |
Penicillamine-induced dermatomyositis.
Topics: Arthritis, Rheumatoid; Humans; Male; Middle Aged; Myositis; Penicillamine | 1981 |
Penicillamine-induced polymyositis in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Male; Middle Aged; Myositis; Penicillamine | 1981 |
Polymyositis with acute myolysis in a patient with rheumatoid arthritis treated with penicillamine and ampicillin.
Topics: Acute Disease; Adult; Ampicillin; Arthritis, Rheumatoid; Female; Humans; Muscular Diseases; Myositis | 1980 |
[Ultrastructural study of a polymyositis caused by D-penicillamine (author's transl)].
Topics: Female; Humans; Microscopy, Electron; Middle Aged; Muscles; Myositis; Penicillamine | 1980 |
D-penicillamine-induced myositis in rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Needle; Electr | 1996 |
Penicillamine-induced polymyositis-dermatomyositis.
Topics: Action Potentials; Arthritis, Rheumatoid; Dermatomyositis; Female; Humans; Middle Aged; Muscle Contr | 1978 |
Penicillamine-induced polymyositis.
Topics: Humans; Myositis; Penicillamine | 1977 |
D-penicillamine-induced polymyositis in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bundle-Branch Block; Electromyography; Female; Humans; Middle Aged; Myositis; | 1976 |
Polymyositis complicating D-penicillamine treatment.
Topics: Adult; Arthritis, Psoriatic; Female; Humans; Liver Cirrhosis, Biliary; Middle Aged; Myositis; Penici | 1991 |
Penicillamine induced myositis: correlation between urinary zinc excretion and serum creatine.
Topics: Adult; Arthritis, Rheumatoid; Creatine; Female; Humans; Myositis; Penicillamine; Zinc | 1991 |
Polymyositis due to D-penicillamine in a patient with systemic sclerosis.
Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic | 1991 |
HLA-D region genes and susceptibility to D-penicillamine-induced myositis.
Topics: HLA-D Antigens; Humans; Myositis; Penicillamine | 1990 |
Penicillamine-induced polymyositis with complete heart block.
Topics: Aged; Arthritis, Rheumatoid; Bundle-Branch Block; Electrocardiography; Heart Block; Humans; Male; My | 1989 |
[D-penicillamine: mechanism of cellular action and induced autoimmune diseases].
Topics: Animals; Anti-Glomerular Basement Membrane Disease; Autoimmune Diseases; Dermatomyositis; Humans; Lu | 1986 |
D-penicillamine-induced polymyositis occurring in patients with rheumatoid arthritis: a report of two cases and demonstration of a positive lymphocyte stimulation test to D-penicillamine.
Topics: Arthritis, Rheumatoid; Female; HLA-DR Antigens; HLA-DR4 Antigen; Humans; Lymphocyte Activation; Midd | 1986 |
[Polymyositis induced by D-penicillamine treatment of rheumatoid arthritis: apropos of 2 cases with antinuclear antibodies].
Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Female; Humans; Myositis; Penicillamine | 1986 |
Penicillamine induced polymyositis and dermatomyositis.
Topics: Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Dermatomyositis; Female | 1987 |
D-penicillamine-induced polymyositis in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; M | 1986 |
Penicillamine-induced polymyositis.
Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic | 1985 |
Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Myositis; Neurom | 1985 |
[Progressive systemic sclerosis with pancytopenia, polymyositis and complete heart block developing after D-penicillamine therapy: a case report].
Topics: Aged; Female; Heart Block; Humans; Myositis; Pancytopenia; Penicillamine; Scleroderma, Systemic | 1985 |
Polymyositis and penicillamine.
Topics: Adult; Autoimmune Diseases; Diagnosis, Differential; Female; Hepatolenticular Degeneration; Homozygo | 1972 |
D-penicillamine in ankylosing spondylitis and polymyositis.
Topics: Adult; Female; Humans; Male; Middle Aged; Myositis; Penicillamine; Spondylitis, Ankylosing | 1974 |
[Penicillamine-induced polymyositis (author's transl)].
Topics: Aged; Antibodies; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoimmune Diseases; Collagen; Cor | 1974 |
The syndrome of myosclerosis.
Topics: Adult; Child; Child, Preschool; Collagen; Diagnosis, Differential; Electromyography; Female; Humans; | 1973 |
Monoclonal gammopathy penicillamine-induced polymyositis and systemic sclerosis.
Topics: Aged; Biopsy; Humans; Hypergammaglobulinemia; Japan; Male; Myositis; Penicillamine; Prednisolone; Sc | 1974 |