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penicillamine and Idiopathic Inflammatory Myopathies

penicillamine has been researched along with Idiopathic Inflammatory Myopathies in 40 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"Between 1979 and 1990 we have seen 8 patients (7 females) with rheumatoid arthritis (RA) who developed a neuro-muscular involvement while on D-penicillamine (D."8.78[Neuromuscular complications of D-penicillamine in rheumatoid arthritis]. ( Bouchet, F; Bussière, JL; Dubost, JJ; Kemeny, JL; Lhopitaux, R; Sauvezie, B; Soubrier, M, 1992)
"D-penicillamine, an agent still used in the treatment of rheumatoid arthritis (RA) may produce inflammatory myopathy or myositis."7.69D-penicillamine-induced myositis in rheumatoid arthritis. ( Chappel, R; Willems, J, 1996)
"Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear."7.68Polymyositis complicating D-penicillamine treatment. ( Asherson, RA; Aydintug, AO; Cervera, R; D'Cruz, D; Hughes, GR; Khamashta, MA; Ramírez, G, 1991)
"Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis."7.67Penicillamine-induced polymyositis with complete heart block. ( Christensen, PD; Sørensen, KE, 1989)
"Eight Australian cases of D-penicillamine induced polymyositis/dermatomyositis (PM/DM) are reported."7.67Penicillamine induced polymyositis and dermatomyositis. ( Carroll, GJ; Dawkins, RL; Garlepp, MJ; Peter, JB; Will, RK, 1987)
"Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis."7.67D-penicillamine-induced polymyositis in patients with rheumatoid arthritis. ( Miyamoto, T; Ogita, T; Okudaira, H; Takahashi, K; Yoshinoya, S; Yoshizawa, H, 1986)
"Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis."7.67Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis. ( De Bruyère, M; Devogelaer, JP; Huaux, JP; Isaac, G; Nagant de Deuxchaisnes, C; Noël, H, 1985)
"Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis."7.66Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis. ( Essigman, WK, 1982)
"Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years."7.66[Is myositis in chronic polyarthritis using d-penicillamine drug-induced?]. ( Bussmann, HU; Jerusalem, F; Schlumpf, U, 1981)
"Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described."7.66Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. ( Doyle, DR; McCurley, TL; Sergent, JS, 1983)
"Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine."7.66Penicillamine-induced polymyositis-dermatomyositis. ( Halberg, P; Højgaard, K; Lyon, BB; Petersen, J; Ullman, S, 1978)
"Between 1979 and 1990 we have seen 8 patients (7 females) with rheumatoid arthritis (RA) who developed a neuro-muscular involvement while on D-penicillamine (D."4.78[Neuromuscular complications of D-penicillamine in rheumatoid arthritis]. ( Bouchet, F; Bussière, JL; Dubost, JJ; Kemeny, JL; Lhopitaux, R; Sauvezie, B; Soubrier, M, 1992)
"D-penicillamine, an agent still used in the treatment of rheumatoid arthritis (RA) may produce inflammatory myopathy or myositis."3.69D-penicillamine-induced myositis in rheumatoid arthritis. ( Chappel, R; Willems, J, 1996)
"Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear."3.68Polymyositis complicating D-penicillamine treatment. ( Asherson, RA; Aydintug, AO; Cervera, R; D'Cruz, D; Hughes, GR; Khamashta, MA; Ramírez, G, 1991)
"Complete heart block with severe Adams-Stokes attacks and polymyositis was observed in a 69-year-old man following 6 weeks penicillamine treatment for suspected rheumatoid arthritis."3.67Penicillamine-induced polymyositis with complete heart block. ( Christensen, PD; Sørensen, KE, 1989)
"Eight Australian cases of D-penicillamine induced polymyositis/dermatomyositis (PM/DM) are reported."3.67Penicillamine induced polymyositis and dermatomyositis. ( Carroll, GJ; Dawkins, RL; Garlepp, MJ; Peter, JB; Will, RK, 1987)
"Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis."3.67D-penicillamine-induced polymyositis in patients with rheumatoid arthritis. ( Miyamoto, T; Ogita, T; Okudaira, H; Takahashi, K; Yoshinoya, S; Yoshizawa, H, 1986)
"Three cases of D-penicillamine (DPA) induced myasthenia gravis (MG) and one case of DPA-induced polymyositis (PM) are reported among four patients suffering from seropositive rheumatoid arthritis."3.67Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis. ( De Bruyère, M; Devogelaer, JP; Huaux, JP; Isaac, G; Nagant de Deuxchaisnes, C; Noël, H, 1985)
"Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis."3.66Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis. ( Essigman, WK, 1982)
"Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years."3.66[Is myositis in chronic polyarthritis using d-penicillamine drug-induced?]. ( Bussmann, HU; Jerusalem, F; Schlumpf, U, 1981)
"Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described."3.66Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. ( Doyle, DR; McCurley, TL; Sergent, JS, 1983)
"Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine."3.66Penicillamine-induced polymyositis-dermatomyositis. ( Halberg, P; Højgaard, K; Lyon, BB; Petersen, J; Ullman, S, 1978)
" A patient and his young sister were shown to be suffering from spinal muscular atrophy with superimposed, excessive proliferative activity of fibroblasts, and in these cases a beneficial effect of penicillamine was demonstrated."3.65The syndrome of myosclerosis. ( Bradley, WG; Gardner-Medwin, D; Hudgson, P; Walton, JN, 1973)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199032 (80.00)18.7374
1990's7 (17.50)18.2507
2000's1 (2.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Essigman, WK1
Swartz, MO1
Silver, RM1
Schlumpf, U1
Bussmann, HU1
Jerusalem, F1
Doyle, DR1
McCurley, TL1
Sergent, JS1
Willson, RA1
McVicker, JH1
Lava, NS1
Mittag, TW1
Ringel, SP1
Wouters, JM1
Van de Putte, LB1
Renier, WO1
Joosten, EM1
Caspi, D1
Fishel, R1
Varon, M1
Yona, E1
Baratz, M1
Yaron, M1
Brousson, A2
Pélissier, J1
Lepeu, G1
Pages, M2
Huttel, JM1
Blotman, F1
Bertrand, A1
Simon, L1
Major, GA1
Fischer, RG1
Pennebaker, JB1
Ostensen, M1
Husby, G1
Aarli, J1
Marty-Double, C1
Pagès, AM1
Pellissier, J1
Garlepp, MJ2
Chappel, R1
Willems, J1
Horinouchi, H1
Kumamoto, T1
Petersen, J1
Halberg, P1
Højgaard, K1
Lyon, BB1
Ullman, S1
Machtey, I1
Cucher, BG2
Goldman, AL2
Dubost, JJ1
Soubrier, M1
Bouchet, F1
Kemeny, JL1
Lhopitaux, R1
Bussière, JL1
Sauvezie, B1
Aydintug, AO1
Cervera, R1
D'Cruz, D1
Ramírez, G1
Asherson, RA1
Khamashta, MA1
Hughes, GR1
Jimenez-Balderas, FJ1
Rangel, J1
Mintz, G1
Santos, JC1
Velasco, JA1
Taneja, V1
Mehra, N1
Singh, YN1
Kumar, A1
Malaviya, A1
Singh, RR1
Christensen, PD1
Sørensen, KE1
Muirden, KD1
Meyer, O1
Smiley, JD1
Moore, SE1
Matsumura, T2
Yuhara, T1
Yamane, K2
Kono, I2
Kabashima, T2
Kashiwagi, H2
Masson, CJ1
Ménard, HA1
Audran, M1
Renier, JC1
Lussier, A1
Myhal, DM1
Carroll, GJ1
Will, RK1
Peter, JB1
Dawkins, RL1
Takahashi, K1
Ogita, T1
Okudaira, H1
Yoshinoya, S1
Yoshizawa, H1
Miyamoto, T1
Leden, I1
Libelius, R1
Devogelaer, JP1
Isaac, G1
Noël, H1
De Bruyère, M1
Huaux, JP1
Nagant de Deuxchaisnes, C1
Sakurai, T1
Yamaguchi, I1
Schraeder, PL1
Peters, HA1
Dahl, DS1
Golding, DN1
Bettendorf, U1
Neuhaus, R1
Bradley, WG1
Hudgson, P1
Gardner-Medwin, D1
Walton, JN1
Nishikai, M1
Funatsu, Y1
Homma, M1

Reviews

5 reviews available for penicillamine and Idiopathic Inflammatory Myopathies

ArticleYear
Immunogenetics of inflammatory myopathies.
    Bailliere's clinical neurology, 1993, Volume: 2, Issue:3

    Topics: Autoantibodies; Complement System Proteins; Humans; Myositis; Penicillamine

1993
[Toxin-induced inflammatory myopathy].
    Ryoikibetsu shokogun shirizu, 2001, Issue:36

    Topics: Anti-Arrhythmia Agents; Antirheumatic Agents; Humans; Myositis; Penicillamine; Procainamide; Toxins,

2001
[Neuromuscular complications of D-penicillamine in rheumatoid arthritis].
    Revue neurologique, 1992, Volume: 148, Issue:3

    Topics: Aged; Arthritis, Rheumatoid; Female; Graves Disease; Humans; Male; Middle Aged; Myasthenia Gravis; M

1992
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986
Molecular mechanisms of autoimmunity.
    The American journal of the medical sciences, 1988, Volume: 295, Issue:5

    Topics: Antibodies, Antinuclear; Autoantibodies; Autoimmune Diseases; B-Lymphocytes; DNA; Humans; Immunoglob

1988

Trials

1 trial available for penicillamine and Idiopathic Inflammatory Myopathies

ArticleYear
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986

Other Studies

35 other studies available for penicillamine and Idiopathic Inflammatory Myopathies

ArticleYear
Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.
    Annals of the rheumatic diseases, 1982, Volume: 41, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Humans; Lupus Erythematosus, Systemic; Male; Myastheni

1982
D-penicillamine induced polymyositis in juvenile chronic arthritis: report of a case.
    The Journal of rheumatology, 1984, Volume: 11, Issue:2

    Topics: Adolescent; Arthritis, Juvenile; Humans; Male; Myositis; Penicillamine

1984
[Is myositis in chronic polyarthritis using d-penicillamine drug-induced?].
    Schweizerische medizinische Wochenschrift, 1981, Jan-03, Volume: 111, Issue:1

    Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gold Sod

1981
Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis.
    Annals of internal medicine, 1983, Volume: 98, Issue:3

    Topics: Arthritis, Rheumatoid; Female; Heart Block; Humans; Middle Aged; Myocarditis; Myositis; Penicillamin

1983
Therapeutic quandary: asymptomatic primary biliary cirrhosis associated with polymyositis.
    Digestive diseases and sciences, 1981, Volume: 26, Issue:4

    Topics: Alkaline Phosphatase; Female; Histocompatibility Antigens Class II; Humans; Liver Cirrhosis, Biliary

1981
D-penicillamine-induced neuromuscular disease in guinea pigs.
    Experimental neurology, 1982, Volume: 76, Issue:1

    Topics: Action Potentials; Animals; Autoantibodies; Disease Models, Animal; Electromyography; Extremities; F

1982
D-penicillamine-induced polymyositis.
    The Netherlands journal of medicine, 1982, Volume: 25, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Myositis; Penicillamine

1982
Multisystem presentation of eosinophilic fasciitis.
    Rheumatology and rehabilitation, 1982, Volume: 21, Issue:4

    Topics: Adult; Ankle Joint; Azathioprine; Blood Sedimentation; Bone Marrow Examination; Elbow Joint; Eosinop

1982
[Polymyositis induced by D-penicillamine].
    Revue du rhumatisme et des maladies osteo-articulaires, 1981, Volume: 48, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Musc

1981
Penicillamine-induced dermatomyositis.
    Journal of the Royal Society of Medicine, 1981, Volume: 74, Issue:5

    Topics: Arthritis, Rheumatoid; Humans; Male; Middle Aged; Myositis; Penicillamine

1981
Penicillamine-induced polymyositis in a patient with rheumatoid arthritis.
    Southern medical journal, 1981, Volume: 74, Issue:10

    Topics: Arthritis, Rheumatoid; Humans; Male; Middle Aged; Myositis; Penicillamine

1981
Polymyositis with acute myolysis in a patient with rheumatoid arthritis treated with penicillamine and ampicillin.
    Arthritis and rheumatism, 1980, Volume: 23, Issue:3

    Topics: Acute Disease; Adult; Ampicillin; Arthritis, Rheumatoid; Female; Humans; Muscular Diseases; Myositis

1980
[Ultrastructural study of a polymyositis caused by D-penicillamine (author's transl)].
    Archives d'anatomie et de cytologie pathologiques, 1980, Volume: 28, Issue:6

    Topics: Female; Humans; Microscopy, Electron; Middle Aged; Muscles; Myositis; Penicillamine

1980
D-penicillamine-induced myositis in rheumatoid arthritis.
    Clinical rheumatology, 1996, Volume: 15, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Needle; Electr

1996
Penicillamine-induced polymyositis-dermatomyositis.
    Scandinavian journal of rheumatology, 1978, Volume: 7, Issue:2

    Topics: Action Potentials; Arthritis, Rheumatoid; Dermatomyositis; Female; Humans; Middle Aged; Muscle Contr

1978
Penicillamine-induced polymyositis.
    Annals of internal medicine, 1977, Volume: 86, Issue:6

    Topics: Humans; Myositis; Penicillamine

1977
D-penicillamine-induced polymyositis in rheumatoid arthritis.
    Annals of internal medicine, 1976, Volume: 85, Issue:5

    Topics: Arthritis, Rheumatoid; Bundle-Branch Block; Electromyography; Female; Humans; Middle Aged; Myositis;

1976
Polymyositis complicating D-penicillamine treatment.
    Postgraduate medical journal, 1991, Volume: 67, Issue:793

    Topics: Adult; Arthritis, Psoriatic; Female; Humans; Liver Cirrhosis, Biliary; Middle Aged; Myositis; Penici

1991
Penicillamine induced myositis: correlation between urinary zinc excretion and serum creatine.
    The Journal of rheumatology, 1991, Volume: 18, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Creatine; Female; Humans; Myositis; Penicillamine; Zinc

1991
Polymyositis due to D-penicillamine in a patient with systemic sclerosis.
    Clinical and experimental dermatology, 1991, Volume: 16, Issue:1

    Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic

1991
HLA-D region genes and susceptibility to D-penicillamine-induced myositis.
    Arthritis and rheumatism, 1990, Volume: 33, Issue:9

    Topics: HLA-D Antigens; Humans; Myositis; Penicillamine

1990
Penicillamine-induced polymyositis with complete heart block.
    European heart journal, 1989, Volume: 10, Issue:11

    Topics: Aged; Arthritis, Rheumatoid; Bundle-Branch Block; Electrocardiography; Heart Block; Humans; Male; My

1989
[D-penicillamine: mechanism of cellular action and induced autoimmune diseases].
    Revue du rhumatisme et des maladies osteo-articulaires, 1986, Volume: 53, Issue:1

    Topics: Animals; Anti-Glomerular Basement Membrane Disease; Autoimmune Diseases; Dermatomyositis; Humans; Lu

1986
D-penicillamine-induced polymyositis occurring in patients with rheumatoid arthritis: a report of two cases and demonstration of a positive lymphocyte stimulation test to D-penicillamine.
    Henry Ford Hospital medical journal, 1986, Volume: 34, Issue:2

    Topics: Arthritis, Rheumatoid; Female; HLA-DR Antigens; HLA-DR4 Antigen; Humans; Lymphocyte Activation; Midd

1986
[Polymyositis induced by D-penicillamine treatment of rheumatoid arthritis: apropos of 2 cases with antinuclear antibodies].
    L'union medicale du Canada, 1986, Volume: 115, Issue:12

    Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Female; Humans; Myositis; Penicillamine

1986
Penicillamine induced polymyositis and dermatomyositis.
    The Journal of rheumatology, 1987, Volume: 14, Issue:5

    Topics: Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Dermatomyositis; Female

1987
D-penicillamine-induced polymyositis in patients with rheumatoid arthritis.
    Arthritis and rheumatism, 1986, Volume: 29, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; M

1986
Penicillamine-induced polymyositis.
    Scandinavian journal of rheumatology, 1985, Volume: 14, Issue:1

    Topics: Female; Humans; Middle Aged; Myositis; Penicillamine; Scleroderma, Systemic

1985
Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis.
    International journal of clinical pharmacology research, 1985, Volume: 5, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Myositis; Neurom

1985
[Progressive systemic sclerosis with pancytopenia, polymyositis and complete heart block developing after D-penicillamine therapy: a case report].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1985, Volume: 74, Issue:7

    Topics: Aged; Female; Heart Block; Humans; Myositis; Pancytopenia; Penicillamine; Scleroderma, Systemic

1985
Polymyositis and penicillamine.
    Archives of neurology, 1972, Volume: 27, Issue:5

    Topics: Adult; Autoimmune Diseases; Diagnosis, Differential; Female; Hepatolenticular Degeneration; Homozygo

1972
D-penicillamine in ankylosing spondylitis and polymyositis.
    Postgraduate medical journal, 1974, Volume: 50 Suppl 2

    Topics: Adult; Female; Humans; Male; Middle Aged; Myositis; Penicillamine; Spondylitis, Ankylosing

1974
[Penicillamine-induced polymyositis (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Dec-06, Volume: 99, Issue:49

    Topics: Aged; Antibodies; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoimmune Diseases; Collagen; Cor

1974
The syndrome of myosclerosis.
    Journal of neurology, neurosurgery, and psychiatry, 1973, Volume: 36, Issue:4

    Topics: Adult; Child; Child, Preschool; Collagen; Diagnosis, Differential; Electromyography; Female; Humans;

1973
Monoclonal gammopathy penicillamine-induced polymyositis and systemic sclerosis.
    Archives of dermatology, 1974, Volume: 110, Issue:2

    Topics: Aged; Biopsy; Humans; Hypergammaglobulinemia; Japan; Male; Myositis; Penicillamine; Prednisolone; Sc

1974