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penicillamine and Hypercapnia

penicillamine has been researched along with Hypercapnia in 10 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
" In wild-type mice, SC-560 (25 micromol/L) reduced resting CBF by 21+/-4% and attenuated the CBF increase produced by topical application of bradykinin (-59%) or calcium ionophore A23187 (-49%) and by systemic hypercapnia (-58%) (P<0."3.71Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. ( Haensel, C; Iadecola, C; Niwa, K; Ross, ME, 2001)
" With Ringer solution superfusion, CBF increased with hypercapnia (+134 +/- 7%; PCO2 = 50-60 mmHg) and topical application of 10 microM ACh (+35 +/- 3%), the NO donor S-nitroso-N-acetylpenicillamine (SNAP, 500 microM; +66 +/- 6%), or 1 mM papaverine (+100 +/- 6%; n = 5)."3.70Superoxide-dependent cerebrovascular effects of homocysteine. ( Iadecola, C; Slungaard, A; Vercellotti, GM; Zhang, F, 1998)
" A beta1-40 did not influence the CBF increases produced by the endothelium-independent vasodilators S-nitroso-N-acetylpenicillamine and hypercapnia."3.70Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. ( Carlson, GA; Iadecola, C; Niwa, K, 2000)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's7 (70.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, F2
Sprague, SM1
Farrokhi, F1
Henry, MN1
Son, MG1
Vollmer, DG1
Xu, HL1
Santizo, RA1
Baughman, VL1
Pelligrino, DA3
Scheckenbach, KE1
Dreier, JP1
Dirnagl, U1
Lindauer, U1
Wang, Q2
Koenig, HM1
Albrecht, RF1
Slungaard, A1
Vercellotti, GM1
Iadecola, C3
Bryan, RM3
Golding, EM2
Robertson, CS1
Niwa, K2
Carlson, GA1
Steenberg, ML1
Johnson, TD1
Haensel, C1
Ross, ME1

Other Studies

10 other studies available for penicillamine and Hypercapnia

ArticleYear
Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury.
    Journal of neurosurgery, 2002, Volume: 97, Issue:4

    Topics: Animals; Blood Pressure; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Cortical Sprea

2002
Nascent EDHF-mediated cerebral vasodilation in ovariectomized rats is not induced by eNOS dysfunction.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:5

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Biological Factors; Blood Pressure; Cerebrovascular C

2003
Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP.
    Experimental neurology, 2006, Volume: 202, Issue:2

    Topics: Analysis of Variance; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorde

2006
The role of endothelium and nitric oxide in rat pial arteriolar dilatory responses to CO2 in vivo.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:6

    Topics: Animals; Arginine; Arterioles; Carbon Dioxide; Endothelium, Vascular; Hypercapnia; Male; Nitric Oxid

1994
Superoxide-dependent cerebrovascular effects of homocysteine.
    The American journal of physiology, 1998, Volume: 274, Issue:6

    Topics: Acetylcholine; Animals; Brain; Cerebrovascular Circulation; Homocysteine; Hypercapnia; Male; Nitric

1998
Calcium-dependent and ATP-sensitive potassium channels and the 'permissive' function of cyclic GMP in hypercapnia-induced pial arteriolar relaxation.
    Brain research, 1998, May-18, Volume: 793, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Benzimidazoles; Blood Pressure; Calcium; Carbon Dioxide; Cerebral A

1998
L-arginine partially restores the diminished CO2 reactivity after mild controlled cortical impact injury in the adult rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:5

    Topics: Animals; Arginine; Arterioles; Brain; Brain Injuries; Carbon Dioxide; Catalase; Free Radical Scaveng

2000
Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:12

    Topics: Acetylcholine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoradiography; Brad

2000
Nitric oxide in the potassium-induced response of the rat middle cerebral artery: a possible permissive role.
    Brain research, 2001, Jan-19, Volume: 889, Issue:1-2

    Topics: Animals; Cerebrovascular Circulation; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hypercap

2001
Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation.
    Circulation research, 2001, Mar-30, Volume: 88, Issue:6

    Topics: Acetylcholine; Analysis of Variance; Animals; Blood Flow Velocity; Bradykinin; Calcimycin; Cerebrova

2001