penicillamine has been researched along with Glioblastoma in 8 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coculture of T98G glioblastoma cells with the myeloid and monocytic cell lines, HL-60, and THP-1 produced minimal amounts of interleukin-8 (IL-8)." | 7.70 | Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines. ( Kasahara, T; Matsuura, M; Mukaida, N; Oda, T, 1998) |
| "Coculture of T98G glioblastoma cells with the myeloid and monocytic cell lines, HL-60, and THP-1 produced minimal amounts of interleukin-8 (IL-8)." | 3.70 | Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines. ( Kasahara, T; Matsuura, M; Mukaida, N; Oda, T, 1998) |
| "Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival." | 1.39 | Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. ( Jiang, A; Jiang, E; Kieran, MW; Mammoto, A; Mammoto, T; Panigrahy, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mammoto, T | 1 |
| Jiang, A | 1 |
| Jiang, E | 1 |
| Panigrahy, D | 1 |
| Kieran, MW | 1 |
| Mammoto, A | 1 |
| Brem, S | 1 |
| Grossman, SA | 1 |
| Carson, KA | 1 |
| New, P | 1 |
| Phuphanich, S | 1 |
| Alavi, JB | 1 |
| Mikkelsen, T | 1 |
| Fisher, JD | 1 |
| Jin, HO | 1 |
| Park, IC | 1 |
| An, S | 1 |
| Lee, HC | 1 |
| Woo, SH | 1 |
| Hong, YJ | 1 |
| Lee, SJ | 1 |
| Park, MJ | 1 |
| Yoo, DH | 1 |
| Rhee, CH | 1 |
| Hong, SI | 1 |
| Oda, T | 1 |
| Kasahara, T | 1 |
| Matsuura, M | 1 |
| Mukaida, N | 1 |
| Adami, A | 1 |
| Crivellente, F | 1 |
| De Prati, AC | 1 |
| Cavalieri, E | 1 |
| Cuzzolin, L | 1 |
| Tommasi, M | 1 |
| Suzuki, H | 1 |
| Benoni, G | 1 |
| Matsumoto, H | 2 |
| Hayashi, S | 2 |
| Hatashita, M | 2 |
| Shioura, H | 2 |
| Ohtsubo, T | 2 |
| Kitai, R | 2 |
| Ohnishi, T | 2 |
| Kano, E | 2 |
| Ohnishi, K | 1 |
| Vanchieri, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of Penicillamine and Reduction of Copper for Angiosuppressive Therapy of Adults With Newly Diagnosed Glioblastoma[NCT00003751] | Phase 2 | 40 participants (Anticipated) | Interventional | 1999-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for penicillamine and Glioblastoma
| Article | Year |
|---|---|
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma.
Topics: Brain Neoplasms; Chelating Agents; Copper; Diet Therapy; Female; Glioblastoma; Humans; Male; Middle | 2005 |
7 other studies available for penicillamine and Glioblastoma
| Article | Year |
|---|---|
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Topics: Animals; Brain; Brain Neoplasms; Cell Count; Cell Line, Tumor; Collagen; Disease Progression; Gliobl | 2013 |
Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Bcl-2-Like Pro | 2006 |
Nitric oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines.
Topics: Animals; Cell Line; Coculture Techniques; Glioblastoma; HL-60 Cells; Humans; Interleukin-8; Macropha | 1998 |
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
Topics: Biotransformation; Brain Neoplasms; Breast Neoplasms; Cell Survival; Enzyme Inhibitors; Female; Glio | 1998 |
Intercellular signaling initiated by nitric oxide produced in heat-shocked human glioblastoma cells.
Topics: Brain Neoplasms; Culture Media; Glioblastoma; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-S | 1999 |
Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma.
Topics: Benzoates; Brain Neoplasms; Cell Division; Coculture Techniques; Genes, p53; Glioblastoma; Guanidine | 1999 |
Cutting copper curbs angiogenesis, studies show.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Chelating Agents; Clinical Trials as Topic; Combined Modal | 2000 |