penicillamine has been researched along with Down Syndrome in 3 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Woo, TY | 1 |
Rasmussen, JE | 1 |
Tu, JB | 1 |
Zellweger, H | 1 |
Gibson, SL | 1 |
Lam, CN | 1 |
McCrae, WM | 1 |
Goldberg, A | 1 |
3 other studies available for penicillamine and Down Syndrome
Article | Year |
---|---|
Disorders of transepidermal elimination. Part 1.
Topics: Adolescent; Adult; Aged; Cartilage Diseases; Child; Child, Preschool; Collagen Diseases; Down Syndro | 1985 |
Blood-serotonin deficiency in Down's syndrome.
Topics: Adolescent; Blood; Brain; Child; Down Syndrome; Humans; Penicillamine; Pyridoxine; Serotonin; Trypto | 1965 |
Blood lead levels in normal and mentally deficiency children.
Topics: Brain Damage, Chronic; Child; Child, Preschool; Down Syndrome; Humans; Intellectual Disability; Lead | 1967 |