penicillamine has been researched along with Delayed Hypersensitivity in 22 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a controlled study involving thirty-four patients levamisole was shown to be as effective as D-penicillamine and more effective than placebo in the treatment of rheumatoid arthritis." | 9.04 | Immunostimulant therapy with levamisole for rheumatoid arthritis. ( Balme, HW; Dieppe, PA; Huskisson, EC; Scott, J; Trapnell, J; Willoughby, DA, 1976) |
| "Intraperitoneal gelatin sponge implants were used in guinea-pigs to examine the effect of D-penicillamine on the delayed hypersensitivity reaction in vivo." | 7.66 | D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs. ( Honma, T; Nakayama, Y, 1982) |
| "Prolonged oral treatment (up to 410 days) of rabbits with D-penicillamine at a dose of 15 mg/kg body weight commencing either before or after immunization and the onset of arthritis, diminished and eventually abolished the delayed hypersensitivity response to intradermally administered tuberculin PPD." | 7.66 | The effects of oral D-penicillamine treatment on experimental arthritis and the associated immune response in rabbits. II. The effects on cellular parameters. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1978) |
| "Oedema was measured after the challenging injection." | 5.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| "In a controlled study involving thirty-four patients levamisole was shown to be as effective as D-penicillamine and more effective than placebo in the treatment of rheumatoid arthritis." | 5.04 | Immunostimulant therapy with levamisole for rheumatoid arthritis. ( Balme, HW; Dieppe, PA; Huskisson, EC; Scott, J; Trapnell, J; Willoughby, DA, 1976) |
| " speciosa root (ASEE), at the doses of 50, 100 and 200 mg/kg in mice, dose-dependently potentiated the delayed-type hypersensitivity reaction induced both by sheep red blood cells (SRBC) and oxazolone." | 3.72 | Investigations into the immunomodulatory activity of Argyreia speciosa. ( Damre, AS; Gokhale, AB; Saraf, MN, 2003) |
| "Intraperitoneal gelatin sponge implants were used in guinea-pigs to examine the effect of D-penicillamine on the delayed hypersensitivity reaction in vivo." | 3.66 | D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs. ( Honma, T; Nakayama, Y, 1982) |
| "Prolonged oral treatment (up to 410 days) of rabbits with D-penicillamine at a dose of 15 mg/kg body weight commencing either before or after immunization and the onset of arthritis, diminished and eventually abolished the delayed hypersensitivity response to intradermally administered tuberculin PPD." | 3.66 | The effects of oral D-penicillamine treatment on experimental arthritis and the associated immune response in rabbits. II. The effects on cellular parameters. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1978) |
| "The effects of different antirheumatic drugs administered according to various dosing regimes on tuberculin hypersensitivity in rats have been assessed quantitating the changes of exudate volume and mononuclear cells immigration at the site of challenge." | 1.26 | Delayed hypersensitivity to tuberculin in rats: effects of antirheumatic drugs. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1979) |
| "Oedema was measured after the challenging injection." | 1.26 | Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs. ( Arrigoni-Martelli, E; Bramm, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| " Dosing with D-penicillamine (25 mg/kg) and levamisole (5 mg/kg) at the time of challenge produced a significant enhancement of the reaction." | 1.26 | Pertussis vaccine pleurisy: a model of delayed hypersensitivity. ( Arrigoni-Martelli, E; Dieppe, PA; Huskisson, EC; Willoughby, DA, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (86.36) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gokhale, AB | 1 |
| Damre, AS | 1 |
| Saraf, MN | 1 |
| HIRSCHMAN, SZ | 1 |
| ISSELBACHER, KJ | 1 |
| Komoriya, K | 1 |
| Tsuchimoto, M | 1 |
| Kunisawa, K | 1 |
| Okamiya, Y | 1 |
| Takeshita, T | 1 |
| Naruchi, T | 1 |
| Yamamoto, I | 1 |
| Tarayre, JP | 1 |
| Lauressergues, H | 1 |
| Nakaike, S | 2 |
| Tanaka, C | 1 |
| Tomita, N | 1 |
| Umemoto, M | 1 |
| Otomo, S | 3 |
| Aihara, H | 3 |
| Honma, T | 1 |
| Nakayama, Y | 1 |
| Jones, SA | 1 |
| Kennedy, AJ | 1 |
| Roberts, NA | 1 |
| Ruenitz, PC | 1 |
| Sorenson, JR | 1 |
| West, GB | 1 |
| Penn, AS | 1 |
| Low, BW | 1 |
| Jaffe, IA | 1 |
| Luo, L | 1 |
| Jacques, JJ | 1 |
| Cao, J | 1 |
| Xu, Q | 1 |
| Koda, A | 1 |
| Huskisson, EC | 3 |
| Scott, J | 1 |
| Balme, HW | 1 |
| Dieppe, PA | 3 |
| Trapnell, J | 1 |
| Willoughby, DA | 3 |
| Bramm, E | 2 |
| Binderup, L | 1 |
| Arrigoni-Martelli, E | 3 |
| Cunningham, FM | 2 |
| Ford-Hutchinson, AW | 2 |
| Smith, MJ | 2 |
| Walker, JR | 2 |
| Oliver, AM | 1 |
| Hunneyball, IM | 1 |
| Stewart, GA | 1 |
| Stanworth, DR | 1 |
| Ishii, N | 1 |
| Ichiyama, S | 1 |
| Ishii, T | 1 |
| Aoki, I | 1 |
| Okuda, K | 1 |
| Nakajima, H | 1 |
| Takeshita, K | 2 |
| Fukazawa, I | 2 |
| Futaki, N | 1 |
| Kameo, K | 2 |
| Tomisawa, K | 2 |
| Adler, SG | 1 |
| Cohen, AH | 1 |
| Border, WA | 1 |
| Harpey, JP | 1 |
| Caille, B | 1 |
| Moulias, R | 1 |
| Goust, JM | 1 |
2 reviews available for penicillamine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Drug-induced autoimmune myasthenia gravis.
Topics: Animals; Antibody Formation; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Lymphocyte Cultu | 1998 |
Hypersensitivity phenomena and the kidney: role of drugs and environmental agents.
Topics: Animals; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents; Antibodies; Captopril; | 1985 |
1 trial available for penicillamine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Immunostimulant therapy with levamisole for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Migration Inhibition; Clinical Trials as Topic; Complement Syst | 1976 |
19 other studies available for penicillamine and Delayed Hypersensitivity
| Article | Year |
|---|---|
Investigations into the immunomodulatory activity of Argyreia speciosa.
Topics: Animals; Antibodies; Blood Cell Count; Convolvulaceae; Cyclophosphamide; Dose-Response Relationship, | 2003 |
THE NEPHROTIC SYNDROME AS A COMPLICATION OF PENICILLAMINE THERAPY FOR HEPATOLENTICULAR DEGENERATION (WILSON'S DISEASE).
Topics: Drug Hypersensitivity; Drug Therapy; Hepatolenticular Degeneration; Humans; Hypersensitivity, Delaye | 1965 |
Abnormality of the delayed type hypersensitivity (DTH) response to Bordetella pertussis in spontaneously hypertensive rats (SHR).
Topics: Animals; Blood Pressure; Bordetella pertussis; Hemolytic Plaque Technique; Hypersensitivity, Delayed | 1984 |
Action of sodium aurothiopropanol, chloroquine, D-penicillamine and levamisole on picryl chloride-delayed hypersensitivity in mice.
Topics: Chloroquine; Dimercaprol; Gold; Hypersensitivity, Delayed; Levamisole; Organogold Compounds; Organom | 1980 |
Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.
Topics: Animals; Arthritis, Experimental; Concanavalin A; Cysteine; Female; Hemolytic Plaque Technique; Hype | 1983 |
D-penicillamine-induced enhancement of the delayed hypersensitivity reaction in guinea-pigs.
Topics: Animals; Ascitic Fluid; Chemotaxis; Drug Hypersensitivity; Exudates and Transudates; Female; Guinea | 1982 |
Assessment of drugs for activity in established type II collagen arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Arthritis; Arthritis, Experimental; Collagen; | 1982 |
Skin reactions of rats to levamisole and D-penicillamine.
Topics: Animals; Drug Hypersensitivity; Female; Hypersensitivity, Delayed; Intradermal Tests; Levamisole; Ma | 1980 |
Protective involvement of nitric oxide in the liver injury induced by delayed-type hypersensitivity to picryl chloride.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Female; Hepatoc | 2000 |
Delayed hypersensitivity to tuberculin in rats: effects of antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Hypersensiti | 1979 |
Effects of D-penicillamine and levamisole on delayed hypersensitivity reactions in the rat and mouse [proceedings].
Topics: Animals; Hypersensitivity, Delayed; Levamisole; Mice; Penicillamine; Rats | 1978 |
The effects of D-pencillamine and levamisole on leucocyte chemotaxis in the rat.
Topics: Animals; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Hypersensitivity, Delayed; In Vitro | 1978 |
The effects of oral D-penicillamine treatment on experimental arthritis and the associated immune response in rabbits. II. The effects on cellular parameters.
Topics: Animals; Arthritis; Cell Migration Inhibition; Female; Hypersensitivity, Delayed; Immunity, Cellular | 1978 |
Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Edema; Female; Freund's Adjuvant; Hyp | 1976 |
Pertussis vaccine pleurisy: a model of delayed hypersensitivity.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Freund's Adjuvant; Hypersensitivity, | 1976 |
Genetic control of delayed-type hypersensitivity to D-penicillamine antigen.
Topics: Animals; Antibodies, Monoclonal; Antigens; Drug Hypersensitivity; Epitopes; Hypersensitivity, Delaye | 1988 |
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acids. Immunomodulating effects.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Butyrates; Carrageenan; Collagen; Female; | 1988 |
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acid derivatives. II. Immunosuppressive effects.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Arthritis, Experimental; Benzoates; Female; Hype | 1988 |
Lupus-like syndrome induced by D-penicillamine in Wilson's disease.
Topics: Adult; Antigen-Antibody Reactions; Arthritis, Rheumatoid; Autoantibodies; Cystinuria; Female; Hapten | 1971 |