Page last updated: 2024-11-07

penicillamine and Cholangitis, Sclerosing

penicillamine has been researched along with Cholangitis, Sclerosing in 7 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.

Research Excerpts

ExcerptRelevanceReference
"Cholangiocarcinoma complicating primary sclerosing cholangitis often was detected at an advanced tumor stage, which precluded effective therapy, and overall median survival was 5 months."2.67Cholangiocarcinoma complicating primary sclerosing cholangitis. ( Coffey, RJ; LaRusso, NF; Nagorney, DM; Rosen, CB; Wiesner, RH, 1991)
"Primary sclerosing cholangitis is a cholestatic disease."2.43D-penicillamine for primary sclerosing cholangitis. ( Chen, W; Klingenberg, SL, 2006)
"Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by a progressive, obliterating fibrosis of the intrahepatic and extrahepatic bile ducts."2.40The management of primary sclerosing cholangitis. ( Chapman, RW; Mitchell, SA, 1998)
"Primary sclerosing cholangitis is a generally progressive, sometimes fatal, chronic hepatobiliary disorder for which no effective medical or surgical therapy now exists."2.40The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice. ( Larusso, NF, 1999)
"The diagnosis of primary sclerosing cholangitis (PSC) is based on the characteristic cholangiographic manifestations of the condition."2.38Surgical pathology of the syndrome of primary sclerosing cholangitis. ( Ludwig, J, 1989)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's5 (71.43)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mitchell, SA1
Chapman, RW1
Klingenberg, SL1
Chen, W1
Larusso, NF3
Angulo, P1
Larson, DR1
Therneau, TM1
Batts, KP1
Lindor, KD1
Rosen, CB1
Nagorney, DM1
Wiesner, RH1
Coffey, RJ1
Kaplan, MM1
Ludwig, J1

Reviews

5 reviews available for penicillamine and Cholangitis, Sclerosing

ArticleYear
The management of primary sclerosing cholangitis.
    Clinics in liver disease, 1998, Volume: 2, Issue:2

    Topics: Adrenal Cortex Hormones; Cholangitis, Sclerosing; Cholestasis; Humans; Immunosuppressive Agents; Met

1998
D-penicillamine for primary sclerosing cholangitis.
    The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1

    Topics: Cholangitis, Sclerosing; Humans; Penicillamine; Randomized Controlled Trials as Topic

2006
The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice.
    Puerto Rico health sciences journal, 1999, Volume: 18, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biopsy; Chelating Age

1999
Medical approaches to primary sclerosing cholangitis.
    Seminars in liver disease, 1991, Volume: 11, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antipruritics; Azathioprine; Cholangitis, Sclerosing

1991
Surgical pathology of the syndrome of primary sclerosing cholangitis.
    The American journal of surgical pathology, 1989, Volume: 13 Suppl 1

    Topics: Biopsy; Cholangitis, Sclerosing; Gallbladder; Humans; Liver; Liver Diseases; Liver Transplantation;

1989

Trials

1 trial available for penicillamine and Cholangitis, Sclerosing

ArticleYear
Cholangiocarcinoma complicating primary sclerosing cholangitis.
    Annals of surgery, 1991, Volume: 213, Issue:1

    Topics: Adenoma, Bile Duct; Adult; Bile Duct Neoplasms; Cholangitis, Sclerosing; Combined Modality Therapy;

1991

Other Studies

1 other study available for penicillamine and Cholangitis, Sclerosing

ArticleYear
Time course of histological progression in primary sclerosing cholangitis.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:11

    Topics: Adolescent; Adult; Aged; Biopsy; Cholagogues and Choleretics; Cholangitis, Sclerosing; Disease Progr

1999