Page last updated: 2024-11-07

penicillamine and Breast Neoplasms

penicillamine has been researched along with Breast Neoplasms in 11 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"The incubation of MCF-7 human breast cancer cells with D-penicillamine plus cupric sulfate resulted in the production of reactive oxygen species within the cell and cytotoxicity that was comparable to free hydrogen peroxide."1.34An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation. ( Gupte, A; Mumper, RJ, 2007)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's4 (36.36)18.2507
2000's3 (27.27)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sciegienka, SJ1
Solst, SR1
Falls, KC1
Schoenfeld, JD1
Klinger, AR1
Ross, NL1
Rodman, SN1
Spitz, DR1
Fath, MA1
Kahan, BC1
Morris, TP1
Saha-Chaudhuri, P1
Heagerty, PJ1
Watts, RN1
Richardson, DR1
BEREZOV, TT1
DOBRININ, YV1
Gupte, A2
Mumper, RJ2
Handel, ML1
Watts, CK1
Sivertsen, S1
Day, RO1
Sutherland, RL1
Calmels, S1
Hainaut, P1
Ohshima, H1
Adami, A1
Crivellente, F1
De Prati, AC1
Cavalieri, E1
Cuzzolin, L1
Tommasi, M1
Suzuki, H1
Benoni, G1
Small, W1
Molteni, A1
Kim, YT1
Taylor, JM1
Ts'ao, CH1
Ward, WF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia[NCT02190903]15 participants (Actual)Interventional2013-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Postoperative Delirium After Hip Fracture Surgery

Delirium will be assessed by the Confusion Assessment Method Instrument (CAM), a validated method of assessing delirium based on the presence of both (1) an acute onset of signs and symptoms with a fluctuating course AND (2) inattention; PLUS (3) disorganized thinking OR (4) an altered level of consciousness. (NCT02190903)
Timeframe: Up to 5 days post hip fracture surgery

InterventionParticipants (Count of Participants)
General Endotracheal Anesthesia2
Regional (Spinal) Anesthesia0

Other Studies

11 other studies available for penicillamine and Breast Neoplasms

ArticleYear
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Antineoplastic Combined Chemotherapy Protocols; Auranofin; Breast Neoplasms; Buthionine Sulfoximine;

2017
Improper analysis of trials randomised using stratified blocks or minimisation.
    Statistics in medicine, 2012, Feb-20, Volume: 31, Issue:4

    Topics: Antineoplastic Agents; Back Injuries; Bias; Breast Neoplasms; Carcinoma; Computer Simulation; Data I

2012
Non-parametric estimation of a time-dependent predictive accuracy curve.
    Biostatistics (Oxford, England), 2013, Volume: 14, Issue:1

    Topics: Area Under Curve; Biomarkers; Breast Neoplasms; Cell Cycle; Computer Simulation; Data Interpretation

2013
The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells. NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner.
    European journal of biochemistry, 2002, Volume: 269, Issue:14

    Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Membrane Permeability; Cell-Free System; Cytosol; De

2002
THE RANGE OF TRANSAMINATION IN CARCINOMA CELLS OF MAMMARY GLAND IN TISSUE CULTURE.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Alanine Transaminase; Amination; Amino Acids; Animals; Aspartate Aminotransferases; Breast Neoplasms

1964
An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation.
    Journal of inorganic biochemistry, 2007, Volume: 101, Issue:4

    Topics: Breast Neoplasms; Catalysis; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid;

2007
Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells.
    Free radical biology & medicine, 2007, Nov-01, Volume: 43, Issue:9

    Topics: Breast Neoplasms; Cell Line, Tumor; Chelating Agents; Copper Sulfate; HL-60 Cells; Humans; Hydrogen

2007
D-penicillamine causes free radical-dependent inactivation of activator protein-1 DNA binding.
    Molecular pharmacology, 1996, Volume: 50, Issue:3

    Topics: Breast Neoplasms; Cell Nucleus; Cysteine; DNA, Neoplasm; Female; Free Radicals; Humans; Hydrogen Per

1996
Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Breast Neoplasms; Carcinoma, Hepatocellular; DNA, Neoplasm; Glutathione; Humans; Liver Neoplasms; Ni

1997
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
    Life sciences, 1998, Volume: 63, Issue:23

    Topics: Biotransformation; Brain Neoplasms; Breast Neoplasms; Cell Survival; Enzyme Inhibitors; Female; Glio

1998
Mechanism of captopril toxicity to a human mammary ductal carcinoma cell line in the presence of copper.
    Breast cancer research and treatment, 1999, Volume: 55, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Breast Neo

1999