penicillamine has been researched along with Breast Cancer in 11 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incubation of MCF-7 human breast cancer cells with D-penicillamine plus cupric sulfate resulted in the production of reactive oxygen species within the cell and cytotoxicity that was comparable to free hydrogen peroxide." | 1.34 | An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation. ( Gupte, A; Mumper, RJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sciegienka, SJ | 1 |
| Solst, SR | 1 |
| Falls, KC | 1 |
| Schoenfeld, JD | 1 |
| Klinger, AR | 1 |
| Ross, NL | 1 |
| Rodman, SN | 1 |
| Spitz, DR | 1 |
| Fath, MA | 1 |
| Kahan, BC | 1 |
| Morris, TP | 1 |
| Saha-Chaudhuri, P | 1 |
| Heagerty, PJ | 1 |
| Watts, RN | 1 |
| Richardson, DR | 1 |
| BEREZOV, TT | 1 |
| DOBRININ, YV | 1 |
| Gupte, A | 2 |
| Mumper, RJ | 2 |
| Handel, ML | 1 |
| Watts, CK | 1 |
| Sivertsen, S | 1 |
| Day, RO | 1 |
| Sutherland, RL | 1 |
| Calmels, S | 1 |
| Hainaut, P | 1 |
| Ohshima, H | 1 |
| Adami, A | 1 |
| Crivellente, F | 1 |
| De Prati, AC | 1 |
| Cavalieri, E | 1 |
| Cuzzolin, L | 1 |
| Tommasi, M | 1 |
| Suzuki, H | 1 |
| Benoni, G | 1 |
| Small, W | 1 |
| Molteni, A | 1 |
| Kim, YT | 1 |
| Taylor, JM | 1 |
| Ts'ao, CH | 1 |
| Ward, WF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia[NCT02190903] | 15 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Delirium will be assessed by the Confusion Assessment Method Instrument (CAM), a validated method of assessing delirium based on the presence of both (1) an acute onset of signs and symptoms with a fluctuating course AND (2) inattention; PLUS (3) disorganized thinking OR (4) an altered level of consciousness. (NCT02190903)
Timeframe: Up to 5 days post hip fracture surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| General Endotracheal Anesthesia | 2 |
| Regional (Spinal) Anesthesia | 0 |
11 other studies available for penicillamine and Breast Cancer
| Article | Year |
|---|---|
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H
Topics: Antineoplastic Combined Chemotherapy Protocols; Auranofin; Breast Neoplasms; Buthionine Sulfoximine; | 2017 |
Improper analysis of trials randomised using stratified blocks or minimisation.
Topics: Antineoplastic Agents; Back Injuries; Bias; Breast Neoplasms; Carcinoma; Computer Simulation; Data I | 2012 |
Non-parametric estimation of a time-dependent predictive accuracy curve.
Topics: Area Under Curve; Biomarkers; Breast Neoplasms; Cell Cycle; Computer Simulation; Data Interpretation | 2013 |
The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells. NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Membrane Permeability; Cell-Free System; Cytosol; De | 2002 |
THE RANGE OF TRANSAMINATION IN CARCINOMA CELLS OF MAMMARY GLAND IN TISSUE CULTURE.
Topics: Alanine Transaminase; Amination; Amino Acids; Animals; Aspartate Aminotransferases; Breast Neoplasms | 1964 |
An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation.
Topics: Breast Neoplasms; Catalysis; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; | 2007 |
Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Chelating Agents; Copper Sulfate; HL-60 Cells; Humans; Hydrogen | 2007 |
D-penicillamine causes free radical-dependent inactivation of activator protein-1 DNA binding.
Topics: Breast Neoplasms; Cell Nucleus; Cysteine; DNA, Neoplasm; Female; Free Radicals; Humans; Hydrogen Per | 1996 |
Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.
Topics: Breast Neoplasms; Carcinoma, Hepatocellular; DNA, Neoplasm; Glutathione; Humans; Liver Neoplasms; Ni | 1997 |
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
Topics: Biotransformation; Brain Neoplasms; Breast Neoplasms; Cell Survival; Enzyme Inhibitors; Female; Glio | 1998 |
Mechanism of captopril toxicity to a human mammary ductal carcinoma cell line in the presence of copper.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 1999 |