penicillamine has been researched along with Brain Neoplasms in 14 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of copper (Cu)-depletion diet and D-penicillamine treatment (CDPT) on both tumor growth and angiogenesis, we studied Fischer-344 rats in which 9L gliosarcoma cells had been subcutaneously implanted." | 3.69 | Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model. ( Ikeda, Y; Nakazawa, S; Yoshida, D, 1995) |
| "Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival." | 1.39 | Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. ( Jiang, A; Jiang, E; Kieran, MW; Mammoto, A; Mammoto, T; Panigrahy, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mammoto, T | 1 |
| Jiang, A | 1 |
| Jiang, E | 1 |
| Panigrahy, D | 1 |
| Kieran, MW | 1 |
| Mammoto, A | 1 |
| Brem, S | 2 |
| Grossman, SA | 1 |
| Carson, KA | 1 |
| New, P | 1 |
| Phuphanich, S | 1 |
| Alavi, JB | 1 |
| Mikkelsen, T | 1 |
| Fisher, JD | 1 |
| Yoshida, D | 3 |
| Ikeda, Y | 3 |
| Nakazawa, S | 3 |
| Jeitner, TM | 1 |
| Renton, FJ | 1 |
| Philipov, P | 1 |
| Adami, A | 1 |
| Crivellente, F | 1 |
| De Prati, AC | 1 |
| Cavalieri, E | 1 |
| Cuzzolin, L | 1 |
| Tommasi, M | 1 |
| Suzuki, H | 1 |
| Benoni, G | 1 |
| Kurimoto, M | 1 |
| Endo, S | 1 |
| Hirashima, Y | 1 |
| Hamada, H | 1 |
| Ogiichi, T | 1 |
| Takaku, A | 1 |
| Matsumoto, H | 2 |
| Hayashi, S | 2 |
| Hatashita, M | 2 |
| Shioura, H | 2 |
| Ohtsubo, T | 2 |
| Kitai, R | 2 |
| Ohnishi, T | 2 |
| Kano, E | 2 |
| Ohnishi, K | 1 |
| Vanchieri, C | 1 |
| Brem, SS | 1 |
| Zagzag, D | 2 |
| Tsanaclis, AM | 2 |
| Gately, S | 1 |
| Elkouby, MP | 1 |
| Brien, SE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of Penicillamine and Reduction of Copper for Angiosuppressive Therapy of Adults With Newly Diagnosed Glioblastoma[NCT00003751] | Phase 2 | 40 participants (Anticipated) | Interventional | 1999-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for penicillamine and Brain Neoplasms
| Article | Year |
|---|---|
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma.
Topics: Brain Neoplasms; Chelating Agents; Copper; Diet Therapy; Female; Glioblastoma; Humans; Male; Middle | 2005 |
13 other studies available for penicillamine and Brain Neoplasms
| Article | Year |
|---|---|
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Topics: Animals; Brain; Brain Neoplasms; Cell Count; Cell Line, Tumor; Collagen; Disease Progression; Gliobl | 2013 |
Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Chelating Agents; Copper; Gliosarcoma; Male; Mic | 1995 |
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion.
Topics: Animals; Brain Neoplasms; Copper; Gliosarcoma; Male; Penicillamine; Rats; Rats, Inbred F344 | 1995 |
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine.
Topics: Animals; Brain Chemistry; Brain Neoplasms; Copper; Gliosarcoma; Male; Neoplasm Transplantation; Peni | 1993 |
Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line; Cysteamine; DNA, Neoplas | 1996 |
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion.
Topics: Brain Neoplasms; Chelating Agents; Deferoxamine; Glioma; Humans; Penicillamine; Trace Elements | 1996 |
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
Topics: Biotransformation; Brain Neoplasms; Breast Neoplasms; Cell Survival; Enzyme Inhibitors; Female; Glio | 1998 |
Growth inhibition and radiosensitization of cultured glioma cells by nitric oxide generating agents.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Gliom | 1999 |
Intercellular signaling initiated by nitric oxide produced in heat-shocked human glioblastoma cells.
Topics: Brain Neoplasms; Culture Media; Glioblastoma; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-S | 1999 |
Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma.
Topics: Benzoates; Brain Neoplasms; Cell Division; Coculture Techniques; Genes, p53; Glioblastoma; Guanidine | 1999 |
Cutting copper curbs angiogenesis, studies show.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Chelating Agents; Clinical Trials as Topic; Combined Modal | 2000 |
Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Capillary Permeability; Cell Division; Copper; Diet; Fi | 1990 |
Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain.
Topics: Animals; Brain Neoplasms; Copper; Glioma; Male; Microscopy, Electron; Neoplasm Transplantation; Peni | 1990 |