penicillamine has been researched along with Benign Neoplasms, Brain in 14 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of copper (Cu)-depletion diet and D-penicillamine treatment (CDPT) on both tumor growth and angiogenesis, we studied Fischer-344 rats in which 9L gliosarcoma cells had been subcutaneously implanted." | 3.69 | Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model. ( Ikeda, Y; Nakazawa, S; Yoshida, D, 1995) |
| "Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy improves its progression-free survival." | 1.39 | Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. ( Jiang, A; Jiang, E; Kieran, MW; Mammoto, A; Mammoto, T; Panigrahy, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mammoto, T | 1 |
| Jiang, A | 1 |
| Jiang, E | 1 |
| Panigrahy, D | 1 |
| Kieran, MW | 1 |
| Mammoto, A | 1 |
| Brem, S | 2 |
| Grossman, SA | 1 |
| Carson, KA | 1 |
| New, P | 1 |
| Phuphanich, S | 1 |
| Alavi, JB | 1 |
| Mikkelsen, T | 1 |
| Fisher, JD | 1 |
| Yoshida, D | 3 |
| Ikeda, Y | 3 |
| Nakazawa, S | 3 |
| Jeitner, TM | 1 |
| Renton, FJ | 1 |
| Philipov, P | 1 |
| Adami, A | 1 |
| Crivellente, F | 1 |
| De Prati, AC | 1 |
| Cavalieri, E | 1 |
| Cuzzolin, L | 1 |
| Tommasi, M | 1 |
| Suzuki, H | 1 |
| Benoni, G | 1 |
| Kurimoto, M | 1 |
| Endo, S | 1 |
| Hirashima, Y | 1 |
| Hamada, H | 1 |
| Ogiichi, T | 1 |
| Takaku, A | 1 |
| Matsumoto, H | 2 |
| Hayashi, S | 2 |
| Hatashita, M | 2 |
| Shioura, H | 2 |
| Ohtsubo, T | 2 |
| Kitai, R | 2 |
| Ohnishi, T | 2 |
| Kano, E | 2 |
| Ohnishi, K | 1 |
| Vanchieri, C | 1 |
| Brem, SS | 1 |
| Zagzag, D | 2 |
| Tsanaclis, AM | 2 |
| Gately, S | 1 |
| Elkouby, MP | 1 |
| Brien, SE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of Penicillamine and Reduction of Copper for Angiosuppressive Therapy of Adults With Newly Diagnosed Glioblastoma[NCT00003751] | Phase 2 | 40 participants (Anticipated) | Interventional | 1999-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for penicillamine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma.
Topics: Brain Neoplasms; Chelating Agents; Copper; Diet Therapy; Female; Glioblastoma; Humans; Male; Middle | 2005 |
13 other studies available for penicillamine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.
Topics: Animals; Brain; Brain Neoplasms; Cell Count; Cell Line, Tumor; Collagen; Disease Progression; Gliobl | 2013 |
Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Chelating Agents; Copper; Gliosarcoma; Male; Mic | 1995 |
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion.
Topics: Animals; Brain Neoplasms; Copper; Gliosarcoma; Male; Penicillamine; Rats; Rats, Inbred F344 | 1995 |
Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-penicillamine.
Topics: Animals; Brain Chemistry; Brain Neoplasms; Copper; Gliosarcoma; Male; Neoplasm Transplantation; Peni | 1993 |
Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line; Cysteamine; DNA, Neoplas | 1996 |
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion.
Topics: Brain Neoplasms; Chelating Agents; Deferoxamine; Glioma; Humans; Penicillamine; Trace Elements | 1996 |
Biotransformation and cytotoxic properties of NO-donors on MCF7 and U251 cell lines.
Topics: Biotransformation; Brain Neoplasms; Breast Neoplasms; Cell Survival; Enzyme Inhibitors; Female; Glio | 1998 |
Growth inhibition and radiosensitization of cultured glioma cells by nitric oxide generating agents.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Gliom | 1999 |
Intercellular signaling initiated by nitric oxide produced in heat-shocked human glioblastoma cells.
Topics: Brain Neoplasms; Culture Media; Glioblastoma; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-S | 1999 |
Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma.
Topics: Benzoates; Brain Neoplasms; Cell Division; Coculture Techniques; Genes, p53; Glioblastoma; Guanidine | 1999 |
Cutting copper curbs angiogenesis, studies show.
Topics: Angiogenesis Inhibitors; Brain Neoplasms; Chelating Agents; Clinical Trials as Topic; Combined Modal | 2000 |
Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Capillary Permeability; Cell Division; Copper; Diet; Fi | 1990 |
Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain.
Topics: Animals; Brain Neoplasms; Copper; Glioma; Male; Microscopy, Electron; Neoplasm Transplantation; Peni | 1990 |