Page last updated: 2024-11-07

penicillamine and Autoimmune Disease

penicillamine has been researched along with Autoimmune Disease in 88 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"In the present study, the side effects of d-Penicillamine therapy in 54 patients with rheumatoid arthritis are analyzed."8.77[Side effects of d-penicillamine in the treatment of rheumatoid arthritis]. ( Bianchini, D; Cataldo, R; Damiani, D; Florean, M; Mazzanti, G; Mesesnel, E; Paladini, G, 1986)
"The anti-rheumatoid drug D-penicillamine (D-pen) has a reactive sulfhydryl group capable of modifying self antigens, and can provoke typical autoantibody-mediated myasthenia gravis (MG), especially in DR1+ individuals."7.70T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes. ( Hill, M; Moss, P; Newsom-Davis, J; Willcox, N; Wordsworth, P, 1999)
"A 51-year-old man developed pemphigus vulgaris, minimal change nephropathy and acute tubular necrosis after 11 months of treatment with penicillamine for rheumatoid arthritis associated with features of Reiter's syndrome."7.67Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis. ( Chia, Y; Pusey, CD; Savill, JS, 1988)
"The development of autoimmune diseases in some patients treated with D-penicillamine (DPA) suggests that the reported occurrence of a conduction disorder at the neuromuscular junction and the development of a reversible myasthenia gravis in rheumatoid disease, progressive systemic sclerosis or Wilson's disease after the use of DPA are part of a general predisposition for autoimmune disease related to DPA therapy."7.67[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis]. ( Cossermelli, W; De Assis, JL; Marchiori, PE; Scaff, M, 1984)
"A pilot study of the effect of D-penicillamine in multiple sclerosis (MS) was undertaken because of D-penicillamine's activity against RNA neurotropic viruses, because it is effective against the auto-immune disease, rheumatoid arthritis, and because both viruses and autoimmunity have been implicated in multiple sclerosis."7.66Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis. ( Alba, A; Berger, AR; Rudez, A; Seelig, MS; Tarlau, M, 1978)
"The authors present 5 cases of pemphigus induced by D-penicillamine in a series of 180 cases of rheumatoid arthritis treated with this medication."7.65[Pemphigus induced by D-penicillamine in rheumatoid arthritis. Study of 5 cases and systematic study of anti-intercellular substance antibodies of the skin in the course of treatment]. ( Benveniste, M; Camus, JP; Crouzet, J; Hewitt, J; Homberg, JC; Lessana, M, 1975)
"Proteinuria is observed in 10% of the patients, often secondary to extramembranous glomerulopathy."5.30[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D]. ( Bridoux, F; Ducq, P; Gheerbrant, JD; Kyndt, X; Makdassi, R; Reumaux, D; Vanhille, P, 1999)
"We report a patient with primary biliary cirrhosis, who developed polymyositis while receiving D-penicillamine therapy."5.29A case of polymyositis in a patient with primary biliary cirrhosis treated with D-penicillamine. ( Ahn, JH; Kim, TH; Peck, KR; Song, YW, 1993)
" Three to eight weeks after D-penicillamine administration in a dosage of 20 to 50 mg per day, 73% of Brown Norway (BN) rats became ill."5.27Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation. ( Andres, GA; Brentjens, JR; Donker, AJ; Venuto, RC; Vladutiu, AO, 1984)
" Its indications in the therapy of RA were defined, and current principles of dosage were presented."5.26Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties. ( Jaffe, IA, 1979)
"In the present study, the side effects of d-Penicillamine therapy in 54 patients with rheumatoid arthritis are analyzed."4.77[Side effects of d-penicillamine in the treatment of rheumatoid arthritis]. ( Bianchini, D; Cataldo, R; Damiani, D; Florean, M; Mazzanti, G; Mesesnel, E; Paladini, G, 1986)
"Mercury and gold salts as well as d-penicillamine can cause glomerulonephritis by an autoimmune mechanism in man."4.77Immunogenetically controlled autoimmune reactions induced by mercury, gold and D-penicillamine in laboratory animals: a review from the vantage point of premarketing safety studies. ( Balazs, T, 1987)
" We tested this hypothesis in an animal model in which penicillamine causes an autoimmune syndrome in Brown Norway rats."3.71Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm. ( Sayeh, E; Uetrecht, JP, 2001)
"The anti-rheumatoid drug D-penicillamine (D-pen) has a reactive sulfhydryl group capable of modifying self antigens, and can provoke typical autoantibody-mediated myasthenia gravis (MG), especially in DR1+ individuals."3.70T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes. ( Hill, M; Moss, P; Newsom-Davis, J; Willcox, N; Wordsworth, P, 1999)
"D-penicillamine (DP) has been previously shown to induce an autoimmune disease in Brown-Norway (BN) rats, characterized by a dermatitis, by the production of antinuclear antibodies, by the formation fo circulating immune complexes, and by linear IgG deposits along the glomerular basement membrane."3.68D-penicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity. ( Druet, P; Mandet, C; Pasquier, R; Pelletier, L; Tournade, H; Vial, MC, 1990)
"The development of autoimmune diseases in some patients treated with D-penicillamine (DPA) suggests that the reported occurrence of a conduction disorder at the neuromuscular junction and the development of a reversible myasthenia gravis in rheumatoid disease, progressive systemic sclerosis or Wilson's disease after the use of DPA are part of a general predisposition for autoimmune disease related to DPA therapy."3.67[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis]. ( Cossermelli, W; De Assis, JL; Marchiori, PE; Scaff, M, 1984)
"A 51-year-old man developed pemphigus vulgaris, minimal change nephropathy and acute tubular necrosis after 11 months of treatment with penicillamine for rheumatoid arthritis associated with features of Reiter's syndrome."3.67Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis. ( Chia, Y; Pusey, CD; Savill, JS, 1988)
"Penicillamine is now established as a useful disease remittive drug in the treatment of rheumatoid arthritis."3.66Penicillamine: an anti-rheumatoid drug. ( Jaffe, IA, 1983)
"The prevalence of autoimmune associations was determined in 113 patients with primary biliary cirrhosis who participated in a therapeutic trial of D-penicillamine."3.66Autoimmune associations in primary biliary cirrhosis. ( Baldus, WP; Culp, KS; Dickson, ER; Duffy, J; Fleming, CR, 1982)
"A pilot study of the effect of D-penicillamine in multiple sclerosis (MS) was undertaken because of D-penicillamine's activity against RNA neurotropic viruses, because it is effective against the auto-immune disease, rheumatoid arthritis, and because both viruses and autoimmunity have been implicated in multiple sclerosis."3.66Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis. ( Alba, A; Berger, AR; Rudez, A; Seelig, MS; Tarlau, M, 1978)
" Masugi nephritis, heterologous and autologous immune complex nephritis as well as D-penicillamine induced glomerulonephritis were studied in rabbits, guinea pigs and rats."3.65Molecular weight analysis of proteinuria in experimental glomerulopathies. ( Batsford, SR; Boesken, WH; Schmitz-Hübner, U; Schneider, G, 1976)
"The authors present 5 cases of pemphigus induced by D-penicillamine in a series of 180 cases of rheumatoid arthritis treated with this medication."3.65[Pemphigus induced by D-penicillamine in rheumatoid arthritis. Study of 5 cases and systematic study of anti-intercellular substance antibodies of the skin in the course of treatment]. ( Benveniste, M; Camus, JP; Crouzet, J; Hewitt, J; Homberg, JC; Lessana, M, 1975)
"In this subset of patients with primary biliary cirrhosis, a significantly higher prevalence (86 percent) of circulating immune complexes was detected compared with those patients showing no autoimmune features (60 percent)."2.65Immune complexes in primary biliary cirrhosis. Higher prevalence of circulating immune complexes in patients with associated autoimmune features. ( Baggenstoss, AH; Dickson, ER; Gupta, RC; McDuffie, FC, 1982)
"Ursodeoxycholic acid has been shown to improve survival free of transplantation in a conclusive fashion."2.40Management of primary biliary cirrhosis and autoimmune cholangitis. ( Angulo, P; Lindor, KD, 1998)
"Drug-induced autoimmune diseases have two immunological peculiarities."2.37[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses]. ( Homberg, JC, 1984)
"Many of the adverse reactions produced by penicillamine and other compounds with an active sulfhydryl group form a distinctive pattern when viewed as a class."2.37Adverse effects profile of sulfhydryl compounds in man. ( Jaffe, IA, 1986)
" The types of cutaneous manifestations may, in some instances, be correlated with the disease being treated and the dosage and duration of penicillamine therapy."2.36Penicillamine: review and cutaneous manifestations. ( Alter, JN; Fisher, M; Levy, RS, 1983)
"Pemphigus is an autoimmune intraepidermal bullous disease involving the skin and mucous membranes."2.36Pemphigus: current concepts. ( , 1980)
"We retrospectively analyzed 235 Wilson disease patients."1.43Concomitant immune-related events in Wilson disease: implications for monitoring chelator therapy. ( Ferenci, P; Gohdes, A; Gotthardt, DN; Pfeiffenberger, J; Schäfer, M; Seessle, J; Stremmel, W; Weiss, KH, 2016)
"Co-occurence of systemic sclerosis and collagenous colitis is particularly rare."1.34Collagenous colitis in a patient with systemic sclerosis: a rare entity. ( Coban, S; Ekiz, F; Ensari, A; Gören, D; Ormeci, N; Savas, B, 2007)
"Two patients had systemic sclerosis and one had rheumatoid arthritis."1.32[Minimal changes nephrotic syndrome associated to penicillamine treatment]. ( Basterrechea, MA; de Arriba, G; García-Martín, F; Giménez-Vega, E; Sánchez, J; Sánchez-Heras, M, 2004)
"Proteinuria is observed in 10% of the patients, often secondary to extramembranous glomerulopathy."1.30[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D]. ( Bridoux, F; Ducq, P; Gheerbrant, JD; Kyndt, X; Makdassi, R; Reumaux, D; Vanhille, P, 1999)
"We report a patient with primary biliary cirrhosis, who developed polymyositis while receiving D-penicillamine therapy."1.29A case of polymyositis in a patient with primary biliary cirrhosis treated with D-penicillamine. ( Ahn, JH; Kim, TH; Peck, KR; Song, YW, 1993)
" Three to eight weeks after D-penicillamine administration in a dosage of 20 to 50 mg per day, 73% of Brown Norway (BN) rats became ill."1.27Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation. ( Andres, GA; Brentjens, JR; Donker, AJ; Venuto, RC; Vladutiu, AO, 1984)
" Its indications in the therapy of RA were defined, and current principles of dosage were presented."1.26Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties. ( Jaffe, IA, 1979)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199062 (70.45)18.7374
1990's14 (15.91)18.2507
2000's8 (9.09)29.6817
2010's4 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rozina, T1
Fastovets, S1
Lee, O1
Kuchieva, A1
Bulanov, N1
Moiseev, S1
Metushi, IG1
Zhu, X2
Uetrecht, J1
Seessle, J1
Gotthardt, DN1
Schäfer, M1
Gohdes, A1
Pfeiffenberger, J1
Ferenci, P1
Stremmel, W1
Weiss, KH1
Li, J1
Liu, F1
Uetrecht, JP3
DACIE, JV1
COSTEA, N1
YAKULIS, V1
HELLER, P1
Basterrechea, MA1
de Arriba, G1
García-Martín, F1
Sánchez-Heras, M1
Giménez-Vega, E1
Sánchez, J1
Shenton, JM1
Chen, J1
Angulo, P1
Lindor, KD1
Chuang, E1
Molitch, ME1
Ekiz, F1
Coban, S1
Savas, B1
Gören, D1
Ensari, A1
Ormeci, N1
Beaumont, JL1
Beaumont, V1
Jacotot, B1
Kaeser, HE1
Levy, RS1
Fisher, M1
Alter, JN1
Homberg, JC2
Donker, AJ1
Venuto, RC1
Vladutiu, AO1
Brentjens, JR1
Andres, GA1
Weening, JJ1
Epstein, O2
Marchiori, PE1
Scaff, M1
Cossermelli, W1
De Assis, JL1
Moutsopoulos, HM1
Giotaki, H1
Maddison, PJ1
Mavridis, AC1
Drosos, AA1
Skopouli, FN1
Jaffe, IA4
Stein, HB1
Chalmers, A1
Schroeder, ML1
Dillon, A1
Thomas, HC1
Brown, D1
Labrooy, J1
Culp, KS1
Fleming, CR1
Duffy, J1
Baldus, WP1
Dickson, ER2
Holborow, EJ1
Mariani, L1
Baratelli, M1
Gupta, RC1
McDuffie, FC1
Baggenstoss, AH1
Seelig, MS2
Barthel, HR1
Hiepe, F1
Monestier, M1
Novick, KE1
Losman, MJ1
Yodfat, O1
Shoenfeld, Y1
Ahn, JH1
Kim, TH1
Peck, KR1
Song, YW1
Ferro, J1
Susano, R1
Gómez, C1
de Quirós, JF1
Nässberger, L1
Mathieson, PW1
Peat, DS1
Short, A1
Watts, RA1
Zettl, UK1
Mix, E1
Zielasek, J1
Stangel, M1
Hartung, HP1
Gold, R1
Kyndt, X1
Ducq, P1
Bridoux, F1
Reumaux, D1
Makdassi, R1
Gheerbrant, JD1
Vanhille, P1
Hill, M1
Moss, P1
Wordsworth, P1
Newsom-Davis, J1
Willcox, N1
White, KL1
David, DW1
Butterworth, LF1
Klykken, PC1
Okada, J1
Kondo, H1
Sayeh, E1
Cozzi, F1
Marson, P1
Rosada, M1
De Silvestro, G1
Bullo, A1
Punzi, L1
Todesco, S1
Seipelt, H1
Feist, D1
Boesken, WH1
Batsford, SR1
Schmitz-Hübner, U1
Schneider, G1
Williams, R1
Eddleston, AL1
Wallach, D1
Pecking, A1
Delvincourt, C1
Cottenot, F1
Najean, Y1
Alba, A1
Berger, AR1
Rudez, A1
Tarlau, M1
Delrieu, F2
Menkes, CJ2
Sainte-Croix, A2
Babinet, P2
Chesneau, AM2
Delbarre, F2
Schumacher, K1
Benveniste, M1
Crouzet, J1
Lessana, M1
Camus, JP1
Hewitt, J1
Hrncír, Z2
Tichý, M1
Herranz, L1
Rovira, A1
Grande, C1
Suarez, A1
Martinez-Ara, J1
Pallardo, LF1
Gómez-Pan, A1
Rook, AH1
Tournade, H1
Pelletier, L1
Pasquier, R1
Vial, MC1
Mandet, C1
Druet, P1
Kjernsmo, A1
Haberhauer, G1
Verroust, PJ1
Weitoft, T1
Domeij-Nyberg, B1
Kerwar, SS1
Oronsky, AL1
Meyer, O1
Howard-Lock, HE1
Lock, CJ1
Mewa, A1
Kean, WF1
Mazzanti, G1
Paladini, G1
Damiani, D1
Bianchini, D1
Florean, M1
Mesesnel, E1
Cataldo, R1
Spears, CJ1
Batchelor, JR1
Smiley, JD1
Moore, SE1
Balazs, T1
Benenson, EV1
Savill, JS1
Chia, Y1
Pusey, CD1
Mackinnon, M1
Cooksley, WG1
Smallwood, RA1
Seideman, P1
Warnes, TW1
Taal, BG1
Schalm, SW1
Stacher, A1
Schraeder, PL1
Peters, HA1
Dahl, DS1
Barnett, EV1
Bluestone, R1
Cracchiolo, A1
Goldberg, LS1
Kantor, GL1
McIntosh, RM1
Currey, HL1
Metz, J1
Bettendorf, U1
Neuhaus, R1
Mlczoch, F1
Kormendy, CG1
Bender, AD1
Becker, K1
Bernasconi, C1
Pontiggia, P1
Lazzarino, M1
Follini, D1
Salvaneschi, L1

Reviews

26 reviews available for penicillamine and Autoimmune Disease

ArticleYear
Management of primary biliary cirrhosis and autoimmune cholangitis.
    Clinics in liver disease, 1998, Volume: 2, Issue:2

    Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Cholangitis; Colchicine; Disease Progression; Drug The

1998
Drug-induced myasthenic syndromes.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 100

    Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Autoimmune Diseas

1984
Penicillamine: review and cutaneous manifestations.
    Journal of the American Academy of Dermatology, 1983, Volume: 8, Issue:4

    Topics: Autoimmune Diseases; Collagen; Dermatitis, Atopic; Drug Eruptions; Elastin; Humans; Lichen Planus; P

1983
[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses].
    Presse medicale (Paris, France : 1983), 1984, Dec-15, Volume: 13, Issue:45

    Topics: Animals; Autoimmune Diseases; Cardiac Glycosides; Chemical and Drug Induced Liver Injury; Drug Combi

1984
T cell subsets in autoimmune and HBV-induced chronic liver disease, HBs antigen carriers with normal histology and primary biliary cirrhosis: a review of the abnormalities and the effects of treatment.
    Journal of clinical immunology, 1982, Volume: 2, Issue:3 Suppl

    Topics: Antibodies, Monoclonal; Autoimmune Diseases; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surfac

1982
Pemphigus: current concepts.
    Annals of internal medicine, 1980, Volume: 92, Issue:3

    Topics: Acantholysis; Adrenal Cortex Hormones; Autoimmune Diseases; Binding Sites, Antibody; Gold; Humans; I

1980
[Anti-inflammatory or antirheumatic agents? Pharmacological activity and therapeutic effectiveness of non-steroid anti-inflammatory drugs: comparative study. III].
    La Clinica terapeutica, 1980, Feb-29, Volume: 92, Issue:4

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Chloro

1980
Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases.
    Springer seminars in immunopathology, 1981, Volume: 4, Issue:2

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Captopril; Cystinuria; Hepatolenticular Degeneration; Hu

1981
[Lupus erythematosus and liver diseases].
    Deutsche medizinische Wochenschrift (1946), 1995, Sep-15, Volume: 120, Issue:37

    Topics: Autoimmune Diseases; Budd-Chiari Syndrome; Chelating Agents; Hepatitis; Hepatitis, Chronic; Hepatole

1995
[Penicillamine--friend or enemy?].
    Harefuah, 1994, Mar-15, Volume: 126, Issue:6

    Topics: Animals; Autoimmune Diseases; Humans; Immune System; Penicillamine; Penicillins

1994
Coexistent membranous nephropathy and ANCA-positive crescentic glomerulonephritis in association with penicillamine.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:5

    Topics: Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies;

1996
Assessment of autoimmunity-inducing potential using the brown Norway rat challenge model.
    Toxicology letters, 2000, Mar-15, Volume: 112-113

    Topics: Animals; Anti-Infective Agents, Local; Antibody Formation; Antidotes; Autoimmune Diseases; Disease M

2000
[Other autoimmune diseases].
    Ryoikibetsu shokogun shirizu, 2000, Issue:31

    Topics: Autoantibodies; Autoimmune Diseases; Halothane; Humans; Metals, Heavy; Penicillamine; Phenytoin

2000
Chronic active hepatitis: immunopathogenesis and immunotherapy.
    Israel journal of medical sciences, 1979, Volume: 15, Issue:3

    Topics: Antibodies, Viral; Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Carrier State; Chronic D

1979
Photopheresis in the treatment of autoimmune disease: experience with pemphigus vulgaris and systemic sclerosis.
    Annals of the New York Academy of Sciences, 1991, Dec-30, Volume: 636

    Topics: Autoimmune Diseases; Humans; Leukapheresis; Pemphigus; Penicillamine; PUVA Therapy; Scleroderma, Sys

1991
Adverse effects profile of sulfhydryl compounds in man.
    The American journal of medicine, 1986, Volume: 80, Issue:3

    Topics: Anemia, Aplastic; Autoimmune Diseases; Captopril; Drug Eruptions; Glomerulonephritis; Humans; Neutro

1986
D-penicillamine: chemistry and clinical use in rheumatic disease.
    Seminars in arthritis and rheumatism, 1986, Volume: 15, Issue:4

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Drug Eruptions; Gold Sodium Thiomalate; Hematologic Dise

1986
[Side effects of d-penicillamine in the treatment of rheumatoid arthritis].
    Minerva medica, 1986, May-31, Volume: 77, Issue:22-23

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Drug Eruptions; Female; Hematologic Disease

1986
Drug-induced autoimmune disease.
    Advances in nephrology from the Necker Hospital, 1987, Volume: 16

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Gold; HLA Antigens; Humans; Hydralazine; Lupus Erythemat

1987
Molecular mechanisms of autoimmunity.
    The American journal of the medical sciences, 1988, Volume: 295, Issue:5

    Topics: Antibodies, Antinuclear; Autoantibodies; Autoimmune Diseases; B-Lymphocytes; DNA; Humans; Immunoglob

1988
Immunogenetically controlled autoimmune reactions induced by mercury, gold and D-penicillamine in laboratory animals: a review from the vantage point of premarketing safety studies.
    Toxicology and industrial health, 1987, Volume: 3, Issue:3

    Topics: Animals; Autoimmune Diseases; Glomerulonephritis; Gold; Mercury; Mice; Mice, Inbred Strains; Penicil

1987
Chronic hepatitis: pathogenesis and treatment.
    Australian and New Zealand journal of medicine, 1986, Volume: 16, Issue:1

    Topics: Adrenal Cortex Hormones; Antigens, Viral; Antiviral Agents; Autoimmune Diseases; Cytotoxicity, Immun

1986
Treatment of primary biliary cirrhosis.
    Seminars in liver disease, 1985, Volume: 5, Issue:3

    Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine

1985
Immunosuppressive drugs in rheumatoid arthritis.
    Modern trends in rheumatology, 1971, Volume: 2

    Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmun

1971
[Penicillamine (dimethylcysteine) in the treatment of autoimmune diseases. (Summary review with reporting of personal experiences)].
    Vnitrni lekarstvi, 1969, Volume: 15, Issue:8

    Topics: Autoimmune Diseases; Collagen Diseases; Erythrocyte Aging; Hemagglutination Tests; Humans; Immunoglo

1969
Chemical interference with aging.
    Gerontologia, 1971, Volume: 17, Issue:1

    Topics: Adrenal Cortex Hormones; Aging; Animals; Antioxidants; Appetite Depressants; Autoimmune Diseases; Br

1971

Trials

5 trials available for penicillamine and Autoimmune Disease

ArticleYear
Immune complexes in primary biliary cirrhosis. Higher prevalence of circulating immune complexes in patients with associated autoimmune features.
    The American journal of medicine, 1982, Volume: 73, Issue:2

    Topics: Antigen-Antibody Complex; Autoantibodies; Autoimmune Diseases; Complement Activation; Humans; Liver

1982
Long-term therapy with plasma exchange in systemic sclerosis: effects on laboratory markers reflecting disease activity.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2001, Volume: 25, Issue:1

    Topics: Adult; Aged; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Biomarkers; Combined Modalit

2001
Chronic active hepatitis: immunopathogenesis and immunotherapy.
    Israel journal of medical sciences, 1979, Volume: 15, Issue:3

    Topics: Antibodies, Viral; Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Carrier State; Chronic D

1979
Cryoglobulins in primary biliary cirrhosis: prevalence and modulation by immunosuppressive therapy.
    Zeitschrift fur Gastroenterologie, 1985, Volume: 23, Issue:5

    Topics: Adult; Aged; Alkaline Phosphatase; Autoantibodies; Autoimmune Diseases; Clinical Trials as Topic; Cr

1985
Immunosuppressive drugs in rheumatoid arthritis.
    Modern trends in rheumatology, 1971, Volume: 2

    Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmun

1971

Other Studies

59 other studies available for penicillamine and Autoimmune Disease

ArticleYear
D-penicillamine-induced autoimmune disorders.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2019, Volume: 51, Issue:12

    Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Autoimmune Diseases; Autoimmunity

2019
D-penicillamine-induced granulomatous hepatitis in brown Norway rats.
    Molecular and cellular biochemistry, 2014, Volume: 393, Issue:1-2

    Topics: Alanine Transaminase; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Chemical and Drug In

2014
Concomitant immune-related events in Wilson disease: implications for monitoring chelator therapy.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Autoimmune Diseases; Chelating Agents; Child; Cross-Sect

2016
Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 120, Issue:2

    Topics: Animals; Autoimmune Diseases; Autoimmunity; Cytokines; Disease Models, Animal; Flow Cytometry; Leuko

2011
[THE COLD HEMAGGLUTININ SYNDROME].
    Medizinische Klinik, 1964, Mar-06, Volume: 59

    Topics: Anemia, Hemolytic; Autoimmune Diseases; Blood Transfusion; Cold Temperature; Cyanosis; Hemagglutinat

1964
EXPERIMENTAL PRODUCTION OF COLD AGGLUTININS IN RABBITS.
    Blood, 1965, Volume: 26

    Topics: Animals; Antibodies; Autoimmune Diseases; Chromatography; Chromium Isotopes; Cold Temperature; Cryog

1965
[Minimal changes nephrotic syndrome associated to penicillamine treatment].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2004, Volume: 24, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Middle

2004
Animal models of idiosyncratic drug reactions.
    Chemico-biological interactions, 2004, Nov-01, Volume: 150, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Animals; Autoimmune Diseases; Drug-Related Side Effects and

2004
Prolactin and autoimmune diseases in humans.
    Acta bio-medica : Atenei Parmensis, 2007, Volume: 78 Suppl 1

    Topics: Aminoquinolines; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bromocriptine; Cabergoline; Cy

2007
Collagenous colitis in a patient with systemic sclerosis: a rare entity.
    Journal of the National Medical Association, 2007, Volume: 99, Issue:6

    Topics: Abdomen; Aged; Autoimmune Diseases; Colitis, Collagenous; Comorbidity; Diarrhea; Female; Humans; Lop

2007
[A further case of hyperlipemia due to auto-antibodies. Its treatment with D-penicillamine].
    Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1967, May-19, Volume: 118, Issue:8

    Topics: Arteriosclerosis Obliterans; Autoimmune Diseases; Female; Humans; Hyperlipidemias; Middle Aged; Peni

1967
Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation.
    Clinical immunology and immunopathology, 1984, Volume: 30, Issue:1

    Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoantibodies; Autoimmune Diseases; Bas

1984
Autoimmune reactions and glomerulonephritis caused by heavy metals and other toxins.
    Developments in toxicology and environmental science, 1983, Volume: 11

    Topics: Animals; Autoimmune Diseases; Captopril; Glomerulonephritis; Gold; Humans; Mercury; Metals; Penicill

1983
Lichen planus and liver disease.
    The British journal of dermatology, 1984, Volume: 111, Issue:4

    Topics: Autoimmune Diseases; Chronic Disease; Female; Hepatitis, Chronic; Humans; Lichen Planus; Liver Cirrh

1984
[Myasthenia gravis induced by D-penicillamine in a patient with progressive systemic sclerosis].
    Arquivos de neuro-psiquiatria, 1984, Volume: 42, Issue:4

    Topics: Adult; Autoimmune Diseases; Female; Humans; Myasthenia Gravis; Neuromuscular Junction; Penicillamine

1984
Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro(SSA) antibody a possible marker of penicillamine-D intolerance.
    Annals of the rheumatic diseases, 1984, Volume: 43, Issue:2

    Topics: Adult; Aged; Antigens; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Fem

1984
Penicillamine: an anti-rheumatoid drug.
    The American journal of medicine, 1983, Dec-30, Volume: 75, Issue:6A

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoimmune Diseases; Drug Administration Schedule;

1983
Selected adverse reactions of D-penicillamine.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1984, Volume: 7, Issue:1

    Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Bronchiolitis, Viral; Cholestasis; Female; Humans

1984
Autoimmune associations in primary biliary cirrhosis.
    Mayo Clinic proceedings, 1982, Volume: 57, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Immunoglobulins; Keratoconj

1982
Drug effects on autoantibodies and immune complexes.
    Agents and actions. Supplements, 1980, Volume: 7

    Topics: Acetylation; Antibodies, Antinuclear; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodie

1980
Auto-immune complications of D-penicillamine--a possible result of zinc and magnesium depletion and of pyridoxine inactivation.
    Journal of the American College of Nutrition, 1982, Volume: 1, Issue:2

    Topics: Autoimmune Diseases; Humans; Magnesium; Magnesium Deficiency; Penicillamine; Pyridoxine; Vitamin B 6

1982
D-penicillamine- and quinidine-induced antinuclear antibodies in A.SW (H-2s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity.
    European journal of immunology, 1994, Volume: 24, Issue:3

    Topics: Amino Acid Sequence; Animals; Antibodies, Antinuclear; Antibodies, Monoclonal; Antibody Specificity;

1994
A case of polymyositis in a patient with primary biliary cirrhosis treated with D-penicillamine.
    The Korean journal of internal medicine, 1993, Volume: 8, Issue:1

    Topics: Autoimmune Diseases; Female; Humans; Liver Cirrhosis, Biliary; Middle Aged; Penicillamine; Polymyosi

1993
[Myasthenia induced by penicillamine: does an interaction with tricyclic antidepressants exist?].
    Revista clinica espanola, 1993, Volume: 192, Issue:7

    Topics: Aged; Antidepressive Agents, Tricyclic; Arthritis, Rheumatoid; Autoimmune Diseases; Drug Interaction

1993
Granulocyte autoantibodies--markers for drug-induced autoimmune adverse effects.
    Clinical nephrology, 1993, Volume: 39, Issue:5

    Topics: Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Autoimmune Diseases; Biomarkers; Glomerulone

1993
Apoptosis of myelin-reactive T cells induced by reactive oxygen and nitrogen intermediates in vitro.
    Cellular immunology, 1997, May-25, Volume: 178, Issue:1

    Topics: Animals; Apoptosis; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Cells, Cultured; DNA Fragmentat

1997
[Extracapillary glomerulonephritis with anti-myeloperoxidase antibodies in 2 patients with systemic scleroderma treated with penicillamine D].
    Presse medicale (Paris, France : 1983), 1999, Jan-16, Volume: 28, Issue:2

    Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Autoimmune Diseases; Female; Glomerulonephritis; Human

1999
T cell responses to D-penicillamine in drug-induced myasthenia gravis: recognition of modified DR1:peptide complexes.
    Journal of neuroimmunology, 1999, Jun-01, Volume: 97, Issue:1-2

    Topics: Aged; Amino Acid Sequence; Antirheumatic Agents; Autoimmune Diseases; Base Sequence; Blood Proteins;

1999
Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm.
    Toxicology, 2001, Jun-21, Volume: 163, Issue:2-3

    Topics: Animals; Autoimmune Diseases; Autoimmunity; Drug Eruptions; Immunoglobulin E; Interferon Inducers; I

2001
[Drug immunosuppression].
    Kinderarztliche Praxis, 1975, Volume: 43, Issue:7

    Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antimetabolites; Arthritis; Arthritis, Juvenile; A

1975
[Studies on juvenile chronic hepatitis].
    Fortschritte der Medizin, 1975, Sep-11, Volume: 93, Issue:25

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Autoantibodies; Autoimmune Diseases; Azathioprine

1975
Molecular weight analysis of proteinuria in experimental glomerulopathies.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1976, Feb-27, Volume: 167, Issue:1

    Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Glomerulo

1976
Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties.
    Scandinavian journal of rheumatology. Supplement, 1979, Issue:28

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Collagen; Cystine; Drug Evaluation; Humans; Penicillamin

1979
[Gougerot-Sjögren's syndrome and pemphigus. Parallel development of the dryness syndrome and auto-immune dermatosis].
    Annales de dermatologie et de venereologie, 1979, Volume: 106, Issue:2

    Topics: Adult; Autoimmune Diseases; Humans; Male; Pemphigus; Penicillamine; Salivary Glands; Sjogren's Syndr

1979
Pilot study of d-penicillamine, vitamins and minerals in multiple sclerosis.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:2

    Topics: Adult; Autoimmune Diseases; Brain; Dose-Response Relationship, Drug; Female; Humans; Magnesium; Male

1978
[Myasthenia gravis and autoimmune thyroiditis during the treatment of rheumatoid polyarthritis withD-penicillamine. Anatomoclinical study of 1 case].
    Annales de medecine interne, 1976, Volume: 127, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Female; Humans; Middle Aged; Myasthenia

1976
[Basis of immunosuppressive effect of D-penecillamine].
    Der Internist, 1975, Volume: 16, Issue:10

    Topics: Antibody Formation; Autoimmune Diseases; Humans; Immunity, Cellular; Immunosuppression Therapy; Immu

1975
[Letter: Myasthenia and autoimmune thyroiditis during rheumatoid polyarthritis treated by D-penicillamine].
    La Nouvelle presse medicale, 1975, Nov-22, Volume: 4, Issue:40

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Middle Aged; Myasthenia Gravis; Penicill

1975
[Pemphigus induced by D-penicillamine in rheumatoid arthritis. Study of 5 cases and systematic study of anti-intercellular substance antibodies of the skin in the course of treatment].
    La Nouvelle presse medicale, 1975, Dec-20, Volume: 4, Issue:44

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Female; Humans; Pemphigus; Penici

1975
[Proteinuria in immunopathological diseases during long-term penicillamine therapy (author's transl)].
    Casopis lekaru ceskych, 1976, May-07, Volume: 115, Issue:18

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Penicillamine; Proteinuria; Scleroderma, Systemi

1976
Autoimmune insulin syndrome in a patient with progressive systemic sclerosis receiving penicillamine.
    Hormone research, 1992, Volume: 37, Issue:1-2

    Topics: Adult; Autoantibodies; Autoimmune Diseases; Blood Glucose; Humans; Insulin; Male; Penicillamine

1992
D-penicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Apr-15, Volume: 144, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; CD8 A

1990
[Analysis of cardiolipin antibodies should be done before penicillamine treatment].
    Lakartidningen, 1989, Nov-29, Volume: 86, Issue:48

    Topics: Autoantibodies; Autoimmune Diseases; Cardiolipins; Humans; Penicillamine; Thromboembolism

1989
Induction of anticentromere antibody in patients receiving treatment with D-penicillamine.
    Klinische Wochenschrift, 1989, May-15, Volume: 67, Issue:10

    Topics: Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Ce

1989
Kinetics of immune deposits in membranous nephropathy.
    Kidney international, 1989, Volume: 35, Issue:6

    Topics: Adult; Animals; Autoimmune Diseases; Disease Models, Animal; Glomerulonephritis; Glomerulonephritis,

1989
[A fatal drug-induced autoimmune syndrome].
    Lakartidningen, 1989, Sep-27, Volume: 86, Issue:39

    Topics: Aged; Autoimmune Diseases; Brain; Humans; Lung; Male; Penicillamine; Radiography; Shock; Syndrome; T

1989
Type II collagen induced arthritis in rats: clinical and immunological studies.
    International journal of tissue reactions, 1985, Volume: 7, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoimmune Disea

1985
[D-penicillamine: mechanism of cellular action and induced autoimmune diseases].
    Revue du rhumatisme et des maladies osteo-articulaires, 1986, Volume: 53, Issue:1

    Topics: Animals; Anti-Glomerular Basement Membrane Disease; Autoimmune Diseases; Dermatomyositis; Humans; Lu

1986
[Immunotropic therapy of rheumatoid arthritis (prerequisites, results and principles)].
    Terapevticheskii arkhiv, 1988, Volume: 60, Issue:4

    Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; I

1988
Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis.
    Clinical nephrology, 1988, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Kidney Tubular Necrosis, Ac

1988
Antiskeletal muscle antibodies during treatment with penicillamine.
    The Journal of rheumatology, 1987, Volume: 14, Issue:3

    Topics: Autoantibodies; Autoimmune Diseases; Enzyme-Linked Immunosorbent Assay; Humans; Muscles; Penicillami

1987
[Immunosuppressive therapy in hematology].
    Folia haematologica (Leipzig, Germany : 1928), 1972, Volume: 97, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Myelophthis

1972
Polymyositis and penicillamine.
    Archives of neurology, 1972, Volume: 27, Issue:5

    Topics: Adult; Autoimmune Diseases; Diagnosis, Differential; Female; Hepatolenticular Degeneration; Homozygo

1972
Cryoglobulinemia and disease.
    Annals of internal medicine, 1970, Volume: 73, Issue:1

    Topics: Adult; Anemia, Hemolytic; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Beta-Globulins

1970
[Letter: Therapy of Reiter's syndrome].
    Die Medizinische Welt, 1974, Sep-06, Volume: 25, Issue:36

    Topics: Adult; Arthritis, Reactive; Autoimmune Diseases; Humans; Male; Penicillamine

1974
[Penicillamine-induced polymyositis (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Dec-06, Volume: 99, Issue:49

    Topics: Aged; Antibodies; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoimmune Diseases; Collagen; Cor

1974
[Autoaggression diseases of the lung].
    Wiener medizinische Wochenschrift (1946), 1972, Sep-16, Volume: 122, Issue:38

    Topics: Antibody Formation; Autoantibodies; Autoimmune Diseases; Azathioprine; Cortisone; Humans; Lung Disea

1972
[Long term and permanent therapy of chronic hepatitis].
    Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:8

    Topics: Autoimmune Diseases; Chronic Disease; Cortisone; Cyclophosphamide; Female; Hepatitis; Hepatitis A; H

1970
[Use of D-penicillamine in the therapy of autoimmune hemopathies with macromolecular antibodies].
    Haematologica, 1970, Volume: 55, Issue:8

    Topics: Antibodies; Autoimmune Diseases; Blood Protein Disorders; Cold Temperature; Cryoglobulins; Humans; M

1970