Page last updated: 2024-11-07

penicillamine and Angiitis

penicillamine has been researched along with Angiitis in 26 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months."7.66Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. ( Banfi, G; Guerra, L; Imbasciati, E; Mihatsch, MJ; Ponticelli, C, 1983)
"Because Wilson disease was never associated with ANCA-related nephritis, this case strongly supports that d-penicillamine can induce ANCA-vasculitis."5.34D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. ( Bienaimé, F; Clerbaux, G; Mougenot, B; Plaisier, E; Ronco, P; Rougier, JP, 2007)
"Case reports have suggested that minocycline, sulfasalazine, and penicillamine are associated with antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis."5.09Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine. ( Choi, HK; Merkel, PA; Niles, JL; Pan, G; Slot, MC; Weissbach, CA, 2000)
" In particular, we describe renal syndromes associated with non-steroidal antiinflammatory drugs, remission-inducing agents (gold and penicillamine) and cytotoxic drugs, secondary amyloidosis, systemic rheumatoid vasculitis, glomerular and tubulo-interstitial nephritis not related to drug therapy."4.79[Renal damage in rheumatoid arthritis]. ( Bruno, M; Cosseddu, D; Linari, F; Manganaro, M; Pellerito, R; Ravarino, N; Torchio, B; Urbano, D, 1994)
" Conditions often associated with rheumatoid arthritis and also thought to have an immunologic basis, such as Sjögren's syndrome, Felty's syndrome, and rheumatoid vasculitis, and reactions to medications, such as gold and penicillamine, reveal an interesting spectrum of immunogenetic relationships."4.76Rheumatoid arthritis: relationship with HLA-D. ( Stastny, P, 1983)
"In this study, we determined the prevalence of exposure to hydralazine, propylthiouracil, and other drugs previously implicated in APV among 30 patients with vasculitis and the highest titers of anti-MPO antibodies newly detected in our laboratory between 1994 and 1998."3.70Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies. ( Choi, HK; Merkel, PA; Niles, JL; Walker, AM, 2000)
"Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months."3.66Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. ( Banfi, G; Guerra, L; Imbasciati, E; Mihatsch, MJ; Ponticelli, C, 1983)
"Penicillamine is now established as a useful disease remittive drug in the treatment of rheumatoid arthritis."3.66Penicillamine: an anti-rheumatoid drug. ( Jaffe, IA, 1983)
"Although rare, vasculitis is a complication of SSc."2.49Systemic vasculitis during the course of systemic sclerosis: report of 12 cases and review of the literature. ( Cacoub, P; Guillevin, L; Hachulla, E; Hatron, PY; Meyer, O; Michon-Pasturel, U; Mouthon, L; Quéméneur, T; Vanhille, P, 2013)
"Because Wilson disease was never associated with ANCA-related nephritis, this case strongly supports that d-penicillamine can induce ANCA-vasculitis."1.34D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease. ( Bienaimé, F; Clerbaux, G; Mougenot, B; Plaisier, E; Ronco, P; Rougier, JP, 2007)
" Over a 2-yr period we have prospectively reviewed 114 patients with a suspected adverse cutaneous reaction to anti-rheumatic drugs."1.29Suspected cutaneous drug toxicity in rheumatoid arthritis--an evaluation. ( Davis, MJ; Dawes, PT; Mattey, DL; Smith, AG; Wilkinson, SM, 1993)
"Vasculitis was confirmed histologically in 96% of the subjects with RV."1.29Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case-control study. ( Breedveld, FC; Hazes, JM; Vandenbroucke, JP; Voskuyl, AE; Westedt, ML; Zwinderman, AH, 1996)
"While rheumatoid arthritis is characteristically an indolent disease, failure to recognize its urgent complications can cause significant morbidity and mortality."1.27Emergencies in rheumatoid arthritis. ( Weiner, SR, 1984)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199012 (46.15)18.7374
1990's9 (34.62)18.2507
2000's3 (11.54)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barsotti, S1
Tripoli, A1
Pollina, LE1
Mosca, M1
Neri, R1
Quéméneur, T1
Mouthon, L1
Cacoub, P1
Meyer, O1
Michon-Pasturel, U1
Vanhille, P1
Hatron, PY1
Guillevin, L1
Hachulla, E1
Bienaimé, F1
Clerbaux, G1
Plaisier, E1
Mougenot, B1
Ronco, P1
Rougier, JP1
Banfi, G1
Imbasciati, E1
Guerra, L1
Mihatsch, MJ1
Ponticelli, C1
Stastny, P1
Jaffe, IA1
Hodson, ME1
Haslam, PL1
Spiro, SG1
Turner-Warwick, M1
Weiner, SR1
Gordon, GV1
Barthel, HR1
Hiepe, F1
Manganaro, M1
Bruno, M1
Ravarino, N1
Pellerito, R1
Cosseddu, D1
Torchio, B1
Urbano, D1
Linari, F1
Wilkinson, SM1
Smith, AG1
Davis, MJ1
Mattey, DL1
Dawes, PT1
Mathieson, PW1
Peat, DS1
Short, A1
Watts, RA1
Voskuyl, AE1
Zwinderman, AH1
Westedt, ML1
Vandenbroucke, JP1
Breedveld, FC1
Hazes, JM1
Pless, M1
Sandson, T1
Qasim, FJ1
Thiru, S1
Gillespie, K1
Collard, CD1
Agah, A1
Reenstra, W1
Buras, J1
Stahl, GL1
Choi, HK2
Merkel, PA2
Walker, AM1
Niles, JL2
Slot, MC1
Pan, G1
Weissbach, CA1
Axson, FA1
Solomon, SD1
Bacon, PA1
Falck, HM1
Törnroth, T1
Kock, B1
Wegelius, O1
Jean-Baptiste, G1
Gladman, DD1
Anhorn, KA1
Dugowson, CE1
Gilliland, BC1

Reviews

9 reviews available for penicillamine and Angiitis

ArticleYear
Histopathology of the muscle in rheumatic diseases.
    Reumatismo, 2018, Oct-03, Volume: 70, Issue:3

    Topics: Adrenal Cortex Hormones; Biopsy; Connective Tissue Diseases; Cyclosporine; Diagnosis, Differential;

2018
Systemic vasculitis during the course of systemic sclerosis: report of 12 cases and review of the literature.
    Medicine, 2013, Volume: 92, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Biomar

2013
Rheumatoid arthritis: relationship with HLA-D.
    The American journal of medicine, 1983, Dec-30, Volume: 75, Issue:6A

    Topics: Adult; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Diabetes Mellitus, Type 1; Felty Syndrome;

1983
[Lupus erythematosus and liver diseases].
    Deutsche medizinische Wochenschrift (1946), 1995, Sep-15, Volume: 120, Issue:37

    Topics: Autoimmune Diseases; Budd-Chiari Syndrome; Chelating Agents; Hepatitis; Hepatitis, Chronic; Hepatole

1995
[Renal damage in rheumatoid arthritis].
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 1994, Volume: 46, Issue:1

    Topics: Adult; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclosporine; Fe

1994
Coexistent membranous nephropathy and ANCA-positive crescentic glomerulonephritis in association with penicillamine.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:5

    Topics: Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies;

1996
Update: treatment of rheumatic disease.
    The Journal of the Medical Society of New Jersey, 1978, Volume: 75, Issue:12

    Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosu

1978
Drug therapy and circulating immune complexes in rheumatoid arthritis.
    Rheumatology and rehabilitation, 1978, Volume: Suppl

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Complement System Proteins; Cyclophosphamide; Felty

1978
Management of rheumatoid arthritis.
    Disease-a-month : DM, 1986, Volume: 32, Issue:1

    Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyc

1986

Trials

1 trial available for penicillamine and Angiitis

ArticleYear
Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antineutrophil Cytoplasmic; Double-Blind Method

2000

Other Studies

16 other studies available for penicillamine and Angiitis

ArticleYear
D-Penicillamine-induced ANCA-associated crescentic glomerulonephritis in Wilson disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2007, Volume: 50, Issue:5

    Topics: Adult; Antibodies, Antineutrophil Cytoplasmic; Chelating Agents; Creatinine; Disease Progression; Fe

2007
Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis.
    Nephron, 1983, Volume: 33, Issue:1

    Topics: Arthritis, Rheumatoid; Female; Fluorescent Antibody Technique; Glomerulonephritis; Humans; Microscop

1983
Penicillamine: an anti-rheumatoid drug.
    The American journal of medicine, 1983, Dec-30, Volume: 75, Issue:6A

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoimmune Diseases; Drug Administration Schedule;

1983
Digital vasculitis in patients with cryptogenic fibrosing alveolitis.
    British journal of diseases of the chest, 1984, Volume: 78, Issue:2

    Topics: Adult; Aged; Female; Fingers; Humans; Immunosuppressive Agents; Male; Middle Aged; Penicillamine; Pr

1984
Emergencies in rheumatoid arthritis.
    American family physician, 1984, Volume: 29, Issue:6

    Topics: Anti-Inflammatory Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Carpal Tunnel Syndrome; Cerv

1984
Rheumatoid vasculitis.
    International journal of dermatology, 1981, Volume: 20, Issue:8

    Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Cyclophosphamide; Humans; Penicillamine; Vasculitis

1981
Suspected cutaneous drug toxicity in rheumatoid arthritis--an evaluation.
    British journal of rheumatology, 1993, Volume: 32, Issue:9

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis,

1993
Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case-control study.
    Annals of the rheumatic diseases, 1996, Volume: 55, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid

1996
Chronic internuclear ophthalmoplegia. A manifestation of D-penicillamine cerebral vasculitis.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 1997, Volume: 17, Issue:1

    Topics: Adult; Antirheumatic Agents; Biopsy; Brain Diseases; Chronic Disease; Female; Follow-Up Studies; Hep

1997
Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: support for a role for Th2 cell activity.
    Clinical and experimental immunology, 1997, Volume: 108, Issue:3

    Topics: Animals; Female; Gold; Immunoglobulin E; Interleukin-4; Male; Penicillamine; Rats; Rats, Inbred BN;

1997
Endothelial nuclear factor-kappaB translocation and vascular cell adhesion molecule-1 induction by complement: inhibition with anti-human C5 therapy or cGMP analogues.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:11

    Topics: Aminoquinolines; Antibodies, Monoclonal; Blotting, Western; Bucladesine; Cell Hypoxia; Cells, Cultur

1999
Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Antibodies; Antibodies, Antineutrophil Cyto

2000
D-penicillamine in the treatment of rheumatoid vasculitis.
    Journal of the South Carolina Medical Association (1975), 1979, Volume: 75, Issue:5

    Topics: Arthritis, Rheumatoid; Humans; Male; Middle Aged; Penicillamine; Vasculitis

1979
Fatal renal vasculitis and minimal change glomerulonephritis complicating treatment with penicillamine. Report on two cases.
    Acta medica Scandinavica, 1979, Volume: 205, Issue:1-2

    Topics: Female; Humans; Kidney Glomerulus; Male; Microcirculation; Middle Aged; Nephrosis, Lipoid; Nephrotic

1979
[Rheumatoid arthritis. Diagnosis, anatomopathology, evolution, prognosis, treatment].
    La Revue du praticien, 1991, Sep-01, Volume: 41, Issue:19

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agent

1991
HLA and disease manifestations in rheumatoid arthritis--a Canadian experience.
    The Journal of rheumatology, 1986, Volume: 13, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Gold; Histocompatibility Antigens Class II; HLA Antigens

1986