penicillamine has been researched along with Amyotrophic Lateral Sclerosis in 10 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zaleska, B | 1 |
| Conradi, S | 1 |
| Ronnevi, LO | 1 |
| Nise, G | 1 |
| Vesterberg, O | 1 |
| Wiedau-Pazos, M | 1 |
| Goto, JJ | 1 |
| Rabizadeh, S | 1 |
| Gralla, EB | 1 |
| Roe, JA | 1 |
| Lee, MK | 1 |
| Valentine, JS | 1 |
| Bredesen, DE | 1 |
| Hottinger, AF | 1 |
| Fine, EG | 1 |
| Gurney, ME | 1 |
| Zurn, AD | 1 |
| Aebischer, P | 1 |
| Gabbianelli, R | 1 |
| Ferri, A | 1 |
| Rotilio, G | 1 |
| Carrì, MT | 1 |
| Bousser, MG | 1 |
| Malier, M | 1 |
| Jusić, A | 1 |
| Sostarko, M | 1 |
| Majić, D | 1 |
| Check, WA | 1 |
| Boothby, JA | 1 |
| DeJesus, PV | 1 |
| Rowland, LP | 1 |
| Currier, RD | 1 |
| Haerer, AF | 1 |
1 review available for penicillamine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
[Progress in the treatment of degenerative diseases of the nervous system. Selected problems].
Topics: Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Humans; Huntington Disease; Lithium; Neostigmin | 1980 |
9 other studies available for penicillamine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Long-time penicillamine-treatment in amyotrophic lateral sclerosis with parallel determination of lead in blood, plasma and urine.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Drug Therapy, Combination; Female; Humans; Lead; Male; M | 1982 |
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Binding Sites; Catalysis; Cell Line; Chelating Ag | 1996 |
The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Stem; Cell Count; Chelating Agents; Copper; Facial Ner | 1997 |
Aberrant copper chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Blotting, Western; Catalase; Cell Survival; Copper; Humans; Neuroblas | 1999 |
Penicillamine in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Drug Evaluation; Female; Humans; Male; Penicillamine | 1979 |
[Spinal amyotrophy, delta-aminolevulinic acid and Metalcaptase (preliminary communication)].
Topics: Adult; Aged; Aminolevulinic Acid; Amyotrophic Lateral Sclerosis; Female; Humans; Levulinic Acids; Ma | 1979 |
Amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Humans; Lead; Neurotoxins; Penicillamine | 1979 |
Reversible forms of motor neuron disease. Lead "neuritis".
Topics: Adult; Amyotrophic Lateral Sclerosis; Blood Urea Nitrogen; Diagnosis, Differential; Electromyography | 1974 |
Amyotrophic lateral sclerosis and metallic toxins.
Topics: Adult; Aged; Agricultural Workers' Diseases; Amyotrophic Lateral Sclerosis; Arsenic; Chelating Agent | 1968 |