penicillamine has been researched along with Adjuvant Arthritis in 33 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of long term D-penicillamine treatment on adjuvant arthritis in the rat were determined in order to establish a possible approach to the laboratory evaluation of anti-rheumatic drugs." | 7.67 | Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat. ( Branceni, D; Delahaye, M; Dunn, CJ; Prouteau, M; Purcell, T, 1984) |
| "Experiments were performed in order to ascertain the action of D-penicillamine (PA) on adjuvant arthritis (AA) in rats and to develop a quantitative evaluation method for PA-like drugs, using Lewis, SD, and Wistar rats." | 7.67 | Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis. ( Aihara, H; Nakaike, S; Otomo, S; Shiono, M; Takeshita, K; Tomita, N, 1985) |
| "D-Penicillamine (D-PA), 80-100 mg/kg/day enhanced the early phase of adjuvant arthritis (AA) in rats when it was administered orally for about 4 weeks after the adjuvant injection day, whereas dexamethasone (1 mg/kg/day, p." | 7.66 | [Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)]. ( Higuchi, S; Kimura, M; Nakaike, S; Ohzeki, M; Otomo, S; Sasajima, M; Tarumoto, Y, 1981) |
| "Treatment of rabbits with D-penicillamine at doses up to 30 mg/kg, beginning either before or after the onset of antigen-induced experimental arthritis, diminished the severity of the inflammatory synovitis in a considerable proportion of animals as judged by both external joint measurements and terminal histopathological assessment." | 7.66 | Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1979) |
| "Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported." | 7.65 | Effect of D(-)penicillamine on chronic experimental arthritis in rabbits. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1977) |
| "SA679 also inhibited the adjuvant arthritis at a dose of 100 mg/kg, but its effect was less potent than that of SA96." | 5.27 | [Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Nakata, K; Sasano, M; Suda, H; Yamauchi, H, 1985) |
| "In our study the effects of angiotension converting enzyme inhibitor captopril and immunosuppressant agent d-penicillamine were investigated on inflammations mediated by kinins and on adjuvant arthritis in rat paw oedema tests." | 3.69 | [Effects pf captopril and D-penicillamine on kinins-mediated and chronic inflammation]. ( Blazsó, G; Gáspár, R, 1996) |
| "The effects of long term D-penicillamine treatment on adjuvant arthritis in the rat were determined in order to establish a possible approach to the laboratory evaluation of anti-rheumatic drugs." | 3.67 | Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat. ( Branceni, D; Delahaye, M; Dunn, CJ; Prouteau, M; Purcell, T, 1984) |
| "Experiments were performed in order to ascertain the action of D-penicillamine (PA) on adjuvant arthritis (AA) in rats and to develop a quantitative evaluation method for PA-like drugs, using Lewis, SD, and Wistar rats." | 3.67 | Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis. ( Aihara, H; Nakaike, S; Otomo, S; Shiono, M; Takeshita, K; Tomita, N, 1985) |
| "Adherent spleen cells from rats with adjuvant arthritis inhibit the incorporation of 3H-thymidine into DNA and 3H-leucine into protein in nonadherent spleen lymphocytes, stimulated by the mitogens Concanavalin A and E." | 3.66 | Splenic suppressor cells in adjuvant arthritic rats: effect of D-penicillamine. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1980) |
| "D-Penicillamine (D-PA), 80-100 mg/kg/day enhanced the early phase of adjuvant arthritis (AA) in rats when it was administered orally for about 4 weeks after the adjuvant injection day, whereas dexamethasone (1 mg/kg/day, p." | 3.66 | [Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)]. ( Higuchi, S; Kimura, M; Nakaike, S; Ohzeki, M; Otomo, S; Sasajima, M; Tarumoto, Y, 1981) |
| "D-penicillamine (D-PA) has beneficial therapeutic effects for patients with rheumatoid arthritis but no convincing explanation has been offered for the mode of action." | 3.66 | Studies of D-penicillamine (3): immunomodulating effects of D-penicillamine. ( Mori, C; Nakaike, S; Ohzeki, M; Otomo, S; Tsuji, I, 1981) |
| "Administration of D-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells." | 3.66 | Immunological effects of D-penicillamine during experimental induced inflammation in rats. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1980) |
| "Treatment of rabbits with D-penicillamine at doses up to 30 mg/kg, beginning either before or after the onset of antigen-induced experimental arthritis, diminished the severity of the inflammatory synovitis in a considerable proportion of animals as judged by both external joint measurements and terminal histopathological assessment." | 3.66 | Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1979) |
| "Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported." | 3.65 | Effect of D(-)penicillamine on chronic experimental arthritis in rabbits. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1977) |
| "Rheumatoid arthritis is a chronic inflammatory synovitis that primarily involves peripheral diarthrodial joints." | 2.37 | NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment. ( Decker, JL; Haraoui, B; Klippel, JH; Malone, DG; Schrieber, L; Steinberg, AD; Wahl, SM; Wilder, RL, 1984) |
| "Treatment with rolipram was followed by inhibition of the early phase of AIA associated with downregulation of both OVA-specific splenocyte proliferation and decreases of IFN-gamma released from the spleen cells but no decreases of the amount of IL-10, or levels of anti-OVA IgG, IgG2a, and IgG1." | 1.34 | Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice. ( Alam, AH; Hossain, MA; Li, X; Takano, H; Taneda, S; Yamaki, K; Yanagisawa, R; Yoshino, S, 2007) |
| "SA679 also inhibited the adjuvant arthritis at a dose of 100 mg/kg, but its effect was less potent than that of SA96." | 1.27 | [Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Nakata, K; Sasano, M; Suda, H; Yamauchi, H, 1985) |
| "actions, which can be disclosed in the adjuvant arthritis as well as in the B." | 1.27 | [The testing of long-term antirheumatics in animals]. ( Bekemeier, H; Hirschelmann, R; Weber, M, 1987) |
| "adjuvant arthritis, were found to increase tumour cell 3H-TdR incorporation, compared to macrophages from nonarthritic rats." | 1.26 | Antirheumatic drugs and macrophage function: effects on tumour cell growth in vitro. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (90.91) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamaki, K | 1 |
| Li, X | 1 |
| Hossain, MA | 1 |
| Alam, AH | 1 |
| Taneda, S | 1 |
| Yanagisawa, R | 1 |
| Takano, H | 1 |
| Yoshino, S | 1 |
| Decker, JL | 1 |
| Malone, DG | 1 |
| Haraoui, B | 1 |
| Wahl, SM | 1 |
| Schrieber, L | 1 |
| Klippel, JH | 1 |
| Steinberg, AD | 1 |
| Wilder, RL | 1 |
| Binderup, L | 5 |
| Bramm, E | 6 |
| Arrigoni-Martelli, E | 6 |
| Nakaike, S | 5 |
| Tanaka, C | 1 |
| Tomita, N | 2 |
| Umemoto, M | 1 |
| Otomo, S | 6 |
| Aihara, H | 4 |
| West, GB | 2 |
| Dunn, CJ | 1 |
| Prouteau, M | 1 |
| Delahaye, M | 1 |
| Purcell, T | 1 |
| Branceni, D | 1 |
| Cashin, CH | 1 |
| Doherty, NS | 1 |
| Jeffries, BL | 1 |
| Buckland-Wright, JC | 1 |
| Higuchi, S | 1 |
| Tarumoto, Y | 1 |
| Kimura, M | 1 |
| Sasajima, M | 1 |
| Ohzeki, M | 2 |
| Tsuji, I | 1 |
| Mori, C | 1 |
| Jones, SA | 1 |
| Kennedy, AJ | 1 |
| Roberts, NA | 1 |
| Gáspár, R | 1 |
| Blazsó, G | 1 |
| Hunneyball, IM | 4 |
| Stewart, GA | 2 |
| Stanworth, DR | 2 |
| Patzschke, K | 1 |
| Wegner, LA | 1 |
| Arrigoni-Martelld, E | 1 |
| Hayashi, M | 2 |
| Matsunaga, K | 1 |
| Okahara, A | 1 |
| Mita, S | 1 |
| Yamauchi, H | 1 |
| Kasamatsu, S | 1 |
| Suda, H | 1 |
| Nakata, K | 1 |
| Sasano, M | 1 |
| Iso, T | 1 |
| Bekemeier, H | 1 |
| Hirschelmann, R | 1 |
| Weber, M | 1 |
| Crossley, MJ | 2 |
| Spowage, M | 2 |
| Takeshita, K | 3 |
| Fukazawa, I | 2 |
| Futaki, N | 1 |
| Kameo, K | 2 |
| Tomisawa, K | 2 |
| Fontagne, J | 1 |
| Loizeau, M | 1 |
| Perret, C | 1 |
| Semichon, M | 1 |
| Rabaud, M | 1 |
| Boucherie, S | 1 |
| Brouilhet, H | 1 |
| Lechat, P | 1 |
| Connolly, KM | 1 |
| Stecher, VJ | 1 |
| Danis, E | 1 |
| Pruden, DJ | 1 |
| LaBrie, T | 1 |
| Legendre, P | 1 |
| Daireaux, M | 1 |
| Langris, M | 1 |
| Pujol, JP | 1 |
| Beliard, R | 1 |
| Loyau, G | 1 |
| Bocquet, J | 1 |
| Pasternak, RD | 1 |
| Marks, RL | 1 |
| Hubbs, SJ | 1 |
| DiPasquale, G | 1 |
| Shiono, M | 1 |
1 review available for penicillamine and Adjuvant Arthritis
| Article | Year |
|---|---|
NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chloroquine; Gluc | 1984 |
32 other studies available for penicillamine and Adjuvant Arthritis
| Article | Year |
|---|---|
Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antirheumatic Agents; Arthritis, Experimental; Auranof | 2007 |
Effect of D-penicillamine in vitro and in vivo on macrophage phagocytosis.
Topics: Animals; Arthritis, Experimental; Female; gamma-Globulins; In Vitro Techniques; Macrophages; Penicil | 1980 |
Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.
Topics: Animals; Arthritis, Experimental; Concanavalin A; Cysteine; Female; Hemolytic Plaque Technique; Hype | 1983 |
Splenic suppressor cells in adjuvant arthritic rats: effect of D-penicillamine.
Topics: Animals; Arthritis; Arthritis, Experimental; Cell Adhesion; Concanavalin A; Female; Leucine; Lipopol | 1980 |
Anti-rheumatic agents and leucocyte migration.
Topics: Animals; Arthritis; Arthritis, Experimental; Chemotaxis, Leukocyte; Levamisole; Passive Cutaneous An | 1983 |
Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat.
Topics: Administration, Oral; Animals; Arthritis; Arthritis, Experimental; Body Weight; Drug Evaluation, Pre | 1984 |
An investigation of the effect of anti-inflammatory and anti-rheumatoid drugs in cell-mediated immune arthritis in guinea-pigs by microfocal radiography.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Disease Models, | 1980 |
[Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)].
Topics: Administration, Oral; Animals; Arthritis; Arthritis, Experimental; Chloroquine; Dexamethasone; Femal | 1981 |
Studies of D-penicillamine (3): immunomodulating effects of D-penicillamine.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Arthritis, Experimental; Concanavalin A; Dose-Response R | 1981 |
Immunological effects of D-penicillamine during experimental induced inflammation in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Cell Adhesion; Cell Separation; Concanavalin A; Female; | 1980 |
Antirheumatic drugs and macrophage function: effects on tumour cell growth in vitro.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Female; Levamiso | 1982 |
Effects of levamisole and D-penicillamine on leucocyte migration into sponge exudates in rats.
Topics: Animals; Arthritis, Experimental; Cell Migration Inhibition; Copper; Exudates and Transudates; Leuko | 1982 |
Assessment of drugs for activity in established type II collagen arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Arthritis; Arthritis, Experimental; Collagen; | 1982 |
[Effects pf captopril and D-penicillamine on kinins-mediated and chronic inflammation].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arthritis, Experimental; Bradykinin; Capillaries; | 1996 |
Characterization of inhibitor(s) of lymphocyte activation in serum from rats with adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Chemical Fractionation; Chromatography, Gel; Concanaval | 1978 |
Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.
Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Blood Cell Count; Chronic Disease; | 1979 |
Penicillamine in experimental models of immunologically mediated inflammation.
Topics: Animals; Arthritis; Arthritis, Experimental; Edema; Levamisole; Penicillamine; Pertussis Vaccine; Ra | 1979 |
[Pharmacokinetic studies following administration of 14 C-D-penicillamine to rats].
Topics: Animals; Arthritis, Experimental; Carbon Radioisotopes; Connective Tissue; Injections, Intra-Articul | 1977 |
Investigations on the influence of cyclophosphamide, gold sodium thiomalate and D-penicillamine on nystatin oedema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Cyclophosphamide; Disease Models, Animal; Female; Gold | 1975 |
Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.
Topics: Animals; Arthritis; Arthritis, Experimental; Biometry; Hindlimb; Penicillamine; Rabbits | 1977 |
Effect of bucillamine (SA96) on type II collagen induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Division; Collagen; | 1991 |
[Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Cysteine; gamma-Globulins; In | 1985 |
[The testing of long-term antirheumatics in animals].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Copper; Delayed- | 1987 |
Pharmacological studies of antigen-induced arthritis in BALB/c mice. II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes.
Topics: Animals; Arthritis; Arthritis, Experimental; Chloroquine; Dapsone; Female; Gold Sodium Thiomalate; M | 1986 |
Studies on the effects of pharmacological agents on antigen-induced arthritis in BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arthritis; Arthritis, Experimental; Azat | 1987 |
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acids. Immunomodulating effects.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Butyrates; Carrageenan; Collagen; Female; | 1988 |
Effects of long-term treatment with D-penicillamine on antigen-induced arthritis in rabbits: studies on in vivo articular chondrocyte damage and in vitro collagen biosynthesis by cultured chondrocytes.
Topics: Animals; Antigens; Arthritis; Arthritis, Experimental; Cartilage, Articular; Collagen; Male; Mycobac | 1987 |
Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying antirheumatic drugs.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experi | 1988 |
Effects of an in vivo D-penicillamine treatment on glycosaminoglycan biosynthesis by synovial fibroblasts from arthritic-rendered rabbits.
Topics: Animals; Arthritis; Arthritis, Experimental; Cells, Cultured; Chromatography, Affinity; Chromatograp | 1988 |
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acid derivatives. II. Immunosuppressive effects.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Arthritis, Experimental; Benzoates; Female; Hype | 1988 |
Effect of antirheumatic agents on the mitogen response of arthritic rat spleen cells.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Chloro | 1985 |
Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Cell Division; Edema; Female; Gold Sodium Thiomalate; L | 1985 |