Page last updated: 2024-11-07

penicillamine and Adjuvant Arthritis

penicillamine has been researched along with Adjuvant Arthritis in 33 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
"The effects of long term D-penicillamine treatment on adjuvant arthritis in the rat were determined in order to establish a possible approach to the laboratory evaluation of anti-rheumatic drugs."7.67Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat. ( Branceni, D; Delahaye, M; Dunn, CJ; Prouteau, M; Purcell, T, 1984)
"Experiments were performed in order to ascertain the action of D-penicillamine (PA) on adjuvant arthritis (AA) in rats and to develop a quantitative evaluation method for PA-like drugs, using Lewis, SD, and Wistar rats."7.67Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis. ( Aihara, H; Nakaike, S; Otomo, S; Shiono, M; Takeshita, K; Tomita, N, 1985)
"D-Penicillamine (D-PA), 80-100 mg/kg/day enhanced the early phase of adjuvant arthritis (AA) in rats when it was administered orally for about 4 weeks after the adjuvant injection day, whereas dexamethasone (1 mg/kg/day, p."7.66[Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)]. ( Higuchi, S; Kimura, M; Nakaike, S; Ohzeki, M; Otomo, S; Sasajima, M; Tarumoto, Y, 1981)
"Treatment of rabbits with D-penicillamine at doses up to 30 mg/kg, beginning either before or after the onset of antigen-induced experimental arthritis, diminished the severity of the inflammatory synovitis in a considerable proportion of animals as judged by both external joint measurements and terminal histopathological assessment."7.66Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1979)
"Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported."7.65Effect of D(-)penicillamine on chronic experimental arthritis in rabbits. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1977)
"SA679 also inhibited the adjuvant arthritis at a dose of 100 mg/kg, but its effect was less potent than that of SA96."5.27[Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Nakata, K; Sasano, M; Suda, H; Yamauchi, H, 1985)
"In our study the effects of angiotension converting enzyme inhibitor captopril and immunosuppressant agent d-penicillamine were investigated on inflammations mediated by kinins and on adjuvant arthritis in rat paw oedema tests."3.69[Effects pf captopril and D-penicillamine on kinins-mediated and chronic inflammation]. ( Blazsó, G; Gáspár, R, 1996)
"The effects of long term D-penicillamine treatment on adjuvant arthritis in the rat were determined in order to establish a possible approach to the laboratory evaluation of anti-rheumatic drugs."3.67Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat. ( Branceni, D; Delahaye, M; Dunn, CJ; Prouteau, M; Purcell, T, 1984)
"Experiments were performed in order to ascertain the action of D-penicillamine (PA) on adjuvant arthritis (AA) in rats and to develop a quantitative evaluation method for PA-like drugs, using Lewis, SD, and Wistar rats."3.67Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis. ( Aihara, H; Nakaike, S; Otomo, S; Shiono, M; Takeshita, K; Tomita, N, 1985)
"Adherent spleen cells from rats with adjuvant arthritis inhibit the incorporation of 3H-thymidine into DNA and 3H-leucine into protein in nonadherent spleen lymphocytes, stimulated by the mitogens Concanavalin A and E."3.66Splenic suppressor cells in adjuvant arthritic rats: effect of D-penicillamine. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1980)
"D-Penicillamine (D-PA), 80-100 mg/kg/day enhanced the early phase of adjuvant arthritis (AA) in rats when it was administered orally for about 4 weeks after the adjuvant injection day, whereas dexamethasone (1 mg/kg/day, p."3.66[Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)]. ( Higuchi, S; Kimura, M; Nakaike, S; Ohzeki, M; Otomo, S; Sasajima, M; Tarumoto, Y, 1981)
"D-penicillamine (D-PA) has beneficial therapeutic effects for patients with rheumatoid arthritis but no convincing explanation has been offered for the mode of action."3.66Studies of D-penicillamine (3): immunomodulating effects of D-penicillamine. ( Mori, C; Nakaike, S; Ohzeki, M; Otomo, S; Tsuji, I, 1981)
"Administration of D-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells."3.66Immunological effects of D-penicillamine during experimental induced inflammation in rats. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1980)
"Treatment of rabbits with D-penicillamine at doses up to 30 mg/kg, beginning either before or after the onset of antigen-induced experimental arthritis, diminished the severity of the inflammatory synovitis in a considerable proportion of animals as judged by both external joint measurements and terminal histopathological assessment."3.66Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1979)
"Preliminary observations on the effect of D(-)penicillamine on chronic antigen-induced experimental arthritis in rabbits are reported."3.65Effect of D(-)penicillamine on chronic experimental arthritis in rabbits. ( Hunneyball, IM; Stanworth, DR; Stewart, GA, 1977)
"Rheumatoid arthritis is a chronic inflammatory synovitis that primarily involves peripheral diarthrodial joints."2.37NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment. ( Decker, JL; Haraoui, B; Klippel, JH; Malone, DG; Schrieber, L; Steinberg, AD; Wahl, SM; Wilder, RL, 1984)
"Treatment with rolipram was followed by inhibition of the early phase of AIA associated with downregulation of both OVA-specific splenocyte proliferation and decreases of IFN-gamma released from the spleen cells but no decreases of the amount of IL-10, or levels of anti-OVA IgG, IgG2a, and IgG1."1.34Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice. ( Alam, AH; Hossain, MA; Li, X; Takano, H; Taneda, S; Yamaki, K; Yanagisawa, R; Yoshino, S, 2007)
"SA679 also inhibited the adjuvant arthritis at a dose of 100 mg/kg, but its effect was less potent than that of SA96."1.27[Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats]. ( Hayashi, M; Iso, T; Kasamatsu, S; Nakata, K; Sasano, M; Suda, H; Yamauchi, H, 1985)
"actions, which can be disclosed in the adjuvant arthritis as well as in the B."1.27[The testing of long-term antirheumatics in animals]. ( Bekemeier, H; Hirschelmann, R; Weber, M, 1987)
"adjuvant arthritis, were found to increase tumour cell 3H-TdR incorporation, compared to macrophages from nonarthritic rats."1.26Antirheumatic drugs and macrophage function: effects on tumour cell growth in vitro. ( Arrigoni-Martelli, E; Binderup, L; Bramm, E, 1982)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199030 (90.91)18.7374
1990's2 (6.06)18.2507
2000's1 (3.03)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamaki, K1
Li, X1
Hossain, MA1
Alam, AH1
Taneda, S1
Yanagisawa, R1
Takano, H1
Yoshino, S1
Decker, JL1
Malone, DG1
Haraoui, B1
Wahl, SM1
Schrieber, L1
Klippel, JH1
Steinberg, AD1
Wilder, RL1
Binderup, L5
Bramm, E6
Arrigoni-Martelli, E6
Nakaike, S5
Tanaka, C1
Tomita, N2
Umemoto, M1
Otomo, S6
Aihara, H4
West, GB2
Dunn, CJ1
Prouteau, M1
Delahaye, M1
Purcell, T1
Branceni, D1
Cashin, CH1
Doherty, NS1
Jeffries, BL1
Buckland-Wright, JC1
Higuchi, S1
Tarumoto, Y1
Kimura, M1
Sasajima, M1
Ohzeki, M2
Tsuji, I1
Mori, C1
Jones, SA1
Kennedy, AJ1
Roberts, NA1
Gáspár, R1
Blazsó, G1
Hunneyball, IM4
Stewart, GA2
Stanworth, DR2
Patzschke, K1
Wegner, LA1
Arrigoni-Martelld, E1
Hayashi, M2
Matsunaga, K1
Okahara, A1
Mita, S1
Yamauchi, H1
Kasamatsu, S1
Suda, H1
Nakata, K1
Sasano, M1
Iso, T1
Bekemeier, H1
Hirschelmann, R1
Weber, M1
Crossley, MJ2
Spowage, M2
Takeshita, K3
Fukazawa, I2
Futaki, N1
Kameo, K2
Tomisawa, K2
Fontagne, J1
Loizeau, M1
Perret, C1
Semichon, M1
Rabaud, M1
Boucherie, S1
Brouilhet, H1
Lechat, P1
Connolly, KM1
Stecher, VJ1
Danis, E1
Pruden, DJ1
LaBrie, T1
Legendre, P1
Daireaux, M1
Langris, M1
Pujol, JP1
Beliard, R1
Loyau, G1
Bocquet, J1
Pasternak, RD1
Marks, RL1
Hubbs, SJ1
DiPasquale, G1
Shiono, M1

Reviews

1 review available for penicillamine and Adjuvant Arthritis

ArticleYear
NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment.
    Annals of internal medicine, 1984, Volume: 101, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chloroquine; Gluc

1984

Other Studies

32 other studies available for penicillamine and Adjuvant Arthritis

ArticleYear
Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice.
    Immunological investigations, 2007, Volume: 36, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antirheumatic Agents; Arthritis, Experimental; Auranof

2007
Effect of D-penicillamine in vitro and in vivo on macrophage phagocytosis.
    Biochemical pharmacology, 1980, Sep-01, Volume: 29, Issue:17

    Topics: Animals; Arthritis, Experimental; Female; gamma-Globulins; In Vitro Techniques; Macrophages; Penicil

1980
Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.
    Japanese journal of pharmacology, 1983, Volume: 33, Issue:5

    Topics: Animals; Arthritis, Experimental; Concanavalin A; Cysteine; Female; Hemolytic Plaque Technique; Hype

1983
Splenic suppressor cells in adjuvant arthritic rats: effect of D-penicillamine.
    Agents and actions. Supplements, 1980, Volume: 7

    Topics: Animals; Arthritis; Arthritis, Experimental; Cell Adhesion; Concanavalin A; Female; Leucine; Lipopol

1980
Anti-rheumatic agents and leucocyte migration.
    Monographs in allergy, 1983, Volume: 18

    Topics: Animals; Arthritis; Arthritis, Experimental; Chemotaxis, Leukocyte; Levamisole; Passive Cutaneous An

1983
Prolonged treatment with D-penicillamine: effects on adjuvant arthritis in the rat.
    Agents and actions, 1984, Volume: 14, Issue:2

    Topics: Administration, Oral; Animals; Arthritis; Arthritis, Experimental; Body Weight; Drug Evaluation, Pre

1984
An investigation of the effect of anti-inflammatory and anti-rheumatoid drugs in cell-mediated immune arthritis in guinea-pigs by microfocal radiography.
    British journal of experimental pathology, 1980, Volume: 61, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Disease Models,

1980
[Studies of D-penicillamine (5): effects on rat adjuvant arthritis (author's transl)].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 78, Issue:3

    Topics: Administration, Oral; Animals; Arthritis; Arthritis, Experimental; Chloroquine; Dexamethasone; Femal

1981
Studies of D-penicillamine (3): immunomodulating effects of D-penicillamine.
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1981, Volume: 77, Issue:3

    Topics: Adjuvants, Immunologic; Animals; Arthritis; Arthritis, Experimental; Concanavalin A; Dose-Response R

1981
Immunological effects of D-penicillamine during experimental induced inflammation in rats.
    Scandinavian journal of immunology, 1980, Volume: 12, Issue:3

    Topics: Animals; Arthritis; Arthritis, Experimental; Cell Adhesion; Cell Separation; Concanavalin A; Female;

1980
Antirheumatic drugs and macrophage function: effects on tumour cell growth in vitro.
    Clinical rheumatology, 1982, Volume: 1, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Female; Levamiso

1982
Effects of levamisole and D-penicillamine on leucocyte migration into sponge exudates in rats.
    International archives of allergy and applied immunology, 1982, Volume: 67, Issue:4

    Topics: Animals; Arthritis, Experimental; Cell Migration Inhibition; Copper; Exudates and Transudates; Leuko

1982
Assessment of drugs for activity in established type II collagen arthritis.
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Arthritis; Arthritis, Experimental; Collagen;

1982
[Effects pf captopril and D-penicillamine on kinins-mediated and chronic inflammation].
    Acta pharmaceutica Hungarica, 1996, Volume: 66, Issue:4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arthritis, Experimental; Bradykinin; Capillaries;

1996
Characterization of inhibitor(s) of lymphocyte activation in serum from rats with adjuvant arthritis.
    Pharmacology, 1978, Volume: 17, Issue:5

    Topics: Animals; Arthritis; Arthritis, Experimental; Chemical Fractionation; Chromatography, Gel; Concanaval

1978
Effect of oral D-penicillamine treatment on experimental arthritis and associated immune responses in rabbits. III: Reduction of the monoarticular arthritis.
    Annals of the rheumatic diseases, 1979, Volume: 38, Issue:3

    Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Blood Cell Count; Chronic Disease;

1979
Penicillamine in experimental models of immunologically mediated inflammation.
    Agents and actions. Supplements, 1979, Issue:5

    Topics: Animals; Arthritis; Arthritis, Experimental; Edema; Levamisole; Penicillamine; Pertussis Vaccine; Ra

1979
[Pharmacokinetic studies following administration of 14 C-D-penicillamine to rats].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:6

    Topics: Animals; Arthritis, Experimental; Carbon Radioisotopes; Connective Tissue; Injections, Intra-Articul

1977
Investigations on the influence of cyclophosphamide, gold sodium thiomalate and D-penicillamine on nystatin oedema and adjuvant arthritis.
    Agents and actions, 1975, Volume: 5, Issue:3

    Topics: Animals; Arthritis; Arthritis, Experimental; Cyclophosphamide; Disease Models, Animal; Female; Gold

1975
Effect of D(-)penicillamine on chronic experimental arthritis in rabbits.
    Annals of the rheumatic diseases, 1977, Volume: 36, Issue:4

    Topics: Animals; Arthritis; Arthritis, Experimental; Biometry; Hindlimb; Penicillamine; Rabbits

1977
Effect of bucillamine (SA96) on type II collagen induced arthritis in rats.
    The Journal of rheumatology, 1991, Volume: 18, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Division; Collagen;

1991
[Pharmacological studies on N-(2-mercapto-2-methylpropanoyl)-L-cysteine(SA96). IV. Effects of SA96 and its main metabolite, SA679, on denaturation of human gamma-globulin and adjuvant arthritis in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 85, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Cysteine; gamma-Globulins; In

1985
[The testing of long-term antirheumatics in animals].
    Die Pharmazie, 1987, Volume: 42, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chloroquine; Copper; Delayed-

1987
Pharmacological studies of antigen-induced arthritis in BALB/c mice. II. The effects of second-line antirheumatic drugs and cytotoxic agents on the histopathological changes.
    Agents and actions, 1986, Volume: 18, Issue:3-4

    Topics: Animals; Arthritis; Arthritis, Experimental; Chloroquine; Dapsone; Female; Gold Sodium Thiomalate; M

1986
Studies on the effects of pharmacological agents on antigen-induced arthritis in BALB/c mice.
    Drugs under experimental and clinical research, 1987, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arthritis; Arthritis, Experimental; Azat

1987
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acids. Immunomodulating effects.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Butyrates; Carrageenan; Collagen; Female;

1988
Effects of long-term treatment with D-penicillamine on antigen-induced arthritis in rabbits: studies on in vivo articular chondrocyte damage and in vitro collagen biosynthesis by cultured chondrocytes.
    International journal of tissue reactions, 1987, Volume: 9, Issue:5

    Topics: Animals; Antigens; Arthritis; Arthritis, Experimental; Cartilage, Articular; Collagen; Male; Mycobac

1987
Alteration of interleukin-1 activity and the acute phase response in adjuvant arthritic rats treated with disease modifying antirheumatic drugs.
    Agents and actions, 1988, Volume: 25, Issue:1-2

    Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experi

1988
Effects of an in vivo D-penicillamine treatment on glycosaminoglycan biosynthesis by synovial fibroblasts from arthritic-rendered rabbits.
    International journal of tissue reactions, 1988, Volume: 10, Issue:3

    Topics: Animals; Arthritis; Arthritis, Experimental; Cells, Cultured; Chromatography, Affinity; Chromatograp

1988
Immunopharmacological studies of new 3-benzoyl-4-mercaptobutyric acid derivatives. II. Immunosuppressive effects.
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:5

    Topics: Animals; Antibody Formation; Antineoplastic Agents; Arthritis, Experimental; Benzoates; Female; Hype

1988
Effect of antirheumatic agents on the mitogen response of arthritic rat spleen cells.
    Research communications in chemical pathology and pharmacology, 1985, Volume: 48, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Chloro

1985
Studies of D-penicillamine on strain variability and lymph node cellularity in adjuvant arthritis.
    Agents and actions, 1985, Volume: 16, Issue:6

    Topics: Animals; Arthritis; Arthritis, Experimental; Cell Division; Edema; Female; Gold Sodium Thiomalate; L

1985