penicillamine has been researched along with Acute Liver Injury, Drug-Induced in 49 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and with therapeutic failure of previous gold salts and/or D-penicillamine therapy." | 9.06 | SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis. ( Ishikawa, K; Sakaguchi, M, 1986) |
| "A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered." | 8.77 | Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985) |
| "A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5." | 7.67 | A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis. ( Coche, E; Devogelaer, JP; Huaux, JP; Nagant de Deuxchaisnes, C; Rahier, J, 1985) |
| "Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine." | 7.66 | Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis. ( Katz, WA; Rosenbaum, J; Schumacher, HR, 1980) |
| "Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis." | 7.66 | Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 7.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| " An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and with therapeutic failure of previous gold salts and/or D-penicillamine therapy." | 5.06 | SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis. ( Ishikawa, K; Sakaguchi, M, 1986) |
| "A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered." | 4.77 | Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985) |
| "A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5." | 3.67 | A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis. ( Coche, E; Devogelaer, JP; Huaux, JP; Nagant de Deuxchaisnes, C; Rahier, J, 1985) |
| "Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine." | 3.66 | Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis. ( Katz, WA; Rosenbaum, J; Schumacher, HR, 1980) |
| "Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis." | 3.66 | Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979) |
| "60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only." | 3.65 | Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976) |
| "Drug-induced autoimmune diseases have two immunological peculiarities." | 2.37 | [Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses]. ( Homberg, JC, 1984) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "In child B acute liver failure developed despite initiation of treatment." | 1.30 | Treatment of copper associated liver disease in childhood. ( Kardoff, R; Melter, M; Rodeck, B, 1999) |
| " In therapeutic dosage it will adequately control joint symptoms in the majority of patients." | 1.26 | Pharmacotherapy of juvenile rheumatoid arthritis. ( Lindsley, CB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (69.39) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 3 (6.12) | 29.6817 |
| 2010's | 9 (18.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Metushi, IG | 1 |
| Zhu, X | 1 |
| Uetrecht, J | 1 |
| Rifkin, J | 1 |
| Miller, MD | 1 |
| Jalali, SM | 1 |
| Najafzadeh, H | 1 |
| Bahmei, S | 1 |
| Singh, V | 1 |
| Joshi, D | 1 |
| Shrivastava, S | 1 |
| Shukla, S | 1 |
| Grauer, JL | 1 |
| Fonteille, J | 1 |
| Zarski, JP | 1 |
| Gintz, B | 1 |
| Phelip, X | 1 |
| Cabanel, G | 1 |
| Homberg, JC | 1 |
| Sternlieb, I | 1 |
| Job-Deslandre, C | 1 |
| Delrieu, F | 1 |
| Rondier, J | 1 |
| Guedri, M | 1 |
| Delbarre, F | 1 |
| Peters, ND | 1 |
| Ejstrup, L | 1 |
| Grasedyck, K | 1 |
| Lindsley, CB | 1 |
| Multz, CV | 1 |
| Jensen, OH | 1 |
| Rosenbaum, J | 1 |
| Katz, WA | 1 |
| Schumacher, HR | 1 |
| Zera, RT | 1 |
| Nagasawa, HT | 1 |
| Jacobs, JW | 1 |
| Van der Weide, FR | 1 |
| Kruijsen, MW | 1 |
| Rodeck, B | 1 |
| Kardoff, R | 1 |
| Melter, M | 1 |
| Deutscher, J | 1 |
| Kiess, W | 1 |
| Scheerschmidt, G | 1 |
| Willgerodt, H | 1 |
| Castilla-Higuero, L | 1 |
| Romero-Gomez, M | 1 |
| Suarez, E | 1 |
| Castro, M | 1 |
| Cao, J | 1 |
| Xu, Q | 1 |
| Koda, A | 1 |
| Prescott, LF | 1 |
| Sutherland, GR | 1 |
| Park, J | 1 |
| Smith, IJ | 1 |
| Proudfoot, AT | 1 |
| Sacher, M | 1 |
| Thaler, H | 1 |
| Wollheim, FA | 1 |
| Lindström, CG | 1 |
| Wallnöfer, H | 1 |
| Crickx, L | 1 |
| Leger, JM | 1 |
| Auquier, L | 1 |
| Abadia, R | 1 |
| Jammet, P | 1 |
| Christoforov, B | 1 |
| Cremer, GA | 1 |
| Tandon, RK | 1 |
| Ishikawa, K | 1 |
| Sakaguchi, M | 1 |
| Guerrero Navarro, L | 1 |
| Molina Lorente, E | 1 |
| Mur Villacampa, M | 1 |
| Revillo Pinilla, P | 1 |
| Berbis, P | 1 |
| Fabre, JF | 1 |
| Privat, Y | 1 |
| Langan, MN | 1 |
| Thomas, P | 1 |
| Roux, H | 1 |
| Bonnefoy-Cudraz, M | 1 |
| Antipoff, GM | 1 |
| Willkens, RF | 1 |
| Kremer, JM | 1 |
| Devogelaer, JP | 1 |
| Huaux, JP | 1 |
| Coche, E | 1 |
| Rahier, J | 1 |
| Nagant de Deuxchaisnes, C | 1 |
| Smallwood, RA | 1 |
| Williams, HA | 1 |
| Rosenoer, VM | 1 |
| Sherlock, S | 1 |
| Cuthbert, MF | 1 |
| Strubelt, O | 1 |
| Siegers, CP | 1 |
| Schütt, A | 1 |
| Lynch, RE | 1 |
| Lee, GR | 1 |
| Cartwright, GE | 1 |
| Rauen, HM | 1 |
| Schriewer, H | 1 |
| Fels, H | 1 |
| Habersang, S | 1 |
| Kozlik, V | 1 |
| Leuschner, F | 1 |
| von Schlichtegroll, A | 1 |
| Rau, R | 1 |
| Weber, S | 1 |
| Böni, A | 1 |
7 reviews available for penicillamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses].
Topics: Animals; Autoimmune Diseases; Cardiac Glycosides; Chemical and Drug Induced Liver Injury; Drug Combi | 1984 |
Copper and the liver.
Topics: Acute Disease; Adult; Age Factors; Animals; Bufo marinus; Carcinoma, Hepatocellular; Chemical and Dr | 1980 |
Fatal cholestatic hepatitis caused by D-penicillamine.
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis; Fatal Outcome; Fe | 1994 |
[Hepatotoxicity of drugs commonly used in rheumatology].
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Dextrop | 1985 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blin | 1985 |
Longterm methotrexate therapy in rheumatoid arthritis: a review.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans | 1985 |
3 trials available for penicillamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury | 1986 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blin | 1985 |
Letter: Cysteamine for paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch | 1974 |
40 other studies available for penicillamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
D-penicillamine-induced granulomatous hepatitis in brown Norway rats.
Topics: Alanine Transaminase; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Chemical and Drug In | 2014 |
Copper-associated hepatitis in a Pembroke Welsh corgi.
Topics: Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Dog Diseases; Dogs; Femal | 2014 |
Protective role of silymarin and D-penicillamine against lead-induced liver toxicity and oxidative stress.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Chemical and Drug | 2017 |
Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat.
Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Chemical and Drug Induced Liver Injury; Die | 2007 |
[Erythema nodosum and cholestatic hepatitis during treatment with D-penicillamine].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Erythema Nodosum; Humans; Male; Middle Aged; Pe | 1983 |
[Cholestatic hepatitis and anti-DNA antibodies induced by D-penicillamine].
Topics: Adult; Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; D | 1982 |
[Penicillin-induced liver involvement in rheumatoid arthritis. A review illustrated by a case report].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pe | 1982 |
[Influence of D-penicillamine on the connective tissue of the liver].
Topics: Animals; Chemical and Drug Induced Liver Injury; Collagen; Humans; Penicillamine; Rats; Thioacetamid | 1981 |
Pharmacotherapy of juvenile rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; | 1981 |
Cholestatic hepatitis caused by penicillamine.
Topics: Arthritis, Rheumatoid; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Cholestasis | 1981 |
[Penicillamine induced liver involvement].
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Penicillamine | 1981 |
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle A | 1980 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis | 1980 |
Treatment of copper associated liver disease in childhood.
Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Drinking; Germany; Humans; Infant; | 1999 |
Potential hepatotoxicity of penicillamine treatment in three patients with Wilson's disease.
Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Child; Hepatolenticular Degeneration; Huma | 1999 |
Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatolenticular Degeneration; | 2000 |
Protective involvement of nitric oxide in the liver injury induced by delayed-type hypersensitivity to picryl chloride.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Female; Hepatoc | 2000 |
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; | 1976 |
Toxic hepatitis after therapeutic doses of benorylate and D-penicillamine.
Topics: Adolescent; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Ther | 1977 |
Liver abnormalities in penicillamine treated rheumatoid arthritis.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases | 1979 |
[Fundamental aspects of diagnosis and therapy of chronic hepatitis and cirrhosis].
Topics: Adult; Antibodies, Antinuclear; Austria; Chemical and Drug Induced Liver Injury; Female; Hepatitis; | 1977 |
[Granulomatous hepatitis and parotiditis induced by d-penicillamine in a case of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Indoleacetic Acids; M | 1979 |
Response to Drs. Langan and Thomas.
Topics: Chemical and Drug Induced Liver Injury; Humans; Penicillamine | 1989 |
[Cholestatic hepatitis caused by D-penicillamine].
Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Penicillamine | 1988 |
[Cholestatic hepatitis: a rare complication of the treatment with D. penicillamine].
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Penicillam | 1987 |
Penicillamine-induced liver disease.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Penicillamine; P | 1987 |
[Liver complications caused by D-penicillamine. Apropos of a case].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle A | 1986 |
A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Huma | 1985 |
Liver-copper levels in liver disease: studies using neutron activation analysis.
Topics: Activation Analysis; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Cholest | 1968 |
Adverse reactions to non-steroidal antirheumatic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Chemical and Drug Induced Liv | 1974 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami | 1974 |
Penicillamine-induced cupriuria in normal subjects and in patients with active liver disease.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aspartate Aminotransferases; Bilirubin; Cerulo | 1973 |
[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat. I].
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1973 |
[The effect of D-penicillamine on the galactosamine hepatitis model in the rat].
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug | 1973 |
[Allergic-toxic liver damage due to D-penicillamine].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver Functio | 1972 |