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penicillamine and Acute Liver Injury, Drug-Induced

penicillamine has been researched along with Acute Liver Injury, Drug-Induced in 49 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Research Excerpts

ExcerptRelevanceReference
" An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and with therapeutic failure of previous gold salts and/or D-penicillamine therapy."9.06SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis. ( Ishikawa, K; Sakaguchi, M, 1986)
"A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered."8.77Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985)
"A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5."7.67A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis. ( Coche, E; Devogelaer, JP; Huaux, JP; Nagant de Deuxchaisnes, C; Rahier, J, 1985)
"Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine."7.66Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis. ( Katz, WA; Rosenbaum, J; Schumacher, HR, 1980)
"Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis."7.66Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."7.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
" An open trial of SA 96 treatment (300 mg/day after meals for 16 weeks) was carried out in 11 patients with definite or classical rheumatoid arthritis and with therapeutic failure of previous gold salts and/or D-penicillamine therapy."5.06SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis. ( Ishikawa, K; Sakaguchi, M, 1986)
"A review of the literature on the longterm use of methotrexate in patients with rheumatoid arthritis (RA) showed that many questions on protocol remain unanswered."4.77Longterm methotrexate therapy in rheumatoid arthritis: a review. ( Kremer, JM, 1985)
"A male aged 72 years suffering from erosive seropositive rheumatoid arthritis developed jaundice after one month on D-penicillamine after a cumulative dose of 5."3.67A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis. ( Coche, E; Devogelaer, JP; Huaux, JP; Nagant de Deuxchaisnes, C; Rahier, J, 1985)
"Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine."3.66Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis. ( Katz, WA; Rosenbaum, J; Schumacher, HR, 1980)
"Liver enzymes were followed in 99 patients treated with D-penicillamine for rheumatoid arthritis."3.66Liver abnormalities in penicillamine treated rheumatoid arthritis. ( Lindström, CG; Wollheim, FA, 1979)
"60 patients with paracetamol poisoning have been treated with intravenous cysteamine, L-methionine, or D-penicillamine and the incidence and severity of hepatic necrosis compared with those observed in 70 patients receiving supportive therapy only."3.65Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning. ( Park, J; Prescott, LF; Proudfoot, AT; Smith, IJ; Sutherland, GR, 1976)
"Drug-induced autoimmune diseases have two immunological peculiarities."2.37[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses]. ( Homberg, JC, 1984)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
"In child B acute liver failure developed despite initiation of treatment."1.30Treatment of copper associated liver disease in childhood. ( Kardoff, R; Melter, M; Rodeck, B, 1999)
" In therapeutic dosage it will adequately control joint symptoms in the majority of patients."1.26Pharmacotherapy of juvenile rheumatoid arthritis. ( Lindsley, CB, 1981)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199034 (69.39)18.7374
1990's3 (6.12)18.2507
2000's3 (6.12)29.6817
2010's9 (18.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Dawson, S1
Stahl, S1
Paul, N1
Barber, J1
Kenna, JG1
Ding, D1
Kelly, R1
Morgan, RE1
van Staden, CJ1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Afshari, CA1
Hamadeh, HK1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Metushi, IG1
Zhu, X1
Uetrecht, J1
Rifkin, J1
Miller, MD1
Jalali, SM1
Najafzadeh, H1
Bahmei, S1
Singh, V1
Joshi, D1
Shrivastava, S1
Shukla, S1
Grauer, JL1
Fonteille, J1
Zarski, JP1
Gintz, B1
Phelip, X1
Cabanel, G1
Homberg, JC1
Sternlieb, I1
Job-Deslandre, C1
Delrieu, F1
Rondier, J1
Guedri, M1
Delbarre, F1
Peters, ND1
Ejstrup, L1
Grasedyck, K1
Lindsley, CB1
Multz, CV1
Jensen, OH1
Rosenbaum, J1
Katz, WA1
Schumacher, HR1
Zera, RT1
Nagasawa, HT1
Jacobs, JW1
Van der Weide, FR1
Kruijsen, MW1
Rodeck, B1
Kardoff, R1
Melter, M1
Deutscher, J1
Kiess, W1
Scheerschmidt, G1
Willgerodt, H1
Castilla-Higuero, L1
Romero-Gomez, M1
Suarez, E1
Castro, M1
Cao, J1
Xu, Q1
Koda, A1
Prescott, LF1
Sutherland, GR1
Park, J1
Smith, IJ1
Proudfoot, AT1
Sacher, M1
Thaler, H1
Wollheim, FA1
Lindström, CG1
Wallnöfer, H1
Crickx, L1
Leger, JM1
Auquier, L1
Abadia, R1
Jammet, P1
Christoforov, B1
Cremer, GA1
Tandon, RK1
Ishikawa, K1
Sakaguchi, M1
Guerrero Navarro, L1
Molina Lorente, E1
Mur Villacampa, M1
Revillo Pinilla, P1
Berbis, P1
Fabre, JF1
Privat, Y1
Langan, MN1
Thomas, P1
Roux, H1
Bonnefoy-Cudraz, M1
Antipoff, GM1
Willkens, RF1
Kremer, JM1
Devogelaer, JP1
Huaux, JP1
Coche, E1
Rahier, J1
Nagant de Deuxchaisnes, C1
Smallwood, RA1
Williams, HA1
Rosenoer, VM1
Sherlock, S1
Cuthbert, MF1
Strubelt, O1
Siegers, CP1
Schütt, A1
Lynch, RE1
Lee, GR1
Cartwright, GE1
Rauen, HM1
Schriewer, H1
Fels, H1
Habersang, S1
Kozlik, V1
Leuschner, F1
von Schlichtegroll, A1
Rau, R1
Weber, S1
Böni, A1

Reviews

7 reviews available for penicillamine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[Autoimmunity induced by drugs. Immunological characteristics and etiopathogenic hypotheses].
    Presse medicale (Paris, France : 1983), 1984, Dec-15, Volume: 13, Issue:45

    Topics: Animals; Autoimmune Diseases; Cardiac Glycosides; Chemical and Drug Induced Liver Injury; Drug Combi

1984
Copper and the liver.
    Gastroenterology, 1980, Volume: 78, Issue:6

    Topics: Acute Disease; Adult; Age Factors; Animals; Bufo marinus; Carcinoma, Hepatocellular; Chemical and Dr

1980
Fatal cholestatic hepatitis caused by D-penicillamine.
    British journal of rheumatology, 1994, Volume: 33, Issue:8

    Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis; Fatal Outcome; Fe

1994
[Hepatotoxicity of drugs commonly used in rheumatology].
    Annales de medecine interne, 1985, Volume: 136, Issue:7

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Dextrop

1985
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
    The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12

    Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blin

1985
Longterm methotrexate therapy in rheumatoid arthritis: a review.
    The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12

    Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans

1985

Trials

3 trials available for penicillamine and Acute Liver Injury, Drug-Induced

ArticleYear
SA 96 (N-(2-mercapto-2-methylpropanoyl)-L-cysteine) in rheumatoid arthritis.
    Scandinavian journal of rheumatology, 1986, Volume: 15, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury

1986
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
    The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12

    Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blin

1985
Letter: Cysteamine for paracetamol overdosage.
    Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864

    Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch

1974

Other Studies

40 other studies available for penicillamine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
D-penicillamine-induced granulomatous hepatitis in brown Norway rats.
    Molecular and cellular biochemistry, 2014, Volume: 393, Issue:1-2

    Topics: Alanine Transaminase; Animals; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Chemical and Drug In

2014
Copper-associated hepatitis in a Pembroke Welsh corgi.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2014, Volume: 55, Issue:6

    Topics: Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Dog Diseases; Dogs; Femal

2014
Protective role of silymarin and D-penicillamine against lead-induced liver toxicity and oxidative stress.
    Toxicology and industrial health, 2017, Volume: 33, Issue:6

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Chemical and Drug

2017
Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:12

    Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Chemical and Drug Induced Liver Injury; Die

2007
[Erythema nodosum and cholestatic hepatitis during treatment with D-penicillamine].
    Presse medicale (Paris, France : 1983), 1983, Sep-17, Volume: 12, Issue:32

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Erythema Nodosum; Humans; Male; Middle Aged; Pe

1983
[Cholestatic hepatitis and anti-DNA antibodies induced by D-penicillamine].
    La Nouvelle presse medicale, 1982, Jul-03, Volume: 11, Issue:31

    Topics: Adult; Antibodies, Antinuclear; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; D

1982
[Penicillin-induced liver involvement in rheumatoid arthritis. A review illustrated by a case report].
    Ugeskrift for laeger, 1982, Jun-28, Volume: 144, Issue:26

    Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged; Pe

1982
[Influence of D-penicillamine on the connective tissue of the liver].
    Die Medizinische Welt, 1981, Jan-16, Volume: 32, Issue:3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Collagen; Humans; Penicillamine; Rats; Thioacetamid

1981
Pharmacotherapy of juvenile rheumatoid arthritis.
    Pediatric clinics of North America, 1981, Volume: 28, Issue:1

    Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury;

1981
Cholestatic hepatitis caused by penicillamine.
    JAMA, 1981, Aug-07, Volume: 246, Issue:6

    Topics: Arthritis, Rheumatoid; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Cholestasis

1981
[Penicillamine induced liver involvement].
    Ugeskrift for laeger, 1981, Dec-14, Volume: 143, Issue:51

    Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Penicillamine

1981
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.
    Annals of the rheumatic diseases, 1980, Volume: 39, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle A

1980
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis

1980
Treatment of copper associated liver disease in childhood.
    European journal of medical research, 1999, Jun-28, Volume: 4, Issue:6

    Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Copper; Drinking; Germany; Humans; Infant;

1999
Potential hepatotoxicity of penicillamine treatment in three patients with Wilson's disease.
    Journal of pediatric gastroenterology and nutrition, 1999, Volume: 29, Issue:5

    Topics: Chelating Agents; Chemical and Drug Induced Liver Injury; Child; Hepatolenticular Degeneration; Huma

1999
Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease.
    Hepatology (Baltimore, Md.), 2000, Volume: 32, Issue:4 Pt 1

    Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Female; Hepatolenticular Degeneration;

2000
Protective involvement of nitric oxide in the liver injury induced by delayed-type hypersensitivity to picryl chloride.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:11

    Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Female; Hepatoc

2000
Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning.
    Lancet (London, England), 1976, Jul-17, Volume: 2, Issue:7977

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury;

1976
Toxic hepatitis after therapeutic doses of benorylate and D-penicillamine.
    Lancet (London, England), 1977, Feb-26, Volume: 1, Issue:8009

    Topics: Adolescent; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Ther

1977
Liver abnormalities in penicillamine treated rheumatoid arthritis.
    Scandinavian journal of rheumatology. Supplement, 1979, Issue:28

    Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases

1979
[Fundamental aspects of diagnosis and therapy of chronic hepatitis and cirrhosis].
    Wiener medizinische Wochenschrift. Supplement, 1977, Volume: 44

    Topics: Adult; Antibodies, Antinuclear; Austria; Chemical and Drug Induced Liver Injury; Female; Hepatitis;

1977
[Granulomatous hepatitis and parotiditis induced by d-penicillamine in a case of rheumatoid arthritis].
    La Nouvelle presse medicale, 1979, Jan-20, Volume: 8, Issue:3

    Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Indoleacetic Acids; M

1979
Response to Drs. Langan and Thomas.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Humans; Penicillamine

1989
[Cholestatic hepatitis caused by D-penicillamine].
    Revista espanola de las enfermedades del aparato digestivo, 1988, Volume: 73, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Humans; Male; Middle Aged; Penicillamine

1988
[Cholestatic hepatitis: a rare complication of the treatment with D. penicillamine].
    Annales de dermatologie et de venereologie, 1987, Volume: 114, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Female; Humans; Penicillam

1987
Penicillamine-induced liver disease.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:12

    Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Penicillamine; P

1987
[Liver complications caused by D-penicillamine. Apropos of a case].
    Revue du rhumatisme et des maladies osteo-articulaires, 1986, Volume: 53, Issue:1

    Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle A

1986
A case of cholestatic hepatitis associated with D-penicillamine therapy for rheumatoid arthritis.
    International journal of clinical pharmacology research, 1985, Volume: 5, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Huma

1985
Liver-copper levels in liver disease: studies using neutron activation analysis.
    Lancet (London, England), 1968, Dec-21, Volume: 2, Issue:7582

    Topics: Activation Analysis; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Cholest

1968
Adverse reactions to non-steroidal antirheumatic drugs.
    Current medical research and opinion, 1974, Volume: 2, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Chemical and Drug Induced Liv

1974
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
    Archives of toxicology, 1974, Volume: 33, Issue:1

    Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami

1974
Penicillamine-induced cupriuria in normal subjects and in patients with active liver disease.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aspartate Aminotransferases; Bilirubin; Cerulo

1973
[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat. I].
    Arzneimittel-Forschung, 1973, Volume: 23

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori

1973
[The effect of D-penicillamine on the galactosamine hepatitis model in the rat].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:1

    Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug

1973
[Allergic-toxic liver damage due to D-penicillamine].
    Schweizerische medizinische Wochenschrift, 1972, Aug-26, Volume: 102, Issue:34

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Liver Functio

1972