penicillamine has been researched along with Abnormalities, Drug-Induced in 25 studies
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate." | 7.67 | D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984) |
| " D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced." | 4.77 | Antirheumatic medication in pregnancy. ( Brooks, PM; Needs, CJ, 1985) |
| "We report a chromosomally normal infant boy with congenital diffuse cutis laxa, severe micrognathia, contractures of all limbs, and central nervous system abnormalities including agenesis of the corpus callosum, born to a woman taking D-penicillamine (DP) for Wilson disease (WD) throughout her pregnancy." | 3.72 | Infant with severe penicillamine embryopathy born to a woman with Wilson disease. ( Hogge, WA; McPherson, E; Pinter, R, 2004) |
| "The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate." | 3.67 | D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984) |
| "D-penicillamine, added to a low copper diet fed through pregnancy or given by gavage to pregnant rts which were on a copper-deficient or a normal diet produced fetal resorptions and malformations." | 3.66 | Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat. ( Hess, RA; Kilburn, KH, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carey, JC | 1 |
| Martinez, L | 1 |
| Balken, E | 1 |
| Leen-Mitchell, M | 1 |
| Robertson, J | 1 |
| Pinter, R | 1 |
| Hogge, WA | 1 |
| McPherson, E | 1 |
| Littler, TR | 1 |
| Kilburn, KH | 1 |
| Hess, RA | 1 |
| Myint, B | 1 |
| Keen, CL | 4 |
| Lönnerdal, B | 3 |
| Hurley, LS | 4 |
| Cohen, NL | 1 |
| Kean, WF | 1 |
| Bellamy, N | 1 |
| Lock, CJ | 1 |
| Adachi, J | 1 |
| Mark-Savage, P | 2 |
| Gabler, W | 1 |
| Brachmann, J | 1 |
| Dörfler, HP | 1 |
| Schmidt, W | 1 |
| Wiley, MJ | 1 |
| Joneja, MG | 1 |
| Solomon, L | 1 |
| Abrams, G | 1 |
| Dinner, M | 1 |
| Berman, L | 1 |
| Corcoran, R | 1 |
| Castles, WJ | 1 |
| Merker, HJ | 1 |
| Franke, L | 1 |
| Günther, T | 1 |
| Rousseaux, CG | 1 |
| MacNabb, LG | 1 |
| Dawson, DA | 1 |
| Wilke, TS | 1 |
| Miehle, W | 1 |
| Byron, MA | 1 |
| Rosa, FW | 1 |
| Needs, CJ | 1 |
| Brooks, PM | 1 |
| Schardein, JL | 1 |
| Steffek, AJ | 2 |
| Verrusio, AC | 1 |
| Watkins, CA | 1 |
| Stivers, FE | 2 |
| Steffer, AJ | 1 |
| Yarington, CT | 2 |
5 reviews available for penicillamine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Determination of human teratogenicity by the astute clinician method: review of illustrative agents and a proposal of guidelines.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Antirheumatic Agents; Congenital Abnormalities; Evid | 2009 |
Anti-rheumatic drugs.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Dapso | 1981 |
[Current aspects of D-penicillamine and pregnancy].
Topics: Abnormalities, Drug-Induced; Arthritis, Rheumatoid; Cystinuria; Female; Hepatolenticular Degeneratio | 1988 |
Antirheumatic medication in pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplas | 1985 |
Current status of drugs as teratogens in man.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticonvulsants; Antineoplastic Agents; Coumarin | 1985 |
20 other studies available for penicillamine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Infant with severe penicillamine embryopathy born to a woman with Wilson disease.
Topics: Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Cutis Laxa; Female; Fetal Diseases; Fetus; | 2004 |
Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Dose-Response Relationship, Drug; Female; Fetal Death; | 1982 |
D-penicillamine-induced cleft palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Maxilla; Mice; Mice, Inbred Strains; Ost | 1984 |
Drug-induced copper deficiency: a model for copper deficiency teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Humans; Penicillamine; Pregnancy; Teratogens; | 1983 |
Molecular localization of copper and zinc in rat fetal liver in dietary and drug-induced copper deficiency.
Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Gel; Copper; Ethylenediamines; Female; Liver; | 1984 |
Bio-inorganic effects of D-penicillamine in children and in the elderly.
Topics: Abnormalities, Drug-Induced; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Cystinuria; Fe | 1984 |
Reduction by copper supplementation of teratogenic effects of D-penicillamine.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Fetus; Food, Fortified; Liver; Male; Manganese | 1983 |
Teratogenesis and low copper status resulting from D-penicillamine in rats.
Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Penicillamine; Pregnancy; Rats; Rats, Inbred S | 1982 |
[Action mechanism of various teratogenic lathyrogens].
Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Aminopropionitrile; Animals; Chemical | 1977 |
Neural tube lesions in the offspring of hamsters given single oral doses of lathyrogens early in gestation.
Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Animals; Brain; Cricetinae; Female; F | 1978 |
Neonatal abnormalities associated with D-penicillamine treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Fetus; Humans; Infant, Newborn; P | 1977 |
Penicillamine therapy and teratogenesis.
Topics: Abnormalities, Drug-Induced; Cystinuria; Female; Humans; Infant, Newborn; Penicillamine; Pregnancy; | 1977 |
The effect of D-penicillamine of the skeletal development of rat foetuses.
Topics: Abnormalities, Drug-Induced; Animals; Apatites; Bone and Bones; Bone Development; Collagen; Extracel | 1975 |
Oral administration of D-penicillamine causes neonatal mortality without morphological defects in CD-1 mice.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Animals, Newborn; Body Weight; Dose-Resp | 1992 |
Joint toxic action of binary mixtures of osteolathyrogens at malformation-inducing concentrations for Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Drug Synergism; Penicillam | 1991 |
Treatment of rheumatic diseases.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Breast Feeding; | 1987 |
Teratogen update: penicillamine.
Topics: Abnormalities, Drug-Induced; Animals; Collagen; Copper; Cutis Laxa; Female; Hepatolenticular Degener | 1986 |
Cleft palate in rodents after maternal treatment with various lathyrogenic agents.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animal Feed; Animals; Cleft Palate; Female; Nitrile | 1972 |
The effect of lathyrogens on developing mid-facial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Diet; Female; Jaw Abnormalities; Lathyrism | 1970 |
The effect of lathyrogens on developing midfacial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Cleft Palate; Diet; Face; Femal | 1971 |