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penicillamine and Abnormalities, Drug-Induced

penicillamine has been researched along with Abnormalities, Drug-Induced in 25 studies

Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate."7.67D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984)
" D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced."4.77Antirheumatic medication in pregnancy. ( Brooks, PM; Needs, CJ, 1985)
"We report a chromosomally normal infant boy with congenital diffuse cutis laxa, severe micrognathia, contractures of all limbs, and central nervous system abnormalities including agenesis of the corpus callosum, born to a woman taking D-penicillamine (DP) for Wilson disease (WD) throughout her pregnancy."3.72Infant with severe penicillamine embryopathy born to a woman with Wilson disease. ( Hogge, WA; McPherson, E; Pinter, R, 2004)
"The teratogenic potential of the lathyrogen, D-penicillamine (DP), was assessed in pregnant mice, especially with respect to its ability to produce cleft palate."3.67D-penicillamine-induced cleft palate in mice. ( Myint, B, 1984)
"D-penicillamine, added to a low copper diet fed through pregnancy or given by gavage to pregnant rts which were on a copper-deficient or a normal diet produced fetal resorptions and malformations."3.66Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat. ( Hess, RA; Kilburn, KH, 1982)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199021 (84.00)18.7374
1990's2 (8.00)18.2507
2000's2 (8.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carey, JC1
Martinez, L1
Balken, E1
Leen-Mitchell, M1
Robertson, J1
Pinter, R1
Hogge, WA1
McPherson, E1
Littler, TR1
Kilburn, KH1
Hess, RA1
Myint, B1
Keen, CL4
Lönnerdal, B3
Hurley, LS4
Cohen, NL1
Kean, WF1
Bellamy, N1
Lock, CJ1
Adachi, J1
Mark-Savage, P2
Gabler, W1
Brachmann, J1
Dörfler, HP1
Schmidt, W1
Wiley, MJ1
Joneja, MG1
Solomon, L1
Abrams, G1
Dinner, M1
Berman, L1
Corcoran, R1
Castles, WJ1
Merker, HJ1
Franke, L1
Günther, T1
Rousseaux, CG1
MacNabb, LG1
Dawson, DA1
Wilke, TS1
Miehle, W1
Byron, MA1
Rosa, FW1
Needs, CJ1
Brooks, PM1
Schardein, JL1
Steffek, AJ2
Verrusio, AC1
Watkins, CA1
Stivers, FE2
Steffer, AJ1
Yarington, CT2

Reviews

5 reviews available for penicillamine and Abnormalities, Drug-Induced

ArticleYear
Determination of human teratogenicity by the astute clinician method: review of illustrative agents and a proposal of guidelines.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:1

    Topics: Abnormalities, Drug-Induced; Antifungal Agents; Antirheumatic Agents; Congenital Abnormalities; Evid

2009
Anti-rheumatic drugs.
    Pharmacology & therapeutics, 1981, Volume: 15, Issue:1

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Dapso

1981
[Current aspects of D-penicillamine and pregnancy].
    Zeitschrift fur Rheumatologie, 1988, Volume: 47 Suppl 1

    Topics: Abnormalities, Drug-Induced; Arthritis, Rheumatoid; Cystinuria; Female; Hepatolenticular Degeneratio

1988
Antirheumatic medication in pregnancy.
    British journal of rheumatology, 1985, Volume: 24, Issue:3

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplas

1985
Current status of drugs as teratogens in man.
    Progress in clinical and biological research, 1985, Volume: 163C

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticonvulsants; Antineoplastic Agents; Coumarin

1985

Other Studies

20 other studies available for penicillamine and Abnormalities, Drug-Induced

ArticleYear
Infant with severe penicillamine embryopathy born to a woman with Wilson disease.
    American journal of medical genetics. Part A, 2004, Jul-30, Volume: 128A, Issue:3

    Topics: Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Cutis Laxa; Female; Fetal Diseases; Fetus;

2004
Neonatal deaths and pulmonary dysplasia due to D-penicillamine in the rat.
    Teratology, 1982, Volume: 26, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Copper; Dose-Response Relationship, Drug; Female; Fetal Death;

1982
D-penicillamine-induced cleft palate in mice.
    Teratology, 1984, Volume: 30, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Maxilla; Mice; Mice, Inbred Strains; Ost

1984
Drug-induced copper deficiency: a model for copper deficiency teratogenicity.
    Teratology, 1983, Volume: 28, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Humans; Penicillamine; Pregnancy; Teratogens;

1983
Molecular localization of copper and zinc in rat fetal liver in dietary and drug-induced copper deficiency.
    Biochemical and biophysical research communications, 1984, Feb-14, Volume: 118, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Gel; Copper; Ethylenediamines; Female; Liver;

1984
Bio-inorganic effects of D-penicillamine in children and in the elderly.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1984, Volume: 7, Issue:1

    Topics: Abnormalities, Drug-Induced; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Cystinuria; Fe

1984
Reduction by copper supplementation of teratogenic effects of D-penicillamine.
    The Journal of nutrition, 1983, Volume: 113, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Fetus; Food, Fortified; Liver; Male; Manganese

1983
Teratogenesis and low copper status resulting from D-penicillamine in rats.
    Teratology, 1982, Volume: 26, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Penicillamine; Pregnancy; Rats; Rats, Inbred S

1982
[Action mechanism of various teratogenic lathyrogens].
    Verhandlungen der Anatomischen Gesellschaft, 1977, Issue:71 Pt 1

    Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Aminopropionitrile; Animals; Chemical

1977
Neural tube lesions in the offspring of hamsters given single oral doses of lathyrogens early in gestation.
    Acta anatomica, 1978, Volume: 100, Issue:3

    Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Animals; Brain; Cricetinae; Female; F

1978
Neonatal abnormalities associated with D-penicillamine treatment during pregnancy.
    The New England journal of medicine, 1977, Jan-06, Volume: 296, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Fetus; Humans; Infant, Newborn; P

1977
Penicillamine therapy and teratogenesis.
    British medical journal, 1977, Mar-26, Volume: 1, Issue:6064

    Topics: Abnormalities, Drug-Induced; Cystinuria; Female; Humans; Infant, Newborn; Penicillamine; Pregnancy;

1977
The effect of D-penicillamine of the skeletal development of rat foetuses.
    Naunyn-Schmiedeberg's archives of pharmacology, 1975, Volume: 287, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Apatites; Bone and Bones; Bone Development; Collagen; Extracel

1975
Oral administration of D-penicillamine causes neonatal mortality without morphological defects in CD-1 mice.
    Journal of applied toxicology : JAT, 1992, Volume: 12, Issue:1

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Animals, Newborn; Body Weight; Dose-Resp

1992
Joint toxic action of binary mixtures of osteolathyrogens at malformation-inducing concentrations for Xenopus embryos.
    Journal of applied toxicology : JAT, 1991, Volume: 11, Issue:6

    Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Drug Synergism; Penicillam

1991
Treatment of rheumatic diseases.
    British medical journal (Clinical research ed.), 1987, Jan-24, Volume: 294, Issue:6566

    Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Breast Feeding;

1987
Teratogen update: penicillamine.
    Teratology, 1986, Volume: 33, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Collagen; Copper; Cutis Laxa; Female; Hepatolenticular Degener

1986
Cleft palate in rodents after maternal treatment with various lathyrogenic agents.
    Teratology, 1972, Volume: 5, Issue:1

    Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animal Feed; Animals; Cleft Palate; Female; Nitrile

1972
The effect of lathyrogens on developing mid-facial structures in the rat.
    Surgical forum, 1970, Volume: 21

    Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Diet; Female; Jaw Abnormalities; Lathyrism

1970
The effect of lathyrogens on developing midfacial structures in the rat.
    The Journal of surgical research, 1971, Volume: 11, Issue:8

    Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Cleft Palate; Diet; Face; Femal

1971