pemoline has been researched along with Liver Failure, Acute in 4 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It typically takes many years before an association of a drug with a rare, serious adverse reaction is established." | 1.37 | Safety assessment in pediatric studies. ( Elzagallaai, A; Etwel, F; Koren, G, 2011) |
| "Pemoline is a CNS stimulant that was introduced in 1975 in the US and was used to treat children with attention deficit hyperactivity disorder." | 1.35 | A surveillance method for the early identification of idiosyncratic adverse drug reactions. ( Bend, JR; Etwel, FA; Koren, G; Rieder, MJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koren, G | 2 |
| Elzagallaai, A | 1 |
| Etwel, F | 1 |
| Abbiati, C | 1 |
| Vecchi, M | 1 |
| Rossi, G | 1 |
| Donata, MF | 1 |
| de Franchis, R | 1 |
| Etwel, FA | 1 |
| Rieder, MJ | 1 |
| Bend, JR | 1 |
| Shevell, M | 1 |
4 other studies available for pemoline and Liver Failure, Acute
| Article | Year |
|---|---|
Safety assessment in pediatric studies.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Canada; Cell Death; Drug Hypersensit | 2011 |
Inappropriate pemoline therapy leading to acute liver failure and liver transplantation.
Topics: Adult; Central Nervous System Stimulants; Female; Humans; Liver Failure, Acute; Liver Transplantatio | 2002 |
A surveillance method for the early identification of idiosyncratic adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Attention Deficit Disorder with Hyperactivity; Central Nerv | 2008 |
Pemoline associated hepatic failure: a critical analysis of the literature.
Topics: Humans; Liver Failure, Acute; Pemoline | 1997 |