pemoline has been researched along with Hepatic Encephalopathy in 2 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pemoline is a central nervous system stimulant used in treating children with attention deficit-hyperactivity disorder." | 2.39 | Pemoline-associated fulminant liver failure: testing the evidence for causation. ( Berkovitch, M; Koren, G; Phillips, J; Pope, E, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berkovitch, M | 1 |
| Pope, E | 1 |
| Phillips, J | 1 |
| Koren, G | 1 |
| Rosh, JR | 1 |
| Dellert, SF | 1 |
| Narkewicz, M | 1 |
| Birnbaum, A | 1 |
| Whitington, G | 1 |
1 review available for pemoline and Hepatic Encephalopathy
| Article | Year |
|---|---|
Pemoline-associated fulminant liver failure: testing the evidence for causation.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Fatal Outcome; Hepatic Encephalopathy; Hu | 1995 |
1 other study available for pemoline and Hepatic Encephalopathy
| Article | Year |
|---|---|
Four cases of severe hepatotoxicity associated with pemoline: possible autoimmune pathogenesis.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Nervous Syst | 1998 |