pemoline has been researched along with Gelineau Syndrome in 13 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case reports hypotension under general anesthesia in a patient taking pemoline." | 7.70 | Severe hypotension in a patient receiving pemoline during general anesthesia. ( Bohringer, CH; Jahr, JS; Mayer, K; Rowell, S, 2000) |
| "Methylphenidate, pemoline, and protriptyline were studied for their treatment efficacy in narcolepsy." | 7.67 | Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. ( Browman, CP; Hajdukovich, R; Mitler, MM; Shafor, R; Timms, RM, 1986) |
| "The authors present five case reports illustrating that 10-20 mg of protriptyline in a single dose at bedtime can effectively control arousal dysfunction (sleep drunkenness and hypersomnia) and the narcolepsycataplexy syndrome without the apparent development of tolerance and without the side effects that are frequent complications of treatment with other agents." | 7.65 | Protriptyline: an effective agent in the treatment of the narcolepsy-cataplexy syndrome and hypersomnia. ( Clark, RW; Hyman, PR; Schmidt, HS, 1977) |
| "Patients (N=151) with narcolepsy who had been unsatisfactorily treated with dextroamphetamine (N=48), methylphenidate (N=66), or pemoline (N=37) were enrolled in this 6-week, open-label, multicenter study." | 5.10 | Efficacy and safety of modafinil for improving daytime wakefulness in patients treated previously with psychostimulants. ( Feldman, NT; Fry, JM; Harsh, J; Schwartz, JR, 2003) |
| "This case reports hypotension under general anesthesia in a patient taking pemoline." | 3.70 | Severe hypotension in a patient receiving pemoline during general anesthesia. ( Bohringer, CH; Jahr, JS; Mayer, K; Rowell, S, 2000) |
| "Methylphenidate, pemoline, and protriptyline were studied for their treatment efficacy in narcolepsy." | 3.67 | Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. ( Browman, CP; Hajdukovich, R; Mitler, MM; Shafor, R; Timms, RM, 1986) |
| "The authors present five case reports illustrating that 10-20 mg of protriptyline in a single dose at bedtime can effectively control arousal dysfunction (sleep drunkenness and hypersomnia) and the narcolepsycataplexy syndrome without the apparent development of tolerance and without the side effects that are frequent complications of treatment with other agents." | 3.65 | Protriptyline: an effective agent in the treatment of the narcolepsy-cataplexy syndrome and hypersomnia. ( Clark, RW; Hyman, PR; Schmidt, HS, 1977) |
| "The clinical symptoms of cataplexy, sleep paralysis, hypnogogic hallucinations, daily naps, and sleep attacks all showed significant improvements." | 2.66 | The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy. ( Brown, D; Brown, L; Hirschowitz, J; Scharf, MB; Woods, M, 1985) |
| "Narcolepsy is a commonly under diagnosed or misdiagnosed problem that results in severe daytime sleepiness." | 2.39 | Narcolepsy. ( Ware, JC, 1996) |
| " Data obtained from a screening questionnaire, sleep diaries, and medical records showed that 22 of our 43 treated narcoleptic subjects reduced their dosage of stimulant medications or had not taken any stimulant medications during a 24-hour monitoring period during which they were expected to be on medication." | 1.30 | Compliance with stimulant medications in patients with narcolepsy. ( Aldrich, MS; Berrios, AM; Rogers, AE; Rosenberg, RS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwartz, JR | 1 |
| Feldman, NT | 1 |
| Fry, JM | 1 |
| Harsh, J | 1 |
| Mitler, MM | 4 |
| Ware, JC | 1 |
| Rogers, AE | 1 |
| Aldrich, MS | 1 |
| Berrios, AM | 1 |
| Rosenberg, RS | 1 |
| Littner, M | 1 |
| Bohringer, CH | 1 |
| Jahr, JS | 1 |
| Rowell, S | 1 |
| Mayer, K | 1 |
| Greenhill, LL | 1 |
| Pliszka, S | 1 |
| Dulcan, MK | 1 |
| Bernet, W | 1 |
| Arnold, V | 1 |
| Beitchman, J | 1 |
| Benson, RS | 1 |
| Bukstein, O | 1 |
| Kinlan, J | 1 |
| McClellan, J | 1 |
| Rue, D | 1 |
| Shaw, JA | 1 |
| Stock, S | 1 |
| Schmidt, HS | 1 |
| Clark, RW | 1 |
| Hyman, PR | 1 |
| Hajdukovic, R | 1 |
| Shafor, R | 1 |
| Hajdukovich, R | 1 |
| Timms, RM | 1 |
| Browman, CP | 1 |
| Scharf, MB | 1 |
| Brown, D | 1 |
| Woods, M | 1 |
| Brown, L | 1 |
| Hirschowitz, J | 1 |
| Sigwald, J | 1 |
| Julou, L | 1 |
| Bouttier, D | 1 |
| Thomas, J | 1 |
2 reviews available for pemoline and Gelineau Syndrome
| Article | Year |
|---|---|
Narcolepsy.
Topics: Amphetamines; Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Humans; Methylp | 1996 |
Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo | 2002 |
4 trials available for pemoline and Gelineau Syndrome
| Article | Year |
|---|---|
Efficacy and safety of modafinil for improving daytime wakefulness in patients treated previously with psychostimulants.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Central Nervous System Stimulants; Dextroamphetamine; | 2003 |
Relative efficacy of drugs for the treatment of sleepiness in narcolepsy.
Topics: Adult; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Codeine; Dextroamphetamine; | 1991 |
Alerting drugs: do they really work?
Topics: Adult; Attention; Central Nervous System Stimulants; Female; Humans; Male; Methylphenidate; Middle A | 1987 |
The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cataplexy; Clinical Trials as Topic; Dextroamphetamin | 1985 |
7 other studies available for pemoline and Gelineau Syndrome
| Article | Year |
|---|---|
Evaluation of treatment with stimulants in narcolepsy.
Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Humans; Male; Methamphetamine; M | 1994 |
Compliance with stimulant medications in patients with narcolepsy.
Topics: Adolescent; Adult; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Methy | 1997 |
Sleep practitioners need to be aware of new changes in the labeling of pemoline (CYLERT)
Topics: Attention Deficit Disorder with Hyperactivity; Awareness; Central Nervous System Stimulants; Disorde | 1999 |
Severe hypotension in a patient receiving pemoline during general anesthesia.
Topics: Anesthesia, General; Central Nervous System Stimulants; Drug Interactions; Female; Humans; Hypotensi | 2000 |
Protriptyline: an effective agent in the treatment of the narcolepsy-cataplexy syndrome and hypersomnia.
Topics: Adult; Cataplexy; Dibenzocycloheptenes; Disorders of Excessive Somnolence; Dreams; Drug Therapy, Com | 1977 |
Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline.
Topics: Adult; Dibenzocycloheptenes; Female; Humans; Male; Methylphenidate; Middle Aged; Narcolepsy; Pemolin | 1986 |
[Therapy of hypersomnia].
Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Centra | 1967 |