pemoline has been researched along with Depression in 8 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is believed to be distinctly different from fatigue seen in other chronic conditions." | 2.48 | Fatigue in multiple sclerosis - a brief review. ( Constantinescu, CS; Gran, B; Induruwa, I, 2012) |
| "Fatigue is among the most common, yet least understood, symptoms of multiple sclerosis (MS) [1." | 2.41 | Fatigue in multiple sclerosis. ( Christodoulou, C; Krupp, LB, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Induruwa, I | 1 |
| Constantinescu, CS | 1 |
| Gran, B | 1 |
| Farmer, P | 1 |
| Unis, AS | 1 |
| Hsu, G | 1 |
| Krupp, LB | 1 |
| Christodoulou, C | 1 |
| Elizur, A | 1 |
| Wintner, I | 1 |
| Davidson, S | 1 |
| Wood, DR | 1 |
| Reimherr, FW | 1 |
| Wender, PH | 1 |
| Johnson, GE | 1 |
| Brown, RT | 1 |
| Borden, KA | 1 |
| Spunt, AL | 1 |
| Medenis, R | 1 |
| Gilbert, JG | 1 |
| Donnelly, KJ | 1 |
| Zimmer, LE | 1 |
| Kubis, JF | 1 |
| Kagan, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study of the Effect of Ozanimod on Fatigue in Multiple Sclerosis Patients[NCT05319093] | 40 participants (Anticipated) | Observational | 2022-04-30 | Not yet recruiting | |||
| Self-Management Program Based on Physical Exercises for People With Multiple Sclerosis With Mild Neurological Impairment: A Randomized Controlled Trial[NCT02607020] | 100 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| A PILOT STUDY OF INTRAVENOUS, SUBANESTHETIC DOSE OF KETAMINE VS PLACEBO, A CROSSOVER DESIGN, FOR MULTIPLE SCLEROSIS RELATED FATIGUE[NCT06064162] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pemoline and Depression
| Article | Year |
|---|---|
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis - a brief review.
Topics: Amantadine; Atrophy; Benzhydryl Compounds; Brain; Clinical Trials as Topic; Cognitive Behavioral The | 2012 |
Fatigue in multiple sclerosis.
Topics: Amantadine; Autoimmune Diseases; Benzhydryl Compounds; Brain; Case Management; Central Nervous Syste | 2001 |
4 trials available for pemoline and Depression
| Article | Year |
|---|---|
The clinical and psychological effects of pemoline in depressed patients--a controlled study.
Topics: Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Female; Humans; Intelligence Tests | 1979 |
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety; Attention Deficit Disorder with Hyperac | 1976 |
Effect of magnesium pemoline and methylphenidate on memory improvement and mood in normal aging subjects.
Topics: Affect; Aged; Anxiety; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Depression; | 1973 |
Clinical trial of pemoline in general practice.
Topics: Adult; Aged; Anxiety; Clinical Trials as Topic; Depression; Family Practice; Fatigue; Female; Humans | 1974 |
2 other studies available for pemoline and Depression
| Article | Year |
|---|---|
Pemoline, depressive symptoms, and escape from dexamethasone suppression.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Depression; Dexamethasone; Humans; Hydroc | 1983 |
Depression following pemoline withdrawal in a hyperactive child.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Depression; Female; Humans; Pemoline; Substanc | 1985 |