pemoline has been researched along with Acute Liver Injury, Drug-Induced in 21 studies
Pemoline: A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
pemoline : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of pemoline-induced autoimmune hepatitis in a 46-yr-old woman who received the drug for management of her multiple sclerosis." | 3.69 | Pemoline-induced autoimmune hepatitis. ( Grace, ND; Kane, M; Sterling, MJ, 1996) |
| " We conclude that pemoline causes toxic liver damage in children." | 2.40 | Pemoline hepatotoxicity in children. ( Marotta, PJ; Roberts, EA, 1998) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "To review the numerous reports of hepatotoxic adverse drug reactions (ADRs) ascribed to pemoline that were sent to the U." | 1.31 | Pemoline hepatotoxicity and postmarketing surveillance. ( Gardner, JE; Safer, DJ; Zito, JM, 2001) |
| "Pemoline (Cylert) is an agent used to treat attention deficit disorders and other behavioral syndromes." | 1.28 | Hepatotoxicity due to pemoline (Cylert): a report of two cases. ( Dubois, RS; Pratt, DS, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Patterson, JF | 1 |
| Sterling, MJ | 1 |
| Kane, M | 1 |
| Grace, ND | 1 |
| McCurry, L | 1 |
| Cronquist, S | 1 |
| Avery, JK | 1 |
| Rosh, JR | 1 |
| Dellert, SF | 1 |
| Narkewicz, M | 1 |
| Birnbaum, A | 1 |
| Whitington, G | 1 |
| Marotta, PJ | 1 |
| Roberts, EA | 1 |
| Safer, DJ | 1 |
| Zito, JM | 1 |
| Gardner, JE | 1 |
| Nehra, A | 1 |
| Mullick, F | 1 |
| Ishak, KG | 1 |
| Zimmerman, HJ | 1 |
| Pratt, DS | 1 |
| Dubois, RS | 1 |
| Elitsur, Y | 1 |
| Jaffe, SL | 1 |
| Gilbert, JG | 1 |
| Donnelly, KJ | 1 |
| Zimmer, LE | 1 |
| Kubis, JF | 1 |
| Markoff, N | 1 |
| Tolman, KG | 1 |
| Freston, JW | 1 |
| Berenson, MM | 1 |
| Sannella, JJ | 1 |
2 reviews available for pemoline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Pemoline hepatotoxicity in children.
Topics: Adolescent; Alkaline Phosphatase; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 1998 |
1 trial available for pemoline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Effect of magnesium pemoline and methylphenidate on memory improvement and mood in normal aging subjects.
Topics: Affect; Aged; Anxiety; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Depression; | 1973 |
18 other studies available for pemoline and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Hepatitis associated with pemoline.
Topics: Chemical and Drug Induced Liver Injury; Child; Humans; Male; Pemoline | 1984 |
Pemoline-induced autoimmune hepatitis.
Topics: Antibodies, Antinuclear; Autoantibodies; Autoimmune Diseases; Central Nervous System Stimulants; Che | 1996 |
Pemoline and hepatotoxicity.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Drug T | 1997 |
Failure to monitor.
Topics: Antidepressive Agents, Tricyclic; Central Nervous System Stimulants; Chemical and Drug Induced Liver | 1997 |
Four cases of severe hepatotoxicity associated with pemoline: possible autoimmune pathogenesis.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autoimmune Diseases; Central Nervous Syst | 1998 |
Pemoline hepatotoxicity and postmarketing surveillance.
Topics: Adolescent; Aged; Aged, 80 and over; Central Nervous System Stimulants; Chemical and Drug Induced Li | 2001 |
Pemoline-associated hepatic injury.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Liver Di | 1990 |
Hepatotoxicity due to pemoline (Cylert): a report of two cases.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans | 1990 |
Pemoline (Cylert)-induced hepatotoxicity.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Female | 1990 |
Pemoline and liver function.
Topics: Attention Deficit Disorder with Hyperactivity; Chemical and Drug Induced Liver Injury; Child; Humans | 1989 |
[New forms of toxic hepatitis. II].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Methyldopa; Pemoline | 1973 |
Hepatotoxicity due to pemoline. Report of two cases.
Topics: Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Inj | 1973 |